KEGG   PATHWAY: mcc00230
Entry
mcc00230                    Pathway                                
Name
Purine metabolism - Macaca mulatta (rhesus monkey)
Class
Metabolism; Nucleotide metabolism
Pathway map
mcc00230  Purine metabolism
mcc00230

Module
mcc_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:mcc00230]
mcc_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mcc00230]
mcc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mcc00230]
mcc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mcc00230]
mcc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mcc00230]
mcc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mcc00230]
mcc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mcc00230]
Other DBs
GO: 0006163 0042278
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100301991  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
100423692  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
100423770  [KO:K22600] [EC:4.6.1.2]
100424648  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
100424944  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100430188  [KO:K12321] [EC:4.6.1.2]
100533956  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
100533957  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
114673584  [KO:K12319] [EC:4.6.1.2]
114674141  [KO:K00939] [EC:2.7.4.3]
677688  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
693937  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
694368  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
694714  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
694743  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
694750  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
694819  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
694868  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
695099  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
695272  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
695649  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
695750  NPR2; atrial natriuretic peptide receptor 2 precursor [KO:K12324] [EC:4.6.1.2]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
696509  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697715  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
698503  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
698560  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
698566  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
698591  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X2 [KO:K01081] [EC:3.1.3.5]
698764  [KO:K00088] [EC:1.1.1.205]
698954  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
699191  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
699309  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
699365  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X2 [KO:K12318] [EC:4.6.1.2]
699401  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
699561  AMPD2; AMP deaminase 2 isoform X4 [KO:K01490] [EC:3.5.4.6]
700039  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
700261  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
700321  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X2 [KO:K01081] [EC:3.1.3.5]
700447  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
700834  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
700964  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
700974  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
701039  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
701344  NUDT9; ADP-ribose pyrophosphatase, mitochondrial precursor [KO:K13988] [EC:3.6.1.13]
701795  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
701796  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
702193  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
702458  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
702529  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
703138  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
703186  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
703680  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 precursor [KO:K18424] [EC:3.6.1.29]
704183  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
704196  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
704250  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
704273  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
704372  NME7; nucleoside diphosphate kinase 7 isoform X2 [KO:K00940] [EC:2.7.4.6]
704424  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
704485  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
704524  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
704688  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
704926  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
705040  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
705246  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
705555  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
705592  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X3 [KO:K13762] [EC:3.1.4.35]
705663  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
705920  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
706248  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
706338  AK1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
706585  ADSSL1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
706615  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
706932  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
707062  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
707445  ALLC; probable allantoicase isoform X2 [KO:K01477] [EC:3.5.3.4]
707554  DGUOK; deoxyguanosine kinase, mitochondrial isoform X2 [KO:K00904] [EC:2.7.1.113]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
708046  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
708155  [KO:K00088] [EC:1.1.1.205]
708307  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
708413  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
708801  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
708898  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
709186  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
709259  ADSL; adenylosuccinate lyase isoform X2 [KO:K01756] [EC:4.3.2.2]
709295  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
709737  AK2; adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
710140  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
710232  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
710619  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
710664  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
710935  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
711783  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
712180  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X8 [KO:K13293] [EC:3.1.4.53]
712629  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
712674  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
712850  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
712959  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
713580  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
714004  [KO:K00365] [EC:1.7.3.3]
714292  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
714698  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
714983  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
715598  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
715621  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
715719  GMPR2; GMP reductase 2 isoform X2 [KO:K00364] [EC:1.7.1.7]
715821  [KO:K07127] [EC:3.5.2.17]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
716159  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
716491  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
716734  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
717046  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
717197  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
717257  ITPA; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
717897  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
717914  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
717946  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
717990  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
717991  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
718311  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
718479  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
719052  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
719662  [KO:K11265] [EC:4.6.1.1]
720171  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
720853  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
721617  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
721710  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
722479  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mcc00030  Pentose phosphate pathway
mcc00220  Arginine biosynthesis
mcc00250  Alanine, aspartate and glutamate metabolism
mcc00260  Glycine, serine and threonine metabolism
mcc00340  Histidine metabolism
mcc00630  Glyoxylate and dicarboxylate metabolism
mcc00730  Thiamine metabolism
mcc00740  Riboflavin metabolism
mcc00790  Folate biosynthesis
KO pathway
ko00230   

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