Entry Name Regulation of lipolysis in adipocytes - Homo sapiens (human)
Description Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map hsa04923 Regulation of lipolysis in adipocytes
Network Element N01708 INS-AKT signaling pathway
Drug D01238 Bucladesine sodium (JAN)
D02702 Talibegron hydrochloride (USAN)
Other DBs Organism Homo sapiens (human) [GN:
hsa ]
Gene 1081 CGA; glycoprotein hormones, alpha polypeptide [KO:K08522 ]
134 ADORA1; adenosine A1 receptor [KO:K04265 ]
2167 FABP4; fatty acid binding protein 4 [KO:K08753 ]
2770 GNAI1; G protein subunit alpha i1 [KO:K04630 ]
2771 GNAI2; G protein subunit alpha i2 [KO:K04630 ]
2773 GNAI3; G protein subunit alpha i3 [KO:K04630 ]
3667 IRS1; insulin receptor substrate 1 [KO:K16172 ]
4886 NPY1R; neuropeptide Y receptor Y1 [KO:K04204 ]
51099 ABHD5; abhydrolase domain containing 5, lysophosphatidic acid acyltransferase [KO:K13699 ] [EC:2.3.1.51 ]
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
5733 PTGER3; prostaglandin E receptor 3 [KO:K04260 ]
63924 CIDEC; cell death inducing DFFA like effector c [KO:K25878 ]
7252 TSHB; thyroid stimulating hormone subunit beta [KO:K05251 ]
7253 TSHR; thyroid stimulating hormone receptor [KO:K04249 ]
8471 IRS4; insulin receptor substrate 4 [KO:K17446 ]
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
8660 IRS2; insulin receptor substrate 2 [KO:K07187 ]
Compound Reference Authors Ahmadian M, Wang Y, Sul HS
Title Lipolysis in adipocytes.
Journal Reference Authors Ahmadian M, Duncan RE, Sul HS
Title The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
Journal Reference Authors Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, Mitchell GA
Title Lipolysis and the integrated physiology of lipid energy metabolism.
Journal Reference Authors Lafontan M
Title Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.
Journal Reference Authors Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title Regulation of adipocyte lipolysis.
Journal Reference Authors Proenca AR, Sertie RA, Oliveira AC, Campana AB, Caminhotto RO, Chimin P, Lima FB
Title New concepts in white adipose tissue physiology.
Journal Reference Authors Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS
Title Regulation of lipolysis in adipocytes.
Journal Reference Authors Lafontan M
Title Advances in adipose tissue metabolism.
Journal Reference Authors Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS
Title Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
Journal Reference Authors Thompson D, Karpe F, Lafontan M, Frayn K
Title Physical activity and exercise in the regulation of human adipose tissue physiology.
Journal Reference Authors Lafontan M, Langin D
Title Lipolysis and lipid mobilization in human adipose tissue.
Journal Reference Authors Arner P, Langin D
Title Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
Journal Reference Authors Brasaemle DL
Title Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
Journal Reference Authors Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ
Title The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.
Journal Reference Authors Bickel PE, Tansey JT, Welte MA
Title PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Journal Reference Authors Grahn THM, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V
Title Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.
Journal Related KO pathway
