KEGG   PATHWAY: umr04150
Entry
umr04150                    Pathway                                
Name
mTOR signaling pathway - Ursus maritimus (polar bear)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
umr04150  mTOR signaling pathway
umr04150

Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103673948  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
103678209  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
103663674  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
103678812  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103676707  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
103671376  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
103661526  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
103660482  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
103671988  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
103675697  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103671228  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
103676644  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
103657687  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
103682324  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X4 [KO:K02152]
103670393  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
103677423  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
103678016  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
103668690  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
103677931  LAMTOR3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
103682474  ragulator complex protein LAMTOR3-like [KO:K04370]
103670017  LAMTOR4; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399]
103675016  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
103658481  FLCN; folliculin [KO:K09594]
103670568  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
103658106  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
103662161  RRAGA; ras-related GTP-binding protein A [KO:K16185]
103674304  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
103660167  RRAGD; ras-related GTP-binding protein D [KO:K16186]
103666359  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
103666492  SESN2; sestrin-2 [KO:K20394]
103681109  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
103670235  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
103658763  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
103673354  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
103668743  WDR24; GATOR complex protein WDR24 [KO:K20408]
103662060  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
103669559  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
103681077  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
103674793  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
103668442  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
103664708  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103675951  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
103665983  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103657265  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
103666660  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103661666  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
103668783  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
103668767  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
103669771  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
103661153  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X3 [KO:K10421]
103674552  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
103662669  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
103665286  LPIN1; phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
103669890  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
103678902  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
103658551  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
103659121  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103662668  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
103663057  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
103677918  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103664763  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
103679516  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103667329  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103675517  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
103662156  RPS6; 40S ribosomal protein S6 [KO:K02991]
103675232  40S ribosomal protein S6-like [KO:K02991]
103668888  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
121101028  40S ribosomal protein S6-like [KO:K02991]
103665631  STRADA; STE20-related kinase adapter protein alpha isoform X2 [KO:K08271]
103659745  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
103681779  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
103662686  CAB39; calcium-binding protein 39 [KO:K08272]
103677613  CAB39L; calcium-binding protein 39-like [KO:K08272]
103670673  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
103664677  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103670250  TSC1; hamartin [KO:K07206]
103668779  TSC2; tuberin isoform X1 [KO:K07207]
103664904  TBC1D7; TBC1 domain family member 7 [KO:K20396]
103660943  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
103667808  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
103675620  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103675048  WNT2B; protein Wnt-2b [KO:K00182]
103676588  WNT2; protein Wnt-2 [KO:K00182]
103678870  WNT3A; protein Wnt-3a [KO:K00312]
103665889  WNT3; proto-oncogene Wnt-3 [KO:K00312]
103666795  WNT4; protein Wnt-4 isoform X2 [KO:K00408]
103675062  WNT5A; protein Wnt-5a [KO:K00444]
103675761  WNT5B; protein Wnt-5b [KO:K00444]
103674134  protein Wnt-7b isoform X1 [KO:K00572]
103669629  protein Wnt-7a [KO:K00572]
103658927  WNT8B; protein Wnt-8b [KO:K00714]
103663793  WNT8A; protein Wnt-8a [KO:K00714]
103678871  WNT9A; protein Wnt-9a [KO:K01064]
103662888  WNT10A; protein Wnt-10a [KO:K01357]
103675619  WNT10B; protein Wnt-10b [KO:K01357]
103678127  WNT11; LOW QUALITY PROTEIN: protein Wnt-11 [KO:K01384]
103676602  WNT16; protein Wnt-16 [KO:K01558]
103658791  FZD1; frizzled-1 [KO:K02432]
103659948  FZD7; LOW QUALITY PROTEIN: frizzled-7 [KO:K02432]
103665868  FZD2; frizzled-2 [KO:K02235]
103675953  FZD3; frizzled-3 [KO:K02329]
103675375  FZD4; frizzled-4 [KO:K02354]
103659958  FZD5; frizzled-5 [KO:K02375]
121106331  FZD8; frizzled-8 [KO:K02375]
103661527  FZD6; frizzled-6 [KO:K02376]
103661238  FZD10; frizzled-10 [KO:K02842]
103670220  FZD9; frizzled-9 [KO:K02842]
103677754  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
103679626  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
103660462  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
103682075  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
103676184  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103682322  TNF; tumor necrosis factor [KO:K03156]
103656234  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121099769  INS; insulin [KO:K04526]
103676495  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103676308  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103660044  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103665736  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103671891  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103665409  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103669173  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K02833]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103669422  NRAS; GTPase NRas [KO:K07828]
103669103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103660807  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
103668171  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103666515  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103671984  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103662712  IRS1; insulin receptor substrate 1 [KO:K16172]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103661921  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103668498  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103670320  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X4 [KO:K20410]
103664688  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
103659306  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
121104446  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103668895  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103672914  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103663385  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
umr00561  Glycerolipid metabolism
umr04010  MAPK signaling pathway
umr04140  Autophagy - animal
umr04151  PI3K-Akt signaling pathway
umr04152  AMPK signaling pathway
umr04810  Regulation of actin cytoskeleton
umr04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system