KEGG   PATHWAY: mcoc03013
Entry
mcoc03013                   Pathway                                
Name
Nucleocytoplasmic transport - Mastomys coucha (southern multimammate mouse)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
mcoc03013  Nucleocytoplasmic transport
mcoc03013

Other DBs
GO: 0050658
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116080451  Aaas; aladin [KO:K14320]
116097540  Nup42; nucleoporin NUP42 isoform X1 [KO:K14321]
116094096  nucleoporin GLE1-like [KO:K18723]
116089927  Gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
116091481  Rae1; mRNA export factor [KO:K14298]
116102688  nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
116101303  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
116089983  Nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
116078136  Nup88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
116075526  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
116076386  Rangap1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
116077072  Ube2i; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
116099971  small ubiquitin-related modifier 2-A-like [KO:K12160]
116101058  small ubiquitin-related modifier 1 [KO:K12160]
116075232  Sumo3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
116077961  Sumo2; small ubiquitin-related modifier 2 [KO:K12160]
116089447  Sumo1; small ubiquitin-related modifier 1 [KO:K12160]
116091730  Nup160; nuclear pore complex protein Nup160 [KO:K14303]
116079124  Nup85; nuclear pore complex protein Nup85 [KO:K14304]
116099412  Sec13; protein SEC13 homolog [KO:K14004]
116075989  Nup107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
116070381  Nup133; nuclear pore complex protein Nup133 [KO:K14300]
116087309  Seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
116097737  Nup43; nucleoporin Nup43 [KO:K14305]
116076073  Nup37; nucleoporin Nup37 [KO:K14302]
116104504  Ahctf1; protein ELYS isoform X1 [KO:K25129]
116102148  Nup62; nuclear pore glycoprotein p62 [KO:K14306]
116085352  Nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
116104498  Nup54; nucleoporin p54 isoform X1 [KO:K14308]
116098720  Nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
116089942  Nup188; nucleoporin NUP188 homolog [KO:K14311]
116083156  Nup155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
116069897  Nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
116090381  Nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
116096356  Ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
116099266  Nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
116093204  Nup210l; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
116104670  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
116082529  Pom121l2; POM121-like protein 2 isoform X1 [KO:K14316]
116071112  Tmem33; transmembrane protein 33 isoform X1 [KO:K20724]
116100741  Tpr; nucleoprotein TPR [KO:K09291]
116099307  nuclear pore complex protein Nup50-like [KO:K14295]
116077215  Nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
116082710  Nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
116086248  Senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
116085870  Kpna1; importin subunit alpha-5 [KO:K23940]
116083841  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
116068745  Kpna7; importin subunit alpha-8 isoform X1 [KO:K15043]
116078757  Kpna2; importin subunit alpha-1 [KO:K15043]
116092989  Kpna4; importin subunit alpha-3 isoform X1 [KO:K23583]
116085368  Kpna3; importin subunit alpha-4 [KO:K23583]
116096716  Kpna6; importin subunit alpha-7 isoform X1 [KO:K15042]
116077210  Kpnb1; importin subunit beta-1 [KO:K14293]
116083645  Tnpo1; transportin-1 isoform X1 [KO:K18752]
116069748  Tnpo2; transportin-2 isoform X1 [KO:K18727]
116098666  Tnpo3; transportin-3 isoform X1 [KO:K15436]
116084532  Ipo4; importin-4 [KO:K20221]
116084133  Ipo5; importin-5 [KO:K20222]
116101349  Ipo7; importin-7 [KO:K20223]
116099829  Ipo8; importin-8 isoform X1 [KO:K18755]
116099741  Ipo9; importin-9 isoform X1 [KO:K20224]
116083750  Ipo11; importin-11 isoform X1 [KO:K25201]
116096513  Ipo13; importin-13 isoform X1 [KO:K25202]
116073257  Snupn; snurportin-1 isoform X1 [KO:K13151]
116070884  Xpo1; exportin-1 [KO:K14290]
116091409  Cse1l; exportin-2 [KO:K18423]
116075937  Xpot; exportin-T [KO:K14288]
116084858  Xpo4; exportin-4 isoform X1 [KO:K25203]
116075317  Xpo5; exportin-5 [KO:K14289]
116102942  Xpo6; exportin-6 isoform X1 [KO:K25204]
116085224  Xpo7; exportin-7 isoform X1 [KO:K18460]
116079025  Ranbp17; ran-binding protein 17 isoform X1 [KO:K24115]
116095815  GTP-binding nuclear protein Ran-like [KO:K07936]
116101594  GTP-binding nuclear protein Ran, testis-specific isoform [KO:K07936]
116091556  Eef1a2; elongation factor 1-alpha 2 isoform X1 [KO:K03231]
116087180  Phax; phosphorylated adapter RNA export protein [KO:K14291]
116095955  Ncbp1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
116085805  Ncbp2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
116092993  Nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
116103035  RNA-binding protein 8A [KO:K12876]
116093246  Rbm8a; RNA-binding protein 8A [KO:K12876]
116096363  Magoh; protein mago nashi homolog [KO:K12877]
116099686  protein mago nashi homolog 2 [KO:K12877]
116076767  Casc3; protein CASC3 [KO:K14323]
116077228  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
116085411  Acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
116085261  Sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
116078500  Rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
116080230  Pnn; pinin [KO:K13114]
116103503  THO complex subunit 4-like [KO:K12881]
116078149  Alyref; THO complex subunit 4 [KO:K12881]
116069459  Upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
116082661  Upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
116077056  Upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
116068944  Upf3a; regulator of nonsense transcripts 3A [KO:K14328]
116094959  Nxf3; nuclear RNA export factor 3 [KO:K14284]
116103509  Nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
116094489  Nxf5; nuclear RNA export factor 5 [KO:K14284]
116088734  nuclear RNA export factor 2-like [KO:K14284]
116094926  Nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
116091100  Nxt1; NTF2-related export protein 1 [KO:K14285]
116074610  Ddx39b; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
116096830  Srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
116076151  Pym1; partner of Y14 and mago isoform X1 [KO:K14294]
116086828  Thoc1; THO complex subunit 1 [KO:K12878]
116067999  THO complex subunit 2 [KO:K12879]
116091324  Thoc2; THO complex subunit 2 [KO:K12879]
116069363  Thoc5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
116077674  Thoc6; THO complex subunit 6 homolog [KO:K13175]
116084919  Thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
116104104  Thoc3; LOW QUALITY PROTEIN: THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
mcoc03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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