KEGG   PATHWAY: tben04010
Entry
tben04010                   Pathway                                
Name
MAPK signaling pathway - Trematomus bernacchii (emerald rockcod)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tben04010  MAPK signaling pathway
tben04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Trematomus bernacchii (emerald rockcod) [GN:tben]
Gene
117468490  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117468561  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117468630  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117468761  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
117468825  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117468872  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
117469240  rras; ras-related protein R-Ras [KO:K07830]
117469261  si:ch211-195b15.8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117469266  [KO:K16342] [EC:3.1.1.4]
117469267  [KO:K16342] [EC:3.1.1.4]
117469485  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
117469588  [KO:K04526]
117469598  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117469987  rasa2; ras GTPase-activating protein 2 [KO:K08053]
117470072  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
117470147  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117470163  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
117470228  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117470326  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
117470331  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
117470402  relb; transcription factor RelB homolog isoform X1 [KO:K09253]
117470704  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
117470712  [KO:K04388] [EC:2.7.11.30]
117470767  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
117470913  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117470937  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
117471062  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
117471063  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117471105  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
117471125  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117471140  [KO:K08052]
117471174  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
117471195  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117471209  [KO:K04434]
117471343  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
117471480  [KO:K04349]
117471504  rras2; ras-related protein R-Ras2 [KO:K07830]
117471526  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
117471609  fosaa; proto-oncogene c-Fos [KO:K04379]
117471613  bdnf; brain-derived neurotrophic factor [KO:K04355]
117471614  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117471647  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117471724  vegfd; vascular endothelial growth factor D [KO:K05449]
117471833  fgf7; fibroblast growth factor 7 [KO:K04358]
117472040  [KO:K04377]
117472121  hspa8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
117472213  [KO:K17386]
117472229  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117472343  [KO:K09784]
117472510  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117472589  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
117472602  fgf5; fibroblast growth factor 5 [KO:K04358]
117472626  [KO:K04352]
117472631  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117472716  efna5b; ephrin-A5b isoform X1 [KO:K05462]
117472725  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117472775  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
117472809  [KO:K03173] [EC:2.3.2.27]
117472832  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
117472851  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
117472853  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117472981  [KO:K05452]
117473020  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117473043  fgf10b; fibroblast growth factor 10b [KO:K04358]
117473092  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
117473213  [KO:K04519]
117473251  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
117473334  [KO:K04392]
117473340  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
117473417  [KO:K04467] [EC:2.7.11.10]
117473439  fgf21; fibroblast growth factor 21 [KO:K22429]
117473473  [KO:K04350]
117473494  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117473506  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
117473515  [KO:K04466] [EC:2.7.11.25]
117473547  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117473618  rac3b; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117473694  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117473856  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117473885  ngfrb; nerve growth factor receptor b [KO:K02583]
117474098  [KO:K04380]
117474460  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117474545  [KO:K04870]
117474546  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117474614  [KO:K04345] [EC:2.7.11.11]
117474698  [KO:K04869]
117474727  [KO:K04358]
117474730  fgf8b; fibroblast growth factor 8b [KO:K04358]
117474756  [KO:K04866]
117474771  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117474903  [KO:K05449]
117475092  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117475117  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117475136  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117475166  [KO:K02187] [EC:3.4.22.56]
117475181  fgf20b; fibroblast growth factor 20b [KO:K04358]
117475204  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117475213  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
117475214  fgf16; fibroblast growth factor 16 [KO:K04358]
117475232  insb; preproinsulin b [KO:K04526]
117475265  [KO:K04348] [EC:3.1.3.16]
117475456  cdc42; cell division control protein 42 homolog [KO:K04393]
117475496  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
117475499  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
117475661  [KO:K04411]
117475749  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117475884  [KO:K12362]
117476053  [KO:K16342] [EC:3.1.1.4]
117476075  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117476294  [KO:K03283]
117476315  fgf10a; fibroblast growth factor 10a [KO:K04358]
117476319  [KO:K03173] [EC:2.3.2.27]
117476469  crkl; crk-like protein [KO:K04438]
117476520  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117476522  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117476691  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117476714  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
117476825  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117476831  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117476832  [KO:K04455]
117477017  crk; adapter molecule crk [KO:K04438]
117477467  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
117477523  angpt2b; angiopoietin-2b [KO:K05466]
117477657  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
117477666  efna3a; ephrin-A3 [KO:K05462]
117477910  daxx; death domain-associated protein 6 [KO:K02308]
117477931  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
117478019  [KO:K04393]
117478025  [KO:K04388] [EC:2.7.11.30]
117478105  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
117478113  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117478258  [KO:K04871]
117478266  efna1a; ephrin-A1a isoform X1 [KO:K05462]
117478284  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
117478427  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
117478437  [KO:K04873]
117478438  [KO:K04381]
117478541  [KO:K18019] [EC:3.1.3.48]
117478737  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
117478923  pgfb; placenta growth factor [KO:K16859]
117478925  [KO:K05462]
117478959  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
117478976  [KO:K04402]
117479039  cacna1bb; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
117479479  map3k12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
117479493  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117479534  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117479549  [KO:K04443] [EC:2.7.11.1]
117479567  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
117479802  [KO:K04861]
117479862  [KO:K17333]
117479971  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117480108  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
117480109  cacng7b; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
117480164  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117480247  fgf4; fibroblast growth factor 4 [KO:K04358]
117480271  fgf3; fibroblast growth factor 3 [KO:K04358]
117480280  fgf19; fibroblast growth factor 19 [KO:K22603]
117480296  [KO:K03283]
117480333  efna1b; ephrin-A1b [KO:K05462]
117480431  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117480520  stmn1b; stathmin 1b [KO:K04381]
117480678  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
117480724  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117480745  efna3b; ephrin-A3b [KO:K05462]
117480752  [KO:K04446]
117481165  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117481257  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117481352  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117481427  map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
117481609  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117481636  [KO:K19662] [EC:2.7.11.13]
117481651  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
117481679  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
117481793  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
117481798  [KO:K04453]
117481856  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117481999  [KO:K25416]
117482107  cacna1ab; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
117482205  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117482305  [KO:K04868]
117482565  [KO:K02580]
117482623  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
117482676  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117482710  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
117483159  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117483241  ntf3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
117483247  [KO:K05461]
117483422  [KO:K04393]
117483428  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117483598  fgf8a; fibroblast growth factor 8 [KO:K04358]
117483619  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b [KO:K04430] [EC:2.7.12.2]
117483801  [KO:K04723]
117483869  elk1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
117484309  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
117484386  [KO:K04359]
117484444  [KO:K04434]
117484613  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
117484832  [KO:K04358]
117484877  cacna1c; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
117484878  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
117484974  [KO:K04858]
117485067  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
117485078  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
117485084  fgf23; fibroblast growth factor 23 [KO:K22428]
117485247  fgf2; fibroblast growth factor 2 [KO:K18497]
117485259  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
117485380  fgf18a; fibroblast growth factor 18a [KO:K04358]
117485435  [KO:K04358]
117485672  [KO:K05085] [EC:2.7.10.1]
117485800  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
117485831  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117485835  fgf9; fibroblast growth factor 4A [KO:K04358]
117486395  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117486461  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
117486509  dusp7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117486523  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117486666  [KO:K04361] [EC:2.7.10.1]
117486741  [KO:K04427] [EC:2.7.11.25]
117486774  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
117486884  [KO:K04441] [EC:2.7.11.24]
117486910  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117486921  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117486937  max; protein max isoform X1 [KO:K04453]
117486939  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117486940  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117487096  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117487113  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
117487131  [KO:K07836]
117487201  [KO:K06268]
117487249  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117487521  nr4a1; LOW QUALITY PROTEIN: nuclear receptor subfamily 4 group A member 1 [KO:K04465]
117487559  [KO:K04852]
117487652  fgf17; fibroblast growth factor 17 [KO:K04358]
117487710  [KO:K12361]
117487719  rela; transcription factor p65 isoform X1 [KO:K04735]
117487764  [KO:K04419] [EC:2.7.11.25]
117487826  cd40lg; CD40 ligand [KO:K04389]
117487849  [KO:K04348] [EC:3.1.3.16]
117488086  tp53; cellular tumor antigen p53 [KO:K04451]
117488280  [KO:K04424] [EC:2.7.11.25]
117488445  [KO:K04449]
117488453  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117488653  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117488687  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
117488699  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117488707  vegfba; vascular endothelial growth factor A [KO:K05448]
117488775  [KO:K04448]
117488821  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117488891  cacna1eb; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
117488900  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
117488942  [KO:K25415]
117489024  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117489256  arrb1; beta-arrestin-1 [KO:K04439]
117489355  tgfa; protransforming growth factor alpha [KO:K08774]
117489464  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
117489480  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
117489544  [KO:K04353]
117489575  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
117489662  [KO:K04423] [EC:2.7.11.25]
117489733  [KO:K04851]
117489744  epha2a; ephrin type-A receptor 2a isoform X1 [KO:K05103] [EC:2.7.10.1]
117489784  ngfb; nerve growth factor [KO:K02582]
117489854  [KO:K04444] [EC:2.7.11.1]
117489860  [KO:K04860]
117489883  [KO:K04465]
117489915  [KO:K04348] [EC:3.1.3.16]
117489956  [KO:K04859]
117490067  [KO:K04438]
117490136  [KO:K04429] [EC:2.7.11.1]
117490519  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117490686  [KO:K05089] [EC:2.7.10.1]
117490687  [KO:K05090] [EC:2.7.10.1]
117490778  [KO:K18496]
117490797  [KO:K04348] [EC:3.1.3.16]
117490930  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117490963  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117491000  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117491053  rapgef2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
117491093  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117491207  [KO:K05460]
117491237  [KO:K04858]
117491315  kras; GTPase KRas isoform X1 [KO:K07827]
117491364  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117491445  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117491463  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117491476  igf2b; insulin-like growth factor 2b [KO:K13769]
117491568  egf; pro-epidermal growth factor [KO:K04357]
117491576  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117491609  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
117491619  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117491654  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117491741  [KO:K22428]
117491789  [KO:K04358]
117491954  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117492091  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117492196  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117492260  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
117492273  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117492277  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117492278  [KO:K03283]
117492288  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117492302  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117492333  [KO:K19662] [EC:2.7.11.13]
117492529  [KO:K04430] [EC:2.7.12.2]
117492572  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117492616  atf4b; activating transcription factor 4b [KO:K04374]
117492626  [KO:K04433] [EC:2.7.12.2]
117492635  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117492642  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117492676  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
117492706  zgc:55558; GTPase HRas [KO:K07827]
117492927  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
117493041  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117493073  cacna1ha; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
117493227  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
117493285  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117493327  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117493329  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117493330  [KO:K04347]
117493337  [KO:K04866]
117493415  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
117493459  [KO:K13377]
117493503  [KO:K04869]
117493507  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117493783  [KO:K04410] [EC:2.7.11.1]
117493790  efna2a; ephrin-A2 isoform X1 [KO:K05462]
117493890  rps6ka5; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
117493994  cacna1sb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
117493999  [KO:K04857]
117494031  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117494080  ngfa; neurotrophin-7 [KO:K02582]
117494117  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117494176  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117494227  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
117494285  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
117494293  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117494336  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117494349  myca; transcriptional regulator Myc-A [KO:K04377]
117494350  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117494408  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117494474  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
117494671  nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
117494692  flna; filamin-A isoform X1 [KO:K04437]
117494701  [KO:K05459]
117494748  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117494784  cdc42l; cell division cycle 42, like [KO:K04393]
117494858  flt3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117494946  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117494993  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117495114  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117495115  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
117495205  mknk1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
117495272  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117495277  fgf22; fibroblast growth factor 22 [KO:K04358]
117495402  [KO:K04407] [EC:2.7.11.1]
117495460  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
117495553  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117495567  [KO:K04386]
117495568  [KO:K04386]
117495604  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
117495666  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117495753  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117495771  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117495950  flt1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117496009  [KO:K25415]
117496095  jun; transcription factor AP-1 [KO:K04448]
117496098  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
117496176  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117496223  [KO:K04449]
117496225  [KO:K04402]
117496521  [KO:K04867]
117496522  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
117496540  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117496834  cacnb2a; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-2a [KO:K04863]
117497008  [KO:K05087] [EC:2.7.10.1]
117497226  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117497237  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117497254  kitlga; kit ligand a [KO:K05461]
117497595  arrb2b; arrestin, beta 2b [KO:K04439]
117497746  [KO:K05462]
117497754  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
117498045  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117498309  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117498380  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117498500  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
117498859  [KO:K04407] [EC:2.7.11.1]
117498986  [KO:K04409] [EC:2.7.11.1]
117499132  [KO:K05449]
117499194  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117499242  [KO:K04865]
117499247  [KO:K05085] [EC:2.7.10.1]
117499411  [KO:K04390]
117499412  [KO:K04390]
117499461  [KO:K04467] [EC:2.7.11.10]
117499472  angpt2a; angiopoietin-2a [KO:K05466]
117499529  [KO:K04406] [EC:2.7.11.1]
117499570  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117499592  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117499595  srfb; serum response factor b isoform X1 [KO:K04378]
117499604  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117499618  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
117499620  rps6ka4; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
117499637  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117499663  hspb1; heat shock protein beta-1 [KO:K04455]
117499747  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117499883  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
117500007  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
117500262  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
117500286  [KO:K25414]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tben04070  Phosphatidylinositol signaling system
tben04110  Cell cycle
tben04115  p53 signaling pathway
tben04210  Apoptosis
tben04310  Wnt signaling pathway
KO pathway
ko04010   

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