Entry
Name
C-type lectin receptor signaling pathway - Oryzias melastigma (Indian medaka)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
oml04625 C-type lectin receptor signaling pathway
Ortholog table
Organism
Oryzias melastigma (Indian medaka) [GN:
oml ]
Gene
112148544 si:dkey-88e18.2; interleukin-12 subunit beta isoform X1 [KO:K05425 ]
112161983 nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
112144868 inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
112145415 itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
112152271 itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
112158759 itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
112142009 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
112155957 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
112153053 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
112158691 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
112160932 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
112152110 nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
112136519 pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
112136702 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
112148878 card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
112148661 malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
112152849 malt3; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
112149154 nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b isoform X1 [KO:K04734 ]
112161658 tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156 ]
112144196 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
112156051 fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
112150613 high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
112149302 arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
112154777 signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
112156680 stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220 ]
112144620 stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
112136442 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
112159170 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922 ] [EC:2.7.1.153 ]
112147562 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
112163049 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
112150193 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
112150308 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
112138447 phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C21790 Mycobacterial trehalose dimycolate
G13115 Mannose-capped lipoarabinomannan
Reference
Authors
Geijtenbeek TB, Gringhuis SI
Title
C-type lectin receptors in the control of T helper cell differentiation.
Journal
Reference
Authors
Hajishengallis G, Lambris JD
Title
Microbial manipulation of receptor crosstalk in innate immunity.
Journal
Reference
Authors
Iliev ID, Leonardi I
Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
Journal
Reference
Authors
Richardson MB, Williams SJ
Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Journal
Reference
Authors
Vautier S, MacCallum DM, Brown GD
Title
C-type lectin receptors and cytokines in fungal immunity.
Journal
Reference
Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
Journal
Reference
Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
Title
DAMP signaling in fungal infections and diseases.
Journal
Reference
Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
Journal
Reference
Authors
Mayer S, Raulf MK, Lepenies B
Title
C-type lectins: their network and roles in pathogen recognition and immunity.
Journal
Reference
Authors
Plato A, Willment JA, Brown GD
Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
Journal
Reference
Authors
Dupaul-Chicoine J, Saleh M
Title
A new path to IL-1beta production controlled by caspase-8.
Journal
Reference
Authors
Batbayar S, Lee DH, Kim HW
Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
Journal
Reference
Authors
Bendickova K, Tidu F, Fric J
Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
Journal
Reference
Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Journal
Reference
Authors
Marakalala MJ, Ndlovu H
Title
Signaling C-type lectin receptors in antimycobacterial immunity.
Journal
Reference
Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
Journal
Reference
Authors
Geijtenbeek TB, Gringhuis SI
Title
Signalling through C-type lectin receptors: shaping immune responses.
Journal
Reference
Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
Journal
KO pathway
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