KEGG   PATHWAY: tben04350
Entry
tben04350                   Pathway                                
Name
TGF-beta signaling pathway - Trematomus bernacchii (emerald rockcod)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
tben04350  TGF-beta signaling pathway
tben04350

Other DBs
GO: 0007179
Organism
Trematomus bernacchii (emerald rockcod) [GN:tben]
Gene
117468630  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117469372  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
117469456  inhbab; inhibin subunit beta Ab [KO:K04667]
117469691  lrrc32; transforming growth factor beta activator LRRC32 [KO:K26316]
117470036  [KO:K04688] [EC:2.7.11.1]
117470084  ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
117470339  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
117470349  bmp16; bone morphogenetic protein 16 [KO:K21283]
117470654  [KO:K04501]
117470704  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
117470712  [KO:K04388] [EC:2.7.11.30]
117471062  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
117471175  [KO:K23605]
117471236  [KO:K04682]
117471319  fbn1; fibrillin-1 [KO:K06825]
117471362  [KO:K11644]
117471464  neo1a; LOW QUALITY PROTEIN: neogenin 1a [KO:K06766]
117471526  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
117471828  [KO:K04677]
117472040  [KO:K04377]
117472229  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117472399  bmpr1ba; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
117472566  [KO:K14736]
117472631  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117472678  [KO:K14736]
117472912  [KO:K04501]
117472958  [KO:K06067] [EC:3.5.1.98]
117472996  [KO:K04382] [EC:3.1.3.16]
117473128  fsta; follistatin-A isoform X1 [KO:K04661]
117473472  nog2; noggin-2 [KO:K04658]
117473540  ndr2; nodal-related 2 [KO:K04666]
117474575  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
117474825  adamtsl7; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
117475017  [KO:K26316]
117475080  [KO:K04382] [EC:3.1.3.16]
117475137  smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
117475331  [KO:K16621]
117475534  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
117475720  [KO:K13596] [EC:2.7.11.30]
117475773  [KO:K04667]
117475968  rgmb; RGM domain family member B [KO:K06847]
117476002  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
117476272  bmpr1bb; LOW QUALITY PROTEIN: bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
117476375  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
117476483  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
117476499  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
117476612  [KO:K16857]
117476798  ndr1; nodal-related 1 [KO:K04666]
117477152  chrd; chordin [KO:K04657]
117477830  bmp8a; bone morphogenetic protein 8A [KO:K16622]
117477914  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
117478025  [KO:K04388] [EC:2.7.11.30]
117478113  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117478356  gdf6b; growth/differentiation factor 6-B [KO:K20012]
117478883  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117479100  bmp4; bone morphogenetic protein 4 [KO:K04662]
117479211  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117479582  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
117479605  fmodb; fibromodulin [KO:K08121]
117479973  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117480485  gdf6a; growth/differentiation factor 6-A [KO:K20012]
117480496  [KO:K23106]
117481007  [KO:K04683]
117481437  [KO:K04678] [EC:2.3.2.26]
117482019  [KO:K04678] [EC:2.3.2.26]
117482168  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
117482309  grem1b; gremlin-1 [KO:K23318]
117482390  smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
117482883  [KO:K06067] [EC:3.5.1.98]
117483095  [KO:K04688] [EC:2.7.11.1]
117483143  lemd3; inner nuclear membrane protein Man1 [KO:K19410]
117483687  [KO:K04513]
117484063  bmp6; bone morphogenetic protein 6 [KO:K16620]
117484109  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
117484151  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
117484615  [KO:K21283]
117484765  [KO:K04500]
117484966  dcn; decorin [KO:K04660]
117484998  [KO:K28359]
117485732  [KO:K13568] [EC:2.7.11.30]
117485984  [KO:K04675] [EC:2.7.11.30]
117485989  inhbb; inhibin beta B chain [KO:K22687]
117486205  [KO:K04670] [EC:2.7.11.30]
117486404  [KO:K04498] [EC:2.3.1.48]
117486411  [KO:K04498] [EC:2.3.1.48]
117486546  fmoda; fibromodulin a [KO:K08121]
117486569  rbl1; retinoblastoma-like protein 1 [KO:K04681]
117486811  [KO:K22687]
117486927  grem1a; gremlin-1a [KO:K23318]
117486952  thbs1b; thrombospondin-1 [KO:K16857]
117487154  gdf5; growth/differentiation factor 5 [KO:K04664]
117487208  [KO:K04673] [EC:2.7.11.30]
117488601  tfa; transferrin-a isoform X1 [KO:K14736]
117488708  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
117488821  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117488822  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
117489039  tmem53; transmembrane protein 53 [KO:K28359]
117489412  [KO:K22687]
117489446  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
117489580  [KO:K13567] [EC:2.7.11.30]
117489628  si:dkey-264d12.4; epithelial membrane protein 3 [KO:K26257]
117489745  skib; v-ski avian sarcoma viral oncogene homolog b [KO:K26503]
117490008  [KO:K04513]
117490009  nbl1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
117490709  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
117490736  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117490737  skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
117491003  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
117491408  smad6b; mothers against decapentaplegic homolog 6b [KO:K04677]
117491556  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
117491728  si:dkey-5i3.5; transmembrane protein 53-A isoform X1 [KO:K28359]
117491752  e2f4; transcription factor E2F4 [KO:K04682]
117491956  rgma; repulsive guidance molecule A [KO:K23096]
117492196  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117492467  [KO:K04498] [EC:2.3.1.48]
117492634  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117492771  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117492884  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
117493207  acvr1l; LOW QUALITY PROTEIN: activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
117493281  nog1; noggin-1 [KO:K04658]
117493459  [KO:K13377]
117494089  [KO:K04513]
117494090  [KO:K04513]
117494127  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117494265  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
117494347  [KO:K26257]
117494349  myca; transcriptional regulator Myc-A [KO:K04377]
117494699  skia; v-ski avian sarcoma viral oncogene homolog a [KO:K26503]
117495189  zfyve9b; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9 [KO:K04679]
117495244  rgmd; RGM domain family, member D [KO:K23096]
117495257  amh; muellerian-inhibiting factor [KO:K04665]
117495941  [KO:K03347]
117496075  tfr1b; transferrin receptor 1b [KO:K06503]
117496685  [KO:K23377]
117496701  [KO:K04681]
117496743  [KO:K04671] [EC:2.7.11.30]
117496815  spaw; southpaw [KO:K04666]
117497282  tgif1; LOW QUALITY PROTEIN: homeobox protein TGIF1 [KO:K19383]
117497318  sin3aa; SIN3 transcription regulator family member Aa isoform X1 [KO:K11644]
117497400  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
117498305  lft1; lefty1 [KO:K04668]
117498361  bmp2b; bone morphogenetic protein 2b [KO:K21283]
117498924  [KO:K04671] [EC:2.7.11.30]
117499473  bmp5; bone morphogenetic protein 5 [KO:K04663]
117499518  [KO:K23318]
117500078  admp; anti-dorsalizing morphogenic protein [KO:K21283]
117500142  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
117500196  skila; LOW QUALITY PROTEIN: ski-like protein [KO:K18499]
117500214  zfyve9a; zinc finger FYVE domain-containing protein 9 [KO:K04679]
117500311  acvr2ba; LOW QUALITY PROTEIN: activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
117500462  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
117500507  hamp; hepcidin-1 [KO:K23106]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
tben04010  MAPK signaling pathway
tben04110  Cell cycle
tben04120  Ubiquitin mediated proteolysis
tben04210  Apoptosis
KO pathway
ko04350   

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