KEGG   PATHWAY: pov04140
Entry
pov04140                    Pathway                                
Name
Autophagy - animal - Paralichthys olivaceus (Japanese flounder)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
pov04140  Autophagy - animal
pov04140

Other DBs
GO: 0006914
Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109623958  dapk2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
109624011  [KO:K10435]
109624327  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109624348  kras; GTPase KRas isoform X1 [KO:K07827]
109624556  [KO:K05087] [EC:2.7.10.1]
109624754  [KO:K04526]
109624819  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
109625047  [KO:K21247]
109625052  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109625132  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
109625184  [KO:K01363] [EC:3.4.22.1]
109625383  [KO:K01365] [EC:3.4.22.15]
109625591  rab8a; ras-related protein Rab-8A [KO:K07901]
109625750  [KO:K04369] [EC:2.7.12.2]
109625757  rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein [KO:K19330]
109625775  atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
109625861  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109625889  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
109625959  wdr41; WD repeat-containing protein 41 [KO:K23610]
109626224  [KO:K15464]
109626262  [KO:K08512]
109626360  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109626411  ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
109626434  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109626467  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
109626552  [KO:K04440] [EC:2.7.11.24]
109626564  [KO:K07359] [EC:2.7.11.17]
109626629  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
109626866  wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
109626878  [KO:K04440] [EC:2.7.11.24]
109626882  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
109626886  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
109626940  becn1; beclin-1 [KO:K08334]
109627007  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
109627110  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
109627181  nrbf2; nuclear receptor-binding factor 2 [KO:K21246]
109627313  rptor; regulatory-associated protein of mTOR [KO:K07204]
109627333  [KO:K07207]
109627373  [KO:K04688] [EC:2.7.11.1]
109627529  rab33b; ras-related protein Rab-33B [KO:K07920]
109627540  [KO:K07920]
109627588  [KO:K07207]
109627598  atg4d; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
109627640  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109627770  cunh9orf72; protein C9orf72 homolog [KO:K23609]
109628034  atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
109628061  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
109628065  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109628135  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
109628158  [KO:K04427] [EC:2.7.11.25]
109628161  [KO:K17603]
109628282  [KO:K16185]
109628416  [KO:K21248]
109628480  [KO:K16172]
109628582  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
109628619  atg101; autophagy-related protein 101 [KO:K19730]
109628631  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
109628717  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
109628753  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
109628754  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
109628963  [KO:K04958]
109628992  [KO:K04958]
109629009  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
109629150  [KO:K07897]
109629191  [KO:K07897]
109629305  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
109629311  [KO:K07897]
109629335  [KO:K07208]
109629812  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
109629836  [KO:K11248]
109629853  [KO:K26797]
109630344  [KO:K10802]
109630509  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109630582  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109630754  [KO:K07203] [EC:2.7.11.1]
109630859  [KO:K04570]
109630907  [KO:K04456] [EC:2.7.11.1]
109631097  cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
109631187  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
109631296  gorasp2; Golgi reassembly-stacking protein 2 [KO:K26797]
109631360  [KO:K06528]
109631417  irs2; insulin receptor substrate 2 [KO:K07187]
109631738  [KO:K21347]
109631906  [KO:K07925]
109632222  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
109632450  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
109632479  [KO:K17603]
109632497  [KO:K08488]
109632517  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109632548  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
109632939  optn; optineurin [KO:K19946]
109633007  [KO:K04440] [EC:2.7.11.24]
109633346  [KO:K08341]
109633349  atg12; ubiquitin-like protein ATG12 [KO:K08336]
109633399  [KO:K21347]
109633432  stx17; syntaxin-17 [KO:K08491]
109633455  rragc; ras-related GTP-binding protein C [KO:K16186]
109633537  atg5; autophagy protein 5 isoform X1 [KO:K08339]
109633574  [KO:K21357] [EC:2.7.11.1]
109633578  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
109633760  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
109633793  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
109633876  [KO:K08512]
109634223  [KO:K04345] [EC:2.7.11.11]
109634335  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
109634439  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109634602  [KO:K04456] [EC:2.7.11.1]
109634617  [KO:K21248]
109634629  [KO:K17603]
109634811  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109634829  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109634873  bad; bcl2-associated agonist of cell death [KO:K02158]
109634880  [KO:K16172]
109634940  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
109635227  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109635228  tp53inp2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
109635382  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
109635707  [KO:K08270]
109635786  [KO:K10802]
109635823  [KO:K07925]
109636059  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
109636207  [KO:K01363] [EC:3.4.22.1]
109636447  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
109636495  atg9a; autophagy-related protein 9A isoform X1 [KO:K17907]
109636526  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
109636617  [KO:K02649]
109636628  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
109636876  rras2; ras-related protein R-Ras2 [KO:K07830]
109636934  snap29; synaptosomal-associated protein 29 [KO:K08509]
109637062  rheb; GTP-binding protein Rheb [KO:K07208]
109637067  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
109637261  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109637645  [KO:K17907]
109637961  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
109637988  [KO:K07920]
109638172  epg5; ectopic P granules protein 5 homolog [KO:K23883]
109638609  [KO:K02649]
109638731  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109638861  [KO:K17907]
109638968  hras; GTPase HRas [KO:K02833]
109639016  atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
109639037  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
109639237  [KO:K00922] [EC:2.7.1.153]
109639250  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109639504  [KO:K04371] [EC:2.7.11.24]
109640085  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
109640138  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
109640140  [KO:K08268]
109640251  [KO:K00922] [EC:2.7.1.153]
109640281  [KO:K02161]
109640306  tsc1; hamartin isoform X1 [KO:K07206]
109640360  [KO:K17908]
109640387  [KO:K17987]
109640571  [KO:K26797]
109640677  [KO:K04371] [EC:2.7.11.24]
109640735  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
109640930  [KO:K07187]
109641181  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
109641427  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
109641467  [KO:K07827]
109641511  smcr8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
109641514  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
109641589  [KO:K04456] [EC:2.7.11.1]
109641639  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
109641748  [KO:K07187]
109641754  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109641834  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
109641991  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
109641999  wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
109642071  [KO:K04456] [EC:2.7.11.1]
109642112  [KO:K23282]
109642173  [KO:K23611]
109642198  [KO:K08803] [EC:2.7.11.1]
109642250  [KO:K04345] [EC:2.7.11.11]
109642367  mras; ras-related protein M-Ras [KO:K07831]
109642569  [KO:K02649]
109642801  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
109642929  [KO:K00922] [EC:2.7.1.153]
109643090  supt20h; transcription factor SPT20 homolog isoform X1 [KO:K21245]
109643180  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
109643323  [KO:K04688] [EC:2.7.11.1]
109643581  [KO:K01379] [EC:3.4.23.5]
109643669  ins; insulin [KO:K04526]
109643848  [KO:K04382] [EC:3.1.3.16]
109644029  [KO:K08803] [EC:2.7.11.1]
109644057  [KO:K08803] [EC:2.7.11.1]
109644058  ctsl; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
109644118  [KO:K01365] [EC:3.4.22.15]
109644187  [KO:K07901]
109644413  [KO:K11248]
109644778  rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589]
109644901  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109645115  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
109645189  [KO:K07925]
109645242  [KO:K22262]
109645317  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109645353  [KO:K07874]
109645588  [KO:K04526]
109645786  [KO:K07206]
109645832  [KO:K20402]
109645834  [KO:K04570]
109646089  [KO:K21348]
109646129  [KO:K26797]
109646274  [KO:K02649]
109646325  [KO:K08342] [EC:3.4.22.-]
109646615  [KO:K17987]
109647008  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
109647251  [KO:K20868]
109647671  [KO:K23282]
109647905  [KO:K01379] [EC:3.4.23.5]
109648166  [KO:K01379] [EC:3.4.23.5]
109648203  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
pov04010  MAPK signaling pathway
pov04141  Protein processing in endoplasmic reticulum
pov04142  Lysosome
pov04150  mTOR signaling pathway
pov04910  Insulin signaling pathway
KO pathway
ko04140   

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