KEGG   PATHWAY: fpg05168
Entry
fpg05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Falco peregrinus (peregrine falcon)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
fpg05168  Herpes simplex virus 1 infection
fpg05168

Organism
Falco peregrinus (peregrine falcon) [GN:fpg]
Gene
106112547  TNFRSF14; TNF receptor superfamily member 14 [KO:K05152]
101911961  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
101921400  TRAF5; TNF receptor associated factor 5 [KO:K09849]
101922064  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101923842  NFKBIA; NFKB inhibitor alpha [KO:K04734]
101920008  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
101924079  BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
101919565  NECTIN1; nectin cell adhesion molecule 1 [KO:K06081]
101914986  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101915334  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
101923738  ITGA5; integrin subunit alpha 5 [KO:K06484]
101924792  ITGB3; integrin subunit beta 3 [KO:K06493]
101917743  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
101913951  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
101910390  CARD9; caspase recruitment domain family member 9 [KO:K12794]
101921672  interferon-like [KO:K05415]
101923177  C3; complement C3 [KO:K03990]
101921265  C5; complement C5 [KO:K03994]
101923386  TLR2; toll like receptor 2 [KO:K10159]
101923563  toll-like receptor 2 type-1 [KO:K10159]
101922907  MYD88; myeloid differentiation primary response 88 [KO:K04729]
101922355  IRF7; interferon regulatory factor 7 [KO:K09447]
101918059  TLR3; toll like receptor 3 [KO:K05401]
101912470  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
101914647  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101912003  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
101917746  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101921035  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
101920039  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
101924267  interleukin-1 receptor antagonist protein-like [KO:K04519]
101912275  C-C motif chemokine 5-like [KO:K12499]
101911163  IL6; interleukin 6 [KO:K05405]
101915475  IL12A; interleukin 12A [KO:K05406]
101920686  IL12B; interleukin 12B [KO:K05425]
101917977  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:5.6.2.6]
101916011  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:5.6.2.6]
101913471  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
101918364  TRAF3; TNF receptor associated factor 3 [KO:K03174]
101911668  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101911068  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
101915699  IFNW1; interferon omega-1 [KO:K05414]
101922902  MB21D1; Mab-21 domain containing 1 [KO:K17834] [EC:2.7.7.86]
101922549  TMEM173; transmembrane protein 173 [KO:K12654]
101924787  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
101913968  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
101916649  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
101910588  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
101916120  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
101910448  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
101914208  EIF2B1; eukaryotic translation initiation factor 2B subunit alpha [KO:K03239]
101920847  EIF2B2; eukaryotic translation initiation factor 2B subunit beta [KO:K03754]
101915275  EIF2B3; eukaryotic translation initiation factor 2B subunit gamma [KO:K03241]
101913310  EIF2B4; eukaryotic translation initiation factor 2B subunit delta [KO:K03680]
101921911  EIF2B5; eukaryotic translation initiation factor 2B subunit epsilon [KO:K03240]
101918377  RNASEL; ribonuclease L [KO:K01165]
101923529  HCFC2; host cell factor C2 [KO:K27390]
101917834  POU2F3; POU class 2 homeobox 3 [KO:K09364]
101914051  POU2F1; POU class 2 homeobox 1 [KO:K09364]
101919760  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
101919412  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
101912299  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101921412  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
101913479  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
101922205  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
101912561  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101916737  ZNF777; zinc finger protein 777 [KO:K09228]
101916909  uncharacterized LOC101916909 [KO:K09228]
101910573  zinc finger protein 436-like [KO:K09228]
101912093  zinc finger protein 208-like [KO:K09228]
101920863  SP7; zinc finger protein 501 [KO:K09228]
106112281  zinc finger protein 142-like [KO:K09228]
101912267  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
106112283  zinc finger protein 883-like [KO:K09228]
101924349  zinc finger protein 26-like [KO:K09228]
101924637  IFNG; interferon gamma [KO:K04687]
101911079  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101919933  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101916887  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
101910511  PML; uncharacterized LOC101910511 [KO:K10054] [EC:2.3.2.-]
101910853  E3 ubiquitin-protein ligase TRIM71-like [KO:K10054] [EC:2.3.2.-]
101910848  TAPBP; TAP binding protein [KO:K08058]
101919727  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
101913856  CALR3; calreticulin 3 [KO:K08057]
101914105  CALR; calreticulin [KO:K08057]
101924893  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
101913477  B2M; beta-2-microglobulin [KO:K08055]
101911209  Fape-DAB; class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
101911566  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
101920105  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101911674  CD74; CD74 molecule [KO:K06505]
101923805  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
101919202  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
101911441  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
101915242  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
101924523  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
101913266  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
101910975  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101918846  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101918868  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101921096  TSC1; tuberous sclerosis 1 [KO:K07206]
101919684  TSC2; tuberous sclerosis 2 [KO:K07207]
101921352  RHEB; Ras homolog enriched in brain [KO:K07208]
101919512  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
101921807  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
101914614  SRSF1; serine and arginine rich splicing factor 1 [KO:K12890]
101918610  SRSF2; serine and arginine rich splicing factor 2 [KO:K12891]
101921747  SRSF3; serine and arginine rich splicing factor 3 [KO:K12892]
101917668  SRSF5; serine and arginine rich splicing factor 5 [KO:K12893]
101911789  serine/arginine-rich splicing factor 5-like [KO:K12893]
101924417  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
101914580  SRSF4; serine and arginine rich splicing factor 4 [KO:K12893]
101924595  SRSF7; serine and arginine rich splicing factor 7 [KO:K12896]
101924764  serine/arginine-rich splicing factor 7-like [KO:K12896]
101920344  nuclear RNA export factor 1-like [KO:K14284]
101915709  ALYREF; Aly/REF export factor [KO:K12881]
101922036  FASLG; Fas ligand [KO:K04389]
101911760  FAS; Fas cell surface death receptor [KO:K04390]
101917376  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
101921498  TRADD; TNFRSF1A associated via death domain [KO:K03171]
101918701  FADD; Fas associated via death domain [KO:K02373]
106113022  CASP8 and FADD-like apoptosis regulator [KO:K04398] [EC:3.4.22.61]
101916968  CASP8; caspase-3 [KO:K04398] [EC:3.4.22.61]
101917399  BID; BH3 interacting domain death agonist [KO:K04726]
101920283  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
101924229  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
101921728  BCL2; BCL2, apoptosis regulator [KO:K02161]
101924628  BCL2L1; BCL2 like 1 [KO:K04570]
101923643  cytochrome c [KO:K08738]
101911538  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
101914844  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
101913355  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
fpg03040  Spliceosome
fpg03050  Proteasome
fpg04115  p53 signaling pathway
fpg04210  Apoptosis
fpg04620  Toll-like receptor signaling pathway
fpg04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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