KEGG   PATHWAY: ccad04110
Entry
ccad04110                   Pathway                                
Name
Cell cycle - Cervus canadensis (wapiti)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
ccad04110  Cell cycle
ccad04110

Other DBs
GO: 0000278
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122430666  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
122424006  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
122429373  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122427215  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122438094  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122447603  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
122447910  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
122420237  RBL2; retinoblastoma-like protein 2 [KO:K16332]
122442277  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
122450301  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
122422660  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
122426238  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
122448331  E2F1; transcription factor E2F1 [KO:K17454]
122426579  E2F2; transcription factor E2F2 [KO:K09389]
122429389  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
122421728  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
122451088  E2F5; transcription factor E2F5 [KO:K04682]
122447349  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
122445248  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
122445589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122420314  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
122452400  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122443885  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
122425874  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
122443073  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
122425381  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
122451212  MYC; myc proto-oncogene protein [KO:K04377]
122452357  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
122452871  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
122452872  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122449984  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
122436995  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
122440415  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
122423697  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122431066  CDKN1C; cyclin-dependent kinase inhibitor 1C isoform X1 [KO:K09993]
122429747  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122421575  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122450896  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
122427513  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122439920  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
122450567  S-phase kinase-associated protein 1-like [KO:K03094]
122420769  S-phase kinase-associated protein 1-like [KO:K03094]
122438828  CUL1; cullin-1 [KO:K03347]
122437764  cullin-1-like [KO:K03347]
122423474  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
122426581  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
122445122  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
122454407  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
122447376  CCNA1; cyclin-A1 [KO:K06627]
122422114  CCNA2; cyclin-A2 [KO:K06627]
122420352  CDT1; DNA replication factor Cdt1 [KO:K10727]
122436972  ORC1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
122426860  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
122422563  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
122453865  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
122438291  ORC5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
122420538  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
122424631  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
122429651  MCM3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
122450837  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
122423764  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
122454021  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
122432807  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
122454839  CDC45; cell division control protein 45 homolog isoform X1 [KO:K06628]
122455302  TICRR; treslin [KO:K26117]
122451018  mdm2-binding protein [KO:K26116]
122436702  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
122438217  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
122440422  DBF4B; protein DBF4 homolog B isoform X1 [KO:K06629]
122446536  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
122434837  G2/mitotic-specific cyclin-B1-like [KO:K05868]
122454476  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
122443546  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
122435261  CCNB3; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3 [KO:K21771]
122448466  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
122439872  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
122421214  14-3-3 protein zeta/delta-like [KO:K16197]
122447948  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
122442084  YWHAQ; 14-3-3 protein theta [KO:K16197]
122450884  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
122435408  14-3-3 protein theta-like [KO:K16197]
122435407  14-3-3 protein theta-like [KO:K16197]
122453085  14-3-3 protein beta/alpha-like [KO:K16197]
122453084  14-3-3 protein zeta/delta-like [KO:K16197]
122453372  14-3-3 protein zeta/delta-like [KO:K16197]
122453373  14-3-3 protein beta/alpha-like [KO:K16197]
122453072  14-3-3 protein zeta/delta-like [KO:K16197]
122453073  14-3-3 protein beta/alpha-like [KO:K16197]
122445227  14-3-3 protein theta-like [KO:K16197]
122447849  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
122433054  YWHAG; 14-3-3 protein gamma [KO:K16198]
122420551  YWHAH; 14-3-3 protein eta [KO:K16198]
122437830  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
122450029  WEE1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
122433204  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
122439555  CCNH; cyclin-H isoform X1 [KO:K06634]
122440488  LOW QUALITY PROTEIN: cyclin-dependent kinase 7-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
122454254  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
122441326  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
122442397  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
122439971  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
122422244  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
122423791  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
122447133  CDC16; cell division cycle protein 16 homolog [KO:K03353]
122423691  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
122439879  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
122452027  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
122438561  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
122431915  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
122442597  anaphase-promoting complex subunit 13-like [KO:K12456]
122445308  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
122449551  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
122446428  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
122437099  CDC20; cell division cycle protein 20 homolog [KO:K03363]
122439607  PTTG1; securin isoform X1 [KO:K06635]
122432455  securin-like [KO:K06635]
122444763  securin-like [KO:K06635]
122427561  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
122434297  SMC1A; structural maintenance of chromosomes protein 1A isoform X1 [KO:K06636]
122446145  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
122450996  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
122434376  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
122445293  STAG1; cohesin subunit SA-1 [KO:K06671]
122435409  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
122423564  DDX11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
122454474  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
122440791  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
122423326  N-acetyltransferase ESCO1-like [KO:K11268] [EC:2.3.1.-]
122425470  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
122453244  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
122447093  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
122422207  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
122446253  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
122430610  uncharacterized protein LOC122430610 isoform X1 [KO:K17390]
122430609  sororin-like isoform X1 [KO:K17390]
122445483  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
122445532  SGO1; shugoshin 1 [KO:K11580]
122439917  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122432467  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
122450320  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
122435910  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
122420615  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
122429142  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
122431123  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
122452515  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
122443734  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
122454737  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
122425547  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
122443397  KNL1; LOW QUALITY PROTEIN: kinetochore scaffold 1 [KO:K11542]
122422769  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
122433378  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
122422382  MAD2L1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
122451966  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
122443380  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
122446172  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
122441337  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
122454263  TRIP13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
122429444  MAD2L1-binding protein isoform X1 [KO:K26093]
122447102  MAD2L1-binding protein-like [KO:K26093]
122440197  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
122434174  FBXO5; F-box only protein 5 isoform X1 [KO:K10292]
122431850  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
122436637  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
122423237  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
122432734  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
122450836  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
122445242  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
122450584  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122427080  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122445826  TP53; cellular tumor antigen P53 [KO:K04451]
122440181  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122432031  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122436847  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122448831  PCNA; proliferating cell nuclear antigen [KO:K04802]
122426260  SFN; 14-3-3 protein sigma [KO:K06644]
122430784  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
122421545  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
122424249  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
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  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
ccad03030  DNA replication
ccad04010  MAPK signaling pathway
ccad04120  Ubiquitin mediated proteolysis
ccad04210  Apoptosis
KO pathway
ko04110   
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