KEGG   PATHWAY: ssc04622
Entry
ssc04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Sus scrofa (pig)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
ssc04622  RIG-I-like receptor signaling pathway
ssc04622

Organism
Sus scrofa (pig) [GN:ssc]
Gene
396723  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
100101927  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100624243  ZNFX1; NFX1-type zinc finger-containing protein 1 [KO:K27391]
100037290  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
100524520  DHX58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
100156979  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100156366  TANK; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator [KO:K12650]
100524397  AZI2; 5-azacytidine-induced protein 2 isoform X1 [KO:K12651]
100518628  TBKBP1; TANK-binding kinase 1-binding protein 1 [KO:K12652]
100127355  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100125828  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100519508  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
396656  IRF3; interferon regulatory factor 3 [KO:K05411]
100037289  IRF7; interferon regulatory factor 7 [KO:K09447]
397686  IFNA1; interferon alpha-1 precursor [KO:K05414]
100153724  IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414]
100153661  interferon alpha-14 precursor [KO:K05414]
100157766  IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414]
100152100  IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414]
100152504  IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414]
100310806  IFN-ALPHAOMEGA; interferon-alphaomega precursor [KO:K05414]
100303758  IFN-ALPHA-5; interferon, alpha 5 precursor [KO:K05414]
100157735  IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414]
100153325  interferon alpha-2 precursor [KO:K05414]
100737904  interferon alpha-1-like [KO:K05414]
100154938  IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414]
100156561  IFN-ALPHA-10; interferon-alpha-10 precursor [KO:K05414]
100156936  interferon alpha-11 precursor [KO:K05414]
100157352  IFN-ALPHA-1; interferon-alpha-1 precursor [KO:K05414]
445459  IFNB1; interferon beta precursor [KO:K05415]
100152132  IFN-OMEGA-3; interferon omega 3 precursor [KO:K05440]
100154098  IFN-OMEGA-5; interferon omega 7 precursor [KO:K05440]
100125969  IFNE; interferon epsilon precursor [KO:K05442]
100303725  IFNK; interferon kappa [KO:K05441]
100620340  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
595129  FADD; FAS-associated death domain protein [KO:K02373]
100524751  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
595105  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100154896  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100135662  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100101471  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100621111  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
406188  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
751869  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
100135665  RELA; transcription factor p65 [KO:K04735]
100513840  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100135663  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
396629  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
396617  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
574062  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100156630  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100155841  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
110260605  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
396880  CXCL8; interleukin-8 precursor [KO:K10030]
397086  TNF; tumor necrosis factor [KO:K03156]
397053  IL12A; interleukin-12 subunit alpha [KO:K05406]
397076  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
494019  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
100523784  ADAR; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase [KO:K12968] [EC:3.5.4.37]
100622285  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
100624570  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
100517591  RNF125; E3 ubiquitin-protein ligase RNF125 isoform X1 [KO:K12170] [EC:2.3.2.27]
100145895  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100739102  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
100462745  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
100518678  NLRX1; NLR family member X1 [KO:K12653]
100217389  TMEM173; stimulator of interferon genes protein [KO:K12654]
100624053  OTUD5; OTU domain-containing protein 5 isoform X2 [KO:K12655] [EC:3.4.19.12]
100156436  SIKE1; suppressor of IKBKE 1 [KO:K12656]
100515940  DDX3X; ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
100624590  ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
100512827  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
100520121  TKFC; triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
ssc04010  MAPK signaling pathway
ssc04120  Ubiquitin mediated proteolysis
ssc04210  Apoptosis
ssc04630  JAK-STAT signaling pathway
KO pathway
ko04622   
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