KEGG   PATHWAY: afb04068
Entry
afb04068                    Pathway                                
Name
FoxO signaling pathway - Anoplopoma fimbria (sablefish)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
afb04068  FoxO signaling pathway
afb04068

Other DBs
GO: 0009267
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129090601  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
129090050  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
129110263  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
129106805  transforming growth factor beta-3 proprotein-like [KO:K13377]
129103200  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
129111052  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
129097102  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
129104613  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
129109188  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129110054  mothers against decapentaplegic homolog 4-like [KO:K04501]
129101770  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
129101981  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
129097247  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
129107736  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
129108459  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
129114179  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
129094555  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
129102391  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129101122  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
129102184  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
129114243  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
129105226  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
129110459  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
129111675  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
129112494  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
129104363  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
129091545  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
129098953  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
129102453  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
129112433  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129090365  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
129090942  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
129096534  crebbpa; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
129097855  crebbpb; LOW QUALITY PROTEIN: CREB binding protein b [KO:K04498] [EC:2.3.1.48]
129099153  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
129092252  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
129098054  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
129093077  solute carrier family 2, facilitated glucose transporter member 4-like isoform X1 [KO:K07191]
129089642  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129091736  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
129102708  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129092535  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129105431  serine/threonine-protein kinase 4-like [KO:K04411]
129100310  igf3; insulin-like growth factor 3 [KO:K05459]
129112224  igf1; insulin-like growth factor I [KO:K05459]
129107750  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
129108015  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
129090325  insulin-like isoform X1 [KO:K04526]
129113266  ins; insulin [KO:K04526]
129089410  insra; LOW QUALITY PROTEIN: insulin receptor a [KO:K04527] [EC:2.7.10.1]
129094199  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
129113916  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
129093522  si:ch73-335l21.1; LOW QUALITY PROTEIN: insulin receptor substrate 1-B [KO:K16172]
129104830  irs2b; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
129111725  insulin receptor substrate 2-like [KO:K07187]
129093242  LOW QUALITY PROTEIN: insulin receptor substrate 2-B [KO:K07187]
129099623  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
129090356  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129115605  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129093032  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129094279  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
129094332  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
129094609  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
129110782  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129101175  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
129112007  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
129102021  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129091729  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
129091327  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
129092009  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
129101396  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129091573  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129092302  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129105750  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129096351  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129091996  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129103636  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129115847  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129116975  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
129106837  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
129097060  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
129109325  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
129099637  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
129110624  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
129113667  forkhead box protein O1-A-like [KO:K07201]
129094210  foxo1a; forkhead box protein O1-A [KO:K07201]
129107035  foxo3b; LOW QUALITY PROTEIN: forkhead box protein O3B [KO:K09408]
129097043  foxo6b; forkhead box protein O6b [KO:K09408]
129090364  foxo4; forkhead box protein O4 [KO:K12358]
129110010  LOW QUALITY PROTEIN: forkhead box protein O3-like [KO:K17847]
129107288  grm1a; metabotropic glutamate receptor 1 [KO:K04603]
129103464  grm1b; metabotropic glutamate receptor 1b [KO:K04603]
129089166  homer protein homolog 3-like [KO:K15010]
129094985  homer protein homolog 3-like isoform X1 [KO:K15010]
129101467  homer1b; homer protein homolog 1b [KO:K15010]
129106389  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
129102299  homer protein homolog 1-like [KO:K15010]
129099566  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
129105887  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
129091008  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
129099056  casein kinase I [KO:K08960] [EC:2.7.11.1]
129105680  il10; interleukin-10 [KO:K05443]
129098137  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
129090086  egf; pro-epidermal growth factor [KO:K04357]
129110777  LOW QUALITY PROTEIN: melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
129111957  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
129098114  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
129095261  son of sevenless homolog 1-like [KO:K03099]
129103159  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
129108847  GTPase HRas [KO:K02833]
129107733  kras; GTPase KRas isoform X1 [KO:K07827]
129097851  zgc:55558; GTPase KRas [KO:K07827]
129112235  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129099416  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
129101790  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129108367  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129112227  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
129094155  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
129100791  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129097938  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129099271  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129099334  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
129099803  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
129105168  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
129112242  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
129112696  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129108921  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129105244  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
129098554  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
129095566  foxg1c; forkhead box protein G1c [KO:K09385]
129092759  foxg1b; forkhead box protein G1b [KO:K09385]
129103534  foxg1a; forkhead box protein G1 [KO:K09385]
129102142  ccnb1; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1 [KO:K05868]
129094805  ccnp; cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
129101484  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
129101764  G2/mitotic-specific cyclin-B2-like [KO:K21770]
129093523  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
129102238  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
129108229  G1/S-specific cyclin-D1-like [KO:K04503]
129112322  G1/S-specific cyclin-D2-like [KO:K10151]
129107686  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
129098265  ccndx; cyclin Dx [KO:K10151]
129101300  cyclin-G2-like [KO:K10146]
129102083  ccng2; cyclin-G2 [KO:K10146]
129096142  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
129095422  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
129112406  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
129106138  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
129112606  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
129108101  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
129107680  rbl2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
129095734  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
129100994  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
129114489  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
129103519  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
129094450  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
129101163  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
129102458  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
129102521  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
129114147  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
129103499  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
129094124  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
129110212  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
129094969  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129090345  cd40lg; CD40 ligand [KO:K04389]
129110607  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
129103521  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
129094418  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
129088810  bcl6ab; BCL6A transcription repressor b isoform X1 [KO:K15618]
129092059  bnip4; BCL2 interacting protein 4 [KO:K15464]
129102765  zgc:73226; LOW QUALITY PROTEIN: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
129109414  atg12; ubiquitin-like protein ATG12 [KO:K08336]
129109586  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
129100969  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
129108062  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
129093128  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
129107785  cat; catalase [KO:K03781] [EC:1.11.1.6]
129107997  uncharacterized protein LOC129107997 [KO:K03781] [EC:1.11.1.6]
129106859  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
129104180  atm; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
129105744  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
129110756  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
129090916  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
129090917  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
129091410  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
129102717  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
129116380  Krueppel-like factor 2 [KO:K17845]
129088848  klf2b; Krueppel-like factor 2b [KO:K17845]
129094121  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
129094803  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
129108694  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
129108680  rag2; LOW QUALITY PROTEIN: V(D)J recombination-activating protein 2 [KO:K10988]
129107157  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
129109145  fbxo32; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
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Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
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Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
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PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
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Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
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Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
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Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
afb00010  Glycolysis / Gluconeogenesis
afb00020  Citrate cycle (TCA cycle)
afb00190  Oxidative phosphorylation
afb04010  MAPK signaling pathway
afb04110  Cell cycle
afb04120  Ubiquitin mediated proteolysis
afb04140  Autophagy - animal
afb04210  Apoptosis
afb04350  TGF-beta signaling pathway
afb04910  Insulin signaling pathway
KO pathway
ko04068   
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