KEGG   PATHWAY: pov04010
Entry
pov04010                    Pathway                                
Name
MAPK signaling pathway - Paralichthys olivaceus (Japanese flounder)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pov04010  MAPK signaling pathway
pov04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109623978  [KO:K04349]
109624050  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
109624117  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
109624327  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109624348  kras; GTPase KRas isoform X1 [KO:K07827]
109624365  hgf; hepatocyte growth factor [KO:K05460]
109624423  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
109624436  [KO:K04348] [EC:3.1.3.16]
109624460  [KO:K04358]
109624486  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109624493  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109624556  [KO:K05087] [EC:2.7.10.1]
109624596  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
109624635  [KO:K22428]
109624637  [KO:K04358]
109624638  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109624744  [KO:K04349]
109624754  [KO:K04526]
109624838  [KO:K04358]
109624905  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109624917  fgf3; fibroblast growth factor 3 [KO:K04358]
109624927  vegfd; vascular endothelial growth factor D [KO:K05449]
109624935  [KO:K05096] [EC:2.7.10.1]
109624936  fgf4; fibroblast growth factor 4 [KO:K04358]
109625052  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109625161  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109625314  fgf22; fibroblast growth factor 22 [KO:K04358]
109625360  [KO:K25415]
109625422  [KO:K04852]
109625451  [KO:K04402]
109625453  [KO:K04347]
109625474  egf; pro-epidermal growth factor [KO:K04357]
109625570  [KO:K04389]
109625664  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109625665  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109625686  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109625750  [KO:K04369] [EC:2.7.12.2]
109625760  [KO:K04527] [EC:2.7.10.1]
109625833  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
109625845  [KO:K04448]
109625861  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109625885  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109625941  [KO:K03173] [EC:2.3.2.27]
109625983  [KO:K12326]
109626123  [KO:K04358]
109626174  [KO:K04519]
109626283  [KO:K03173] [EC:2.3.2.27]
109626344  [KO:K04429] [EC:2.7.11.1]
109626345  [KO:K04455]
109626349  [KO:K04454]
109626378  crkl; crk-like protein [KO:K04438]
109626434  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109626437  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109626445  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
109626466  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109626472  [KO:K04360] [EC:2.7.10.1]
109626552  [KO:K04440] [EC:2.7.11.24]
109626672  [KO:K07861]
109626687  [KO:K04430] [EC:2.7.12.2]
109626716  fgf21; fibroblast growth factor 21 [KO:K22429]
109626878  [KO:K04440] [EC:2.7.11.24]
109626924  [KO:K04461] [EC:3.1.3.16]
109626935  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109627122  [KO:K04854]
109627261  [KO:K04358]
109627375  vegfc; vascular endothelial growth factor C [KO:K05449]
109627423  fgf8; fibroblast growth factor 8 [KO:K04358]
109627446  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109627471  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109627519  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109627602  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109627640  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109627744  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109627745  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109627792  [KO:K04453]
109627793  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
109627823  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
109627836  [KO:K04379]
109627986  [KO:K16859]
109628059  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
109628065  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109628142  [KO:K04373] [EC:2.7.11.1]
109628154  tgfb3; transforming growth factor beta-3 [KO:K13377]
109628158  [KO:K04427] [EC:2.7.11.25]
109628310  hspb1; heat shock protein beta-1 [KO:K04455]
109628428  [KO:K03283]
109628432  [KO:K03283]
109628476  [KO:K04457] [EC:3.1.3.16]
109628555  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
109628630  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
109628686  [KO:K04348] [EC:3.1.3.16]
109628711  [KO:K16510] [EC:2.7.11.1]
109628857  [KO:K05084] [EC:2.7.10.1]
109628858  [KO:K04465]
109628888  [KO:K04376]
109628905  [KO:K04444] [EC:2.7.11.1]
109629054  [KO:K04444] [EC:2.7.11.1]
109629172  [KO:K04393]
109629213  [KO:K04443] [EC:2.7.11.1]
109629252  [KO:K04441] [EC:2.7.11.24]
109629507  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
109629542  [KO:K04467] [EC:2.7.11.10]
109629552  [KO:K04421] [EC:2.7.11.25]
109629696  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109629793  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
109629839  [KO:K04421] [EC:2.7.11.25]
109629885  myc; myc proto-oncogene protein [KO:K04377]
109629944  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
109630221  nf1; neurofibromin isoform X1 [KO:K08052]
109630234  [KO:K04350]
109630251  [KO:K04429] [EC:2.7.11.1]
109630298  [KO:K04457] [EC:3.1.3.16]
109630368  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
109630415  [KO:K13375]
109630421  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
109630550  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109630558  [KO:K05093] [EC:2.7.10.1]
109630593  [KO:K04441] [EC:2.7.11.24]
109630731  [KO:K04437]
109630732  [KO:K04851]
109630748  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109630790  [KO:K03283]
109630822  [KO:K04441] [EC:2.7.11.24]
109630850  [KO:K05103] [EC:2.7.10.1]
109630891  map3k21; mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
109630907  [KO:K04456] [EC:2.7.11.1]
109630938  [KO:K04864]
109630994  [KO:K04441] [EC:2.7.11.24]
109631016  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109631170  [KO:K04390]
109631351  map3k20; mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
109631386  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
109631395  [KO:K02187] [EC:3.4.22.56]
109631409  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
109631692  [KO:K05466]
109631876  [KO:K04381]
109631953  [KO:K04388] [EC:2.7.11.30]
109631959  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109631969  tgfb2; transforming growth factor beta-2 [KO:K13376]
109632425  [KO:K16859]
109632446  [KO:K04378]
109632474  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
109632517  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109632528  angpt2; angiopoietin-2 [KO:K05466]
109632543  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
109632675  [KO:K04358]
109632696  [KO:K04858]
109632699  [KO:K04861]
109632701  [KO:K05461]
109632714  [KO:K04441] [EC:2.7.11.24]
109632715  [KO:K04441] [EC:2.7.11.24]
109632742  [KO:K05460]
109632765  fgf23; fibroblast growth factor 23 [KO:K22428]
109632862  [KO:K04850]
109632883  ntf3; neurotrophin-3 [KO:K04356]
109632980  efna1; ephrin-A1 [KO:K05462]
109632997  [KO:K05462]
109633007  [KO:K04440] [EC:2.7.11.24]
109633056  [KO:K19663] [EC:2.7.11.13]
109633076  [KO:K04426] [EC:2.7.11.25]
109633104  [KO:K04381]
109633109  [KO:K03283]
109633140  efna3; ephrin-A3 [KO:K05462]
109633291  [KO:K04873]
109633293  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109633307  [KO:K04872]
109633318  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
109633551  [KO:K02583]
109633575  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
109633630  mef2c; myocyte-specific enhancer factor 2C [KO:K04454]
109633665  [KO:K08845] [EC:2.7.11.1]
109633771  [KO:K04348] [EC:3.1.3.16]
109633786  [KO:K05093] [EC:2.7.10.1]
109633794  rasa1; ras GTPase-activating protein 1 [KO:K04352]
109633912  [KO:K03173] [EC:2.3.2.27]
109633940  [KO:K04466] [EC:2.7.11.25]
109633975  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109633980  [KO:K02583]
109633989  [KO:K04430] [EC:2.7.12.2]
109633995  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
109634040  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109634223  [KO:K04345] [EC:2.7.11.11]
109634317  [KO:K04433] [EC:2.7.12.2]
109634381  [KO:K04438]
109634384  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
109634418  [KO:K08053]
109634498  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
109634602  [KO:K04456] [EC:2.7.11.1]
109634633  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109634877  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109634900  [KO:K04451]
109634942  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
109635017  [KO:K05084] [EC:2.7.10.1]
109635036  [KO:K04860]
109635098  [KO:K02582]
109635185  [KO:K04864]
109635227  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109635271  [KO:K04423] [EC:2.7.11.25]
109635299  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109635371  [KO:K05465]
109635388  [KO:K04423] [EC:2.7.11.25]
109635410  stk4; serine/threonine-protein kinase 4 [KO:K04411]
109635456  ngf; beta-nerve growth factor [KO:K02582]
109635540  [KO:K04353]
109635565  [KO:K04411]
109635615  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109635636  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
109635763  fgf1; fibroblast growth factor 1 [KO:K18496]
109635835  [KO:K04438]
109635858  [KO:K04429] [EC:2.7.11.1]
109635968  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109636028  [KO:K04379]
109636083  max; protein max isoform X1 [KO:K04453]
109636158  [KO:K13377]
109636175  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109636253  [KO:K05462]
109636295  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
109636299  sos2; son of sevenless homolog 2 [KO:K03099]
109636300  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
109636370  [KO:K04402]
109636442  [KO:K04445] [EC:2.7.11.1]
109636485  [KO:K05866] [EC:3.1.3.48]
109636548  jund; transcription factor jun-D [KO:K04449]
109636607  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
109636707  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109636733  [KO:K04373] [EC:2.7.11.1]
109636771  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
109636804  ret; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109636875  [KO:K04347]
109636876  rras2; ras-related protein R-Ras2 [KO:K07830]
109636944  [KO:K12326]
109636948  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109636971  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
109637026  [KO:K04358]
109637050  [KO:K09782]
109637101  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109637250  fgf7; fibroblast growth factor 7 [KO:K04358]
109637261  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109637295  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
109637303  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
109637331  [KO:K04358]
109637498  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109637499  [KO:K04402]
109637590  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
109637639  [KO:K04735]
109637656  [KO:K04419] [EC:2.7.11.25]
109637668  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
109637696  [KO:K04414] [EC:2.7.11.1]
109637735  [KO:K05091] [EC:2.7.10.1]
109638020  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
109638097  [KO:K05452]
109638259  [KO:K04868]
109638270  [KO:K19662] [EC:2.7.11.13]
109638435  fgf16; fibroblast growth factor 16 [KO:K04358]
109638437  [KO:K04674] [EC:2.7.11.30]
109638459  [KO:K08774]
109638461  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
109638508  [KO:K04859]
109638546  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
109638578  [KO:K05103] [EC:2.7.10.1]
109638586  [KO:K04851]
109638628  [KO:K04424] [EC:2.7.11.25]
109638650  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
109638701  [KO:K04870]
109638710  [KO:K04392]
109638820  [KO:K04412]
109638926  [KO:K18018] [EC:3.1.3.48]
109638934  [KO:K04863]
109638968  hras; GTPase HRas [KO:K02833]
109638971  igf2; insulin-like growth factor II isoform X1 [KO:K13769]
109638988  [KO:K04441] [EC:2.7.11.24]
109639059  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109639091  [KO:K04849]
109639118  [KO:K05462]
109639125  [KO:K05462]
109639132  [KO:K04388] [EC:2.7.11.30]
109639241  [KO:K17386]
109639255  [KO:K04867]
109639258  [KO:K04359]
109639271  [KO:K04374]
109639272  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109639279  [KO:K07860]
109639281  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
109639297  efna5; ephrin-A5 isoform X1 [KO:K05462]
109639301  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109639409  [KO:K04866]
109639428  [KO:K04344]
109639443  [KO:K04856]
109639448  [KO:K04347]
109639486  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109639494  [KO:K19662] [EC:2.7.11.13]
109639495  [KO:K04855]
109639504  [KO:K04371] [EC:2.7.11.24]
109639599  [KO:K02187] [EC:3.4.22.56]
109639654  [KO:K05459]
109639727  [KO:K05449]
109639804  [KO:K04360] [EC:2.7.10.1]
109639862  [KO:K04358]
109639982  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
109640033  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
109640036  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
109640071  [KO:K04865]
109640168  [KO:K25416]
109640172  [KO:K04344]
109640231  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
109640382  [KO:K07861]
109640607  [KO:K04465]
109640677  [KO:K04371] [EC:2.7.11.24]
109640682  [KO:K02583]
109640767  igf1; insulin-like growth factor I [KO:K05459]
109640782  [KO:K03156]
109640863  [KO:K04348] [EC:3.1.3.16]
109641260  [KO:K04519]
109641267  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109641285  fgf18; fibroblast growth factor 18 isoform X1 [KO:K04358]
109641290  fgf2; fibroblast growth factor 2 [KO:K18497]
109641399  grb2; growth factor receptor-bound protein 2 [KO:K04364]
109641467  [KO:K07827]
109641502  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
109641504  [KO:K04429] [EC:2.7.11.1]
109641589  [KO:K04456] [EC:2.7.11.1]
109641595  [KO:K04393]
109641798  [KO:K04849]
109641881  [KO:K04429] [EC:2.7.11.1]
109641948  [KO:K16342] [EC:3.1.1.4]
109642014  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109642071  [KO:K04456] [EC:2.7.11.1]
109642209  [KO:K05090] [EC:2.7.10.1]
109642250  [KO:K04345] [EC:2.7.11.11]
109642325  [KO:K25415]
109642360  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109642362  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109642367  mras; ras-related protein M-Ras [KO:K07831]
109642369  [KO:K04362] [EC:2.7.10.1]
109642431  [KO:K13376]
109642436  [KO:K04434]
109642445  [KO:K04393]
109642565  [KO:K04436]
109642696  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109642729  [KO:K04353]
109642921  [KO:K04377]
109642946  [KO:K04358]
109642986  [KO:K04853]
109643023  [KO:K04429] [EC:2.7.11.1]
109643127  kitlg; kit ligand [KO:K05461]
109643194  [KO:K04402]
109643219  [KO:K04410] [EC:2.7.11.1]
109643296  [KO:K04873]
109643298  [KO:K04872]
109643299  [KO:K04871]
109643474  [KO:K04393]
109643580  [KO:K04374]
109643669  ins; insulin [KO:K04526]
109643727  [KO:K04527] [EC:2.7.10.1]
109643736  [KO:K04852]
109643755  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
109643812  [KO:K04853]
109643961  jun; transcription factor AP-1 [KO:K04448]
109644018  [KO:K04467] [EC:2.7.11.10]
109644052  [KO:K02580]
109644299  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
109644407  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109644436  [KO:K04373] [EC:2.7.11.1]
109644700  [KO:K04468] [EC:2.7.11.24]
109644732  [KO:K04723]
109644756  [KO:K18019] [EC:3.1.3.48]
109644802  daxx; death domain-associated protein 6 [KO:K02308]
109645078  [KO:K09253]
109645097  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109645211  [KO:K04468] [EC:2.7.11.24]
109645229  [KO:K17333]
109645298  [KO:K04466] [EC:2.7.11.25]
109645500  [KO:K18496]
109645588  [KO:K04526]
109645661  [KO:K06268]
109645700  [KO:K04871]
109645710  [KO:K22603]
109645801  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
109645897  [KO:K05096] [EC:2.7.10.1]
109645925  [KO:K04361] [EC:2.7.10.1]
109646087  [KO:K04375]
109646294  [KO:K25414]
109646379  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109646414  [KO:K03099]
109646467  [KO:K04449]
109646791  [KO:K04361] [EC:2.7.10.1]
109646857  [KO:K04869]
109646860  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109646979  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
109647001  [KO:K04380]
109647136  [KO:K04362] [EC:2.7.10.1]
109647322  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109647356  [KO:K04433] [EC:2.7.12.2]
109647439  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109647461  [KO:K04388] [EC:2.7.11.30]
109647470  [KO:K04358]
109648142  [KO:K04379]
109648170  [KO:K04378]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pov04070  Phosphatidylinositol signaling system
pov04110  Cell cycle
pov04115  p53 signaling pathway
pov04210  Apoptosis
pov04310  Wnt signaling pathway
KO pathway
ko04010   

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