KEGG   PATHWAY: pov04068
Entry
pov04068                    Pathway                                
Name
FoxO signaling pathway - Paralichthys olivaceus (Japanese flounder)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
pov04068  FoxO signaling pathway
pov04068

Other DBs
GO: 0009267
Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109630415  transforming growth factor beta-1-like [KO:K13375]
109642431  transforming growth factor beta-2-like [KO:K13376]
109631969  tgfb2; transforming growth factor beta-2 [KO:K13376]
109628154  tgfb3; transforming growth factor beta-3 [KO:K13377]
109636158  transforming growth factor beta-3-like [KO:K13377]
109638437  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
109631953  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
109647461  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
109639132  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
109642417  mothers against decapentaplegic homolog 4 [KO:K04501]
109626289  mothers against decapentaplegic homolog 4-like [KO:K04501]
109641002  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
109643214  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
109637282  mothers against decapentaplegic homolog 3 [KO:K23605]
109624649  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
109645115  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
109625889  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
109626467  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
109633767  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
109639846  prkab1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
109643260  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
109640188  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
109643729  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
109629372  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
109643044  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
109641129  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
109644700  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
109645211  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
109647460  skp2; S-phase kinase-associated protein 2 [KO:K03875]
109643735  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
109627395  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
109627429  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
109643520  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
109626906  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
109638720  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
109634091  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
109641940  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
109634843  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
109626552  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
109626878  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109633007  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109626434  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109635565  serine/threonine-protein kinase 3/4-like [KO:K04411]
109635410  stk4; serine/threonine-protein kinase 4 [KO:K04411]
109639654  insulin-like growth factor I [KO:K05459]
109640767  igf1; insulin-like growth factor I [KO:K05459]
109624556  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109625052  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109645588  insulin-like [KO:K04526]
109643669  ins; insulin [KO:K04526]
109624754  insulin-like [KO:K04526]
109643727  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
109625760  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
109628480  insulin receptor substrate 1-B-like [KO:K16172]
109634880  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
109631417  irs2; insulin receptor substrate 2 [KO:K07187]
109641748  insulin receptor substrate 2-B-like [KO:K07187]
109640930  insulin receptor substrate 2-like isoform X1 [KO:K07187]
109630509  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109634439  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109639237  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109640251  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
109642929  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
109642569  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109638609  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
109636617  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
109626360  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109646274  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
109626882  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
109629542  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109644018  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109637101  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109644901  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109634811  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109641589  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
109630907  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109628065  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109634602  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109642071  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
109642399  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
109632568  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
109633033  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
109630569  sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
109629892  serine/threonine-protein kinase Sgk3-like [KO:K13304] [EC:2.7.11.1]
109628830  forkhead box protein O1-A-like isoform X1 [KO:K07201]
109630392  forkhead box protein O1-A-like [KO:K07201]
109631763  forkhead box protein O6-like [KO:K09408]
109636277  forkhead box protein O3-like [KO:K09408]
109636142  forkhead box protein O3-like [KO:K09408]
109635999  forkhead box protein O3-like [KO:K09408]
109648255  forkhead box protein O3-like [KO:K09408]
109628045  forkhead box protein O6-like [KO:K12358]
109633011  forkhead box protein O3-like [KO:K17847]
109633074  forkhead box protein O6-like [KO:K17847]
109636085  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
109636627  homer3; homer protein homolog 3 isoform X1 [KO:K15010]
109625053  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
109626421  homer1; homer protein homolog 1 isoform X1 [KO:K15010]
109637861  homer protein homolog 3-like isoform X1 [KO:K15010]
109638110  homer protein homolog 1-like isoform X1 [KO:K15010]
109628931  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
109647386  casein kinase I-like isoform X1 [KO:K08960] [EC:2.7.11.1]
109641075  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
109631714  interleukin-6 [KO:K05405]
109629080  il10; interleukin-10 [KO:K05443]
109634199  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109625474  egf; pro-epidermal growth factor [KO:K04357]
109646379  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109646791  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
109645925  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
109641399  grb2; growth factor receptor-bound protein 2 [KO:K04364]
109636299  sos2; son of sevenless homolog 2 [KO:K03099]
109646414  son of sevenless homolog 1-like [KO:K03099]
109638968  hras; GTPase HRas [KO:K02833]
109641467  GTPase HRas-like [KO:K07827]
109624348  kras; GTPase KRas isoform X1 [KO:K07827]
109637498  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109635227  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109633665  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
109624327  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109625750  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109639504  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
109640677  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109630822  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109632714  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
109632715  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109629252  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
109630593  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
109630994  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109638988  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109629344  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
109639479  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
109645763  foxg1; forkhead box protein G1 [KO:K09385]
109634492  forkhead box protein G1-like [KO:K09385]
109646153  forkhead box protein G1-like [KO:K09385]
109640910  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
109647535  G2/mitotic-specific cyclin-B2-like [KO:K21770]
109634457  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
109640808  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
109625110  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109642994  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
109632688  G1/S-specific cyclin-D2-like [KO:K10151]
109623974  G1/S-specific cyclin-D2-like [KO:K10151]
109637130  cyclin-G2-like [KO:K10146]
109646257  cyclin-G2-like [KO:K10146]
109638248  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
109627635  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
109629024  LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1-like [KO:K06625]
109632907  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
109632735  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
109624669  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109646631  retinoblastoma-like protein 2 [KO:K16332]
109646908  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
109639337  plk2; serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
109644828  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
109628079  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
109644407  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109637499  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109636370  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
109639301  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109625451  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109643194  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109625570  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109645590  bcl2l11; bcl-2-like protein 11 [KO:K16341]
109645712  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
109646012  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
109639306  B-cell lymphoma 6 protein homolog [KO:K15618]
109625465  bcl6; B-cell lymphoma 6 protein [KO:K15618]
109633760  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
109626224  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
109633349  atg12; ubiquitin-like protein ATG12 [KO:K08336]
109641639  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
109633346  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
109634940  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
109624557  cat; catalase [KO:K03781] [EC:1.11.1.6]
109635940  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
109634588  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
109629738  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
109647304  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
109640646  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
109631238  g6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
109644036  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
109644038  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
109637262  klf2; Krueppel-like factor 2 [KO:K17845]
109625307  Krueppel-like factor 2 [KO:K17845]
109646393  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
109625525  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
109624264  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
109624278  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
109632250  fbxo32; F-box only protein 32 [KO:K10305]
109635955  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
pov00010  Glycolysis / Gluconeogenesis
pov00020  Citrate cycle (TCA cycle)
pov00190  Oxidative phosphorylation
pov04010  MAPK signaling pathway
pov04110  Cell cycle
pov04120  Ubiquitin mediated proteolysis
pov04140  Autophagy - animal
pov04210  Apoptosis
pov04350  TGF-beta signaling pathway
pov04910  Insulin signaling pathway
KO pathway
ko04068   
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