KEGG   PATHWAY: bbis04726
Entry
bbis04726                   Pathway                                
Name
Serotonergic synapse - Bison bison bison (American bison)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
bbis04726  Serotonergic synapse
bbis04726

Other DBs
GO: 0007210
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104981427  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
104989308  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
104981803  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
104992528  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
105002581  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
104992358  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104997112  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104981877  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104986422  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
104999154  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
104991117  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
104996774  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
104987189  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
104994462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104984484  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104984486  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104991589  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105000232  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104995001  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105000525  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104986737  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105000236  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104995620  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104998054  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104994440  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
104994441  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
104994471  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104994473  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
104985773  cytochrome P450 2C42-like [KO:K07413] [EC:1.14.14.1]
104983529  cytochrome P450 2C21-like isoform X1 [KO:K07413] [EC:1.14.14.1]
104983530  cytochrome P450 2C31-like [KO:K07413] [EC:1.14.14.1]
104990182  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
104990186  LOW QUALITY PROTEIN: cytochrome P450 2C18 [KO:K07413] [EC:1.14.14.1]
105002722  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
104991248  cytochrome P450 2D14 isoform X1 [KO:K07414] [EC:1.14.14.1]
105002568  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105002577  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105002593  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105002602  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105002609  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
104984606  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
104999056  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
104993944  arachidonate 12-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
104993949  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
104990750  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
104993943  arachidonate 15-lipoxygenase isoform X1 [KO:K00460] [EC:1.13.11.33]
104990752  arachidonate 15-lipoxygenase B-like isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
104990889  LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
104997385  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
104998056  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104981326  HTR3A; 5-hydroxytryptamine receptor 3A isoform X1 [KO:K04819]
105000015  5-hydroxytryptamine receptor 3C-like [KO:K04819]
105000017  HTR3E; 5-hydroxytryptamine receptor 3E isoform X1 [KO:K04819]
105000018  HTR3C; 5-hydroxytryptamine receptor 3C [KO:K04819]
104981489  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
104996288  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
104981057  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
104990228  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
104989972  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
104989974  neuroendocrine secretory protein 55 [KO:K04632]
104984593  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104999887  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105003252  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104989318  LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2-like [KO:K04943]
104989473  potassium voltage-gated channel subfamily D member 2 [KO:K04892]
104992822  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
104999749  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
105002321  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
104986831  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
104987491  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
104992582  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
104999693  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
104981099  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
104994385  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
104984759  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
104980519  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105003815  5-hydroxytryptamine receptor 5B [KO:K04161]
104981671  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
104994506  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
104997186  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105004321  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
104995929  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104987131  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104992176  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104999981  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
104986263  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104990266  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
104998683  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105003123  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105005375  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105003360  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105005584  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
104997725  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
104991180  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104988445  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104999859  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
104996170  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104985138  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
104988446  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
104990595  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104985538  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104996902  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105003692  HRAS; GTPase HRas [KO:K02833]
105000225  KRAS; GTPase KRas isoform X1 [KO:K07827]
104981582  NRAS; GTPase NRas [KO:K07828]
104999018  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
104999381  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105004742  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104999898  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
104988635  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
104984881  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
104993623  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
104992012  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
105001769  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
105004144  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
bbis00380  Tryptophan metabolism
bbis00590  Arachidonic acid metabolism
bbis04020  Calcium signaling pathway
bbis04721  Synaptic vesicle cycle
bbis04976  Bile secretion
KO pathway
ko04726   
LinkDB

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