KEGG   PATHWAY: bbis04020
Entry
bbis04020                   Pathway                                
Name
Calcium signaling pathway - Bison bison bison (American bison)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
bbis04020  Calcium signaling pathway
bbis04020

Other DBs
GO: 0019722
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104979663  TBXA2R; thromboxane A2 receptor [KO:K04264]
104979859  OXTR; oxytocin receptor [KO:K04229]
104979885  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
104979941  MCOLN1; LOW QUALITY PROTEIN: mucolipin-1 [KO:K04992]
104980001  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
104980024  TPCN1; two pore calcium channel protein 1 [KO:K16896]
104980395  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
104980414  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104980419  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
104980493  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
104980519  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
104980870  TACR1; substance-P receptor [KO:K04222]
104980934  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
104981040  VEGFC; vascular endothelial growth factor C [KO:K05449]
104981057  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
104981188  PTAFR; platelet-activating factor receptor [KO:K04279]
104981292  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
104981571  CASQ2; calsequestrin-2 [KO:K23445]
104981573  NGF; beta-nerve growth factor [KO:K02582]
104981877  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104981942  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
104982045  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104982050  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
104982098  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
104982242  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
104982278  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104982625  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
104982764  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
104982967  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
104983051  [KO:K05863]
104983199  [KO:K10785]
104983412  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104984129  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104984197  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
104984455  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
104984484  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104984486  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104984516  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
104984663  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
104984839  P2RX6; P2X purinoceptor 6 [KO:K05221]
104985011  [KO:K26467]
104985040  TNNC2; troponin C, skeletal muscle [KO:K12042]
104985106  [KO:K04282]
104985118  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104985417  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
104985506  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
104985546  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
104985586  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
104985766  PDGFC; platelet-derived growth factor C [KO:K05450]
104985977  CALML5; calmodulin-like protein 5 [KO:K02183]
104986047  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
104986130  NTSR1; neurotensin receptor type 1 [KO:K04211]
104986156  CALML3; calmodulin-like protein 3 [KO:K02183]
104986328  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
104986422  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
104986612  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
104986667  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
104986673  ORAI3; protein orai-3 [KO:K16058]
104986737  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104986775  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
104986929  FGF4; fibroblast growth factor 4 [KO:K04358]
104986933  TPCN2; two pore calcium channel protein 2 [KO:K14077]
104987053  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
104987054  FGF19; fibroblast growth factor 19 [KO:K22603]
104987189  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
104987248  VEGFB; vascular endothelial growth factor B [KO:K16858]
104987347  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
104987448  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104987616  CALM2; calmodulin [KO:K02183]
104987781  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
104987815  PDGFD; platelet-derived growth factor D [KO:K05450]
104988001  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
104988024  EDNRA; endothelin-1 receptor [KO:K04197]
104988058  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
104988255  FGF7; fibroblast growth factor 7 [KO:K04358]
104988572  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
104988586  STIM2; stromal interaction molecule 2 [KO:K18196]
104988664  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
104988719  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
104988723  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
104988876  [KO:K04358]
104988909  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104989034  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104989301  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104989616  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
104989620  P2RX4; P2X purinoceptor 4 [KO:K05218]
104989624  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
104989626  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
104989806  AVPR1A; vasopressin V1a receptor [KO:K04226]
104989914  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
104989972  [KO:K04632]
104989974  [KO:K04632]
104990128  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
104990172  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104990190  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
104990228  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
104990237  P2RX3; P2X purinoceptor 3 [KO:K05217]
104990532  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104990628  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
104990684  ADORA2B; adenosine receptor A2b [KO:K04267]
104990937  [KO:K04809]
104991117  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
104991434  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
104991444  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104991501  [KO:K04282]
104991589  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
104991621  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104991623  RYR3; ryanodine receptor 3 [KO:K04963]
104991731  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104991863  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104991914  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
104991955  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
104992083  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104992091  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
104992215  FGF6; fibroblast growth factor 6 [KO:K04358]
104992296  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104992321  CALM1; calmodulin [KO:K02183]
104992344  FGF23; fibroblast growth factor 23 [KO:K22428]
104992358  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104992445  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104992537  FGF17; fibroblast growth factor 17 [KO:K04358]
104992549  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104992905  FGF5; fibroblast growth factor 5 [KO:K04358]
104993058  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
104993226  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104993343  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104993434  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
104993567  CASQ1; calsequestrin-1 [KO:K23468]
104993807  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
104994008  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104994009  P2RX1; P2X purinoceptor 1 [KO:K05215]
104994013  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
104994019  FIGF; vascular endothelial growth factor D [KO:K05449]
104994159  F2R; proteinase-activated receptor 1 [KO:K03914]
104994273  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
104994431  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
104994462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104994516  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104994625  TACR3; neuromedin-K receptor [KO:K04224]
104994644  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104995001  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104995034  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
104995440  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
104995459  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
104995549  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
104995615  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
104995622  FGF21; fibroblast growth factor 21 [KO:K22429]
104995643  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
104995715  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
104996088  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
104996248  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104996288  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
104996289  ADRB2; beta-2 adrenergic receptor [KO:K04142]
104996312  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
104996314  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104996405  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
104996518  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
104996751  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104996772  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
104996774  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
104996813  FGF9; fibroblast growth factor 9 [KO:K04358]
104996840  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104996912  FGF18; fibroblast growth factor 18 [KO:K04358]
104996977  BDKRB2; B2 bradykinin receptor [KO:K03916]
104996978  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
104997048  [KO:K04603]
104997112  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104997136  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
104997202  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
104997287  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
104997328  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104997460  TACR2; substance-K receptor isoform X1 [KO:K04223]
104997490  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
104997505  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104997518  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104997530  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
104997606  P2RX2; P2X purinoceptor 2 [KO:K05216]
104997723  CALM3; calmodulin [KO:K02183]
104997800  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
104997904  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
104997987  FGF10; fibroblast growth factor 10 [KO:K04358]
104998013  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
104998117  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104998408  [KO:K02183]
104998489  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104998543  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
104998666  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
104998760  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
104998785  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
104998820  AVPR1B; vasopressin V1b receptor [KO:K04227]
104998967  ORAI2; LOW QUALITY PROTEIN: protein orai-2 [KO:K16057]
104999154  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
104999482  [KO:K10785]
104999550  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104999563  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104999564  EDNRB; LOW QUALITY PROTEIN: endothelin B receptor [KO:K04198]
104999763  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
104999819  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
104999887  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104999898  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
104999933  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
105000192  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
105000232  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105000236  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105000258  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
105000347  SMIM6; small integral membrane protein 6 [KO:K26468]
105000373  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
105000525  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105000537  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105000668  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
105001032  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105001132  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105001191  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105001346  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
105001616  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105001755  AGTR1; type-1 angiotensin II receptor [KO:K04166]
105001963  FGF20; fibroblast growth factor 20 [KO:K04358]
105002056  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
105002073  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105002184  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105002480  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
105002554  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105002777  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
105002795  FGF8; fibroblast growth factor 8 [KO:K04358]
105002846  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105002851  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105003134  RYR2; ryanodine receptor 2 [KO:K04962]
105003136  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105003222  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105003247  FGF2; fibroblast growth factor 2 [KO:K18497]
105003252  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105003265  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
105003266  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
105003731  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105003772  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
105003788  [KO:K05863]
105003815  [KO:K04161]
105003971  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105004232  TRDN; triadin [KO:K23449]
105004251  PLN; cardiac phospholamban [KO:K05852]
105004477  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
105004479  DRD1; D(1A) dopamine receptor [KO:K04144]
105004725  HRH1; histamine H1 receptor [KO:K04149]
105004782  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
105004836  [KO:K04603]
105005003  SLN; sarcolipin [KO:K22642]
105005203  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105005253  TFEB; transcription factor EB [KO:K15590]
105005452  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
105005595  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
bbis04010  MAPK signaling pathway
bbis04070  Phosphatidylinositol signaling system
bbis04210  Apoptosis
bbis04720  Long-term potentiation
bbis04730  Long-term depression
KO pathway
ko04020   

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