Rx-to-OTC Switch List in the USA Rx-to-OTC Switch List in the USA| Approved | KEGG | Active ingredient | Category |
| 1976 | D00663 | Brompheniramine maleate | antihistamine |
| D00665 | Chlorpheniramine maleate | antihistamine | |
| D01022 | Oxymetazoline hydrochloride | nasal decongestant | |
| D00485 | Pseudoephedrine hydrochloride | nasal decongestant | |
| D05649 | Pseudoephedrine sulfate | nasal decongestant | |
| D00757 | Xylometazoline hydrochloride | nasal decongestant | |
| 1978 | D02327 | Doxylamine succinate (NDA) | sleep-aid |
| 1979 | D00088 | Hydrocortisone | antipruritic (anti-itch) |
| D00165 | Hydrocortisone acetate | antipruritic (anti-itch) | |
| 1980 | Acidulated phosphate fluoride rinse | dental rinse | |
| D00943 | Sodium fluoride rinse | dental rinse | |
| D05919 | Stannous fluoride gel | anticaries gel | |
| D05919 | Stannous fluoride rinse | dental rinse | |
| D04018 | Ephedrine sulfate | anorectal/vasoconstrictor | |
| D01386 | Epinephrine hydrochloride | anorectal/vasoconstrictor | |
| D00511 | Phenylephrine hydrochloride | anorectal/vasoconstrictor | |
| 1981 | D00665 | Chlorpheniramine maleate (NDA) | antihistamine |
| D01224 | Phenylpropanolamine hydrochloride (NDA) | nasal decongestant | |
| D00669 | Diphenhydramine hydrochloride (NDA) | antitussive | |
| 1982 | D00339 | Haloprogin | antifungal |
| D00882 | Miconazole nitrate | antifungal | |
| D00669 | Diphenhydramine hydrochloride | sleep-aid | |
| D03854 | Diphenhydramine monocitrate | sleep-aid | |
| D00735 | Dyclonine hydrochloride | oral anesthetic | |
| D03704 | Dexbrompheniramine maleate (NDA) | antihistamine | |
| D05649 | Pseudoephedrine sulfate (NDA) | nasal decongestant | |
| D01782 | Triprolidine hydrochloride | antihistamine | |
| 1984 | D00126 | Ibuprofen (NDA) | internal analgesic/antipyretic |
| 1985 | D03704 | Dexbrompheniramine maleate | antihistamine |
| D00669 | Diphenhydramine hydrochloride | antihistamine | |
| D00485 | Pseudoephedrine hydrochloride(NDA) | nasal decongestant | |
| D01782 | Triprolidine hydrochloride (NDA) | antihistamine | |
| 1986 | D01022 | Oxymetazoline hydrochloride (NDA) | occular vasoconstrictor |
| D00486 | Pyrantel pamoate | anthelmintic | |
| 1987 | D00863 | Povidone iodine sponge (NDA) | antimicrobial |
| D00669 | Diphenhydramine hydrochloride | antiemetic | |
| D03704 | Dexbrompheniramine maleate (NDA) | antihistamine | |
| D01389 | Chlophedianol hydrochloride | antitussive | |
| D02327 | Doxylamine succinate | antihistamine | |
| 1988 | D08144 | Loperamide (NDA) | antidiarrheal |
| 1989 | D09004 D04682 | Hydrogenated soybean oil and lecithin | cholecystokinetic |
| D00126 D00485 | Ibuprofen, Pseudoephedrine hydrochloride (NDA) | analgesic/decongestant | |
| D00282 | Clotrimazole (NDA) | antifungal | |
| 1990 | D05443 | Permethrin (NDA) | pediculicide (head lice) |
| D00282 | Clotrimazole (NDA) | anticandidal | |
| D00882 | Miconazole nitrate | anticandidal | |
| 1991 | D00088 | Hydrocortisone | antipruritic (anti-itch) |
| D00165 | Hydrocortisone acetate | antipruritic (anti-itch) | |
| 1992 | D00666 | Clemastine fumarate (NDA) | antihistamine |
| D00666 D01224 | Clemastine fumarate in combination with phenylpropanolamine hydrochloride (NDA) | antihistamine/decongestant | |
| D00668 | Dexchlorpheniramine maleate | antihistamine | |
| 1994 | D00970 | Naproxen sodium (NDA) | internal analgesic/antipyretic |
| D02133 | Pheniramine maleate with naphazoline hydrochloride (NDA) | ophthalmic antihistamine/decongestant | |
| D02950 D00743 | Antazoline phosphate with naphazoline hydrochloride (NDA) | ophthalmic antihistamine/decongestant | |
| 1995 | D00318 | Famotidine (NDA) | acid reducer |
| D00126 | Ibuprofen suspension 100mg/5ml for pediatric use (NDA) | internal analgesic/antipyretic | |
| D00295 | Cimetidine (NDA) | acid reducer | |
| D00132 | Ketoprofen (NDA) | internal analgesic | |
| D00422 | Ranitidine (NDA) | acid reducer | |
| D00880 | Butoconazole nitrate (NDA) | anticandidal | |
| 1996 | D00418 | Minoxidil (NDA) | hair grower |
| D05157 | Nicotine polacrilex (NDA) | smoking cessation | |
| D00440 | Nizatidine (NDA) | acid reducer | |
| D00882 | Miconazole nitrate (NDA) | anticandidal | |
| D03365 | Nicotine transdermal system (NDA) | smoking cessation | |
| D00282 | Clotrimazole (NDA) | anticandidal | |
| D03365 | Nicotine transdermal system (NDA) | smoking cessation | |
| D03085 | Bentoquatam (NDA) | poison ivy protection | |
| 1997 | D00526 | Cromolyn sodium (NDA) | allergy prevention & treatment |
| D00890 | Tioconazole (NDA) | anticandidal | |
| D08144 D05841 | Loperamide, Simethicone (NDA) | antidiarrheal/antigas | |
| D06226 | Triclosan (dentifrice) (NDA) | antigingivitis | |
| D00351 | Ketoconazole (NDA) | dandruff shampoo | |
| D00418 | Minoxidil (NDA) | hair grower | |
| 1998 | D00109 D00528 D00217 | Aspirin, Caffeine, Acetaminophen (NDA) | migraine |
| D00882 | Miconazole nitrate (NDA) | anticandidal | |
| 1999 | D02219 | Terbinafine hydrochloride (NDA) | antifungal |
| D00295 | Cimetidine suspension (NDA) | acid reducer | |
| D00970 D00485 | Naproxen sodium, Pseudoephedrine hydrochloride (NDA) | analgesic/decongestant | |
| 2000 | D00126 | Ibuprofen (NDA) | migraine |
| D00126 | Ibuprofen (NDA) | migraine | |
| D03884 | Docosanol (NDA) | cold sore/fever blister | |
| D00318 D00932 D00731 | Famotidine, Calcium carbonate, Magnesium hydroxide (NDA) | heartburn, acid indigestion | |
| 2001 | D01093 | Butenafine hydrochloride (NDA) | athlete's foot, jock itch, ringworm |
| 2002 | D00126 D00485 | Ibuprofen, Pseudoephedrine hydrochloride, suspension for pediatric use (NDA) | analgesic/decongestant |
| D00337 | Guaifenesin extended-release tablet (NDA) | expectorant | |
| D05157 | Nicotine polacrilex troche/lozenge (NDA) | smoking cessation | |
| D00364 | Loratadine (NDA) | antihistamine | |
| D00364 D05649 | Loratadine, Pseudoephededrine sulfate (NDA) | antihistamine/decongestant | |
| 2003 | D05259 | Omeprazole magnesium | acid reducer to treat frequent heartburn |
| D00364 | Loratadine (NDA) | hives relief | |
| 2005 | D03854 D00126 D00669 | Diphenhydramine citrate & Ibuprofen (NDA) Diphenhydramine hydrochloride & Ibuprofen potassium (NDA) |
analgesic sleep-aid |
| 2006 | D03932 | Ecamsule (combined with avobenzone and octocrylene (NDA) | sunscreen |
| D00950 | Levonorgestrel (NDA) | contraceptive | |
| D03370 | Polyethylene glycol 3350 (NDA) | laxative | |
| D08105 | Ketotifen (NDA) | antihistamine eye | |
| 2007 | D04028 | Orlistat (NDA) | weight loss aid |
| D00664 D00485 | Cetirizine HCl & Pseudoephedrine HCl (NDA) | antihistamine/decongestant | |
| D00664 | Cetirizine HCl (NDA) | antihistamine, hives relief | |
| 2009 | D00355 | Lansoprazole (NDA) | acid reducer to treat frequent heartburn |
| D00950 | Levonorgestrel (NDA) | contraceptive | |
| D00455 D01203 | Omeprazole and sodium bicarbonate (NDA) | acid reducer to treat frequent heartburn | |
| 2010 | D00126 D00511 | Ibuprofen and phenylephrine HCl (NDA) | analgesic/decongestant |
| 2011 | D00671 | Fexofenadine hydrochloride (NDA) | antihistamine |
| D10252 | Fexofenadine hydrochloride and pseudoephedrine HCl (NDA) | antihistamine/decongestant | |
| 2013 | D00465 | Oxybutynin (NDA) | overactive bladder |
| D00983 | Triamcinolone acetonide (NDA) | intranasal steroid for allergic rhinitis | |
| 2014 | D01984 | Esomeprazole magnesium (NDA) | acid reducer to treat frequent heartburn |
| D01708 | Fluticasone propionate (NDA) | intranasal steroid for upper respiratory allergies | |
| 2015 | D00246 | Budesonide (NDA) | intranasal steroid for allergic rhinitis |
| 2016 | D01112 | Adapalene (sNDA) | acne |
| D06315 | Fluticasone furoate (sNDA) | intranasal steroid for upper respiratory allergies | |
| 2017 | D08118 | Levocetirizine dihydrochloride (NDA) | antihistamine |
| D02076 | Brimonidine tartrate (NDA) | relief of redness of the eye due to minor eye irritations | |
| 2020 | D00904 | Diclofenac sodium (sNDA) | topical pain |
| D01192 | Olopatadine hydrochloride (sNDA) | antihistamine and redness reliever | |
| D11897 | Acetaminophen and ibuprofen (NDA) | oral analgesic | |
| D00804 | Ivermectin (sNDA) | lice treatment | |
| 2021 | D00659 | Azelastine hydrochloride (NDA) | antihistamine |
| D06552 | Alcaftadine (sNDA) | antihistamine | |
| 2022 | D00690 | Mometasone furoate (NDA) | antihistamine |
| 2023 | D01340 | Naloxone hydrochloride (NDA) | treatment of known or suspected opioid overdose |