KEGG   PATHWAY: jcu03040
Entry
jcu03040                    Pathway                                
Name
Spliceosome - Jatropha curcas (Barbados nut)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
jcu03040  Spliceosome
jcu03040

Other DBs
GO: 0005681
Organism
Jatropha curcas (Barbados nut) [GN:jcu]
Gene
119369130  U1 spliceosomal RNA [KO:K14276]
119369705  U1 spliceosomal RNA [KO:K14276]
119370970  U1 spliceosomal RNA [KO:K14276]
119371071  U1 spliceosomal RNA [KO:K14276]
119371219  U2 spliceosomal RNA [KO:K14277]
119369796  U2 spliceosomal RNA [KO:K14277]
119370035  U2 spliceosomal RNA [KO:K14277]
119370179  U2 spliceosomal RNA [KO:K14277]
119369282  U2 spliceosomal RNA [KO:K14277]
119369278  U2 spliceosomal RNA [KO:K14277]
119369150  U2 spliceosomal RNA [KO:K14277]
119370011  U2 spliceosomal RNA [KO:K14277]
119370018  U4 spliceosomal RNA [KO:K14278]
119371532  U4 spliceosomal RNA [KO:K14278]
119370791  U4 spliceosomal RNA [KO:K14278]
119371389  U4 spliceosomal RNA [KO:K14278]
119370942  U5 spliceosomal RNA [KO:K14279]
119370181  U5 spliceosomal RNA [KO:K14279]
119369698  U6 spliceosomal RNA [KO:K14280]
119370887  U6 spliceosomal RNA [KO:K14280]
119370052  U6 spliceosomal RNA [KO:K14280]
105635165  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
105637649  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
105634868  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
105636104  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 [KO:K12813] [EC:5.6.2.6]
105641019  LOW QUALITY PROTEIN: pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
105644577  pre-mRNA-processing factor 17 isoform X2 [KO:K12816]
105649984  pre-mRNA-splicing factor 18 [KO:K12817]
105635125  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
105629274  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
105630557  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 isoform X1 [KO:K12818] [EC:5.6.2.6]
105629272  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 isoform X1 [KO:K12818] [EC:5.6.2.6]
105644782  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 [KO:K12818] [EC:5.6.2.6]
105632138  pre-mRNA-splicing factor SLU7 [KO:K12819]
105629126  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
105636798  small nuclear ribonucleoprotein-associated protein B' [KO:K11086]
105650012  small nuclear ribonucleoprotein SmD1a [KO:K11087]
105643427  small nuclear ribonucleoprotein SmD1a [KO:K11087]
105634151  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
110010431  probable small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096]
105635230  small nuclear ribonucleoprotein SmD3b [KO:K11088]
105628956  small nuclear ribonucleoprotein E isoform X1 [KO:K11097]
105628767  probable small nuclear ribonucleoprotein F [KO:K11098]
105642007  probable small nuclear ribonucleoprotein F [KO:K11098]
105634702  probable small nuclear ribonucleoprotein G [KO:K11099]
105629065  probable small nuclear ribonucleoprotein G [KO:K11099]
105633939  U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
105642542  U1 small nuclear ribonucleoprotein A [KO:K11091]
105632759  U1 small nuclear ribonucleoprotein C [KO:K11095]
105650080  U1 small nuclear ribonucleoprotein C isoform X1 [KO:K11095]
105630810  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
105650819  pre-mRNA-processing protein 40A [KO:K12821]
105644574  RNA-binding protein 25 isoform X1 [KO:K12822]
105634265  DEAD-box ATP-dependent RNA helicase 46 [KO:K12823] [EC:5.6.2.7]
105631470  LOW QUALITY PROTEIN: DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
105638901  ATP-dependent RNA helicase RhlE [KO:K12823] [EC:5.6.2.7]
105640316  DEAD-box ATP-dependent RNA helicase 30 [KO:K12823] [EC:5.6.2.7]
105643743  DEAD-box ATP-dependent RNA helicase 14 [KO:K12823] [EC:5.6.2.7]
105631467  LOW QUALITY PROTEIN: DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
105648004  pre-mRNA-processing protein 40C [KO:K12824]
105639549  transcription initiation factor TFIID subunit 15b isoform X1 [KO:K13098]
105647258  U2 small nuclear ribonucleoprotein A' [KO:K11092]
105639332  U2 small nuclear ribonucleoprotein B'' 2 [KO:K11094]
105628916  probable splicing factor 3A subunit 1 [KO:K12825]
105642294  splicing factor 3A subunit 2 [KO:K12826]
105648337  splicing factor SF3a60 homolog [KO:K12827]
105631598  splicing factor 3B subunit 1 [KO:K12828]
105634996  spliceosome-associated protein 130 A [KO:K12830]
105648958  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
105635716  RNA-binding protein 7 isoform X1 [KO:K12831]
105628631  splicing factor 3B subunit 4 isoform X1 [KO:K12831]
105646349  splicing factor 3B subunit 4 isoform X1 [KO:K12831]
105632149  uncharacterized protein At4g14342 [KO:K12832]
105635110  splicing factor 3B subunit 6-like protein [KO:K12833]
105628948  splicing factor 3B subunit 6-like protein [KO:K12833]
105630205  PHD finger-like domain-containing protein 5A [KO:K12834]
105646575  PHD finger-like domain-containing protein 5A [KO:K12834]
105642634  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
105635158  splicing factor U2af small subunit B [KO:K12836]
105629504  splicing factor U2af small subunit B [KO:K12836]
105637384  splicing factor U2af small subunit B [KO:K12836]
105629249  splicing factor U2af large subunit B isoform X1 [KO:K12837]
105632172  splicing factor U2af large subunit A [KO:K12837]
105639578  splicing factor U2af large subunit B isoform X1 [KO:K12837]
105629729  survival of motor neuron-related-splicing factor 30 [KO:K12839]
105636858  DNA-damage-repair/toleration protein DRT111, chloroplastic isoform X1 [KO:K12840]
105628929  protein RRC1 isoform X1 [KO:K12842]
105650034  sm-like protein LSM2 [KO:K12621]
105629113  sm-like protein LSM3A [KO:K12622]
105642505  sm-like protein LSM4 [KO:K12623]
105647497  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
105644417  sm-like protein LSM5 [KO:K12624]
105644477  sm-like protein LSM5 [KO:K12624]
105636672  sm-like protein LSM36B [KO:K12625]
105628682  sm-like protein LSM7 [KO:K12626]
105636398  sm-like protein LSM8 [KO:K12627]
105636400  sm-like protein LSM8 [KO:K12627]
105634759  LOW QUALITY PROTEIN: protein RDM16 [KO:K12843]
105645054  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
105631241  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
105644568  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
105635579  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
105641037  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
105638213  SART-1 family protein DOT2 isoform X1 [KO:K11984]
105647441  zinc finger matrin-type protein 2 [KO:K12848]
105639207  pre-mRNA-splicing factor 38 [KO:K12849]
105645186  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
105635155  DExH-box ATP-dependent RNA helicase DExH12 [KO:K12854] [EC:5.6.2.6]
105646958  protein STABILIZED1 [KO:K12855]
105634843  pre-mRNA-processing-splicing factor 8A isoform X1 [KO:K12856]
105636685  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
105636318  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
105629575  thioredoxin-like protein YLS8 [KO:K12859]
105632854  thioredoxin-like protein YLS8 isoform X1 [KO:K12859]
105638413  pre-mRNA-processing factor 19 homolog 1 [KO:K10599] [EC:2.3.2.27]
105647737  CDC5; cell division cycle 5-like protein [KO:K12860]
105634324  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
105643444  protein pleiotropic regulatory locus 1 [KO:K12862]
105633133  protein CWC15 homolog [KO:K12863]
105636125  beta-catenin-like protein 1 [KO:K12864]
105629667  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
105636278  heat shock 70 kDa protein 1 [KO:K03283]
105630293  heat shock cognate 70 kDa protein [KO:K03283]
105630294  heat shock 70 kDa protein 5 [KO:K03283]
105640140  stromal 70 kDa heat shock-related protein, chloroplastic isoform X1 [KO:K03283]
105647756  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein 2 [KO:K03283]
105647772  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein [KO:K03283]
105647790  heat shock cognate 70 kDa protein 2 [KO:K03283]
105647830  heat shock 70 kDa protein 4 [KO:K03283]
105647198  polyglutamine-binding protein 1 isoform X1 [KO:K12865]
105646900  SNW/SKI-interacting protein isoform X1 [KO:K06063]
105649472  pre-mRNA-splicing factor SYF1 [KO:K12867]
105641802  pre-mRNA-splicing factor syf2 [KO:K12868]
105630526  LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
105641590  LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
105641436  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
105635884  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
105639997  coiled-coil domain-containing protein 12 [KO:K12871]
105637413  zinc finger CCCH domain-containing protein 40 [KO:K12872]
105637083  protein BUD31 homolog 1 [KO:K12873]
105629467  protein BUD31 homolog 2 [KO:K12873]
105631199  RNA helicase aquarius [KO:K12874]
105627963  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
105628920  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
105648305  RNA-binding protein Y14 [KO:K12876]
105643230  protein mago nashi homolog [KO:K12877]
105631259  THO complex subunit 1 [KO:K12878]
105634157  THO complex subunit 2 [KO:K12879]
105629302  THO complex subunit 3 isoform X1 [KO:K12880]
105628230  LOW QUALITY PROTEIN: THO complex subunit 4A [KO:K12881]
105648321  nuclear cap-binding protein subunit 1 [KO:K12882]
105646896  nuclear cap-binding protein subunit 2 [KO:K12883]
105636510  UBP1-associated protein 2B isoform X1 [KO:K12741]
105634342  UBP1-associated protein 2B [KO:K12741]
105631444  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
105633126  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
105633948  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
105649656  UBP1-associated protein 2C [KO:K12741]
105648932  UBP1-associated protein 2A [KO:K12741]
105646503  UBP1-associated protein 2A [KO:K12741]
105640629  glycine-rich RNA-binding protein 2, mitochondrial [KO:K12741]
105642523  serine/arginine-rich-splicing factor SR34 isoform X2 [KO:K12890]
105642413  serine/arginine-rich splicing factor SR34A [KO:K12890]
105647491  serine/arginine-rich splicing factor SR30 isoform X1 [KO:K12890]
105641314  serine/arginine-rich splicing factor SC35 [KO:K12891]
105642811  serine/arginine-rich splicing factor RS31 [KO:K12893]
105642133  serine/arginine-rich splicing factor RS2Z33 isoform X1 [KO:K12896]
105644565  serine/arginine-rich splicing factor RSZ21 isoform X1 [KO:K12896]
105628513  serine/arginine-rich splicing factor SR45a isoform X2 [KO:K12897]
105645778  serine/arginine-rich splicing factor SR45a [KO:K12897]
105630031  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
105631853  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
105648953  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
105647605  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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