Entry Name Herpes simplex virus 1 infection - Phalacrocorax carbo (great cormorant)
Description Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Organism Phalacrocorax carbo (great cormorant) [GN:
pcao ]
Gene 104045459 CARD9; caspase recruitment domain-containing protein 9 [KO:K12794 ]
104045422 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
104048535 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
104046505 TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
104044252 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit {ECO:0000250 [KO:K06269 ] [EC:3.1.3.16 ]
104039359 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
104039608 EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239 ]
104040054 EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754 ]
104053018 EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241 ]
104041237 EIF2B4; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit delta [KO:K03680 ]
104052256 EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
104041914 POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364 ]
104041888 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
104052259 LOW QUALITY PROTEIN: interferon alpha/beta receptor 1-like [KO:K05133 ]
104045017 CD74; LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain [KO:K06505 ]
104053577 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
104051583 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
104042153 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
104044331 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
104051690 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
104048078 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
104046665 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1-like [KO:K12890 ]
104040733 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893 ]
104045773 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
104040888 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 7-like [KO:K12896 ]
104051447 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
104051511 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
104051842 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
104041883 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Granger SW, Rickert S
Title LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal Reference Authors Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal Reference Authors MacLeod IJ, Minson T
Title Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal Reference Authors Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal Reference Authors Gianni T, Campadelli-Fiume G
Title The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal Reference Authors Spear PG
Title Herpes simplex virus: receptors and ligands for cell entry.
Journal Reference Authors Boutell C, Everett RD
Title The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal Reference Authors Ma Y, He B
Title Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal Reference Authors Su C, Zhan G, Zheng C
Title Evasion of host antiviral innate immunity by HSV-1, an update.
Journal Reference Authors Melchjorsen J, Matikainen S, Paludan SR
Title Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal Reference Authors Morrison LA
Title The Toll of herpes simplex virus infection.
Journal Reference Authors Zheng C
Title Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal Reference Authors Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal Reference Authors Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal Reference Authors Sanchez R, Mohr I
Title Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal Reference Authors Wysocka J, Herr W
Title The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal Reference Authors Fleming SB
Title Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal Reference Authors Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal Reference Authors Gu H, Zheng Y, Roizman B
Title Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal Reference Authors Tavalai N, Stamminger T
Title Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal Reference Authors Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal Reference Authors Neumann J, Eis-Hubinger AM, Koch N
Title Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal Reference Authors Liu X, Cohen JI
Title The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal Reference Authors Vink EI, Smiley JR, Mohr I
Title Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal Reference Authors Sandri-Goldin RM
Title The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal Reference Authors Sandri-Goldin RM
Title Viral regulation of mRNA export.
Journal Reference Authors Yu X, He S
Title The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal Related pcao04620 Toll-like receptor signaling pathway
pcao04622 RIG-I-like receptor signaling pathway
KO pathway LinkDB All DBs
