Entry Name Inflammatory mediator regulation of TRP channels - Eumetopias jubatus (Steller sea lion)
Description The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive dorsal root ganglion (DRG) neuron cell bodies including their peripheral and central projections. These channels can be modulated indirectly by inflammatory mediators such as PGE2, bradykinin, ATP, NGF, and proinflammatory cytokines that are generated during tissue injury. While the noxious heat receptor TRPV1 is sensitized (that is, their excitability can be increased) by post-translational modifications upon activation of G-protein coupled receptors (GPCRs) or tyrosine kinase receptors, the receptors for inflammatory mediators, the same action appears to mainly desensitize TRPM8, the main somatic innocuous cold sensor. This aforementioned sensitization could allow the receptor to become active at body temperature, so it not only contributes toward thermal hypersensitivity but also is possibly a substrate for ongoing persistent pain.
Class Organismal Systems; Sensory systemBRITE hierarchy
Pathway map eju04750 Inflammatory mediator regulation of TRP channels
Other DBs Organism Eumetopias jubatus (Steller sea lion) [GN:
eju ]
Gene 114197913 GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
114198742 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
114200135 ASIC4; LOW QUALITY PROTEIN: acid-sensing ion channel 4 [KO:K04831 ]
114202299 TRPV3; transient receptor potential cation channel subfamily V member 3 [KO:K04972 ]
114202302 TRPV1; transient receptor potential cation channel subfamily V member 1 [KO:K05222 ]
114202334 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
114205617 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
114206954 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114207120 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
114207665 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
114210851 TRPM8; transient receptor potential cation channel subfamily M member 8 [KO:K04983 ]
114211898 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114213130 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
114213789 TRPA1; transient receptor potential cation channel subfamily A member 1 [KO:K04984 ]
114214078 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114216392 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
114219127 TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973 ]
114219135 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
114222155 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
114222643 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114223136 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
114224631 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114226659 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04742 (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C12083 (5Z,7E,9E,14Z,17Z)-Icosapentaenoate
C20698 2-Aminoethyl diphenylborinate
Reference Authors Wang H, Woolf CJ
Title Pain TRPs.
Journal Reference Authors Levine JD, Alessandri-Haber N
Title TRP channels: targets for the relief of pain.
Journal Reference Authors Cheng JK, Ji RR
Title Intracellular signaling in primary sensory neurons and persistent pain.
Journal Reference Authors Julius D
Title TRP channels and pain.
Journal Reference Authors Patapoutian A, Peier AM, Story GM, Viswanath V
Title ThermoTRP channels and beyond: mechanisms of temperature sensation.
Journal Reference Authors Dhaka A, Viswanath V, Patapoutian A
Title Trp ion channels and temperature sensation.
Journal Reference Authors Story GM
Title The emerging role of TRP channels in mechanisms of temperature and pain sensation.
Journal Reference Authors Velazquez KT, Mohammad H, Sweitzer SM
Title Protein kinase C in pain: involvement of multiple isoforms.
Journal Reference Authors Zhang X, Huang J, McNaughton PA
Title NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
Journal Reference Authors Bessac BF, Jordt SE
Title Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
Journal Reference Authors Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P
Title 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Journal Reference Authors Latorre R, Brauchi S, Madrid R, Orio P
Title A cool channel in cold transduction.
Journal Reference Authors Babes A, Ciobanu AC, Neacsu C, Babes RM
Title TRPM8, a sensor for mild cooling in mammalian sensory nerve endings.
Journal Reference Authors Loyd DR, Henry MA, Hargreaves KM
Title Serotonergic neuromodulation of peripheral nociceptors.
Journal Reference Authors Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW
Title Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Journal Reference Authors Mandadi S, Armati PJ, Roufogalis BD
Title Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling.
Journal Related KO pathway
