KEGG   PATHWAY: umr04151
Entry
umr04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Ursus maritimus (polar bear)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
umr04151  PI3K-Akt signaling pathway
umr04151

Other DBs
GO: 0043491
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656186  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103656210  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
103656231  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103656237  VWF; von Willebrand factor isoform X1 [KO:K03900]
103656511  ITGB1; integrin beta-1 [KO:K05719]
103656694  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103656761  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103656765  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
103656869  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
103656923  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103656927  [KO:K05084] [EC:2.7.10.1]
103657071  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103657101  FGF21; fibroblast growth factor 21 [KO:K22429]
103657110  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
103657113  NTF4; LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
103657125  FLT3LG; LOW QUALITY PROTEIN: fms-related tyrosine kinase 3 ligand [KO:K05454]
103657330  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X5 [KO:K03456]
103657380  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
103657624  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103657625  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
103657802  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103657814  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103657902  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
103658031  [KO:K10159]
103658054  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
103658340  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
103658377  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
103658669  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
103658731  [KO:K04548]
103658734  [KO:K04546]
103658736  COL1A2; collagen alpha-2(I) chain [KO:K06236]
103658774  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
103658796  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103658814  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
103658858  ITGB8; integrin beta-8 [KO:K06591]
103658871  IL6; interleukin-6 [KO:K05405]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103658932  [KO:K09047]
103658995  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103659105  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103659121  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103659146  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103659279  MTCP1; protein p13 MTCP-1 [KO:K16837]
103659367  BDNF; brain-derived neurotrophic factor [KO:K04355]
103659497  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103659532  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
103659593  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103659636  ITGA4; integrin alpha-4 [KO:K06483]
103659655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
103659802  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103659892  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103659965  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103660044  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103660144  KITLG; LOW QUALITY PROTEIN: kit ligand [KO:K05461]
103660368  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103660496  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103660497  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103660550  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
103660572  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103660581  [KO:K06240]
103660792  THBS2; thrombospondin-2 [KO:K04659]
103660943  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
103660945  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
103660958  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103660962  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
103661017  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661328  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
103661362  IL7; interleukin-7 [KO:K05431]
103661444  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
103661509  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
103661546  ANGPT1; angiopoietin-1 [KO:K05465]
103661560  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103661676  CSF3; granulocyte colony-stimulating factor [KO:K05423]
103661697  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103661742  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
103661804  IL2; interleukin-2 [KO:K05429]
103661850  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103661898  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103661921  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103662147  [KO:K05414]
103662148  [KO:K05414]
103662149  [KO:K05414]
103662150  IFNB1; interferon beta [KO:K05415]
103662156  RPS6; 40S ribosomal protein S6 [KO:K02991]
103662531  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103662543  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103662668  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
103662712  IRS1; insulin receptor substrate 1 [KO:K16172]
103662788  FN1; fibronectin isoform X1 [KO:K05717]
103662830  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
103662858  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
103662859  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103662926  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
103662965  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103663028  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103663057  [KO:K03259]
103663059  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103663109  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103663192  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103663212  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
103663361  [KO:K04545]
103663385  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
103663498  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
103663512  LAMA2; laminin subunit alpha-2 [KO:K05637]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103663691  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103663709  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103663832  IL4; interleukin-4 [KO:K05430]
103664050  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103664092  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
103664148  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103664157  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
103664242  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
103664292  FGF9; fibroblast growth factor 9 [KO:K04358]
103664318  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103664410  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103664454  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103664600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103664603  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
103664633  ITGA2; integrin alpha-2 [KO:K06481]
103664645  FGF10; fibroblast growth factor 10 [KO:K04358]
103664656  LAMA1; laminin subunit alpha-1 [KO:K05637]
103664663  GHR; growth hormone receptor isoform X1 [KO:K05080]
103664677  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103664690  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
103664716  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
103664719  PRLR; prolactin receptor [KO:K05081]
103664763  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
103664781  FGF18; fibroblast growth factor 18 [KO:K04358]
103664837  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103664851  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103664853  LAMA3; laminin subunit alpha-3 [KO:K06240]
103665227  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103665316  AREG; amphiregulin [KO:K09782]
103665349  FGF5; fibroblast growth factor 5 [KO:K04358]
103665393  EREG; proepiregulin [KO:K09784]
103665409  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103665536  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103665582  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
103665592  ITGA2B; integrin alpha-IIb [KO:K06476]
103665736  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103665746  ITGB4; integrin beta-4 [KO:K06525]
103665892  ITGB3; integrin beta-3 [KO:K06493]
103665901  [KO:K05438]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103665983  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103666113  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103666328  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
103666330  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
103666378  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
103666628  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
103666660  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103666834  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103666985  [KO:K05414]
103667004  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103667087  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
103667175  [KO:K06630]
103667232  VTN; vitronectin [KO:K06251]
103667329  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103667498  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
103667602  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
103667631  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
103667808  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
103668071  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103668115  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103668144  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
103668378  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
103668409  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103668413  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
103668461  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103668498  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103668704  EFNA1; ephrin-A1 [KO:K05462]
103668705  EFNA4; ephrin-A4 [KO:K05462]
103668717  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
103668779  TSC2; tuberin isoform X1 [KO:K07207]
103668783  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
103668888  [KO:K02991]
103668926  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
103668927  [KO:K06237]
103669052  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
103669054  CHRM2; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M2 [KO:K04130]
103669173  [KO:K02833]
103669282  TNN; tenascin-N [KO:K06252]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103669293  TNR; tenascin-R [KO:K06252]
103669422  NRAS; GTPase NRas [KO:K07828]
103669449  NGF; beta-nerve growth factor [KO:K02582]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103669726  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
103669748  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
103670041  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103670054  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103670120  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
103670210  YWHAG; 14-3-3 protein gamma [KO:K16198]
103670250  TSC1; hamartin [KO:K07206]
103670382  TLR4; toll-like receptor 4 [KO:K10160]
103670411  LAMC3; laminin subunit gamma-3 [KO:K06247]
103670437  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
103670500  TNC; tenascin [KO:K06252]
103670504  [KO:K04736]
103670589  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103670673  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103670947  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103671056  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
103671076  PGF; placenta growth factor isoform X1 [KO:K16859]
103671137  FGF3; fibroblast growth factor 3 [KO:K04358]
103671138  FGF19; fibroblast growth factor 19 [KO:K22603]
103671139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103671504  BCL2L11; bcl-2-like protein 11 isoform X8 [KO:K16341]
103671814  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
103671891  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103672380  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103672393  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103672470  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103672489  LAMB3; laminin subunit beta-3 [KO:K06244]
103672510  LAMC2; laminin subunit gamma-2 [KO:K06246]
103672511  LAMC1; laminin subunit gamma-1 [KO:K05635]
103672592  G6PC1; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
103672599  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
103672737  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103672740  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
103672804  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103672837  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103673110  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
103673220  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
103673291  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
103673325  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103673473  THBS1; thrombospondin-1 [KO:K16857]
103673589  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
103673653  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
103673796  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103674284  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
103674345  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
103674493  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
103674619  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
103674633  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
103674660  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103674704  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
103674717  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
103674931  [KO:K04659]
103675032  YWHAQ; 14-3-3 protein theta [KO:K16197]
103675103  LAMB2; laminin subunit beta-2 [KO:K06243]
103675138  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103675167  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
103675205  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
103675232  [KO:K02991]
103675428  COL2A1; collagen alpha-1(II) chain [KO:K19719]
103675500  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103675517  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
103675667  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
103675680  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
103675743  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103675745  FGF23; fibroblast growth factor 23 [KO:K22428]
103675746  FGF6; fibroblast growth factor 6 [KO:K04358]
103675807  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
103675824  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103675826  FGF16; fibroblast growth factor 16 [KO:K04358]
103675835  FOXO3; forkhead box protein O3 [KO:K09408]
103676121  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103676164  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
103676186  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
103676245  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
103676308  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103676372  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103676409  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
103676491  HSP90B1; endoplasmin [KO:K09487]
103676495  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103676520  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103676585  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103676724  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103676755  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103676930  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103676958  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103676964  [KO:K06253]
103676980  LAMA4; laminin subunit alpha-4 [KO:K06241]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103677485  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
103677601  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103677760  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103677885  SPP1; osteopontin isoform X1 [KO:K06250]
103677918  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103677947  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103678196  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103678244  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103678373  PRL; prolactin [KO:K05439]
103678405  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103678568  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103678657  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103678709  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
103678724  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103678821  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
103678867  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103679149  ITGA11; integrin alpha-11 [KO:K06587]
103679274  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
103679288  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
103679375  VEGFC; vascular endothelial growth factor C [KO:K05449]
103679423  BAD; bcl2-associated agonist of cell death [KO:K02158]
103679434  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
103679516  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103679547  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103679584  RELA; transcription factor p65 [KO:K04735]
103679680  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103679944  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103680018  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103680385  [KO:K05414]
103680386  [KO:K05414]
103680680  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103680734  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103680775  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
103681110  OSM; oncostatin-M isoform X1 [KO:K05418]
103681113  YWHAH; 14-3-3 protein eta [KO:K16198]
103681372  FGF20; fibroblast growth factor 20 [KO:K04358]
103681497  THBS4; thrombospondin-4 [KO:K04659]
103681653  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
103681664  [KO:K16197]
103681679  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103681779  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
103681822  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
103681833  [KO:K06238]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103682042  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
103682158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
103682181  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
103682282  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103682333  TNXB; tenascin-X [KO:K06252]
103682402  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103682503  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103682591  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
121099769  INS; insulin [KO:K04526]
121100753  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121101028  [KO:K02991]
121102101  [KO:K25415]
121102439  PSPN; persephin [KO:K25416]
121102598  FGF22; fibroblast growth factor 22 [KO:K04358]
121103043  [KO:K05414]
121103680  EFNA3; ephrin-A3 [KO:K05462]
121104719  FGF4; fibroblast growth factor 4 [KO:K04358]
121105017  CHAD; chondroadherin [KO:K06248]
121105172  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
umr00010  Glycolysis / Gluconeogenesis
umr04010  MAPK signaling pathway
umr04012  ErbB signaling pathway
umr04062  Chemokine signaling pathway
umr04064  NF-kappa B signaling pathway
umr04068  FoxO signaling pathway
umr04110  Cell cycle
umr04115  p53 signaling pathway
umr04150  mTOR signaling pathway
umr04210  Apoptosis
umr04370  VEGF signaling pathway
umr04510  Focal adhesion
umr04620  Toll-like receptor signaling pathway
umr04630  JAK-STAT signaling pathway
umr04662  B cell receptor signaling pathway
umr04910  Insulin signaling pathway
KO pathway
ko04151   

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