Homo sapiens (human): 7124
Help
Entry
7124 CDS
T01001
Symbol
TNF, DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
Name
(RefSeq) tumor necrosis factor
KO
K03156
tumor necrosis factor superfamily, member 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04010
MAPK signaling pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04061
Viral protein interaction with cytokine and cytokine receptor
hsa04064
NF-kappa B signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04150
mTOR signaling pathway
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04350
TGF-beta signaling pathway
hsa04380
Osteoclast differentiation
hsa04612
Antigen processing and presentation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04640
Hematopoietic cell lineage
hsa04650
Natural killer cell mediated cytotoxicity
hsa04657
IL-17 signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04668
TNF signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04930
Type II diabetes mellitus
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05205
Proteoglycans in cancer
hsa05310
Asthma
hsa05321
Inflammatory bowel disease
hsa05322
Systemic lupus erythematosus
hsa05323
Rheumatoid arthritis
hsa05330
Allograft rejection
hsa05332
Graft-versus-host disease
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06223
TNF signaling (cancer)
nt06231
Apoptosis (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06517
TLR signaling
nt06524
Apoptosis
nt06527
Necroptosis
Element
N00145
Extrinsic apoptotic pathway
N00151
TNF-NFKB signaling pathway
N00374
TNF-IRF1 signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00436
HIV Tat to TLR2/4-NFKB signaling pathway
N00444
TNF-p38 signaling pathway
N00446
TNF-JNK signaling pathway
N00994
AGE-RAGE signaling pathway
N00996
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01566
TLR5-NFKB signaling pathway
N01621
TNF-RIPK1/3 signaling pathway
Disease
H00079
Asthma
H00080
Systemic lupus erythematosus
H00083
Allograft rejection
H00084
Graft-versus-host disease
H00361
Malaria
Drug target
Adalimumab:
D02597
<JP/US>
Afelimomab:
D07436
Certolizumab pegol:
D03441
<JP/US>
Etanercept:
D00742
<JP/US>
Golimumab:
D04358
<JP/US>
Infliximab:
D02598
<JP/US>
Lenalidomide (
DG00744
):
D04687
<JP/US>
D09813
<JP>
Lenercept:
D04690
Licaminlimab:
D12420
Nerelimomab:
D05146
Onercept:
D05263
Opinercept:
D11703
Ozoralizumab:
D09944
<JP>
Pegsunercept:
D05393
Pirfenidone:
D01583
<JP/US>
Placulumab:
D10320
Pomalidomide:
D08976
<JP/US>
Thalidomide:
D00754
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7124 (TNF)
04350 TGF-beta signaling pathway
7124 (TNF)
04064 NF-kappa B signaling pathway
7124 (TNF)
04668 TNF signaling pathway
7124 (TNF)
04071 Sphingolipid signaling pathway
7124 (TNF)
04150 mTOR signaling pathway
7124 (TNF)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
7124 (TNF)
04061 Viral protein interaction with cytokine and cytokine receptor
7124 (TNF)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
7124 (TNF)
04217 Necroptosis
7124 (TNF)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
7124 (TNF)
04620 Toll-like receptor signaling pathway
7124 (TNF)
04621 NOD-like receptor signaling pathway
7124 (TNF)
04622 RIG-I-like receptor signaling pathway
7124 (TNF)
04625 C-type lectin receptor signaling pathway
7124 (TNF)
04650 Natural killer cell mediated cytotoxicity
7124 (TNF)
04612 Antigen processing and presentation
7124 (TNF)
04660 T cell receptor signaling pathway
7124 (TNF)
04657 IL-17 signaling pathway
7124 (TNF)
04664 Fc epsilon RI signaling pathway
7124 (TNF)
09152 Endocrine system
04920 Adipocytokine signaling pathway
7124 (TNF)
09158 Development and regeneration
04380 Osteoclast differentiation
7124 (TNF)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
7124 (TNF)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7124 (TNF)
05170 Human immunodeficiency virus 1 infection
7124 (TNF)
05161 Hepatitis B
7124 (TNF)
05160 Hepatitis C
7124 (TNF)
05171 Coronavirus disease - COVID-19
7124 (TNF)
05164 Influenza A
7124 (TNF)
05168 Herpes simplex virus 1 infection
7124 (TNF)
05163 Human cytomegalovirus infection
7124 (TNF)
05169 Epstein-Barr virus infection
7124 (TNF)
05165 Human papillomavirus infection
7124 (TNF)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
7124 (TNF)
05132 Salmonella infection
7124 (TNF)
05131 Shigellosis
7124 (TNF)
05135 Yersinia infection
7124 (TNF)
05133 Pertussis
7124 (TNF)
05134 Legionellosis
7124 (TNF)
05152 Tuberculosis
7124 (TNF)
09174 Infectious disease: parasitic
05146 Amoebiasis
7124 (TNF)
05144 Malaria
7124 (TNF)
05145 Toxoplasmosis
7124 (TNF)
05140 Leishmaniasis
7124 (TNF)
05142 Chagas disease
7124 (TNF)
05143 African trypanosomiasis
7124 (TNF)
09163 Immune disease
05310 Asthma
7124 (TNF)
05322 Systemic lupus erythematosus
7124 (TNF)
05323 Rheumatoid arthritis
7124 (TNF)
05321 Inflammatory bowel disease
7124 (TNF)
05330 Allograft rejection
7124 (TNF)
05332 Graft-versus-host disease
7124 (TNF)
09164 Neurodegenerative disease
05010 Alzheimer disease
7124 (TNF)
05014 Amyotrophic lateral sclerosis
7124 (TNF)
05020 Prion disease
7124 (TNF)
05022 Pathways of neurodegeneration - multiple diseases
7124 (TNF)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
7124 (TNF)
05418 Fluid shear stress and atherosclerosis
7124 (TNF)
05410 Hypertrophic cardiomyopathy
7124 (TNF)
05414 Dilated cardiomyopathy
7124 (TNF)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
7124 (TNF)
04940 Type I diabetes mellitus
7124 (TNF)
04936 Alcoholic liver disease
7124 (TNF)
04932 Non-alcoholic fatty liver disease
7124 (TNF)
04931 Insulin resistance
7124 (TNF)
04933 AGE-RAGE signaling pathway in diabetic complications
7124 (TNF)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
7124 (TNF)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
7124 (TNF)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7124 (TNF)
Cytokines and growth factors [BR:
hsa04052
]
Cytokines
Tumor necrosis fators
7124 (TNF)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Cytokines
7124 (TNF)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TNF
Motif
Other DBs
NCBI-GeneID:
7124
NCBI-ProteinID:
NP_000585
OMIM:
191160
HGNC:
11892
Ensembl:
ENSG00000232810
UniProt:
P01375
Q5STB3
Structure
PDB
LinkDB
All DBs
Position
6:31575565..31578336
Genome browser
AA seq
233 aa
AA seq
DB search
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
NT seq
702 nt
NT seq
+upstream
nt +downstream
nt
atgagcactgaaagcatgatccgggacgtggagctggccgaggaggcgctccccaagaag
acaggggggccccagggctccaggcggtgcttgttcctcagcctcttctccttcctgatc
gtggcaggcgccaccacgctcttctgcctgctgcactttggagtgatcggcccccagagg
gaagagttccccagggacctctctctaatcagccctctggcccaggcagtcagatcatct
tctcgaaccccgagtgacaagcctgtagcccatgttgtagcaaaccctcaagctgagggg
cagctccagtggctgaaccgccgggccaatgccctcctggccaatggcgtggagctgaga
gataaccagctggtggtgccatcagagggcctgtacctcatctactcccaggtcctcttc
aagggccaaggctgcccctccacccatgtgctcctcacccacaccatcagccgcatcgcc
gtctcctaccagaccaaggtcaacctcctctctgccatcaagagcccctgccagagggag
accccagagggggctgaggccaagccctggtatgagcccatctatctgggaggggtcttc
cagctggagaagggtgaccgactcagcgctgagatcaatcggcccgactatctcgacttt
gccgagtctgggcaggtctactttgggatcattgccctgtga
Homo sapiens (human): 3569
Help
Entry
3569 CDS
T01001
Symbol
IL6, BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Name
(RefSeq) interleukin 6
KO
K05405
interleukin 6
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01523
Antifolate resistance
hsa04060
Cytokine-cytokine receptor interaction
hsa04061
Viral protein interaction with cytokine and cytokine receptor
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04218
Cellular senescence
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04640
Hematopoietic cell lineage
hsa04657
IL-17 signaling pathway
hsa04659
Th17 cell differentiation
hsa04668
TNF signaling pathway
hsa04672
Intestinal immune network for IgA production
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05144
Malaria
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05321
Inflammatory bowel disease
hsa05323
Rheumatoid arthritis
hsa05332
Graft-versus-host disease
hsa05410
Hypertrophic cardiomyopathy
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06183
Yersinia
nt06219
JAK-STAT signaling (cancer)
nt06227
Nuclear receptor signaling (cancer)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06360
Cushing syndrome
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06517
TLR signaling
nt06518
JAK-STAT signaling
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00139
FUS-DDIT3 fusion to CEBPB-mediated transcription
N00317
AhR signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00994
AGE-RAGE signaling pathway
N00996
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01306
AngII-AT1R-NOX2 signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01556
IL6 family to Jak-STAT signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00084
Graft-versus-host disease
H00286
Crohn disease
H00630
Rheumatoid arthritis
H01479
Castleman disease
H01672
Juvenile idiopathic arthritis
Drug target
Olokizumab:
D12487
Pirfenidone:
D01583
<JP/US>
Pomalidomide:
D08976
<JP/US>
Siltuximab:
D09669
<US>
Sirukumab:
D10080
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3569 (IL6)
04668 TNF signaling pathway
3569 (IL6)
04066 HIF-1 signaling pathway
3569 (IL6)
04068 FoxO signaling pathway
3569 (IL6)
04151 PI3K-Akt signaling pathway
3569 (IL6)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3569 (IL6)
04061 Viral protein interaction with cytokine and cytokine receptor
3569 (IL6)
09140 Cellular Processes
09143 Cell growth and death
04218 Cellular senescence
3569 (IL6)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
3569 (IL6)
04620 Toll-like receptor signaling pathway
3569 (IL6)
04621 NOD-like receptor signaling pathway
3569 (IL6)
04623 Cytosolic DNA-sensing pathway
3569 (IL6)
04625 C-type lectin receptor signaling pathway
3569 (IL6)
04659 Th17 cell differentiation
3569 (IL6)
04657 IL-17 signaling pathway
3569 (IL6)
04672 Intestinal immune network for IgA production
3569 (IL6)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3569 (IL6)
05202 Transcriptional misregulation in cancer
3569 (IL6)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3569 (IL6)
05161 Hepatitis B
3569 (IL6)
05171 Coronavirus disease - COVID-19
3569 (IL6)
05164 Influenza A
3569 (IL6)
05162 Measles
3569 (IL6)
05168 Herpes simplex virus 1 infection
3569 (IL6)
05163 Human cytomegalovirus infection
3569 (IL6)
05167 Kaposi sarcoma-associated herpesvirus infection
3569 (IL6)
05169 Epstein-Barr virus infection
3569 (IL6)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
3569 (IL6)
05132 Salmonella infection
3569 (IL6)
05135 Yersinia infection
3569 (IL6)
05133 Pertussis
3569 (IL6)
05134 Legionellosis
3569 (IL6)
05152 Tuberculosis
3569 (IL6)
09174 Infectious disease: parasitic
05146 Amoebiasis
3569 (IL6)
05144 Malaria
3569 (IL6)
05142 Chagas disease
3569 (IL6)
05143 African trypanosomiasis
3569 (IL6)
09163 Immune disease
05323 Rheumatoid arthritis
3569 (IL6)
05321 Inflammatory bowel disease
3569 (IL6)
05332 Graft-versus-host disease
3569 (IL6)
09164 Neurodegenerative disease
05010 Alzheimer disease
3569 (IL6)
05020 Prion disease
3569 (IL6)
05022 Pathways of neurodegeneration - multiple diseases
3569 (IL6)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3569 (IL6)
05410 Hypertrophic cardiomyopathy
3569 (IL6)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
3569 (IL6)
04932 Non-alcoholic fatty liver disease
3569 (IL6)
04931 Insulin resistance
3569 (IL6)
04933 AGE-RAGE signaling pathway in diabetic complications
3569 (IL6)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
3569 (IL6)
01523 Antifolate resistance
3569 (IL6)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
3569 (IL6)
Cytokines and growth factors [BR:
hsa04052
]
Cytokines
Interleukins
3569 (IL6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IL6
IL11
IL23
Phage_int_SAM_1
GCSF
Motif
Other DBs
NCBI-GeneID:
3569
NCBI-ProteinID:
NP_000591
OMIM:
147620
HGNC:
6018
Ensembl:
ENSG00000136244
UniProt:
P05231
Q75MH2
B4DVM1
Structure
PDB
LinkDB
All DBs
Position
7:22727200..22731998
Genome browser
AA seq
212 aa
AA seq
DB search
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
NT seq
639 nt
NT seq
+upstream
nt +downstream
nt
atgaactccttctccacaagcgccttcggtccagttgccttctccctggggctgctcctg
gtgttgcctgctgccttccctgccccagtacccccaggagaagattccaaagatgtagcc
gccccacacagacagccactcacctcttcagaacgaattgacaaacaaattcggtacatc
ctcgacggcatctcagccctgagaaaggagacatgtaacaagagtaacatgtgtgaaagc
agcaaagaggcactggcagaaaacaacctgaaccttccaaagatggctgaaaaagatgga
tgcttccaatctggattcaatgaggagacttgcctggtgaaaatcatcactggtcttttg
gagtttgaggtatacctagagtacctccagaacagatttgagagtagtgaggaacaagcc
agagctgtgcagatgagtacaaaagtcctgatccagttcctgcagaaaaaggcaaagaat
ctagatgcaataaccacccctgacccaaccacaaatgccagcctgctgacgaagctgcag
gcacagaaccagtggctgcaggacatgacaactcatctcattctgcgcagctttaaggag
ttcctgcagtccagcctgagggctcttcggcaaatgtag
Homo sapiens (human): 3592
Help
Entry
3592 CDS
T01001
Symbol
IL12A, CLMF, IL-12A, NFSK, NKSF1, P35
Name
(RefSeq) interleukin 12A
KO
K05406
interleukin 12A
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04620
Toll-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05321
Inflammatory bowel disease
hsa05330
Allograft rejection
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06183
Yersinia
nt06219
JAK-STAT signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06517
TLR signaling
nt06518
JAK-STAT signaling
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01557
IL12/23 to Jak-STAT signaling pathway
N01566
TLR5-NFKB signaling pathway
Drug target
Apilimod mesylate:
D06556
Briakinumab:
D09588
Lisofylline:
D04748
Ustekinumab:
D09214
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3592 (IL12A)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3592 (IL12A)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3592 (IL12A)
04622 RIG-I-like receptor signaling pathway
3592 (IL12A)
04625 C-type lectin receptor signaling pathway
3592 (IL12A)
04658 Th1 and Th2 cell differentiation
3592 (IL12A)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3592 (IL12A)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
3592 (IL12A)
05164 Influenza A
3592 (IL12A)
05162 Measles
3592 (IL12A)
05168 Herpes simplex virus 1 infection
3592 (IL12A)
09171 Infectious disease: bacterial
05133 Pertussis
3592 (IL12A)
05134 Legionellosis
3592 (IL12A)
05152 Tuberculosis
3592 (IL12A)
09174 Infectious disease: parasitic
05146 Amoebiasis
3592 (IL12A)
05144 Malaria
3592 (IL12A)
05145 Toxoplasmosis
3592 (IL12A)
05140 Leishmaniasis
3592 (IL12A)
05142 Chagas disease
3592 (IL12A)
05143 African trypanosomiasis
3592 (IL12A)
09163 Immune disease
05321 Inflammatory bowel disease
3592 (IL12A)
05330 Allograft rejection
3592 (IL12A)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3592 (IL12A)
09167 Endocrine and metabolic disease
04940 Type I diabetes mellitus
3592 (IL12A)
04936 Alcoholic liver disease
3592 (IL12A)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
3592 (IL12A)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3592 (IL12A)
Cytokines and growth factors [BR:
hsa04052
]
Cytokines
Interleukins
3592 (IL12A)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Cytokines
3592 (IL12A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IL12
Motif
Other DBs
NCBI-GeneID:
3592
NCBI-ProteinID:
NP_000873
OMIM:
161560
HGNC:
5969
Ensembl:
ENSG00000168811
UniProt:
P29459
O60595
Structure
PDB
LinkDB
All DBs
Position
3:159988835..159996019
Genome browser
AA seq
253 aa
AA seq
DB search
MWPPGSASQPPPSPAAATGLHPAARPVSLQCRLSMCPARSLLLVATLVLLDHLSLARNLP
VATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACL
PLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLL
MDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRA
VTIDRVMSYLNAS
NT seq
762 nt
NT seq
+upstream
nt +downstream
nt
atgtggccccctgggtcagcctcccagccaccgccctcacctgccgcggccacaggtctg
catccagcggctcgccctgtgtccctgcagtgccggctcagcatgtgtccagcgcgcagc
ctcctccttgtggctaccctggtcctcctggaccacctcagtttggccagaaacctcccc
gtggccactccagacccaggaatgttcccatgccttcaccactcccaaaacctgctgagg
gccgtcagcaacatgctccagaaggccagacaaactctagaattttacccttgcacttct
gaagagattgatcatgaagatatcacaaaagataaaaccagcacagtggaggcctgttta
ccattggaattaaccaagaatgagagttgcctaaattccagagagacctctttcataact
aatgggagttgcctggcctccagaaagacctcttttatgatggccctgtgccttagtagt
atttatgaagacttgaagatgtaccaggtggagttcaagaccatgaatgcaaagcttctg
atggatcctaagaggcagatctttctagatcaaaacatgctggcagttattgatgagctg
atgcaggccctgaatttcaacagtgagactgtgccacaaaaatcctcccttgaagaaccg
gatttttataaaactaaaatcaagctctgcatacttcttcatgctttcagaattcgggca
gtgactattgatagagtgatgagctatctgaatgcttcctaa
Homo sapiens (human): 3593
Help
Entry
3593 CDS
T01001
Symbol
IL12B, CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2
Name
(RefSeq) interleukin 12B
KO
K05425
interleukin 12B
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04620
Toll-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05321
Inflammatory bowel disease
hsa05330
Allograft rejection
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06183
Yersinia
nt06219
JAK-STAT signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06517
TLR signaling
nt06518
JAK-STAT signaling
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01557
IL12/23 to Jak-STAT signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00089
IFN-gamma/IL-12 axis
Drug target
Apilimod mesylate:
D06556
Briakinumab:
D09588
Lisofylline:
D04748
Ustekinumab:
D09214
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3593 (IL12B)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3593 (IL12B)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3593 (IL12B)
04622 RIG-I-like receptor signaling pathway
3593 (IL12B)
04625 C-type lectin receptor signaling pathway
3593 (IL12B)
04658 Th1 and Th2 cell differentiation
3593 (IL12B)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3593 (IL12B)
05205 Proteoglycans in cancer
3593 (IL12B)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
3593 (IL12B)
05164 Influenza A
3593 (IL12B)
05162 Measles
3593 (IL12B)
05168 Herpes simplex virus 1 infection
3593 (IL12B)
09171 Infectious disease: bacterial
05133 Pertussis
3593 (IL12B)
05134 Legionellosis
3593 (IL12B)
05152 Tuberculosis
3593 (IL12B)
09174 Infectious disease: parasitic
05146 Amoebiasis
3593 (IL12B)
05145 Toxoplasmosis
3593 (IL12B)
05140 Leishmaniasis
3593 (IL12B)
05142 Chagas disease
3593 (IL12B)
05143 African trypanosomiasis
3593 (IL12B)
09163 Immune disease
05321 Inflammatory bowel disease
3593 (IL12B)
05330 Allograft rejection
3593 (IL12B)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3593 (IL12B)
09167 Endocrine and metabolic disease
04940 Type I diabetes mellitus
3593 (IL12B)
04936 Alcoholic liver disease
3593 (IL12B)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
3593 (IL12B)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3593 (IL12B)
Cytokines and growth factors [BR:
hsa04052
]
Cytokines
Interleukins
3593 (IL12B)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Cytokines
3593 (IL12B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IL12p40_C
Ig_3
Ig_5
Ig_2
Ig_4
fn3
ig
Motif
Other DBs
NCBI-GeneID:
3593
NCBI-ProteinID:
NP_002178
OMIM:
161561
HGNC:
5970
Ensembl:
ENSG00000113302
UniProt:
P29460
Structure
PDB
LinkDB
All DBs
Position
5:complement(159314780..159330487)
Genome browser
AA seq
328 aa
AA seq
DB search
MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITW
TLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQ
KEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERV
RGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKN
LQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVIC
RKNASISVRAQDRYYSSSWSEWASVPCS
NT seq
987 nt
NT seq
+upstream
nt +downstream
nt
atgtgtcaccagcagttggtcatctcttggttttccctggtttttctggcatctcccctc
gtggccatatgggaactgaagaaagatgtttatgtcgtagaattggattggtatccggat
gcccctggagaaatggtggtcctcacctgtgacacccctgaagaagatggtatcacctgg
accttggaccagagcagtgaggtcttaggctctggcaaaaccctgaccatccaagtcaaa
gagtttggagatgctggccagtacacctgtcacaaaggaggcgaggttctaagccattcg
ctcctgctgcttcacaaaaaggaagatggaatttggtccactgatattttaaaggaccag
aaagaacccaaaaataagacctttctaagatgcgaggccaagaattattctggacgtttc
acctgctggtggctgacgacaatcagtactgatttgacattcagtgtcaaaagcagcaga
ggctcttctgacccccaaggggtgacgtgcggagctgctacactctctgcagagagagtc
agaggggacaacaaggagtatgagtactcagtggagtgccaggaggacagtgcctgccca
gctgctgaggagagtctgcccattgaggtcatggtggatgccgttcacaagctcaagtat
gaaaactacaccagcagcttcttcatcagggacatcatcaaacctgacccacccaagaac
ttgcagctgaagccattaaagaattctcggcaggtggaggtcagctgggagtaccctgac
acctggagtactccacattcctacttctccctgacattctgcgttcaggtccagggcaag
agcaagagagaaaagaaagatagagtcttcacggacaagacctcagccacggtcatctgc
cgcaaaaatgccagcattagcgtgcgggcccaggaccgctactatagctcatcttggagc
gaatgggcatctgtgccctgcagttag
DBGET
integrated database retrieval system