Entry
Name
RIG-I-like receptor signaling pathway - Mus musculus (house mouse)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
mmu04622 RIG-I-like receptor signaling pathway
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
98999 Znfx1; zinc finger, NFX1-type containing 1 [KO:K27391 ]
228607 Mavs; mitochondrial antiviral signaling protein [KO:K12648 ]
22031 Traf3; TNF receptor-associated factor 3 [KO:K03174 ]
21353 Tank; TRAF family member-associated Nf-kappa B activator [KO:K12650 ]
16151 Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210 ]
71609 Tradd; TNFRSF1A-associated via death domain [KO:K03171 ]
14082 Fadd; Fas associated via death domain [KO:K02373 ]
18036 Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581 ]
18035 Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
15945 Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
72512 Sting1; stimulator of interferon response cGAMP interactor 1 [KO:K12654 ]
23988 Pin1; peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578 ] [EC:5.2.1.8 ]
241593 Pin1rt1; peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1 [KO:K09578 ] [EC:5.2.1.8 ]
Compound
Reference
Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Journal
Reference
Authors
Takeuchi O, Akira S
Title
MDA5/RIG-I and virus recognition.
Journal
Reference
Authors
Yoneyama M, Fujita T
Title
RNA recognition and signal transduction by RIG-I-like receptors.
Journal
Reference
Authors
Nakhaei P, Genin P, Civas A, Hiscott J
Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
Journal
Reference
Authors
Moore CB, Ting JP
Title
Regulation of mitochondrial antiviral signaling pathways.
Journal
Reference
Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Journal
Reference
Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Title
Approaching the RNA ligand for RIG-I?
Journal
Reference
Authors
Saito T, Gale M Jr
Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
Journal
Reference
Authors
Kawai T, Akira S
Title
Toll-like receptor and RIG-I-like receptor signaling.
Journal
Reference
Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Journal
Reference
Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
Journal
Reference
Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
Journal
Reference
Authors
Liu G, Gack MU
Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
Journal
Related pathway
KO pathway
LinkDB
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