KEGG   PATHWAY: oki00310
Entry
oki00310                    Pathway                                
Name
Lysine degradation - Oncorhynchus kisutch (coho salmon)
Class
Metabolism; Amino acid metabolism
Pathway map
oki00310  Lysine degradation
oki00310

Module
oki_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:oki00310]
Other DBs
GO: 0006554
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109897782  alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
109868429  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
109896943  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X2 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
109889674  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial isoform X1 [KO:K15791] [EC:1.2.4.-]
109867047  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial isoform X1 [KO:K15791] [EC:1.2.4.-]
109881454  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
109894507  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658] [EC:2.3.1.61]
109882951  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658] [EC:2.3.1.61]
109904051  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
109897784  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
109867126  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
109877283  glutaryl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00252] [EC:1.3.8.6]
109893438  glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
109893485  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
109894276  trifunctional enzyme subunit alpha, mitochondrial-like [KO:K07515] [EC:4.2.1.17 1.1.1.211]
109904291  trifunctional enzyme subunit alpha, mitochondrial-like [KO:K07515] [EC:4.2.1.17 1.1.1.211]
109882746  ehhadh; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
109889724  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
109876661  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
116363890  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like [KO:K00022] [EC:1.1.1.35]
109872993  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
109866314  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
109889018  hykk; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
109864600  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase isoform X1 [KO:K18202] [EC:4.2.3.134]
109909225  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
109870539  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
109905387  histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
109908869  histone-lysine N-methyltransferase 2A isoform X4 [KO:K09186] [EC:2.1.1.354]
109869140  kmt2d; histone-lysine N-methyltransferase 2D isoform X2 [KO:K09187] [EC:2.1.1.354]
109878425  histone-lysine N-methyltransferase 2D-like isoform X1 [KO:K09187] [EC:2.1.1.354]
109871531  histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
109875158  histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
109909640  histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
109899297  histone-lysine N-methyltransferase 2C-like isoform X1 [KO:K09188] [EC:2.1.1.354]
109900891  histone-lysine N-methyltransferase 2A isoform X1 [KO:K14959] [EC:2.1.1.354]
109907621  histone-lysine N-methyltransferase 2B-like isoform X1 [KO:K14959] [EC:2.1.1.354]
109901820  histone-lysine N-methyltransferase 2A-like isoform X1 [KO:K14959] [EC:2.1.1.354]
109903796  histone-lysine N-methyltransferase 2B-like [KO:K14959] [EC:2.1.1.354]
109864517  inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
109885967  inactive histone-lysine N-methyltransferase 2E-like isoform X1 [KO:K09189] [EC:2.1.1.354]
109868353  setd1b; histone-lysine N-methyltransferase SETD1B isoform X1 [KO:K11422] [EC:2.1.1.354]
109878662  histone-lysine N-methyltransferase SETD1A isoform X1 [KO:K11422] [EC:2.1.1.354]
109892528  histone-lysine N-methyltransferase SETD1B-A-like isoform X1 [KO:K11422] [EC:2.1.1.354]
116375924  histone-lysine N-methyltransferase SETD1A-like isoform X1 [KO:K11422] [EC:2.1.1.354]
109873484  histone-lysine N-methyltransferase SETD1B-A [KO:K11422] [EC:2.1.1.354]
109864768  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
109870190  histone-lysine N-methyltransferase PRDM9 isoform X1 [KO:K20796] [EC:2.1.1.354]
109905914  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
109879688  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
109882336  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
109907687  histone-lysine N-methyltransferase ASH1L-like isoform X1 [KO:K06101] [EC:2.1.1.354]
109882341  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
109903805  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
109867980  histone-lysine N-methyltransferase Smyd1 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
109885002  N-lysine methyltransferase SMYD2-A-like isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
109866615  N-lysine methyltransferase SMYD2-A [KO:K11426] [EC:2.1.1.354 2.1.1.357]
109874027  histone-lysine N-methyltransferase Smyd1-like isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
109903900  smyd3; histone-lysine N-methyltransferase SMYD3 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
109896149  histone-lysine N-methyltransferase SMYD1 isoform X2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
109869445  histone-lysine N-methyltransferase SUV39H1-like [KO:K11419] [EC:2.1.1.355]
109907876  histone-lysine N-methyltransferase SUV39H1 isoform X2 [KO:K11419] [EC:2.1.1.355]
109908559  histone-lysine N-methyltransferase SUV39H1 isoform X1 [KO:K11419] [EC:2.1.1.355]
109868032  histone-lysine N-methyltransferase EHMT1-like isoform X1 [KO:K11420] [EC:2.1.1.355]
109877723  histone-lysine N-methyltransferase EHMT1 isoform X2 [KO:K11420] [EC:2.1.1.355]
109873685  histone-lysine N-methyltransferase EHMT1 isoform X5 [KO:K11420] [EC:2.1.1.355]
109907615  ehmt2; histone-lysine N-methyltransferase EHMT2 isoform X1 [KO:K11420] [EC:2.1.1.355]
109903715  histone-lysine N-methyltransferase EHMT2 isoform X2 [KO:K11420] [EC:2.1.1.355]
109883759  histone-lysine N-methyltransferase SETDB1-B isoform X1 [KO:K11421] [EC:2.1.1.366]
109907679  histone-lysine N-methyltransferase SETDB1-A [KO:K11421] [EC:2.1.1.366]
109886460  histone-lysine N-methyltransferase SETDB1-B-like isoform X1 [KO:K11421] [EC:2.1.1.366]
109883463  histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
116368086  histone-lysine N-methyltransferase SETDB2-like isoform X1 [KO:K18494] [EC:2.1.1.355]
109898428  PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
109890898  prdm2; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
109907953  PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
109891924  histone-lysine N-methyltransferase EZH1-like isoform X1 [KO:K17451] [EC:2.1.1.356]
109898438  histone-lysine N-methyltransferase EZH1-like isoform X1 [KO:K17451] [EC:2.1.1.356]
109909923  ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
109898049  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
109873277  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [KO:K15588] [EC:2.1.1.357]
109892779  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like [KO:K15588] [EC:2.1.1.357]
109880548  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like [KO:K15588] [EC:2.1.1.357]
109878333  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like isoform X1 [KO:K15588] [EC:2.1.1.357]
109880778  histone-lysine N-methyltransferase NSD2-like isoform X1 [KO:K11424] [EC:2.1.1.357]
109885984  histone-lysine N-methyltransferase NSD2-like isoform X1 [KO:K11424] [EC:2.1.1.357]
109894919  histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
109881240  histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
109882680  histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
109897856  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
109902511  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4 [KO:K11427] [EC:2.1.1.360]
109868488  N-lysine methyltransferase KMT5A-A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
109892437  N-lysine methyltransferase KMT5A-A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
109880068  N-lysine methyltransferase KMT5A [KO:K11428] [EC:2.1.1.361]
109874149  prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
109888842  histone-lysine N-methyltransferase KMT5B [KO:K11429] [EC:2.1.1.362]
109898722  uncharacterized protein LOC109898722 isoform X1 [KO:K11429] [EC:2.1.1.362]
116374488  uncharacterized protein LOC116374488 isoform X1 [KO:K11429] [EC:2.1.1.362]
109880608  histone-lysine N-methyltransferase KMT5B-like isoform X1 [KO:K11429] [EC:2.1.1.362]
109880610  histone-lysine N-methyltransferase KMT5B-like isoform X1 [KO:K11429] [EC:2.1.1.362]
109867243  histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
109905594  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K04462] [EC:2.1.1.367]
109909385  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K04462] [EC:2.1.1.367]
109883894  histone-lysine N-methyltransferase PRDM16-like [KO:K22410] [EC:2.1.1.367]
109906987  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
109873436  trimethyllysine dioxygenase, mitochondrial-like [KO:K00474] [EC:1.14.11.8]
109873804  tmlhe; trimethyllysine dioxygenase, mitochondrial isoform X1 [KO:K00474] [EC:1.14.11.8]
109905018  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
109907444  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
109876466  aldehyde dehydrogenase family 3 member A2-like isoform X1 [KO:K00128] [EC:1.2.1.3]
109876471  aldehyde dehydrogenase, dimeric NADP-preferring-like isoform X1 [KO:K00128] [EC:1.2.1.3]
109864438  aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
109893142  aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
109901850  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
109883854  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
109902815  4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109874841  4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109895543  gamma-butyrobetaine dioxygenase-like [KO:K00471] [EC:1.14.11.1]
109885080  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
109907903  plod1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X2 [KO:K00473] [EC:1.14.11.4]
109885636  LOW QUALITY PROTEIN: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [KO:K13645] [EC:1.14.11.4]
109882381  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like isoform X1 [KO:K13645] [EC:1.14.11.4]
109886259  multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3-like [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
109868586  cercam; inactive glycosyltransferase 25 family member 3 [KO:K11703] [EC:2.4.1.50]
109897892  procollagen galactosyltransferase 2-like [KO:K11703] [EC:2.4.1.50]
109892347  procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
109871829  procollagen galactosyltransferase 2-like [KO:K11703] [EC:2.4.1.50]
109893165  procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
109897253  procollagen galactosyltransferase 1-like isoform X1 [KO:K11703] [EC:2.4.1.50]
109902553  procollagen galactosyltransferase 2 isoform X1 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
oki00020  Citrate cycle (TCA cycle)
oki00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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