KEGG   PATHWAY: padl04060
Entry
padl04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Pygoscelis adeliae (Adelie penguin)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
padl04060  Cytokine-cytokine receptor interaction
padl04060

Organism
Pygoscelis adeliae (Adelie penguin) [GN:padl]
Gene
103925924  CCL21; C-C motif chemokine 21 [KO:K16062]
103916603  C-C motif chemokine 4-like [KO:K12964]
103916604  C-C motif chemokine 4 homolog [KO:K12964]
103913292  CCL17; C-C motif chemokine 17 [KO:K21083]
103916602  C-C motif chemokine 5-like [KO:K12499]
103917477  CCL28; C-C motif chemokine 28 [KO:K05513]
103917869  CCL20; C-C motif chemokine 20 [KO:K14625]
103917696  interleukin-8-like [KO:K10030]
103917698  interleukin-8 [KO:K10030]
103917699  C-X-C motif chemokine 5-like [KO:K10030]
103917711  LOW QUALITY PROTEIN: interleukin-8-like [KO:K10030]
103913969  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103915777  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
103922462  lymphotactin-like [KO:K05507]
103913297  CX3CL1; fractalkine [KO:K05508]
103915856  IL4; interleukin-4 [KO:K05430]
103926225  interleukin-7-like [KO:K05431]
103920895  IL15; interleukin-15 isoform X1 [KO:K05433]
103915854  interleukin-5-like [KO:K05428]
103926084  somatotropin [KO:K05438]
103919057  PRL; prolactin [KO:K05439]
103925631  THPO; thrombopoietin [KO:K06854]
103918452  IL6; interleukin-6 [KO:K05405]
103925294  IL12A; interleukin-12 subunit alpha [KO:K05406]
103912251  IL12B; interleukin-12 subunit beta [KO:K05425]
103919782  IL10; interleukin-10 [KO:K05443]
103919842  interleukin-20-like [KO:K22667]
103919961  IL22; interleukin-22 [KO:K05445]
103921639  interferon lambda-3-like [KO:K22669]
103921082  interferon beta-like [KO:K05414]
103920369  interferon epsilon-like [KO:K05414]
103919962  IFNG; interferon gamma [KO:K04687]
103912923  interleukin-1 beta-like [KO:K04519]
103921543  IL18; interleukin-18 [KO:K05482]
103913220  IL17A; interleukin-17A [KO:K05489]
103913222  interleukin-17F-like [KO:K05494]
103912243  IL17B; interleukin-17B [KO:K05490]
103920116  IL17D; interleukin-17D [KO:K05492]
103922720  IL16; pro-interleukin-16 [KO:K22628]
103925944  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
103914004  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103912847  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
103924981  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103919210  EDA; ectodysplasin-A [KO:K05480]
103923574  NGF; beta-nerve growth factor [KO:K02582]
103915905  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
103913012  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
103923375  CD40LG; CD40 ligand [KO:K03161]
103924772  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
103916133  TGFB2; transforming growth factor beta-2 [KO:K13376]
103912969  TGFB3; transforming growth factor beta-3 [KO:K13377]
103913759  GDF2; growth/differentiation factor 2 [KO:K05503]
103919653  BMP10; bone morphogenetic protein 10 [KO:K22670]
103917706  BMP3; bone morphogenetic protein 3 [KO:K05496]
103914037  GDF10; bone morphogenetic protein 3B [KO:K22674]
103925477  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
103914781  INHBA; inhibin beta A chain [KO:K04667]
103919646  INHBB; inhibin beta B chain [KO:K22687]
103923273  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
103912367  nodal homolog [KO:K04666]
103923138  GDF9; growth/differentiation factor 9 [KO:K22673]
103925443  INHBC; inhibin beta C chain [KO:K22688]
103921165  AMH; muellerian-inhibiting factor [KO:K04665]
103913163  BMP2; bone morphogenetic protein 2 [KO:K21283]
103913979  bone morphogenetic protein 7-like [KO:K21283]
103915984  BMP4; bone morphogenetic protein 4 [KO:K04662]
103912387  GDF5; growth/differentiation factor 5 [KO:K04664]
103913247  GDF7; growth/differentiation factor 7 [KO:K20013]
103923623  BMP15; bone morphogenetic protein 15 [KO:K05498]
103924618  BMP5; bone morphogenetic protein 5 [KO:K04663]
103919079  BMP6; bone morphogenetic protein 6 [KO:K16620]
103919285  BMP7; bone morphogenetic protein 7 [KO:K16621]
103923777  bone morphogenetic protein 8A-like [KO:K16622]
103914404  CCR8; C-C chemokine receptor type 8 [KO:K04183]
103923017  LOW QUALITY PROTEIN: C-C chemokine receptor type 8-like [KO:K04183]
103923016  CCR9; C-C chemokine receptor type 9 [KO:K04184]
103923007  ACKR4; atypical chemokine receptor 4 [KO:K04186]
103921613  CCR7; C-C chemokine receptor type 7 [KO:K04182]
103914385  CCR4; C-C chemokine receptor type 4 [KO:K04179]
103922998  C-C chemokine receptor type 2-like [KO:K04180]
103922999  C-C chemokine receptor type 5-like [KO:K04180]
103921313  CCR6; C-C chemokine receptor type 6 [KO:K04181]
103914253  C-X-C chemokine receptor type 2-like [KO:K05050]
103916409  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
103912661  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103914172  ACKR3; atypical chemokine receptor 3 [KO:K04304]
103922994  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
103922997  XCR1; chemokine XC receptor 1 [KO:K04193]
103914395  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
103920842  interleukin-2 receptor subunit alpha-like [KO:K05068]
103924145  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103923348  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
103913920  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
103921479  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
103922822  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
103913921  IL21R; interleukin-21 receptor [KO:K05075]
103923033  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
103924143  LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738]
103924175  LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738]
103922494  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
103923032  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
103923052  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
103923359  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
103923353  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
103917288  GHR; growth hormone receptor [KO:K05080]
103912213  PRLR; prolactin receptor isoform X1 [KO:K05081]
103925226  MPL; thrombopoietin receptor [KO:K05082]
103913974  LEPR; leptin receptor [KO:K05062]
103919426  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
103925922  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
103914046  IL12RB2; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2 [KO:K05064]
103914045  IL23R; interleukin-23 receptor [KO:K05065]
103919427  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
103925913  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
103921463  LIFR; leukemia inhibitory factor receptor [KO:K05058]
103921462  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
103921561  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103920314  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
103912707  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
103917617  IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137]
103923762  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
103923722  IFNLR1; interferon lambda receptor 1 [KO:K05140]
103920316  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103920254  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103912749  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
103920255  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103918827  interleukin-1 receptor type 1-like [KO:K04386]
103925383  IL1RAP; LOW QUALITY PROTEIN: interleukin-1 receptor accessory protein [KO:K04723]
103918872  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
103918828  interleukin-1 receptor type 1-like [KO:K05172]
103918829  IL18R1; interleukin-18 receptor 1 [KO:K05173]
103918830  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
103918873  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
103924365  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
103921966  T-cell surface glycoprotein CD4-like [KO:K06454]
103915746  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103922177  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
103918051  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
103913947  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
103920656  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
103913942  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103913258  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
103918848  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
103925538  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
103915202  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103914945  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
103919228  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
103917992  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
103921878  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103924872  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
103917954  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
103918024  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
103917579  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
103918791  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
103915814  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
103920106  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
103921946  RELL2; RELT-like protein 2 [KO:K26541]
103914697  RELL1; RELT-like protein 1 [KO:K26541]
103917369  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103919595  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103917105  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103913390  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
103912640  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
103923542  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
103915643  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
103913389  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
103925326  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
103925325  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
103925849  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
103919510  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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