KEGG   PATHWAY: ipu04910
Entry
ipu04910                    Pathway                                
Name
Insulin signaling pathway - Ictalurus punctatus (channel catfish)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
ipu04910  Insulin signaling pathway
ipu04910

Organism
Ictalurus punctatus (channel catfish) [GN:ipu]
Gene
108259964  insulin [KO:K04526]
108259786  insulin [KO:K04526]
108280599  insulin [KO:K04526]
108267827  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
108278298  insulin receptor substrate 1-B isoform X1 [KO:K16172]
108267519  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
108267420  insulin receptor substrate 2-B [KO:K07187]
108266735  irs2b; insulin receptor substrate 2 [KO:K07187]
108278674  irs4a; insulin receptor substrate 2-B isoform X1 [KO:K07187]
108258957  irs2a; insulin receptor substrate 2a [KO:K07187]
108272037  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
108260231  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108275608  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108276156  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108280664  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108271155  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108257355  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
108264442  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
108263416  akt3a; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108264340  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108269621  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108259077  akt3b; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108258646  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b isoform X1 [KO:K03083] [EC:2.7.11.26]
108266408  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108256446  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
108279630  glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
108269700  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108280818  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
100528446  pp1b; serine/threonine-protein phosphatase pp1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108259981  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
108274218  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
108279957  ppp1r3aa; uncharacterized protein ppp1r3aa [KO:K07189]
108262159  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
108276554  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
108274298  ppp1r3cb; protein phosphatase 1 regulatory subunit 3C-B isoform X1 [KO:K07189]
108269743  ppp1r3ca; protein phosphatase 1, regulatory subunit 3Ca [KO:K07189]
108276522  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
108276525  protein phosphatase 1 regulatory subunit 3C [KO:K07189]
108279331  protein phosphatase 1 regulatory subunit 3B [KO:K07189]
108264241  protein phosphatase 1 regulatory subunit 3E [KO:K07189]
108265993  si:ch211-167b20.8; uncharacterized protein si:ch211-167b20.8 [KO:K07189]
108275498  ppp1r3da; protein phosphatase 1, regulatory subunit 3Da [KO:K07189]
108281031  ppp1r3db; protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
128628641  uncharacterized protein LOC128628641 isoform X1 [KO:K07189]
108273676  phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
108280550  phkg1a; phosphorylase kinase, gamma 1a (muscle) isoform X1 [KO:K00871] [EC:2.7.11.19]
108261814  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
108261822  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
108259255  phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
108267555  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
108270185  calm1a; calmodulin-1a [KO:K02183]
108277932  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
108279128  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
100305090  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
108263280  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
100528973  calml4a; calmodulin-like protein 4a [KO:K02183]
108258233  calmodulin-1b [KO:K02183]
100528746  calml6; calmodulin-like protein 6 [KO:K02183]
108267457  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
108263284  glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
108270071  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
108279009  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
108271336  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
108258341  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108267323  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
108270713  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
100528913  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
108274040  prkar1ab; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b [KO:K04739]
108275286  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X2 [KO:K04739]
108259493  prkar1aa; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a [KO:K04739]
108254707  prkar2ab; protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
108265715  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
108258796  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
108272659  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
108256376  lipeb; hormone-sensitive lipase isoform X2 [KO:K07188] [EC:3.1.1.79]
108265357  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
108267450  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
108267905  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
108266247  flot1b; flotillin-1b [KO:K07192]
108260094  flot2a; flotillin-2a isoform X1 [KO:K07192]
108278196  flot2b; flotillin-2b isoform X1 [KO:K07192]
108280786  SH2B adapter protein 2 [KO:K07193]
108263511  sorbin and SH3 domain-containing protein 1 isoform X4 [KO:K06086]
108277804  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
108276857  E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
108260055  adapter molecule crk [KO:K04438]
108278795  crk-like protein [KO:K04438]
108278187  adapter molecule crk [KO:K04438]
108279164  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
108265900  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
108274200  rho-related GTP-binding protein RhoQ [KO:K07194]
108273525  exocyst complex component 7 isoform X1 [KO:K07195]
108257160  trip10a; cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
108256078  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
108259993  acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
108255442  acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
108273998  fatty acid synthase isoform X1 [KO:K00665] [EC:2.3.1.85]
108263365  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
108263366  hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
108255852  hk2; hexokinase-2 isoform X1 [KO:K00844] [EC:2.7.1.1]
108265751  hexokinase-4 [KO:K12407] [EC:2.7.1.2]
108260283  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
108258037  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100528577  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
108277360  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X2 [KO:K07199]
108280523  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108267467  prkag2b; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
108258362  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
108266105  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
108256599  prkag2a; 5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
108271958  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
108277356  foxo1b; forkhead box protein O1-B isoform X1 [KO:K07201]
108277791  foxo1a; forkhead box protein O1-A [KO:K07201]
108267918  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5 [KO:K07202]
108274326  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108274343  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
100528077  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
108255669  fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
100528384  fbp1a; fructose-1,6-bisphosphatase 1a [KO:K03841] [EC:3.1.3.11]
108255972  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
108263838  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
108265039  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108272627  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
108260512  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
108278249  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100304560  rps6; 40S ribosomal protein S6 [KO:K02991]
108279290  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108276381  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
108260188  eif4e1b; eukaryotic translation initiation factor 4E-1B isoform X2 [KO:K03259]
108263665  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
100528371  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
108269089  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X2 [KO:K03259]
108261064  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
108255875  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
108279310  tsc1b; TSC complex subunit 1b [KO:K07206]
108258582  tuberin isoform X1 [KO:K07207]
100528708  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
108271576  GTP-binding protein Rheb [KO:K07208]
108278747  bada; uncharacterized protein bada [KO:K02158]
108267538  badb; BCL2 associated agonist of cell death b [KO:K02158]
108265869  SHC-transforming protein 1 isoform X1 [KO:K06279]
108270761  SHC-transforming protein 2 [KO:K17447]
108279345  shc3; SHC-transforming protein 3 [KO:K17448]
108256494  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
100528114  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
108270875  son of sevenless homolog 1 isoform X1 [KO:K03099]
108263000  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
128631210  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100528230  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
108259582  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
108258948  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
108274959  kras; GTPase KRas isoform X2 [KO:K07827]
100305071  GTPase NRas [KO:K07828]
108255753  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
108279928  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108276324  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X5 [KO:K04366] [EC:2.7.11.1]
108255012  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124627985  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100528123  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
108271291  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
108255782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108256206  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108264982  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
108278138  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
108270792  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
108265889  ETS domain-containing protein Elk-1 [KO:K04375]
108258328  socs1b; suppressor of cytokine signaling 1b [KO:K04694]
108276845  socs1a; suppressor of cytokine signaling 1a [KO:K04694]
128628654  suppressor of cytokine signaling 2-like [KO:K04695]
100528984  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
108274104  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
108270091  socs4; suppressor of cytokine signaling 4 [KO:K04697]
108265420  ptpn1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
108280478  ptprfb; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
108271782  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X2 [KO:K05695] [EC:3.1.3.48]
108278622  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108274025  mapk8b; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
108263675  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108278438  mapk10; mitogen-activated protein kinase 10 isoform X6 [KO:K04440] [EC:2.7.11.24]
108265675  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108277646  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A isoform X1 [KO:K15909] [EC:3.1.3.86]
108268863  inppl1b; inositol polyphosphate phosphatase-like 1b isoform X1 [KO:K15909] [EC:3.1.3.86]
108263413  inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
ipu00010  Glycolysis / Gluconeogenesis
ipu00061  Fatty acid biosynthesis
ipu00500  Starch and sucrose metabolism
ipu04010  MAPK signaling pathway
ipu04070  Phosphatidylinositol signaling system
ipu04210  Apoptosis
KO pathway
ko04910   
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