KEGG   PATHWAY: xla04350
Entry
xla04350                    Pathway                                
Name
TGF-beta signaling pathway - Xenopus laevis (African clawed frog)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
xla04350  TGF-beta signaling pathway
xla04350

Other DBs
GO: 0007179
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
398045  chrd.1.S; chordin precursor [KO:K04657]
108716939  chrd.1.L; chordin-like [KO:K04657]
108716188  chrd.2.L; chordin-like [KO:K04657]
373646  nog.L; noggin precursor [KO:K04658]
503510  nog2.L; noggin 2 L homeolog precursor [KO:K04658]
108703173  nog2.S; noggin-2 [KO:K04658]
108704141  nog.S; noggin-like [KO:K04658]
108697874  nbl1.S; neuroblastoma suppressor of tumorigenicity 1-like [KO:K19558]
373697  nbl1.L; neuroblastoma suppressor of tumorigenicity 1 precursor [KO:K19558]
399094  grem1.L; gremlin-1 precursor [KO:K23318]
379508  thbs1.L; thrombospondin 1 L homeolog precursor [KO:K16857]
779026  thbs1.S; thrombospondin-1 [KO:K16857]
444234  dcn.S; decorin S homeolog precursor [KO:K04660]
447482  dcn.L; decorin L homeolog precursor [KO:K04660]
108708911  fmod.S; fibromodulin [KO:K08121]
398193  lefty.S; left-right determination factor S homeolog precursor [KO:K04668]
373829  lefty.L; left-right determination factor L homeolog precursor [KO:K04668]
399282  fst.L; follistatin precursor [KO:K04661]
108707293  fst.S; follistatin-like isoform X1 [KO:K04661]
397873  bmp2.L; bone morphogenetic protein 2-B precursor [KO:K21283]
378780  bmp2.S; bone morphogenetic protein 2-A precursor [KO:K21283]
100036830  admp2.L; antidorsalizing morphogenetic protein 2 L homeolog precursor [KO:K21283]
108713078  admp.L; bone morphogenetic protein 2 [KO:K21283]
398053  admp.S; anti-dorsalizing morphogenic protein S homeolog precursor [KO:K21283]
397874  bmp4.L; bone morphogenetic protein 4 precursor [KO:K04662]
399322  bmp4.S; bone morphogenetic protein 4 precursor [KO:K04662]
734440  bmp6.S; bone morphogenetic protein 6 S homeolog precursor [KO:K16620]
108719128  bmp6.L; bone morphogenetic protein 6 [KO:K16620]
108702893  inhbb.S; inhibin beta B chain [KO:K22687]
399280  inhbb.L; inhibin subunit beta B L homeolog precursor [KO:K22687]
398723  tf.L; serotransferrin-B precursor [KO:K14736]
379502  tf.S; serotransferrin-A precursor [KO:K14736]
108718013  bmp5.S; bone morphogenetic protein 5 isoform X2 [KO:K04663]
108716914  bmp5.L; bone morphogenetic protein 5 [KO:K04663]
380560  bmp7.1.L; bone morphogenetic protein 7, gene 1 L homeolog [KO:K16621]
379625  bmp7.2.L; bone morphogenetic protein 7 precursor [KO:K16621]
108712945  bmp7.2.S; bone morphogenetic protein 7-like [KO:K16621]
108702613  bmp7.1.S; bone morphogenetic protein 7 [KO:K16621]
108709602  bone morphogenetic protein 8A [KO:K16622]
108707514  bone morphogenetic protein 8B [KO:K16622]
446295  gdf5.L; growth differentiation factor 5 L homeolog precursor [KO:K04664]
108702362  gdf5.S; growth/differentiation factor 5 [KO:K04664]
108719358  growth/differentiation factor 6-A [KO:K20012]
399144  gdf6.S; growth differentiation factor 6 S homeolog precursor [KO:K20012]
108717203  gdf7.L; growth/differentiation factor 6-A [KO:K20013]
373820  gdf7.S; growth differentiation factor 7 S homeolog precursor [KO:K20013]
108719965  amh.L; muellerian-inhibiting factor [KO:K04665]
108706872  amh.S; muellerian-inhibiting factor [KO:K04665]
108712369  interferon gamma [KO:K04687]
101027283  ifng.L; interferon gamma [KO:K04687]
100137625  tnf.L; tumor necrosis factor L homeolog [KO:K03156]
108700235  tnf.S; tumor necrosis factor [KO:K03156]
108710296  thsd4.L; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
108712946  thsd4.S; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
108712909  fbn1.S; fibrillin-1 [KO:K06825]
108711397  fbn1.L; fibrillin-1 [KO:K06825]
398322  ltbp1.S; latent transforming growth factor beta binding protein 1 S homeolog precursor [KO:K19559]
108716682  ltbp1.L; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
397778  tgfb1.L; transforming growth factor beta-1 proprotein precursor [KO:K13375]
108700276  tgfb1.S; transforming growth factor beta-1 proprotein-like [KO:K13375]
373801  tgfb2.L; transforming growth factor beta-2 proprotein precursor [KO:K13376]
108717706  tgfb2.S; transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
108720005  inhba.S; inhibin beta A chain [KO:K04667]
108718985  inhba.L; inhibin beta A chain [KO:K04667]
108707740  inhbc.2.L; inhibin beta C chain [KO:K22688]
108709130  inhbc.1.S; inhibin beta B chain [KO:K22688]
108709859  inhbc.2.S; inhibin beta C chain [KO:K22688]
378661  inhbc.1.L; inhibin subunit beta C L homeolog precursor [KO:K22688]
378543  nodal1.L; nodal homolog precursor [KO:K04666]
373597  nodal3.2.L; nodal homolog 3-B precursor [KO:K04666]
398068  nodal.L; nodal homolog 4-A precursor [KO:K04666]
108712279  nodal homolog 2-A [KO:K04666]
108711635  nodal homolog 2-A-like [KO:K04666]
108712673  nodal1.S; nodal homolog isoform X1 [KO:K04666]
108712674  nodal homolog 2-B [KO:K04666]
108697489  nodal.S; nodal homolog 4-B [KO:K04666]
373558  nodal6.L; nodal homolog 6 L homeolog precursor [KO:K04666]
373585  nodal5.2.L; nodal homolog 5, gene 2 L homeolog precursor [KO:K04666]
734176  nodal6.S; nodal homolog 6 S homeolog precursor [KO:K04666]
780748  nodal5.L; nodal homolog 5 L homeolog precursor [KO:K04666]
108710348  nodal homolog 3-A-like [KO:K04666]
378537  nodal3.1.L; nodal homolog 3-A precursor [KO:K04666]
108711649  nodal homolog 3-B-like [KO:K04666]
108711650  nodal homolog 3-B-like [KO:K04666]
397835  nodal2.L; nodal homolog 2-A precursor [KO:K04666]
397711  bmpr1a.L; bone morphogenetic protein receptor type 1A L homeolog precursor [KO:K04673] [EC:2.7.11.30]
397712  bmpr1a.S; bone morphogenetic protein receptor type 1A S homeolog precursor [KO:K04673] [EC:2.7.11.30]
108706748  bmpr1b.S; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
108710900  bmpr1b.L; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
399083  acvr1.S; activin A receptor type 1 S homeolog precursor [KO:K04675] [EC:2.7.11.30]
399103  acvr1.L; activin A receptor type 1 L homeolog precursor [KO:K04675] [EC:2.7.11.30]
108708536  acvrl1.L; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
108708988  acvrl1.S; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
397981  bmpr2.S; bone morphogenetic protein receptor type II S homeolog [KO:K04671] [EC:2.7.11.30]
108701455  bmpr2.L; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
399283  acvr2a.L; activin receptor type-2A precursor [KO:K04670] [EC:2.7.11.30]
495087  acvr2a.S; uncharacterized protein LOC495087 precursor [KO:K04670] [EC:2.7.11.30]
108700348  hjv.S; hemojuvelin [KO:K23100]
108699361  hjv.L; hemojuvelin [KO:K23100]
100381051  neo1.L; neogenin isoform X1 [KO:K06766]
108712989  neo1.S; neogenin isoform X1 [KO:K06766]
108711816  transferrin receptor protein 2 isoform X2 [KO:K23910]
108718059  tfrc.S; transferrin receptor protein 1 [KO:K06503]
108716958  tfrc.L; transferrin receptor protein 1 [KO:K06503]
108712829  rgma.S; repulsive guidance molecule A [KO:K23096]
380244  rgma.L; repulsive guidance molecule BMP co-receptor a L homeolog precursor [KO:K23096]
108717359  rgmb.L; RGM domain family member B [KO:K06847]
108707225  rgmb.S; RGM domain family member B [KO:K06847]
108709904  anti-Muellerian hormone type-2 receptor-like [KO:K04672] [EC:2.7.11.30]
399295  tgfbr1.S; transforming growth factor beta receptor I S homeolog precursor [KO:K04674] [EC:2.7.11.30]
108719029  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
108719963  tgfbr2.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108718935  tgfbr2.L; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108702885  tgfbr2l.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
373815  tgfbr2l.L; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
380309  emp3.L; epithelial membrane protein 3 L homeolog [KO:K26257]
495386  emp3.S; epithelial membrane protein 3 S homeolog [KO:K26257]
108710039  lrrc32.1.S; transforming growth factor beta activator LRRC32 [KO:K26316]
108707633  lrrc32.1.L; transforming growth factor beta activator LRRC32 [KO:K26316]
108698893  lrrc32.2.L; transforming growth factor beta activator LRRC32 [KO:K26316]
100158336  nrros.S; negative regulator of reactive oxygen species S homeolog precursor [KO:K26317]
108717140  nrros.L; transforming growth factor beta activator LRRC33 [KO:K26317]
399454  acvr1b.S; activin A receptor type 1B S homeolog precursor [KO:K13567] [EC:2.7.11.30]
108708537  acvr1b.L; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
397859  acvr2b.S; activin A receptor type 2B S homeolog precursor [KO:K13596] [EC:2.7.11.30]
399277  acvr2b.L; activin receptor type-2B precursor [KO:K13596] [EC:2.7.11.30]
108702964  acvr1c.S; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
108701335  acvr1c.L; activin receptor type-1C-like [KO:K13568] [EC:2.7.11.30]
394401  bambi.L; BMP and activin membrane-bound inhibitor L homeolog precursor [KO:K10162]
447302  bambi.S; BMP and activin membrane-bound inhibitor S homeolog precursor [KO:K10162]
379664  smad1.L; SMAD family member 1 L homeolog [KO:K04676]
399457  smad1.S; SMAD family member 1 S homeolog [KO:K04676]
379659  smad9.S; SMAD family member 9 S homeolog [KO:K16791]
100337601  smad9.L; SMAD family member 9 L homeolog [KO:K16791]
108703982  mothers against decapentaplegic homolog 9-like [KO:K16791]
399442  smad2.L; SMAD family member 2 L homeolog [KO:K04500]
432023  smad2.S; SMAD family member 2 S homeolog [KO:K04500]
378633  smad3.L; SMAD family member 3 L homeolog [KO:K23605]
108712801  smad3.S; mothers against decapentaplegic homolog 3 [KO:K23605]
403356  smad4.2.L; SMAD family member 4, gene 2 L homeolog 2 [KO:K04501]
780764  smad4.L; SMAD family member 4, gene 1 L homeolog [KO:K04501]
108700426  smad4.2.S; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
108707339  smad4.S; mothers against decapentaplegic homolog 4 [KO:K04501]
399369  smad6.L; SMAD family member 6 L homeolog [KO:K04677]
108699473  smad6.2.L; mothers against decapentaplegic homolog 6 [KO:K04677]
100037050  smad6.S; uncharacterized protein LOC100037050 [KO:K04677]
394331  smad7.L; SMAD family member 7 L homeolog [KO:K19631]
108707343  smad7.S; mothers against decapentaplegic homolog 7 [KO:K19631]
398131  smurf1.L; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
398372  smurf2.S; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
108701209  E3 ubiquitin-protein ligase SMURF2-like isoform X2 [KO:K04678] [EC:2.3.2.26]
108703087  smurf1.S; E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
373733  zfyve9.L; zinc finger FYVE-type containing 9 L homeolog [KO:K04679]
108707248  zfyve16.S; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
108717655  zfyve16.L; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
108715600  zfyve9.S; zinc finger FYVE domain-containing protein 9 [KO:K04679]
108714482  rbx1.L; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
108715730  rbx1.S; RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
734414  cul1.S; cullin 1 S homeolog [KO:K03347]
734526  cul1.L; uncharacterized protein LOC734526 [KO:K03347]
380538  skp1.L; S-phase kinase-associated protein 1 [KO:K03094]
108712619  skp1.S; S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
108719215  rock1.L; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
108695261  rock1.S; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
398563  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
379827  ppp2r1a.L; protein phosphatase 2 regulatory subunit A, alpha L homeolog [KO:K03456]
380100  ppp2r1b.S; protein phosphatase 2 regulatory subunit A, beta S homeolog [KO:K03456]
394339  ppp2r1a.S; protein phosphatase 2 regulatory subunit A, alpha S homeolog [KO:K03456]
399343  ppp2cb.L; protein phosphatase 2, catalytic subunit, beta isozyme L homeolog [KO:K04382] [EC:3.1.3.16]
380045  ppp2cal.S; protein phosphatase 2 catalytic subunit alpha-like S homeolog [KO:K04382] [EC:3.1.3.16]
108706827  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108712618  ppp2ca.S; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
394276  rps6kb1.S; ribosomal protein S6 kinase B1 S homeolog [KO:K04688] [EC:2.7.11.1]
394347  rps6kb1.L; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
108696828  hamp2.L; hepcidin [KO:K23106]
108696829  hepcidin [KO:K23106]
108705601  hepcidin [KO:K23106]
447463  id2.S; DNA-binding protein inhibitor ID-2-B [KO:K17693]
398111  id2.L; DNA-binding protein inhibitor ID-2-A [KO:K17693]
379222  id3.L; DNA-binding protein inhibitor ID-3-A [KO:K17694]
379447  id3.S; DNA-binding protein inhibitor ID-3-B [KO:K17694]
100337509  id4.L; inhibitor of DNA binding 4, HLH protein L homeolog [KO:K17695]
380396  id4.S; DNA-binding protein inhibitor ID-4 [KO:K17695]
431930  rbl1.L; retinoblastoma-like 1 L homeolog [KO:K04681]
108702771  rbl1.S; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
446541  e2f4.S; transcription factor E2F4 [KO:K04682]
108719317  e2f5.L; transcription factor E2F5 isoform X1 [KO:K04682]
108695369  e2f5.S; transcription factor E2F5 [KO:K04682]
108714169  e2f4.L; transcription factor E2F4-like [KO:K04682]
494744  tfdp1.L; transcription factor Dp-1 L homeolog [KO:K04683]
447406  tfdp1.S; transcription factor Dp-1 S homeolog [KO:K04683]
495689  crebbp.L; CREB binding protein L homeolog [KO:K04498] [EC:2.3.1.48]
108714480  ep300.L; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108715729  ep300.S; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
373795  crebbp.S; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
431939  sp1.L; transcription factor Sp1 isoform X2 [KO:K04684]
108709905  sp1.S; transcription factor Sp1 [KO:K04684]
108705373  skil.S; ski-like protein isoform X2 [KO:K18499]
108717014  skil.L; ski-like protein [KO:K18499]
399309  ski.L; SKI proto-oncogene L homeolog [KO:K26503]
394271  ski.S; ski oncogene [KO:K26503]
398130  sin3a.S; SIN3 transcription regulator family member A S homeolog [KO:K11644]
108711311  sin3a.L; paired amphipathic helix protein Sin3a [KO:K11644]
379083  hdac1.S; probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
397868  hdac1.L; probable histone deacetylase 1-A [KO:K06067] [EC:3.5.1.98]
399252  hdac2.S; histone deacetylase 2 S homeolog [KO:K06067] [EC:3.5.1.98]
108716821  hdac2.L; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
398304  ncor1.S; nuclear receptor corepressor 1 [KO:K04650]
108707936  ncor1.L; nuclear receptor corepressor 1-like isoform X9 [KO:K04650]
108719207  tgif1.L; homeobox protein AKR [KO:K19383]
380112  tgif1.S; TGFB induced factor homeobox 1 S homeolog [KO:K19383]
447470  tgif2.S; TGFB induced factor homeobox 2 S homeolog [KO:K19553]
447461  tgif2.L; TGFB induced factor homeobox 2 L homeolog [KO:K19553]
379052  myc.S; transcriptional regulator Myc-A [KO:K04377]
399315  myc.L; transcriptional regulator Myc-B [KO:K04377]
779240  cdkn2b.L; cyclin-dependent kinase inhibitor 2B L homeolog [KO:K04685]
108706939  cdkn2b.S; cyclin-dependent kinase inhibitor 2A [KO:K04685]
398033  pitx2.L; paired like homeodomain 2 L homeolog [KO:K04686]
373586  pitx2.S; paired like homeodomain 2 S homeolog [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
xla04010  MAPK signaling pathway
xla04110  Cell cycle
xla04120  Ubiquitin mediated proteolysis
xla04210  Apoptosis
KO pathway
ko04350   
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