KEGG   PATHWAY: bgar04820
Entry
bgar04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Bufo gargarizans (Asiatic toad)
Class
Cellular Processes; Cell motility
Pathway map
bgar04820  Cytoskeleton in muscle cells
bgar04820

Organism
Bufo gargarizans (Asiatic toad) [GN:bgar]
Gene
122940020  COL1A1; collagen alpha-1(I) chain [KO:K06236]
122945757  COL3A1; collagen alpha-1(III) chain [KO:K19720]
122943156  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
122943595  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
122944412  COL5A2; collagen alpha-2(V) chain [KO:K19721]
122945995  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
122946023  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
122946233  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
122919696  collagen alpha-1(I) chain-like [KO:K19721]
122927169  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
122935352  collagen alpha-1(IX) chain-like [KO:K08131]
122931555  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
122941569  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
122925864  DCN; decorin [KO:K04660]
122924677  VCAN; versican core protein [KO:K06793]
122931722  ELN; elastin [KO:K14211]
122937796  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
122944801  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
122945163  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
122945708  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
122939368  collagen alpha-6(VI) chain-like [KO:K06238]
122922235  THBS1; thrombospondin-1 [KO:K16857]
122936138  THBS4; thrombospondin-4 [KO:K04659]
122929708  cartilage oligomeric matrix protein [KO:K04659]
122933981  THBS2; thrombospondin-2 [KO:K04659]
122927624  FBN1; fibrillin-1 [KO:K06825]
122924601  FBN2; fibrillin-2 [KO:K23342]
122946111  fibrillin-2-like [KO:K23342]
122930649  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
122930650  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
122919426  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
122946309  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122923568  FBLN1; fibulin-1 isoform X1 [KO:K17307]
122929027  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
122922027  NID2; LOW QUALITY PROTEIN: nidogen-2 [KO:K06826]
122944776  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
122934633  SDC1; syndecan-1 [KO:K06257]
122938239  SDC2; syndecan-2 [KO:K16336]
122933070  SDC3; syndecan-3 [KO:K16337]
122940940  syndecan 4-B-like [KO:K16338]
122928691  AGRN; LOW QUALITY PROTEIN: agrin [KO:K06254]
122919958  BGN; biglycan [KO:K08118]
122939164  desmoglein-2-like isoform X1 [KO:K07597]
122928520  PKP2; plakophilin-2 isoform X1 [KO:K12642]
122940155  junction plakoglobin isoform X1 [KO:K10056]
122938204  desmoplakin isoform X1 [KO:K10381]
122924497  vimentin-like [KO:K07606]
122939580  VIM; vimentin isoform X1 [KO:K07606]
122936146  desmin-like [KO:K07610]
122944910  DES; desmin isoform X1 [KO:K07610]
122935397  LAMA2; laminin subunit alpha-2 [KO:K05637]
122938098  LAMA1; laminin subunit alpha-1 [KO:K05637]
122924791  ITGA1; integrin alpha-1 [KO:K06480]
122924792  ITGA2; integrin alpha-2 [KO:K06481]
122940098  ITGA2B; integrin alpha-IIb [KO:K06476]
122940317  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
122944389  ITGA4; integrin alpha-4 [KO:K06483]
122931413  ITGA5; integrin alpha-5 [KO:K06484]
122944564  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122933339  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
122937824  ITGA8; integrin alpha-8 [KO:K06584]
122938035  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
122921379  ITGA10; integrin alpha-10 [KO:K06586]
122929534  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
122946190  ITGAV; integrin alpha-V [KO:K06487]
122937735  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122940129  ITGB3; integrin beta-3 [KO:K06493]
122942615  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
122942561  ITGB5; integrin beta-5 [KO:K06588]
122945583  ITGB6; integrin beta-6 [KO:K06589]
122931006  ITGB7; integrin beta-7 [KO:K06590]
122937964  ITGB8; integrin beta-8 [KO:K06591]
122922490  talin-1 isoform X1 [KO:K06271]
122927709  TLN2; talin-2 isoform X1 [KO:K06271]
122942597  VCL; vinculin isoform X1 [KO:K05700]
122920281  ACTN3; alpha-actinin-3 [KO:K21073]
122933745  ACTN2; alpha-actinin-2 [KO:K21073]
122944482  ACTB; actin, cytoplasmic 1 [KO:K05692]
122939974  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122940672  SGCA; alpha-sarcoglycan [KO:K12565]
122939084  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
122941641  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
122928403  SGCD; delta-sarcoglycan [KO:K12563]
122931095  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
122939562  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
122928534  SSPN; sarcospan [KO:K22194]
122930949  DMD; dystrophin isoform X1 [KO:K10366]
122941854  SNTA1; alpha-1-syntrophin [KO:K24063]
122938862  SNTB1; LOW QUALITY PROTEIN: beta-1-syntrophin [KO:K24064]
122920803  SNTB2; beta-2-syntrophin [KO:K24064]
122937857  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
122927771  FLNC; filamin-C isoform X1 [KO:K27393]
122922716  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
122929152  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
122921494  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
122934425  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
122930299  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
122945984  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
122939957  ANK3; ankyrin-3 isoform X1 [KO:K09259]
122946377  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
122934234  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
122923941  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
122921660  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
122920830  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
122927991  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
122920163  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
122939890  myosin-4 [KO:K24220]
122931092  MYH15; myosin-15 [KO:K24220]
122945959  myosin-4-like [KO:K24220]
122940014  MYH7B; LOW QUALITY PROTEIN: myosin-7B [KO:K24220]
122946721  myosin-4-like [KO:K24220]
122946722  myosin-4-like [KO:K24220]
122940394  myosin-1B-like [KO:K24220]
122923509  myosin-7 [KO:K17751]
122923525  myosin-6 isoform X1 [KO:K17751]
122928993  myosin-10-like isoform X1 [KO:K10352]
122944012  MYH9; myosin-9 [KO:K10352]
122944451  MYH11; myosin-11 isoform X1 [KO:K10352]
122940249  MYH10; myosin-10 isoform X1 [KO:K10352]
122944788  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
122922870  myosin light chain 3-like [KO:K12749]
122939246  myosin light chain 3-like [KO:K12749]
122940868  MYL4; myosin light chain 4 [KO:K12750]
122934995  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
122927385  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122941730  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
122928130  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
122928626  MYBPC2; myosin-binding protein C, fast-type isoform X1 [KO:K12558]
122928627  myosin-binding protein C, fast-type-like isoform X1 [KO:K12558]
122920210  MYBPC3; myosin-binding protein C, cardiac-type isoform X1 [KO:K12568]
122920171  actin, alpha skeletal muscle 3 [KO:K10354]
122924331  actin, alpha cardiac muscle 1 [KO:K12314]
122921503  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
122933741  ACTRT3; LOW QUALITY PROTEIN: actin-related protein T3 [KO:K12314]
122934088  actin, alpha cardiac muscle 2 [KO:K12314]
122935926  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
122923360  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
122926458  troponin I, slow skeletal muscle-like [KO:K10371]
122933293  TNNI1; troponin I, slow skeletal muscle isoform X1 [KO:K10371]
122928656  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
122940876  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
122920958  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
122921125  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
122928655  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
122933273  troponin T, cardiac muscle isoforms-like [KO:K12045]
122922586  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
122927707  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K09290]
122919644  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
122944640  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
122941056  telethonin [KO:K19879]
122944867  NEB; nebulin isoform X1 [KO:K18267]
122938486  nebulette isoform X1 [KO:K25865]
122923277  nebulette-like [KO:K25865]
122942440  MYOZ1; myozenin-1 [KO:K26050]
122943440  MYOZ2; myozenin-2 [KO:K26050]
122928368  MYOZ3; myozenin-3 [KO:K26050]
122939894  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
122926303  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
122940882  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
122927946  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
122930265  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
122924085  F-actin-capping protein subunit beta isoform X1 [KO:K10365]
122938046  xin actin-binding repeat-containing protein 1-like [KO:K27381]
122944915  XIRP2; LOW QUALITY PROTEIN: xin actin-binding repeat-containing protein 2 [KO:K27381]
122923835  nebulin-related-anchoring protein-like [KO:K24421]
122940170  MYPN; myopalladin isoform X1 [KO:K22028]
122942612  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
122944415  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
122925923  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
122922069  TMOD4; tropomodulin-4 [KO:K10370]
122929642  tropomodulin-2-like [KO:K10370]
122921337  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
122927634  tropomodulin-3-like [KO:K10370]
122939984  ZYX; zyxin isoform X1 [KO:K06273]
122945941  FHL1; four and a half LIM domains protein 1 [KO:K14365]
122932512  FHL2; four and a half LIM domains protein 2 [KO:K14380]
122932820  four and a half LIM domains protein 2-like [KO:K14380]
122932991  FHL3; four and a half LIM domains protein 3 [KO:K24414]
122927927  LMOD2; leiomodin-2 [KO:K22030]
122928734  leiomodin-1-like [KO:K22030]
122943533  leiomodin-3-like [KO:K22030]
122943566  leiomodin-3-like [KO:K22030]
122932749  LMOD1; leiomodin-1 [KO:K22030]
122940149  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
122941113  ankyrin repeat domain-containing protein 2-like [KO:K21434]
122941157  ankyrin repeat domain-containing protein 2-like [KO:K21434]
122944470  FMNL2; LOW QUALITY PROTEIN: formin-like protein 2 [KO:K23957]
122930868  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
122940371  FMNL1; formin-like protein 1 [KO:K23957]
122921244  INF2; inverted formin-2 isoform X1 [KO:K23958]
122921900  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
122931045  disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
122928298  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
122919660  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
122932031  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
122938901  MYOM1; myomesin-1 isoform X1 [KO:K24495]
122932417  MYOM3; myomesin-3 [KO:K24495]
122934083  MYOM2; myomesin-2 isoform X1 [KO:K24495]
122928697  ENO1; enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
122926968  ENO3; beta-enolase [KO:K01689] [EC:4.2.1.11]
122943537  ANK2; ankyrin-2 isoform X1 [KO:K09255]
122922674  tripartite motif-containing protein 54-like [KO:K10653]
122937955  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
122923370  E3 ubiquitin-protein ligase TRIM63-like [KO:K10655] [EC:2.3.2.27]
122932856  E3 ubiquitin-protein ligase TRIM63-like [KO:K10655] [EC:2.3.2.27]
122921072  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
122933357  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
122933472  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
122937790  OBSCN; LOW QUALITY PROTEIN: obscurin [KO:K17531] [EC:2.7.11.1]
122921245  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
122938806  PLEC; plectin isoform X1 [KO:K10388]
122923375  SYNE3; nesprin-3 isoform X1 [KO:K21761]
122933657  SYNE1; nesprin-1 isoform X1 [KO:K19326]
122921513  SYNE2; LOW QUALITY PROTEIN: nesprin-2 [KO:K19346]
122943474  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
122939252  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
122943803  TMEM43; transmembrane protein 43 [KO:K27488]
122946631  EMD; emerin isoform X1 [KO:K12569]
122933816  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
122921622  LMNA; lamin [KO:K12641]
122924605  LMNB1; lamin-B1 [KO:K07611]
122946192  LMNB2; lamin-B2 [KO:K07611]
122927596  lamin-L(III)-like isoform X1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
bgar04512  ECM-receptor interaction
bgar04814  Motor proteins
KO pathway
ko04820   
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