 Exocytosis
|
Calcium ion-dependent exocytosis
|
 Synaptotagmins
|
Septins
|
DOC-2 proteins
|
Acrosomal exocytosis proteins
|
 K01317 ACR; acrosin [EC:3.4.21.10]
K07966 B4GALT1; beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
K19919 CRISP1_2_3; cysteine-rich secretory protein 1/2/3
K19920 EQTN; equatorin
K05193 GLRA1; glycine receptor alpha-1
K05196 GLRB; glycine receptor beta
K08671 PCSK4; proprotein convertase subtilisin/kexin type 4 [EC:3.4.21.-]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K19921 PKDREJ; polycystic kidney disease and receptor for egg jelly-related protein
K15291 RIMS1, RIM1; regulating synaptic membrane exocytosis protein 1
K15297 RIMS2, RIM2; regulating synaptic membrane exocytosis protein 2
K15298 RIMS3, RIM3; regulating synaptic membrane exocytosis protein 3
K15299 RIMS4, RIM4; regulating synaptic membrane exocytosis protein 4
K19922 TSPOAP1, BZRAP1, RIMBP1; peripheral-type benzodiazepine receptor-associated protein 1
K26225 RIMBP3; RIMS-binding protein 3
K06257 SDC1, CD138; syndecan 1
K19923 SPESP1; sperm equatorial segment protein 1
K19924 SPINK13; serine protease inhibitor Kazal-type 13
K19925 TNP2; nuclear transition protein 2
K12013 TRIM36; tripartite motif-containing protein 36 [EC:2.3.2.27]
K19926 ZP1; zona pellucida sperm-binding protein 1
K19927 ZP2; zona pellucida sperm-binding protein 2
K19928 ZP3; zona pellucida sperm-binding protein 3
|
Phospholipases
|
Kinases and associated proteins
|
Others
|
Small GTPases and associated proteins
|
Rab GTPases
|
K07882 RAB3A; Ras-related protein Rab-3A
K06108 RAB3B; Ras-related protein Rab-3B
K07883 RAB3C; Ras-related protein Rab-3C
K07884 RAB3D; Ras-related protein Rab-3D
K07901 RAB8A, MEL; Ras-related protein Rab-8A
K07902 RAB8B; Ras-related protein Rab-8B
K07903 RAB10; Ras-related protein Rab-10
K07907 RAB12; Ras-related protein Rab-12
K07913 RAB26; Ras-related protein Rab-26
K07885 RAB27A; Ras-related protein Rab-27A
K07886 RAB27B; Ras-related protein Rab-27B
K07914 RAB37; Ras-related protein Rab-37
|
Rab associated proteins
|
Rho GTPases
|
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07857 RHOC; Ras homolog gene family, member C
K07872 RHOF, RIF; Ras homolog gene family, member F
K07864 RHOJ, TCL; Ras homolog gene family, member J
K07194 RHOQ, TC10; Ras homolog gene family, member Q
K07865 RHOU, WRCH1; Ras homolog gene family, member U
K07866 RHOV, WRCH2; Ras homolog gene family, member V
|
Other small GTPases and associated proteins
|
Tethering complex
|
Exocyst complex
|
Exocyst complex assembly proteins
|
K19987 EXOC3L1; exocyst complex component 3-like protein
K19988 EXOC3L2; exocyst complex component 3-like protein 2
K19989 TNFAIP2, EXOC3L3; tumor necrosis factor alpha-induced protein 2
K06491 NCAM, CD56; neural cell adhesion molecule
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K25768 RALGAPA; Ral GTPase-activating protein subunit alpha
K25769 RALGAPB; Ral GTPase-activating protein subunit beta
K10881 SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
K17945 TPM1_2; tropomyosin, fungi type
|
Others
|
Exomer complex
|
ER-PM contacts associated proteins
|
K24964 BLTP1, CSF1; Bridge-like lipid transfer protein family member 1
K29084 LTAP1; lipid transport auxiliary protein 1
K28063 ESYT, TCB, SYT; extended synaptotagmin
K20464 OSBPL5, ORP5; oxysterol-binding protein-related protein 5
K26240 C2CD2L, C2CD2, TMEM24; phospholipid transfer protein
K16056 ORAI1; calcium release-activated calcium channel protein 1
K16057 ORAI2; calcium release-activated calcium channel protein 2
K16058 ORAI3; calcium release-activated calcium channel protein 3
K16059 STIM1; stromal interaction molecule 1
K29085 SCS2_22; vesicle-associated membrane protein-associated protein
|
Others
|
|
SNARE
|
|
Endocytosis
|
Clathrin-mediated endocytosis
|
Clathrin
|
Dynamin
|
AP-2 complex
|
Other core components
|
Low-density lipoprotein receptor (LDLR) family proteins
|
K12473 LDLR; low-density lipoprotein receptor
K04550 LRP1, CD91; low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)
K20049 LRP1B; low-density lipoprotein receptor-related protein 1B
K06233 LRP2; low density lipoprotein-related protein 2
K20050 LRP3_10_12; low-density lipoprotein receptor-related protein 3/10/12
K20051 LRP4, MEGF7; low-density lipoprotein receptor-related protein 4
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K20052 LRP8, APOER2; low-density lipoprotein receptor-related protein 8
K20053 VLDLR; very low-density lipoprotein receptor
|
LDLR adaptor proteins
|
GPCR adaptor proteins
|
K04439 ARRB; beta-arrestin
K20059 LDB19, ART1; arrestin-related trafficking adapter 1
K20060 ECM21, CSR2, ART2_8; arrestin-related trafficking adapter 2/8
K20061 ALY1_2, ART3_6; arrestin-related trafficking adapter 3/6
K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
K20063 RIM8, ART9; arrestin-related trafficking adapter 9
|
Receptor tyrosine kinase (RTK) adaptor proteins
|
Inositol 5-phosphatases
|
Kinases
|
Ubiquitin E3 ligases
|
Others
|
K04559 HIP1; huntingtin interacting protein 1
K20040 HIP1R, SLA2; huntingtin-interacting protein 1-related protein
K06106 CTTN, EMS1; cortactin
K08054 CANX; calnexin
K11247 SH3GL; endophilin-A
K11248 SH3GLB1; endophilin-B1
K21269 SH3GLB2; endophilin-B2
K15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1
K20065 SGIP1; SH3-containing GRB2-like protein 3-interacting protein 1
K20066 SH3BP4; SH3 domain-binding protein 4
K20067 STON; stonin
K20068 REPS; RalBP1-associated Eps domain-containing protein
K20069 NECAP1_2; adaptin ear-binding coat-associated protein 1/2
K20031 ZDHHC6; palmitoyltransferase ZDHHC6 [EC:2.3.1.225]
K21437 ANKRD13; ankyrin repeat domain-containing protein 13
K21953 SHKBP1; SH3KBP1-binding protein 1
K22936 CNPY1_2; protein canopy 1/2
K23532 WDFY2; WD repeat and FYVE domain-containing protein 2
K23878 AAGAB; alpha- and gamma-adaptin-binding protein p34
K24177 SERINC4; serine incorporator 4
K25655 SERINC5; serine incorporator 5
K24402 MXRA8; matrix remodeling-associated protein 8
K24403 KIAA0319, AAVR; dyslexia-associated protein KIAA0319
K25217 LMBR1; limb region 1 protein
K12469 EHD2; EH domain-containing protein 2
K25572 EHBP1; EH domain-binding protein 1
K26150 UNC93B; MFS transporter, NAG-T family, unc-93 homolog B
K26401 TOM1, TOM1L1_2; target of Myb membrane trafficking protein 1 and related proteins
K15493 CALY; neuron-specific vesicular protein calcyon
K27410 CCDC32; coiled-coil domain-containing protein 32
K27870 TGOLN; trans-Golgi network integral membrane protein
K27926 RFTN; raftlin
K28033 MAL; myelin and lymphocyte protein
|
Lipid raft mediated endocytosis
|
Caveolin-mediated endocytosis
|
Flotillin-dependent endocytosis
|
GRAF1-dependent endocytosis
|
Arf6-dependent endocytosis
|
K07941 ARF6; ADP-ribosylation factor 6
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
|
RhoA-dependent endocytosis
|
Phagocytosis
|
Fc receptors
|
Integrins (complement receptors)
|
Opsonins
|
K06856 IGH; immunoglobulin heavy chain
K03990 C3; complement component 3
K16857 THBS1; thrombospondin 1
K04659 THBS2S; thrombospondin 2/3/4/5
K10066 COLEC11; collectin sub-family member 11
K10062 COLEC12; collectin sub-family member 12
K03991 MBL; mannose-binding lectin
K10067 SFTPA; pulmonary surfactant-associated protein A
K10068 SFTPD, SFTP4; pulmonary surfactant-associated protein D
K03986 C1QA; complement C1q subcomponent subunit A
K03987 C1QB; complement C1q subcomponent subunit B
K03988 C1QG; complement C1q subcomponent subunit C
K01330 C1R; complement component 1, r subcomponent [EC:3.4.21.41]
K01331 C1S; complement component 1, s subcomponent [EC:3.4.21.42]
K23284 C1QL; C1q-related factor
|
Toll-like receptors
|
C-lectin receptors
|
Scavenger receptors
|
Coronins
|
Others
|
Macropinocytosis
|
Ras GTPases
|
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04393 CDC42; cell division control protein 42
|
Kinases
|
Phospholipase C
|
Sorting nexins
|
Others
|
Bin/Amphiphysin/Rvs (BAR) family proteins
|
Rab GTPases and associated proteins
|
Rab GTPases
|
K07887 RAB5A; Ras-related protein Rab-5A
K07888 RAB5B; Ras-related protein Rab-5B
K07889 RAB5C; Ras-related protein Rab-5C
|
Rab associated proteins
|
Arf GTPases and associated proteins
|
Others
|
|
Endosome - Lysosome transport
|
Rab GTPases and associated proteins
|
Rab GTPases
|
K07887 RAB5A; Ras-related protein Rab-5A
K07888 RAB5B; Ras-related protein Rab-5B
K07889 RAB5C; Ras-related protein Rab-5C
K07897 RAB7A, YPT7; Ras-related protein Rab-7A [EC:3.6.5.2]
K07898 RAB7B; Ras-related protein Rab-7B
K07907 RAB12; Ras-related protein Rab-12
K07890 RAB21; Ras-related protein Rab-21
|
FTS/Hook/FHIP (FHF) complex
|
FERRY complex
|
Rab associated proteins
|
K13883 RILP; Rab-interacting lysosomal protein
K20173 RILPL1; RILP-like protein 1
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K00914 PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
K20162 DENND3; DENN domain-containing protein 3
K20165 TBC1D2; TBC1 domain family member 2A
K18469 TBC1D5; TBC1 domain family member 5
K20168 TBC1D15; TBC1 domain family member 15
K20174 OSBPL1_2, ORP1_2; oxysterol-binding protein-related protein 1/2
K20175 ANKRD27; ankyrin repeat domain-containing protein 27
K23460 CHM, CHML; Rab proteins geranylgeranyltransferase component A
K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
K20176 SGSM3, MAP; small G protein signaling modulator 3
K21954 FYCO1; FYVE and coiled-coil domain-containing protein 1
K15620 GOLPH3, GPP34; golgi phosphoprotein 3
K26227 ALS2CL; ALS2 C-terminal-like protein
K26496 RAB5IF; GEL complex subunit OPTI
K26676 NSG1; neuronal vesicle trafficking-associated protein 1
K26677 NSG2; neuronal vesicle trafficking-associated protein 2
K15493 CALY; neuron-specific vesicular protein calcyon
K07856 RHOB; Ras homolog gene family, member B
K28414 DENND10; DENN domain-containing protein 10
K20284 RABGAP1, GAPCENA; Rab GTPase-activating protein 1
|
Arf GTPases and associated proteins
|
Arf GTPases
|
BLOC-one-related complex (BORC)
|
K20185 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1
K16750 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2
K20002 SNAPIN, BLOC1S7; SNARE-associated protein Snapin
K20818 KXD1, BORCS4; KxDL motif-containing protein 1
K20819 BORCS5, LOH12CR1; BLOC-1 related complex subunit 5
K20820 BORCS6; BLOC-1 related complex subunit 6
K20821 BORCS7; BLOC-1 related complex subunit 7
K20822 MEF2BNB, BORCS8; BLOC-1 related complex subunit 8
|
N-acetyl transferase complex C (NatC)
|
Other Arf associated proteins
|
Endosomal sorting complexes required for transport (ESCRT)
|
ESCRT-0 complex
|
ESCRT-I complex
|
ESCRT-II complex
|
ESCRT-III complex
|
ESCRT associated proteins
|
K12199 VTA1, LIP5; vacuolar protein sorting-associated protein VTA1
K12200 PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein
K26228 ARRDC1; arrestin domain-containing protein 1
K26229 ARRDC2_3; arrestin domain-containing protein 2/3
K26230 ARRDC4; arrestin domain-containing protein 4
K26401 TOM1, TOM1L1_2; target of Myb membrane trafficking protein 1 and related proteins
K28543 UBAP1L; ubiquitin-associated protein 1-like
K29039 CDIP1; cell death-inducing p53-target protein 1
|
Tethering complex
|
Acidification regulators
|
Others
|
AP-3 complex
|
BLOC-1 complex
|
K20185 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1
K16750 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2
K20186 BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3
K08366 BLOC1S4, CNO; biogenesis of lysosome-related organelles complex 1 subunit 4
K20187 BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5
K20188 BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6
K20002 SNAPIN, BLOC1S7; SNARE-associated protein Snapin
K20189 DTNBP1, BLOC1S8; dysbindin
|
BLOC-1 complex (yeast)
|
K22238 BLI1; biogenesis of lysosome-related organelles complex 1 subunit BLI1
K22239 BLS1; biogenesis of lysosome-related organelles complex 1 subunit BLS1
K22240 CNL1; biogenesis of lysosome-related organelles complex 1 subunit CNL1
K22241 SNN1; biogenesis of lysosome-related organelles complex 1 subunit SNN1
K22242 VAB2; biogenesis of lysosome-related organelles complex 1 subunit VAB2
K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
|
BLOC-2 complex
|
BLOC-3 complex
|
Ferlins
|
Lysosomal membrane proteins
|
Others
|
|
Protein recycling
|
Rab GTPases and associated proteins
|
Rab GTPases
|
K07879 RAB4A, RAB4; Ras-related protein Rab-4A
K07880 RAB4B; Ras-related protein Rab-4B
K07903 RAB10; Ras-related protein Rab-10
K07904 RAB11A; Ras-related protein Rab-11A
K07905 RAB11B; Ras-related protein Rab-11B
K06109 RAB13; Ras-related protein Rab-13
K07881 RAB14; Ras-related protein Rab-14
K07908 RAB15; Ras-related protein Rab-15
K07909 RAB17; Ras-related protein Rab-17
K07891 RAB22; Ras-related protein Rab-22
K06234 RAB23; Ras-related protein Rab-23
K07906 RAB25; Ras-related protein Rab-25
K07876 RAB35, RAB1C; Ras-related protein Rab-35
|
Rab4 associated proteins
|
Rab11 associated proteins
|
Other Rab GTPase associated proteins
|
Others
|
Glutamate receptor-interacting proteins (GRIPs)
|
GRIP associated proteins
|
EARP complex
|
WASH complex
|
Retriever complex
|
CCC complex
|
Others
|
K23289 EIPR1, TSSC1; EARP and GARP complex-interacting protein 1
K17924 SNX10_11; sorting nexin-10/11
K17936 SNX27; sorting nexin-27
K22938 SDCCAG3, ENTR1; serologically defined colon cancer antigen 3
K21440 ANKRD50; ankyrin repeat domain-containing protein 50
K23791 PHETA; sesquipedalian
K23950 MAGEL2; MAGE-like protein 2
K24964 BLTP1, CSF1; Bridge-like lipid transfer protein family member 1
K28442 TMEM170A; transmembrane protein 170A
K25112 TMX2; thioredoxin-related transmembrane protein 2
K26497 TMEM230; transmembrane protein 230
K27081 SORC1; VPS10 domain-containing receptor SorCS1
K27082 SORC2; VPS10 domain-containing receptor SorCS2
|
|
Endosome - Golgi transport
|
Rab GTPases and associated proteins
|
Rab GTPases
|
K07893 RAB6A_C_D; Ras-related protein Rab-6A/C/D [EC:3.6.5.2]
K07894 RAB6B; Ras-related protein Rab-6B [EC:3.6.5.2]
K07897 RAB7A, YPT7; Ras-related protein Rab-7A [EC:3.6.5.2]
K07898 RAB7B; Ras-related protein Rab-7B
K07899 RAB9A, RAB9; Ras-related protein Rab-9A
K07900 RAB9B; Ras-related protein Rab-9B
|
Retromer subcomplex
|
Rab associated proteins
|
Arf GTPases and associated proteins
|
Arf GTPases
|
K07937 ARF1_2; ADP-ribosylation factor 1/2
K07938 ARF3; ADP-ribosylation factor 3
K07939 ARF4; ADP-ribosylation factor 4
K07940 ARF5; ADP-ribosylation factor 5
K07942 ARL1; ADP-ribosylation factor-like protein 1
K07952 ARFRP1; ADP-ribosylation factor related protein 1
|
Arf GTPase associated proteins
|
Tethering complex
|
Others
|
AP-1 complex
|
AP-3 complex
|
AP-4 complex
|
GGA
|
Aftiphilin/p200/gamma-synergin complex
|
Others
|
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K00921 PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K20313 PLEKHA3, FAPP1; pleckstrin homology domain-containing family A member 3
K08051 PLEKHA8, FAPP2; pleckstrin homology domain containing family A member 8
K20314 ARFIP; arfaptin
K20315 ARHGAP21_23; Rho GTPase-activating protein 21/23
K01349 FURIN, PCSK3; furin [EC:3.4.21.75]
K20316 SCOC; short coiled-coil protein
K20317 SPAG9, JIP4; c-Jun-amino-terminal kinase-interacting protein 4
K20318 SYS1; protein SYS1
K10362 MYO18; myosin XVIII
K23290 PACS1; phosphofurin acidic cluster sorting protein 1
K23540 GOLIM4; golgi integral membrane protein 4
K28026 TMEM87; transmembrane protein 87
K23541 TMEM165, GDT1; Ca2+/H+ antiporter, TMEM165/GDT1 family
K23542 TMEM199; TMEM199 family protein
K23543 CCDC115; coiled-coil domain-containing protein 115
K23544 SERINC1; serine incorporator 1
K25661 SERINC3; serine incorporator 3
K17918 SNX3_12; sorting nexin-3/12
K17922 SNX8, MVP1; sorting nexin-8
K26678 MON2; protein MON2
K26679 ATP9A; phospholipid-transporting ATPase IIA [EC:7.6.2.1]
K26680 DOP1, DOPEY; protein dopey
K27258 WLS; protein wntless
K28435 TMEM181; transmembrane protein 181
K24181 LRBA; lipopolysaccharide-responsive and beige-like anchor protein
K24404 KIAA0319L; dyslexia-associated protein KIAA0319-like protein
K24498 SORL1; sortilin-related receptor
K27083 SORC3; VPS10 domain-containing receptor SorCS3
K24721 CLINT1, EPN4; clathrin interactor 1
K15493 CALY; neuron-specific vesicular protein calcyon
K26747 LYSET, TMEM251; lysosomal enzyme trafficking factor
K27870 TGOLN; trans-Golgi network integral membrane protein
K27894 HID1; protein HID1
K28326 FAM177; protein FAM177
K26750 TVP15; golgi apparatus membrane protein TVP15
K26751 TVP18; golgi apparatus membrane protein TVP18
K26752 TVP23; golgi apparatus membrane protein TVP23
K26753 TVP38; golgi apparatus membrane protein TVP38
K23481 VPS1; vacuolar protein sorting-associated protein 1
K28985 PEP1, VPS10, VTH; vacuolar protein sorting/targeting protein 10
K28986 VPS17; vacuolar protein sorting-associated protein 17
|
|
Endoplasmic reticulum (ER) - Golgi transport
|
Forward pathways
|
Coat protein complex II (COP-II)
|
TRAPP complex I
|
p24 family proteins
|
PDI family proteins
|
K09580 PDIA1, P4HB; protein disulfide-isomerase A1 [EC:5.3.4.1]
K09581 PDIA2; protein disulfide-isomerase A2 [EC:5.3.4.1]
K08056 PDIA3, GRP58; protein disulfide-isomerase A3 [EC:5.3.4.1]
K09582 PDIA4, ERP72; protein disulfide-isomerase A4 [EC:5.3.4.1]
K09583 PDIA5; protein disulfide-isomerase A5 [EC:5.3.4.1]
K09584 PDIA6, TXNDC7; protein disulfide-isomerase A6 [EC:5.3.4.1]
K20354 PDILT; protein disulfide-isomerase-like protein of the testis
K20355 ERP27; endoplasmic reticulum protein 27
K09586 ERP29; endoplasmic reticulum protein 29
K17264 ERP44, TXNDC4; endoplasmic reticulum resident protein 44
K13984 TXNDC5, ERP46; thioredoxin domain-containing protein 5 [EC:5.3.4.1]
K05360 TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]
K26746 TMX1_4; thioredoxin-related transmembrane protein 1/4
K09585 TMX3, TXNDC10; protein disulfide-isomerase [EC:5.3.4.1]
K20356 AGR2; anterior gradient protein 2
K20357 AGR3; anterior gradient protein 3
K09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]
|
Rab GTPases
|
K07874 RAB1A; Ras-related protein Rab-1A
K07875 RAB1B; Ras-related protein Rab-1B
K07877 RAB2A; Ras-related protein Rab-2A
K07878 RAB2B; Ras-related protein Rab-2B
|
Rab associated proteins
|
ER-Golgi intermediate compartment (ERGIC) proteins
|
Retrieval pathways
|
Coat protein complex I (COP-I)
|
NRZ (DSL1) complex
|
Golgi to ER traffic proteins (GET)
|
Rab GTPases
|
K07893 RAB6A_C_D; Ras-related protein Rab-6A/C/D [EC:3.6.5.2]
K07919 RAB33A; Ras-related protein Rab-33A
K07920 RAB33B; Ras-related protein Rab-33B
|
Rab associated proteins
|
Others
|
Oxysterol-binding proteins
|
K20456 OSBP; oxysterol-binding protein 1
K20462 OSBP2, ORP4; oxysterol-binding protein 2
K20174 OSBPL1_2, ORP1_2; oxysterol-binding protein-related protein 1/2
K20463 OSBPL3_6_7, ORP3_6_7; oxysterol-binding protein-related protein 3/6/7
K20464 OSBPL5, ORP5; oxysterol-binding protein-related protein 5
K22285 OSBPL8, ORP8; oxysterol-binding protein-related protein 8
K20465 OSBPL9_10_11, ORP9_10_11; oxysterol-binding protein-related protein 9/10/11
|
FXYD proteins
|
YIPF proteins
|
ER membrane protein complex
|
SEC61 complex
|
K10956 SEC61A; protein transport protein SEC61 subunit alpha
K09481 SEC61B, SBH2; protein transport protein SEC61 subunit beta
K07342 SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
|
TRAP complex
|
Multi-pass translocon (MPT) complex
|
Post-GPI attachment to proteins factors (PGAP)
|
Others
|
K19998 SCFD1, SLY1; sec1 family domain-containing protein 1
K19934 SDF4; calcium-binding protein
K20479 WHAMM; WASP homolog-associated protein with actin, membranes and microtubules
K19872 FKTN; fukutin [EC:2.7.8.-]
K19873 FKRP; fukutin-related protein [EC:2.7.8.-]
K21957 FAM20A; pseudokinase FAM20A
K20825 FAM20B; glycosaminoglycan xylosylkinase [EC:2.7.1.-]
K21958 FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1]
K19874 SEPN1; selenoprotein N
K20392 PRAF2; PRA1 family protein 2
K20393 ARL6IP5, PRAF3; PRA1 family protein 3
K24864 ARL6IP1; ADP-ribosylation factor-like protein 6-interacting protein 1
K20724 TMEM33; transmembrane protein 33
K20721 RTN1; reticulon-1
K20722 RTN2; reticulon-2
K20723 RTN3; reticulon-3
K20720 RTN4; reticulon-4
K29083 RTNLB; reticulon-like protein B
K23554 GRAMD4; GRAM domain-containing protein 4
K23555 LMF1; lipase maturation factor 1
K06096 VAPA; vesicle-associated membrane protein-associated protein A
K29033 MOSPD2; motile sperm domain-containing protein 2
K21413 ANKS1; ankyrin repeat and SAM domain-containing protein 1
K21414 ANKS4B, HARP; ankyrin repeat and SAM domain-containing protein 4B
K21848 ARV1; lipid intermediate transporter
K21849 KEG1; beta-1,6-glucan synthesis-associated protein KEG1
K21850 KRE6; beta-glucan synthesis-associated protein KRE6
K15620 GOLPH3, GPP34; golgi phosphoprotein 3
K22128 PIEZO1_2, FAM38; piezo-type mechanosensitive ion channel component 1/2
K22556 MANF, ARMET; mesencephalic astrocyte-derived neurotrophic factor
K22697 SAMD8; ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.48 3.1.4.62]
K17339 ATL; atlastin [EC:3.6.5.-]
K23292 LNPK; endoplasmic reticulum junction formation protein lunapark
K28793 TMCC; transmembrane and coiled-coil domains protein
K13254 SPAST; spastin [EC:5.6.1.1]
K12360 CLN8; ceroid-lipofuscinosis neuronal protein 8
K23951 DYM; dymeclin
K28900 PITPNA_B; phosphatidylinositol transfer class I subfamily
K24069 PITPNM; phosphatidylinositol transfer class IIA subfamily
K24996 STEEP1; STING ER exit protein
K25381 FRRS1L; DOMON domain-contaning protein FRRS1L
K25789 JAGN; protein jagunal
K29103 PAQR3; progestin and adipoQ receptor family member 3
K26681 INSIG; insulin-induced protein
K26682 SCAP; sterol regulatory element-binding protein cleavage-activating protein
K07197 SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1
K09107 SREBP2, SREBF2; sterol regulatory element-binding transcription factor 2
K28167 SPRING1; SREBP regulating gene protein
K26683 GOLT1, GOT1; vesicle transport protein GOT1
K27761 GIMAP4; GTPase IMAP family member 4
K28402 FAM8A1; protein FAM8A1
K28439 TMEM39; transmembrane protein 39
K29086 SAYSD1; SAYSvFN domain-containing protein 1
K28681 PVA, VAP27; plant VAMP family protein
K22698 SEY1; protein SEY1 [EC:3.6.5.-]
K29087 NVJ2; nucleus-vacuole junction protein 2
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|
Autophagy
|
Autophagosome formation proteins
|
ULK complex
|
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08331 ATG13; autophagy-related protein 13
K17589 RB1CC1; RB1-inducible coiled-coil protein 1
K19730 ATG101; autophagy-related protein 101
|
Atg1 complex
|
K08269 ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K08331 ATG13; autophagy-related protein 13
K08329 ATG17; autophagy-related protein 17
K21143 ATG29; autophagy-related protein 29
K21144 ATG31; autophagy-related protein 31
|
PI3K complex
|
K00914 PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K08333 PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
K17889 ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
K08335 ATG14; autophagy-related protein 14
K08334 BECN, VPS30, ATG6; beclin
K21246 NRBF2; nuclear receptor-binding factor 2
K21145 ATG38; autophagy-related protein 38
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ATG9 transmembrane protein
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K17907 ATG9; autophagy-related protein 9
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Atg18-Atg2 complex
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K17908 WIPI1_2, ATG18; autophagy-related protein 18
K17906 ATG2; autophagy-related protein 2
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Atg12 conjugation proteins
|
K08336 ATG12; ubiquitin-like protein ATG12
K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
K17888 ATG10L, ATG10; ubiquitin-like-conjugating enzyme ATG10
K08338 ATG10; ubiquitin-like-conjugating enzyme ATG10
K08339 ATG5; autophagy-related protein 5
K17890 ATG16L1; autophagy-related protein 16-1
K20868 ATG16L2; autophagy-related protein 16-2
K08340 ATG16; autophagy-related protein 16
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Atg8 conjugation proteins
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Cytoplasm to vacuolar targeting (CVT) pathway
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Selective cargos
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Cargo receptors
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K21997 ATG19_34; autophagy-related protein 19/34
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Scaffold protein
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K08330 ATG11; autophagy-related protein 11
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Other Cvt associated proteins
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K21996 SNX41_42; sorting nexin-41/42
K17919 SNX4; sorting nexin-4
K17900 ATG15, AUT5; lipase ATG15 [EC:3.1.1.3]
K17909 ATG23; autophagy-related protein 23
K21141 ATG27; autophagy-related protein 27
K08332 VAC8; vacuolar protein 8
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Mitophagy
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Cargo receptors
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K14381 SQSTM1; sequestosome 1
K15464 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
K15465 BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
K17984 ATG32; autophagy-related protein 32
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Scaffold proteins
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K08330 ATG11; autophagy-related protein 11
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PINK1-Parkin associated proteins
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Other mitophagy associated proteins
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K00844 HK; hexokinase [EC:2.7.1.1]
K09558 BAG4; BCL2-associated athanogene 4
K22255 ATPIF1; ATPase inhibitor, mitochondrial
K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
K07197 SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1
K10260 FBXW7, SEL10; F-box and WD-40 domain protein 7
K22256 SIAH3; seven in absentia homolog 3
K21343 USP15; ubiquitin carboxyl-terminal hydrolase 15 [EC:3.4.19.12]
K11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]
K17771 TOM7; mitochondrial import receptor subunit TOM7
K22257 SPATA18; mitochondria-eating protein
K17986 FUNDC1; FUN14 domain-containing protein 1
K24308 FUNDC2; FUN14 domain-containing protein 2
K10435 MAP1LC; microtubule-associated protein 1 light chain
K19717 ATG33; autophagy-related protein 33
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Pexophagy
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Selective cargos
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Cargo receptors
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K14381 SQSTM1; sequestosome 1
K22258 ATG36; autophagy-related protein 36
K22259 ATG30; autophagy-related protein 30
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Other pexophagy associated proteins
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Aggrephagy
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Xenophagy
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Cargo receptors
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Other xenophagy associated proteins
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K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K07902 RAB8B; Ras-related protein Rab-8B
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
K04556 PARK2; parkin [EC:2.3.2.31]
K12654 STING1, TMEM173, MITA; stimulator of interferon genes protein
K06832 LGALS8; galectin-8
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ER-phagy
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ER-phagy recepters
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K23880 RETREG; reticulophagy regulator
K28115 CCPG1; cell cycle progression protein 1
K28116 CDK5RAP3; CDK5 regulatory subunit-associated protein 3
K14381 SQSTM1; sequestosome 1
K20723 RTN3; reticulon-3
K12275 SEC62; translocation protein SEC62
K17339 ATL; atlastin [EC:3.6.5.-]
K28117 TEX264; testis-expressed protein 264
K25828 CALCOCO1; calcium-binding and coiled-coil domain-containing protein 1
K28118 ATG40; autophagy-related protein 40
K28119 ATG39; autophagy-related protein 39
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Other ER-phagy associated proteins
|
ER stress-related proteins
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K09490 HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]
K09487 HSP90B, TRA1; heat shock protein 90kDa beta
K09027 XBP1; X box-binding protein 1
K03237 EIF2S1; translation initiation factor 2 subunit 1
K22188 CLCC1; chloride channel CLIC-like protein 1
K28120 PIGBOS1; protein PIGBOS1
K14009 BCAP31, BAP31; B-cell receptor-associated protein 31
K29039 CDIP1; cell death-inducing p53-target protein 1
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Chaperone mediated autophagy (CMA)
|
Other autophagy associated proteins
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RNautophagy/DNautophagy
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Micronucleophagy
|
Midbophagy
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Glycophagy
|
TRIM-directed selective autophagy
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ER-mitochondria tethering complex
|
mTORC1 complex
|
mTORC2 complex
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SEACIT/GATOR1 complex
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SEACAT/GATOR2 complex
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KICSTOR complex
|
Rab GTPases
|
K07874 RAB1A; Ras-related protein Rab-1A
K07875 RAB1B; Ras-related protein Rab-1B
K07901 RAB8A, MEL; Ras-related protein Rab-8A
K07925 RAB39B; Ras-related protein Rab-39B
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Rab associated proteins
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Others
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K07198 PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K17606 IGBP1, TAP42; immunoglobulin-binding protein 1
K17988 TECPR1; tectonin beta-propeller repeat-containing protein 1
K17603 ZFYVE1; zinc finger FYVE domain-containing protein 1
K22265 NLRP4; NACHT, LRR and PYD domains-containing protein 4
K22266 NLRP10; NACHT, LRR and PYD domains-containing protein 10
K21249 UVRAG; UV radiation resistance-associated gene protein
K25948 RUBCNL; protein associated with UVRAG as autophagy enhancer
K19330 RUBCN; run domain Beclin-1 interacting and cysteine-rich containing protein
K06902 UMF1; MFS transporter, UMF1 family
K14209 SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter)
K06819 NRP2; neuropilin 2
K23299 WDFY1; WD repeat and FYVE domain-containing protein 1
K24777 WDFY4; WD repeat and FYVE domain-containing protein 4
K22991 WDR45, WIPI4, WIPI3; WD repeat-containing protein 45
K23881 TECPR2; tectonin beta-propeller repeat-containing protein 2
K23882 CISD2; CDGSH iron-sulfur domain-containing protein 2
K23883 EPG5; ectopic P granules protein 5
K23884 WAC; WW domain-containing adapter protein with coiled-coil
K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
K24045 JMY; junction-mediating and -regulatory protein
K24928 TTC5; tetratricopeptide repeat protein 5
K25663 FEZ1; fasciculation and elongation protein zeta-1
K25668 FEZ2; fasciculation and elongation protein zeta-2
K25949 CCDC50; coiled-coil domain-containing protein 50
K26231 GPRASP1; G-protein coupled receptor-associated sorting protein 1
K26232 DDIT4L, CHRB; DNA damage-inducible transcript 4-like protein
K27309 TMEM59; transmembrane protein 59
K28394 TMEM74; transmembrane protein 74
K24550 BCAS3; breast carcinoma-amplified sequence 3
K27411 PHAF1; phagosome assembly factor 1
K27476 PHF23; PHD finger protein 23
K27569 EVA1; protein eva-1
K27570 DAP; death-associated protein 1
K27762 GIMAP6; GTPase IMAP family member 6
K28938 IRGQ; immunity-related GTPase family Q protein
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Others
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NADPH oxidases (Nox) and associated proteins
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NADPH oxidases
|
Nox associated proteins
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K08009 CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
K08011 NCF1, P47PHOX; neutrophil cytosolic factor 1
K08010 NCF2, P67PHOX; neutrophil cytosolic factor 2
K08012 NCF4, P40PHOX; neutrophil cytosolic factor 4
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K21432 NOXA1; NADPH oxidase activator 1
K17934 NOXO1, SNX28; NADPH oxidase organizer 1
K17233 DUOXA1; dual oxidase maturation factor 1
K17232 DUOXA2; dual oxidase maturation factor 2
K24032 SH3PXD2; SH3 and PX domain-containing protein 2
K28845 TXNDC11; thioredoxin domain-containing protein 11
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Actin-binding proteins
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Myosins
|
Arp2/3 complex
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K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758 ARPC2; actin related protein 2/3 complex, subunit 2
K05756 ARPC3; actin related protein 2/3 complex, subunit 3
K05755 ARPC4; actin related protein 2/3 complex, subunit 4
K05754 ARPC5; actin related protein 2/3 complex, subunit 5
K17260 ACTR2, ARP2; actin-related protein 2
K18584 ACTR3, ARP3; actin-related protein 3
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Nucleation-promoting factors (NPFs)
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Others
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Mucins
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MARVEL domain-containing proteins
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Specific organelles associated proteins
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Melanosome
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K07918 RAB32; Ras-related protein Rab-32
K07923 RAB38; Ras-related protein Rab-38
K20175 ANKRD27; ankyrin repeat domain-containing protein 27
K21851 SGSM2, RUTBC1; small G protein signaling modulator 2
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Auto phagosome
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K07912 RAB24; Ras-related protein Rab-24
K07919 RAB33A; Ras-related protein Rab-33A
K07920 RAB33B; Ras-related protein Rab-33B
K24799 TBC1D25; TBC1 domain family member 25
K17890 ATG16L1; autophagy-related protein 16-1
K20868 ATG16L2; autophagy-related protein 16-2
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Lipid droplets
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K07910 RAB18; Ras-related protein Rab-18
K21407 APMAP; adipocyte plasma membrane-associated protein
K27760 GIMAP2; GTPase IMAP family member 2
K27773 GIMAP7; GTPase IMAP family member 7
K19365 BSCL2; seipin
K28099 FITM1; fat storage-inducing transmembrane protein 1
K28100 FITM2; fat storage-inducing transmembrane protein 2 [EC:3.6.1.-]
K28352 C18ORF32; UPF0729 protein C18orf32
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Mitochondrion
|
K07918 RAB32; Ras-related protein Rab-32
|
Rho GTPase associated proteins
|
Rho GTPase-activating proteins
|
K08878 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
K20629 ABR; active breakpoint cluster region-related protein
K18470 ARHGAP1, CDC42GAP; Rho GTPase-activating protein 1
K20630 CHN1_2, ARHGAP2_3; chimaerin
K20122 ARHGAP4; Rho GTPase-activating protein 4
K13709 ARHGAP5; Rho GTPase-activating protein 5
K20631 ARHGAP6; Rho GTPase-activating protein 6
K20632 DLC; deleted in liver cancer protein
K20633 ARHGAP8, BPGAP1; Rho GTPase-activating protein 8
K20634 ARHGAP9; Rho GTPase-activating protein 9
K13736 ARHGAP10; Rho GTPase-activating protein 10
K20635 ARHGAP11; Rho GTPase-activating protein 11
K20636 ARHGAP12_27; Rho GTPase-activating protein 12/27
K07526 SRGAP; SLIT-ROBO Rho GTPase activating protein
K20637 ARHGAP15; Rho GTPase-activating protein 15
K20638 ARHGAP17, RICH1; Rho GTPase-activating protein 17
K20639 ARHGAP18_28_40; Rho GTPase-activating protein 18/28/40
K20640 ARHGAP19; Rho GTPase-activating protein 19
K20641 ARHGAP20; Rho GTPase-activating protein 20
K20315 ARHGAP21_23; Rho GTPase-activating protein 21/23
K20642 ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25
K20071 ARHGAP26, GRAF; Rho GTPase-activating protein 26
K20644 ARHGAP29; Rho GTPase-activating protein 29
K20645 ARHGAP30; Rho GTPase-activating protein 30
K20646 ARHGAP31, CDGAP; Rho GTPase-activating protein 31
K20647 ARHGAP32; Rho GTPase-activating protein 32
K17933 ARHGAP33, SNX26; Rho GTPase-activating protein 33
K05732 ARHGAP35, GRLF1; glucocorticoid receptor DNA-binding factor 1
K20648 ARHGAP36; Rho GTPase-activating protein 36
K20649 ARHGAP39; Rho GTPase-activating protein 39
K20650 OPHN1, ARHGAP41; oligophrenin-1
K20651 ARHGAP42, GRAF3; Rho GTPase-activating protein 42
K20652 SH3BP1, ARHGAP43; SH3-domain binding protein 1
K21067 ARHGAP44, RICH2; Rho GTPase-activating protein 44
K26415 ARHGAP45; Rho GTPase-activating protein 45
K20653 GMIP, ARHGAP46; GEM interacting protein
K20654 TAGAP, ARHGAP47; T-cell activation Rho GTPase-activating protein
K20655 SYDE; Rho GTPase-activating protein SYDE
K20643 RGD1; Rho GTPase-activating protein RGD1
K18439 ARAP1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
K18440 ARAP2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
K12490 ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
K16733 RACGAP1, Tum; Rac GTPase-activating protein 1
K08773 RALBP1; RalA-binding protein 1
K10360 MYO9; myosin IX
K24353 UBXN11; UBX domain-containing protein 11
K28947 ROPGAP1S; Rho GTPase-activating protein 1/2/3/4/5
K28948 ROPGAP6_7, PHGAP; Rho GTPase-activating protein 6/7
K28950 REN1; Rho GTPase-activating protein REN1
|
Rho guanine nucleotide exchange factors (GEFs)
|
Membrane Trafficking