KEGG   PATHWAY: morg04921
Entry
morg04921                   Pathway                                
Name
Oxytocin signaling pathway - Microtus oregoni (creeping vole)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
morg04921  Oxytocin signaling pathway
morg04921

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121460479  Oxt; oxytocin-neurophysin 1 [KO:K05243]
121441355  Oxtr; oxytocin receptor [KO:K04229]
121442696  oxytocin receptor [KO:K04229]
121454687  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
121458090  Hras; GTPase HRas [KO:K02833]
121466497  Kras; GTPase KRas isoform X1 [KO:K07827]
121437938  Nras; GTPase NRas [KO:K07828]
121443425  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121466018  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121459389  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121455158  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
121465529  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
121465746  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121465816  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
121465889  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
121449910  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
121455411  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121465985  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
121456806  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
121448148  Jun; transcription factor AP-1 [KO:K04448]
121452580  Fos; proto-oncogene c-Fos [KO:K04379]
121455823  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
121454505  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121457865  G1/S-specific cyclin-D1 [KO:K04503]
121452930  ETS domain-containing protein Elk-1-like [KO:K04375]
121449131  ETS domain-containing protein Elk-1 [KO:K04375]
121449089  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
121432610  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
121465671  Ryr3; ryanodine receptor 3 [KO:K04963]
121436384  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
121435453  Trpm2; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
121436285  Kcnj2; inward rectifier potassium channel 2 [KO:K04996]
121456875  Kcnj12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
121461274  Kcnj4; inward rectifier potassium channel 4 [KO:K04998]
121452111  Kcnj14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
121460541  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121454560  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121465646  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121460033  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121436286  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121458065  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
121449728  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
121458115  Eef2k; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
121459489  Eef2; elongation factor 2 [KO:K03234]
121449503  LOW QUALITY PROTEIN: elongation factor 2-like [KO:K03234]
121441414  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121454953  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121444334  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
121442677  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
121444275  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
121456214  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
121442316  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
121432546  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
121441448  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
121433143  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
121459135  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
121434621  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
121464258  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
121455299  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
121465155  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
121436329  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
121461071  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
121457335  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
121436318  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
121436177  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
121449686  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
121450003  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
121450002  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
121440758  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121433763  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
121435401  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121462368  calmodulin-1 [KO:K02183]
121465992  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
121432548  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
121432747  calmodulin-like protein 3 [KO:K02183]
121432887  Calm2; calmodulin-2 [KO:K02183]
121434435  Calm1; calmodulin-1 [KO:K02183]
121449209  Calm3; calmodulin-3 [KO:K02183]
121461739  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121453244  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121438600  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121459616  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
121451753  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
121440145  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
121460203  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
121447567  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121434994  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121446125  Rgs2; regulator of G-protein signaling 2 [KO:K18154]
121461962  Rcan1; calcipressin-1 isoform X1 [KO:K17901]
121446232  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
121432949  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
121447974  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121438000  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
121446539  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
121439948  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
121447397  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
121441426  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
121437621  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
121435945  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
121459565  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121445229  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121438612  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121440610  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121449426  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121453240  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
121445161  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
121439958  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
121452870  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
121432285  Gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
121458314  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
121452993  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
121441819  Nppa; natriuretic peptides A [KO:K12334]
121448783  natriuretic peptides A-like [KO:K12334]
121450605  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
121458452  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
121461750  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121460317  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121447126  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
121433988  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121452863  myosin light polypeptide 6 [KO:K12751]
121459549  Myl6b; myosin light chain 6B isoform X1 [KO:K12751]
121459568  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
121434397  myosin light polypeptide 6-like [KO:K12751]
121460155  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
121464249  actin, cytoplasmic 1-like [KO:K05692]
121464845  actin, cytoplasmic 1 [KO:K05692]
121465257  actin, cytoplasmic 2-like [KO:K05692]
121444092  actin, cytoplasmic 2 [KO:K05692]
121444606  actin, cytoplasmic 2 [KO:K05692]
121445957  actin, cytoplasmic 1 [KO:K05692]
121432295  actin, cytoplasmic 1-like [KO:K05692]
121464173  Rhoa; transforming protein RhoA [KO:K04513]
121439342  transforming protein RhoA-like isoform X1 [KO:K04513]
121453250  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
121443343  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.1]
121438936  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121432519  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121454539  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121446369  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121432896  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121464440  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121445870  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
121450029  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
121440831  neuroendocrine secretory protein 55-like [KO:K04632]
121440830  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
121459308  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121433645  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
121439713  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121439725  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121434995  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
121461694  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121441427  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121446853  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
121461516  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121463621  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
121455756  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121451033  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121464390  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121458947  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121437910  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121446778  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121434752  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121446774  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
121452362  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121456538  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
121456743  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
121460112  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121433213  Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
121461817  Kcnj6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
121442059  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
121452002  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
121459895  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
121435589  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
PMID:18655881
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
PMID:20626426
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
PMID:21981277
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
PMID:22190926
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
PMID:19840865
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
PMID:12009385
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
PMID:16787565
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
PMID:11861513
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
PMID:12433531
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
PMID:22902539
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
PMID:14715914
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
PMID:18555543
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Int J Cancer 72:340-4 (1997)
DOI:10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-I
Reference
PMID:23356278
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
PMID:16966388
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
PMID:20141572
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
PMID:22227279
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
PMID:23335873
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
PMID:16156781
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
morg00590  Arachidonic acid metabolism
morg04010  MAPK signaling pathway
morg04020  Calcium signaling pathway
morg04110  Cell cycle
KO pathway
ko04921   
LinkDB

DBGET integrated database retrieval system