KEGG   PATHWAY: ajm04217
Entry
ajm04217                    Pathway                                
Name
Necroptosis - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
ajm04217  Necroptosis
ajm04217

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119060225  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119061887  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
119036073  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119043073  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
119051788  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
119054065  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
119054066  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
119055846  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
119047780  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
119047782  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K10630] [EC:2.3.2.31]
119037290  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
119064715  sharpin [KO:K20894]
119047302  SPATA2L; spermatogenesis-associated protein 2-like protein isoform X1 [KO:K17595]
119065229  SPATA2; spermatogenesis-associated protein 2 [KO:K17595]
119046463  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
119041863  FADD; FAS-associated death domain protein [KO:K02373]
119065511  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119047616  LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
119065514  CFLAR; LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
119037319  RIPK3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
119063653  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
119037697  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
119038077  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119052888  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
119061401  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
119035353  ADP,ATP carrier protein 1, mitochondrial [KO:K05863]
119036890  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
119037676  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
119045737  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
119046880  ADP,ATP carrier protein [KO:K05863]
119062994  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
119050103  ADP/ATP translocase 3-like [KO:K05863]
119034620  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
119056480  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
119037617  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
119038134  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119053810  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
119047138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
119062384  GLUD1; glutamate dehydrogenase 1, mitochondrial [KO:K00261] [EC:1.4.1.3]
119056723  glutamate dehydrogenase 2, mitochondrial [KO:K00261] [EC:1.4.1.3]
119039442  glutamine synthetase 2 cytoplasmic-like [KO:K01915] [EC:6.3.1.2]
119049602  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
119049888  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
119057055  PYGL; glycogen phosphorylase, liver form isoform X1 [KO:K00688] [EC:2.4.1.1]
119050292  PYGM; glycogen phosphorylase, muscle form isoform X1 [KO:K00688] [EC:2.4.1.1]
119042614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119046845  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119062834  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119043723  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
119043839  LOW QUALITY PROTEIN: ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
119043840  ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
119041028  ferritin light chain-like [KO:K00522] [EC:1.16.3.1]
119034792  LOW QUALITY PROTEIN: ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
119052992  LOW QUALITY PROTEIN: ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
119036075  FTL; ferritin light chain [KO:K13625]
119036273  ferritin light chain 1-like [KO:K13625]
119061350  ferritin light chain-like [KO:K13625]
119046380  ferritin light chain-like [KO:K13625]
119047967  ferritin light chain-like [KO:K13625]
119055902  LOW QUALITY PROTEIN: ferritin light chain-like [KO:K13625]
119064316  ferritin light chain 1-like [KO:K13625]
119065016  ferritin light chain-like [KO:K13625]
119059728  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
119061268  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
119061284  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
119061309  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
119061310  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
119043192  ALOX15; LOW QUALITY PROTEIN: polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
119050263  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
119036522  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
119041337  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
119048932  MLKL; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
119060793  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
119045100  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
119051579  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
119036945  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119038029  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119051385  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
119060758  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
119045049  interleukin-1 beta-like [KO:K04519]
119065847  IL1B; interleukin-1 beta [KO:K04519]
119051612  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
119038286  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
119059877  CHMP3; charged multivesicular body protein 3 [KO:K12193]
119045042  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
119037229  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
119062435  vacuolar-sorting protein SNF7 [KO:K12194]
119047756  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
119046713  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
119058657  CHMP6; charged multivesicular body protein 6 [KO:K12195]
119043160  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
119061876  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
119057574  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
119051304  charged multivesicular body protein 1b [KO:K12197]
119047340  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
119057660  charged multivesicular body protein 1b-2 [KO:K12197]
119040934  LOW QUALITY PROTEIN: charged multivesicular body protein 5-like [KO:K12198]
119053825  CHMP5; charged multivesicular body protein 5 [KO:K12198]
119054708  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
119057606  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
119065843  IL1A; interleukin-1 alpha [KO:K04383]
119057841  IL33; interleukin-33 isoform X1 [KO:K12967]
119037404  HMGB1; high mobility group protein B1 [KO:K10802]
119043451  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
119041884  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722]
119054722  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
119065454  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119057762  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119058844  interferon alpha-4-like [KO:K05414]
119045866  interferon alpha-7 [KO:K05414]
119045867  interferon alpha-4 [KO:K05414]
119056303  interferon alpha-4-like [KO:K05414]
119049818  interferon alpha-4-like [KO:K05414]
119055662  IFNB1; interferon beta [KO:K05415]
119042309  IFNG; interferon gamma [KO:K04687]
119035720  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119035719  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119051850  IFNGR1; interferon gamma receptor 1 [KO:K05132]
119035735  IFNGR2; interferon gamma receptor 2 [KO:K05133]
119042494  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119048039  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
119046817  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
119055683  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
119062093  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
119040310  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
119052142  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119062106  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
119052172  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
119037510  signal transducer and activator of transcription 5B [KO:K11224]
119035652  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
119037294  IRF9; interferon regulatory factor 9 [KO:K04693]
119063844  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
119056324  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
119062550  TIR domain-containing adapter molecule 2-like [KO:K05409]
119063741  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
119036871  TLR3; toll-like receptor 3 [KO:K05401]
119040646  ZBP1; Z-DNA-binding protein 1 [KO:K12965]
119052641  USP21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
119042610  SQSTM1; sequestosome-1 [KO:K14381]
119037939  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119041136  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-beta-3 [KO:K04079]
119046156  heat shock protein 90-5, chloroplastic-like [KO:K04079]
119061428  endoplasmin homolog [KO:K04079]
119047198  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119047665  heat shock protein 81-1 [KO:K04079]
119051859  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
119044455  PARP1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
119044372  BID; BH3-interacting domain death agonist [KO:K04726]
119037607  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
119050676  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
119044166  core histone macro-H2A.1 isoform X1 [KO:K11251]
119038057  histone H2A.V-like [KO:K11251]
119038200  core histone macro-H2A.2 [KO:K11251]
119039156  histone H2A-beta, sperm-like [KO:K11251]
119039160  histone H2A type 1 [KO:K11251]
119039161  histone H2A type 1 [KO:K11251]
119039170  histone H2A type 1-H-like isoform X1 [KO:K11251]
119042325  histone H2A [KO:K11251]
119042840  histone H2A.J [KO:K11251]
119051749  histone H2A.Z-like [KO:K11251]
119052881  histone H2A.V [KO:K11251]
119045693  histone H2A type 3 [KO:K11251]
119046594  histone H2A-like [KO:K11251]
119054095  histone H2A.Z [KO:K11251]
119054892  histone H2A type 1 [KO:K11251]
119054924  histone H2A type 1-like [KO:K11251]
119054925  histone H2A type 1 [KO:K11251]
119054926  histone H2A type 1 [KO:K11251]
119054927  histone H2A type 1-like [KO:K11251]
119054928  histone H2A type 1-like [KO:K11251]
119054981  histone H2A type 1-like [KO:K11251]
119055454  histone H2A type 2-A-like [KO:K11251]
119055455  histone H2A type 2-A [KO:K11251]
119055461  histone H2A-Bbd type 2/3-like [KO:K11251]
119055462  histone H2A-Bbd type 2/3-like [KO:K11251]
119055500  histone H2A-Bbd type 2/3-like [KO:K11251]
119065754  histone H2A type 2-B [KO:K11251]
119065765  histone H2A type 2-C [KO:K11251]
119050787  histone H2AX [KO:K11251]
119039978  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
119052887  PPIA; peptidyl-prolyl cis-trans isomerase A isoform X1 [KO:K03767] [EC:5.2.1.8]
119046943  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
119050176  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
119050178  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
119057839  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
119057575  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
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Related
pathway
ajm00250  Alanine, aspartate and glutamate metabolism
ajm04210  Apoptosis
ajm04668  TNF signaling pathway
ajm04922  Glucagon signaling pathway
KO pathway
ko04217   
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