KEGG   PATHWAY: aof04120
Entry
aof04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Asparagus officinalis (garden asparagus)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
aof04120  Ubiquitin mediated proteolysis
aof04120

Other DBs
GO: 0016567
Organism
Asparagus officinalis (garden asparagus) [GN:aof]
Gene
109851589  polyubiquitin-like [KO:K08770]
109845481  polyubiquitin [KO:K08770]
109823688  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
109823689  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109825718  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109836785  ubiquitin-60S ribosomal protein L40 [KO:K02927]
109820108  ubiquitin-40S ribosomal protein S27a [KO:K02977]
109819701  ubiquitin-activating enzyme E1 1-like [KO:K03178] [EC:6.2.1.45]
109850544  ubiquitin-activating enzyme E1 2-like [KO:K03178] [EC:6.2.1.45]
109830587  SUMO-activating enzyme subunit 1B-1-like [KO:K10684] [EC:6.2.1.45]
109847240  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
109848222  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
109828004  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
109832941  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
109843910  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
109844830  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
109821867  ubiquitin-conjugating enzyme E2 7-like [KO:K10573] [EC:2.3.2.23]
109849353  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
109829969  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
109843037  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
109850452  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
109840664  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109848594  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
109848598  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
109821811  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109840154  ubiquitin-conjugating enzyme E2 30-like isoform X1 [KO:K06689] [EC:2.3.2.23]
109844326  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
109847352  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
109842730  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
109850825  ubiquitin-conjugating enzyme E2-17 kDa-like isoform X1 [KO:K06689] [EC:2.3.2.23]
109850518  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
109833367  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
109829888  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
109822445  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
109822488  ubiquitin-conjugating enzyme E2 7-like isoform X1 [KO:K10575] [EC:2.3.2.23]
109849614  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
109824402  ubiquitin-conjugating enzyme E2 5-like isoform X1 [KO:K10576] [EC:2.3.2.23]
109840316  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
109850990  ubiquitin-conjugating enzyme E2 5-like isoform X1 [KO:K10576] [EC:2.3.2.23]
109836590  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
109844035  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
109835650  SUMO-conjugating enzyme SCE1 [KO:K10577]
109837828  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
109842674  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
109844945  ubiquitin-conjugating enzyme E2 34-like isoform X1 [KO:K04554] [EC:2.3.2.23]
109826418  ubiquitin-conjugating enzyme E2 27-like [KO:K04649] [EC:2.3.2.23]
109837349  ubiquitin-conjugating enzyme E2 27-like isoform X1 [KO:K04649] [EC:2.3.2.23]
109824212  NEDD8-conjugating enzyme Ubc12-like isoform X1 [KO:K10579] [EC:2.3.2.34]
109830156  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
109839861  ubiquitin-conjugating enzyme E2 36-like isoform X1 [KO:K10580] [EC:2.3.2.23]
109848243  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
109848528  putative ubiquitin-conjugating enzyme E2 38 isoform X1 [KO:K10581] [EC:2.3.2.24]
109842102  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
109850883  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
109822604  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
109822620  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
109840382  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
109841370  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
109849909  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
109849453  ubiquitin-conjugating enzyme 15 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109835275  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109834079  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109833828  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
109823025  E3 ubiquitin-protein ligase UPL6 isoform X1 [KO:K10589] [EC:2.3.2.26]
109827658  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
109829956  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
109843377  E3 ubiquitin-protein ligase UPL4-like [KO:K10590] [EC:2.3.2.26]
109824337  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UPL1-like [KO:K10592] [EC:2.3.2.26]
109823827  E3 ubiquitin-protein ligase UPL1-like [KO:K10592] [EC:2.3.2.26]
109822081  LOW QUALITY PROTEIN: probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
109830806  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
109830144  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
109820153  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
109825095  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
109836425  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
109826111  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
109829111  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
109840005  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
109821618  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
109839916  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109836781  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109836939  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
109844799  E3 ubiquitin-protein ligase SINAT5-like isoform X1 [KO:K04506] [EC:2.3.2.27]
109849336  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109848758  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
109820258  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
109847375  LOW QUALITY PROTEIN: WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
109829680  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109836496  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109822045  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109819832  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
109842700  E4 SUMO-protein ligase PIAL2-like isoform X1 [KO:K04706] [EC:2.3.2.-]
109844218  E4 SUMO-protein ligase PIAL2-like isoform X1 [KO:K04706] [EC:2.3.2.-]
109842946  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
109823394  ERAD-associated E3 ubiquitin-protein ligase HRD1-like [KO:K10601] [EC:2.3.2.27]
109820613  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
109834335  E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
109828983  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
109844953  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
109849771  cullin-1-like isoform X1 [KO:K03347]
109833624  SKP1-like protein 1B isoform X1 [KO:K03094]
109833626  SKP1-like protein 1B [KO:K03094]
109833628  SKP1-like protein 1B [KO:K03094]
109833636  SKP1-like protein 1B [KO:K03094]
109843537  SKP1-like protein 12 [KO:K03094]
109839776  SKP1-like protein 5 [KO:K03094]
109836006  SKP1-like protein 5 [KO:K03094]
109850444  SKP1-like protein 1B [KO:K03094]
109837704  SKP1-like protein 1A [KO:K03094]
109837708  SKP1-like protein 3 [KO:K03094]
109837709  SKP1-like protein 12 [KO:K03094]
109825128  F-box protein SKP2A-like [KO:K03875]
109838057  F-box protein SKP2A-like isoform X1 [KO:K03875]
109829817  elongin-C [KO:K03872]
109841278  uncharacterized protein LOC109841278 [KO:K03873]
109832605  LOW QUALITY PROTEIN: cullin-3A-like [KO:K03869]
109833879  cullin-3A-like [KO:K03869]
109846322  LOW QUALITY PROTEIN: cullin-4-like [KO:K10609]
109848632  LOW QUALITY PROTEIN: cullin-4-like [KO:K10609]
109825984  DNA damage-binding protein 1a [KO:K10610]
109821912  DNA damage-binding protein 2-like [KO:K10140]
109837752  DNA damage-binding protein 2 isoform X1 [KO:K10140]
109825496  DNA excision repair protein ERCC-8-like [KO:K10570]
109820058  light-mediated development protein DET1 [KO:K10571]
109843282  anaphase-promoting complex subunit 11-like [KO:K03358]
109850503  anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
109851071  anaphase-promoting complex subunit 2 [KO:K03349]
109824569  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109825028  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109825403  cell division cycle 20.5, cofactor of APC complex-like isoform X1 [KO:K03363]
109830713  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109830716  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109825458  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109826733  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109827047  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109849084  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109846979  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109847632  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109837013  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
109849028  cell division cycle 20.5, cofactor of APC complex-like [KO:K03363]
109829848  protein FIZZY-RELATED 3 [KO:K03364]
109837829  protein FIZZY-RELATED 2-like [KO:K03364]
109849585  anaphase-promoting complex subunit 1 [KO:K03348]
109833413  cell division cycle protein 27 homolog B [KO:K03350]
109840472  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
109833096  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
109848685  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 6 [KO:K03353]
109824509  anaphase-promoting complex subunit 8 [KO:K03355]
109842848  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
109827755  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
aof03050  Proteasome
KO pathway
ko04120   
LinkDB

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