Entry
Name
Autophagy - animal - Paralichthys olivaceus (Japanese flounder)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Paralichthys olivaceus (Japanese flounder) [GN:
pov ]
Gene
109630509 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109634439 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109640251 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
109642929 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
109642569 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
109638609 phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
109636617 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
109626360 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
109646274 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
109633760 bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
109626224 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
109632222 deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402 ]
109628717 ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
109628034 atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906 ]
109640360 LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908 ]
109626866 wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908 ]
109641999 wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908 ]
109641834 wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991 ]
109627110 wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991 ]
109643090 supt20h; transcription factor SPT20 homolog isoform X1 [KO:K21245 ]
109641511 smcr8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611 ]
109642173 Smith-Magenis syndrome chromosomal region candidate gene 8 protein-like [KO:K23611 ]
109631187 tank; TRAF family member-associated NF-kappa-B activator [KO:K12650 ]
109648203 atg14; beclin 1-associated autophagy-related key regulator [KO:K17889 ]
109635228 tp53inp2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247 ]
109628753 uvrag; UV radiation resistance-associated gene protein [KO:K21249 ]
109625757 rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein [KO:K19330 ]
109636059 eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
109637961 atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888 ]
109639016 atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343 ]
109631097 cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724 ]
109641639 gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
109633346 gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
109634940 gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
109640735 map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
109641754 map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
109624011 microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435 ]
109625775 atg4b; cysteine protease ATG4B isoform X1 [KO:K08342 ] [EC:3.4.22.-]
109646089 calcium-binding and coiled-coil domain-containing protein 2-like isoform X1 [KO:K21348 ]
109626262 vesicle-associated membrane protein 8-like isoform X1 [KO:K08512 ]
109647671 pleckstrin homology domain-containing family M member 1-like [KO:K23282 ]
109642112 putative pleckstrin homology domain-containing family M member 1P [KO:K23282 ]
109628754 vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
109642801 vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
109632548 vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
109633578 vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
109629812 vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
109625132 lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
Compound
C00350 Phosphatidylethanolamine
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Meijer AJ, Codogno P.
Title
Regulation and role of autophagy in mammalian cells.
Journal
Reference
Authors
Deretic V.
Title
Autophagy in innate and adaptive immunity.
Journal
Reference
Authors
Levine B, Yuan J.
Title
Autophagy in cell death: an innocent convict?
Journal
Reference
Authors
Tanida I, Ueno T, Kominami E.
Title
LC3 conjugation system in mammalian autophagy.
Journal
Reference
Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
Title
Autophagy in metazoans: cell survival in the land of plenty.
Journal
Reference
Authors
Reggiori F, Klionsky DJ.
Title
Autophagosomes: biogenesis from scratch?
Journal
Reference
Authors
Klionsky DJ, Emr SD.
Title
Autophagy as a regulated pathway of cellular degradation.
Journal
Reference
Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
Title
Lysosomal proteolysis in skeletal muscle.
Journal
Reference
Authors
He C, Klionsky DJ
Title
Regulation mechanisms and signaling pathways of autophagy.
Journal
Reference
Authors
Yang Z, Klionsky DJ
Title
An overview of the molecular mechanism of autophagy.
Journal
Reference
Authors
Yang Z, Klionsky DJ
Title
Mammalian autophagy: core molecular machinery and signaling regulation.
Journal
Reference
Authors
Chen Y, Klionsky DJ
Title
The regulation of autophagy - unanswered questions.
Journal
Reference
Authors
Mizushima N, Yoshimori T, Ohsumi Y
Title
The role of Atg proteins in autophagosome formation.
Journal
Reference
Authors
Russell RC, Yuan HX, Guan KL
Title
Autophagy regulation by nutrient signaling.
Journal
Reference
Authors
Noda NN, Fujioka Y
Title
Atg1 family kinases in autophagy initiation.
Journal
Related pathway
pov04141 Protein processing in endoplasmic reticulum
KO pathway
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