KEGG   PATHWAY: nasi04932
Entry
nasi04932                   Pathway                                
Name
Non-alcoholic fatty liver disease - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). NASH may further lead to cirrhosis and hepatocellular carcinoma (HCC). This map shows a stage-dependent progression of NAFLD. In the first stage of NAFLD, excess lipid accumulation has been demonstrated. The main cause is the induction of insulin resistance, which leads to a defect in insulin suppression of free fatty acids (FAAs) disposal. In addition, two transcription factors, SREBP-1c and PPAR-alpha, activate key enzymes of lipogenesis and increase the synthesis of FAAs in liver. In the second stage, as a consequence of the progression to NASH, the production of reactive oxygen species (ROS) is enhanced due to oxidation stress through mitochondrial beta-oxidation of fatty acids and endoplamic reticulum (ER) stress, leading to lipid peroxidation. The lipid peroxidation can further cause the production of cytokines (Fas ligand, TNF-alpha, IL-8 and TGF), promoting cell death, inflammation and fibrosis. The activation of JNK, which is induced by ER stress, TNF-alpha and FAAs, is also associated with NAFLD progression. Increased JNK promotes cytokine production and initiation of HCC.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
nasi04932  Non-alcoholic fatty liver disease
nasi04932

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112395338  IL6; interleukin-6 [KO:K05405]
112401726  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
112410494  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112395421  TNF; tumor necrosis factor [KO:K03156]
112391694  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112393728  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112402272  RELA; transcription factor p65 [KO:K04735]
112402369  INS; insulin [KO:K04526]
112400209  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112396733  IRS1; insulin receptor substrate 1 [KO:K16172]
112405567  IRS2; insulin receptor substrate 2 [KO:K07187]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415396  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
112415982  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112402081  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
112411563  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
112404728  SREBF1; sterol regulatory element-binding protein 1 [KO:K07197]
112399806  MLX; max-like protein X isoform X1 [KO:K09113]
112401145  MLXIPL; carbohydrate-responsive element-binding protein isoform X1 [KO:K09113]
112408761  MLXIP; MLX-interacting protein isoform X1 [KO:K09113]
112401742  PKLR; pyruvate kinase PKLR isoform X1 [KO:K12406] [EC:2.7.1.40]
112411701  LEP; leptin [KO:K05424]
112412971  LEPR; leptin receptor isoform X1 [KO:K05062]
112415302  ADIPOQ; adiponectin [KO:K07296]
112412401  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
112391697  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
112405979  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112407082  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
112412979  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
112408820  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
112411852  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
112405875  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
112394236  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112413792  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112413934  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
112394646  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112394700  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112394582  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
112396459  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
112414286  CDC42; cell division control protein 42 homolog [KO:K04393]
112399896  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112401971  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
112395723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112412478  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112413113  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112398389  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
112410245  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
112411269  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112409119  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
112394907  FOS; proto-oncogene c-Fos [KO:K04379]
112407080  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
112398992  IL1A; interleukin-1 alpha [KO:K04383]
112398981  IL1B; interleukin-1 beta [KO:K04519]
112413114  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112415136  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
112392377  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
112411197  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
112391613  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112405659  CXCL8; interleukin-8 [KO:K10030]
112415266  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
112398926  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
112401166  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112394733  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112394394  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112398987  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
112415661  BAX; apoptosis regulator BAX [KO:K02159]
112399577  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
112407903  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112409526  cytochrome c-like [KO:K08738]
112396438  cytochrome c-like [KO:K08738]
112403640  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112406320  cytochrome c [KO:K08738]
112414113  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112394162  cytochrome c-like [KO:K08738]
112391536  cytochrome c 2 [KO:K08738]
112409662  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112406937  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
112402423  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
112404308  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
112412202  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
112408591  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
112404044  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112404389  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
112397996  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112414589  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112394284  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112408227  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
112394690  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112400130  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
112411425  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112391782  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112409216  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112399448  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112400192  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112405799  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112414924  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112406732  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112393871  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112398101  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112407866  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112416055  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112406354  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
112405478  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
112414932  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
112393039  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
112396997  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
112409395  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
112402591  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112395231  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
112407930  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112402152  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112396567  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
112395486  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112390907  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112396332  NDUFS7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112402525  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
112399795  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112402670  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
112390876  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112402686  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112407909  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112405719  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
112401142  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112397075  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112403809  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112399364  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112400398  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112398719  cytochrome b-c1 complex subunit 7-like [KO:K00417]
112407331  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
112401388  cytochrome b-c1 complex subunit 8 [KO:K00418]
112415117  cytochrome b-c1 complex subunit 9 [KO:K00419]
112396394  cytochrome b-c1 complex subunit 10 [KO:K00420]
112393437  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112410961  cytochrome c oxidase subunit 5A, mitochondrial isoform X1 [KO:K02264]
112398970  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112397274  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112399312  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112392309  cytochrome c oxidase subunit 6B1 [KO:K02267]
112398864  cytochrome c oxidase subunit 6C-like [KO:K02268]
112413993  cytochrome c oxidase subunit 6C-like [KO:K02268]
112407288  cytochrome c oxidase subunit 6C [KO:K02268]
112394363  cytochrome c oxidase subunit 6C-like [KO:K02268]
112405272  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112392299  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
112390829  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112400382  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112390686  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
112390687  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
112392581  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112402273  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
Compound
C00031  D-Glucose
C00162  Fatty acid
Reference
PMID:23545492
  Authors
Naik A, Kosir R, Rozman D
  Title
Genomic aspects of NAFLD pathogenesis.
  Journal
Genomics 102:84-95 (2013)
DOI:10.1016/j.ygeno.2013.03.007
Reference
PMID:19352614
  Authors
Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L
  Title
Molecular mechanisms involved in NAFLD progression.
  Journal
J Mol Med (Berl) 87:679-95 (2009)
DOI:10.1007/s00109-009-0464-1
Reference
PMID:22705006
  Authors
Seki E, Brenner DA, Karin M
  Title
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
  Journal
Gastroenterology 143:307-20 (2012)
DOI:10.1053/j.gastro.2012.06.004
Reference
PMID:21038418
  Authors
Tilg H, Moschen AR
  Title
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis.
  Journal
Hepatology 52:1836-46 (2010)
DOI:10.1002/hep.24001
Reference
PMID:16364488
  Authors
Larter CZ, Farrell GC
  Title
Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
  Journal
J Hepatol 44:253-61 (2006)
DOI:10.1016/j.jhep.2005.11.030
Reference
PMID:22570745
  Authors
Farrell GC, van Rooyen D, Gan L, Chitturi S
  Title
NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.
  Journal
Gut Liver 6:149-71 (2012)
DOI:10.5009/gnl.2012.6.2.149
Reference
PMID:20619513
  Authors
Shapiro H, Tehilla M, Attal-Singer J, Bruck R, Luzzatti R, Singer P
  Title
The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease.
  Journal
Clin Nutr 30:6-19 (2011)
DOI:10.1016/j.clnu.2010.06.001
Reference
PMID:20303879
  Authors
Hotamisligil GS
  Title
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.
  Journal
Cell 140:900-17 (2010)
DOI:10.1016/j.cell.2010.02.034
Reference
PMID:17498512
  Authors
Parekh S, Anania FA
  Title
Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease.
  Journal
Gastroenterology 132:2191-207 (2007)
DOI:10.1053/j.gastro.2007.03.055
Reference
PMID:16374858
  Authors
Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, Czaja MJ
  Title
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
  Journal
Hepatology 43:163-72 (2006)
DOI:10.1002/hep.20999
Reference
PMID:22940046
  Authors
Leung TM, Nieto N
  Title
CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease.
  Journal
J Hepatol 58:395-8 (2013)
DOI:10.1016/j.jhep.2012.08.018
Reference
PMID:14685853
  Authors
Zafrani ES
  Title
Non-alcoholic fatty liver disease: an emerging pathological spectrum.
  Journal
Virchows Arch 444:3-12 (2004)
DOI:10.1007/s00428-003-0943-7
Reference
PMID:12891546
  Authors
Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ
  Title
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.
  Journal
Gastroenterology 125:437-43 (2003)
DOI:10.1016/S0016-5085(03)00907-7
Reference
PMID:16406828
  Authors
Begriche K, Igoudjil A, Pessayre D, Fromenty B
  Title
Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.
  Journal
Mitochondrion 6:1-28 (2006)
DOI:10.1016/j.mito.2005.10.004
Reference
PMID:9285483
  Authors
Leonarduzzi G, Scavazza A, Biasi F, Chiarpotto E, Camandola S, Vogel S, Dargel R, Poli G
  Title
The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis.
  Journal
FASEB J 11:851-7 (1997)
DOI:10.1096/fasebj.11.11.9285483
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18242193
  Authors
Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM
  Title
Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases.
  Journal
Free Radic Biol Med 44:1259-72 (2008)
DOI:10.1016/j.freeradbiomed.2007.12.029
Reference
PMID:18061659
  Authors
Serviddio G, Sastre J, Bellanti F, Vina J, Vendemiale G, Altomare E
  Title
Mitochondrial involvement in non-alcoholic steatohepatitis.
  Journal
Mol Aspects Med 29:22-35 (2008)
DOI:10.1016/j.mam.2007.09.014
Reference
PMID:23299992
  Authors
Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B
  Title
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.
  Journal
Hepatology 58:1497-507 (2013)
DOI:10.1002/hep.26226
Related
pathway
nasi00061  Fatty acid biosynthesis
nasi00190  Oxidative phosphorylation
nasi03320  PPAR signaling pathway
nasi04141  Protein processing in endoplasmic reticulum
nasi04151  PI3K-Akt signaling pathway
nasi04210  Apoptosis
nasi04668  TNF signaling pathway
nasi04920  Adipocytokine signaling pathway
nasi04930  Type II diabetes mellitus
KO pathway
ko04932   
LinkDB

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