KEGG   PATHWAY: pki04218
Entry
pki04218                    Pathway                                
Name
Cellular senescence - Paramormyrops kingsleyae
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
pki04218  Cellular senescence
pki04218

Other DBs
GO: 0090398
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111838013  transforming growth factor beta-1-like [KO:K13375]
111841476  transforming growth factor beta-1-like isoform X1 [KO:K13375]
111835201  transforming growth factor beta-2-like isoform X1 [KO:K13376]
111851556  tgfb2; transforming growth factor beta-2 [KO:K13376]
111844437  transforming growth factor beta-3-like [KO:K13377]
111852442  tgfb3; transforming growth factor beta-3 [KO:K13377]
111851387  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111838972  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111857200  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111857846  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
111842093  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111856558  mothers against decapentaplegic homolog 2-like [KO:K04500]
111845594  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
111859259  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
111856032  cyclin-dependent kinase 4-like isoform X1 [KO:K02089] [EC:2.7.11.22]
111854375  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111843897  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111851863  G1/S-specific cyclin-D1 [KO:K04503]
111836806  G1/S-specific cyclin-D2-like [KO:K10151]
111851230  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
111858241  G1/S-specific cyclin-D2-like [KO:K10151]
111857566  ccnd2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
111852988  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111838068  rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
111835320  rbl1; retinoblastoma-like protein 1 [KO:K04681]
111832715  rbl2; retinoblastoma-like protein 2 [KO:K16332]
111842303  e2f1; transcription factor E2F1 [KO:K17454]
111859627  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
111852468  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
111844317  transcription factor E2F3-like [KO:K06620]
111846201  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
111851889  transcription factor E2F4-like [KO:K04682]
111847680  transcription factor E2F4-like isoform X1 [KO:K04682]
111836364  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111860453  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111853566  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111860909  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111853393  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111835615  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111834821  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111847640  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
111860386  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111856594  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111851322  forkhead box protein O1-A-like [KO:K07201]
111850649  forkhead box protein O1-A-like [KO:K07201]
111856450  foxo3; forkhead box protein O3 [KO:K09408]
111857894  forkhead box protein O3-like [KO:K09408]
111852946  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
111844683  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
111843121  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
111854723  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111834093  G1/S-specific cyclin-E2-like [KO:K06626]
111846461  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
111835809  G1/S-specific cyclin-E2-like [KO:K06626]
111860372  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111835639  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111842358  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111841791  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111841989  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111841995  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111843853  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111846291  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111856890  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111837240  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111860223  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111842728  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
111842729  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111853508  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111842404  GTPase KRas-like [KO:K07827]
111845660  kras; GTPase KRas isoform X1 [KO:K07827]
111853914  nras; GTPase NRas [KO:K07828]
111841178  ras-related protein R-Ras2 isoform X1 [KO:K07830]
111836888  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
111851762  mras; ras-related protein M-Ras [KO:K07831]
111849456  ras-related protein M-Ras-like [KO:K07831]
111840699  GTPase HRas-like [KO:K02833]
111859528  hras; GTPase HRas [KO:K02833]
111838854  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111852355  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111850633  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111860965  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111861008  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111833412  hamartin-like [KO:K07206]
111842691  tsc1; hamartin isoform X1 [KO:K07206]
111835364  hamartin-like isoform X1 [KO:K07206]
111858859  tsc2; tuberin isoform X1 [KO:K07207]
111849730  rheb; GTP-binding protein Rheb [KO:K07208]
111854337  rhebl1; GTPase RhebL1 [KO:K07208]
111834305  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111853698  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111858884  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111855069  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
111833037  ccna2; cyclin-A2 [KO:K06627]
111840430  ccna1; cyclin-A1 [KO:K06627]
111840972  mybl2; myb-related protein B isoform X1 [KO:K21769]
111834733  protein lin-9 homolog isoform X1 [KO:K21773]
111841357  protein lin-9 homolog isoform X1 [KO:K21773]
111833694  lin37; protein lin-37 homolog isoform X1 [KO:K21774]
111852391  lin52; protein lin-52 homolog [KO:K21775]
111835502  lin54; protein lin-54 homolog isoform X1 [KO:K21776]
111859498  protein lin-54 homolog isoform X1 [KO:K21776]
111850249  histone-binding protein RBBP7 [KO:K10752]
111854300  rbbp4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
111843373  foxm1; forkhead box protein M1 [KO:K09406]
111841624  transcriptional regulator Myc-1-like [KO:K04377]
111846207  transcriptional regulator Myc-2-like [KO:K04377]
111851197  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
111850623  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
111854492  cellular tumor antigen p53-like isoform X1 [KO:K04451]
111854445  rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
111834692  F-box/WD repeat-containing protein 11-like isoform X1 [KO:K03362]
111859864  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
111833267  homeodomain-interacting protein kinase 2-like isoform X1 [KO:K08826] [EC:2.7.11.1]
111838794  homeodomain-interacting protein kinase 2-like isoform X1 [KO:K08826] [EC:2.7.11.1]
111846574  hipk3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
111855735  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
111840498  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111842088  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111849258  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111842149  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111850693  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111855133  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
111855420  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111837477  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111840300  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
111845607  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111836645  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111860367  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111835825  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111857802  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111850597  protein C-ets-1-like [KO:K02678]
111849333  ets1; protein C-ets-1 isoform X1 [KO:K02678]
111836901  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
111847733  map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
111848425  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111859759  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
111835993  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111845666  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111845679  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111840348  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111853904  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111856186  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111844594  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111839168  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111839275  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111839280  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111839282  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111846472  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111853734  cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111835495  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
111844972  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
111846694  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
111860540  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
111856891  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
111833865  mre11; double-strand break repair protein MRE11 [KO:K10865]
111857452  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
111860659  nbn; nibrin isoform X1 [KO:K10867]
111844902  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
111852734  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
111836291  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
111855130  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
111852617  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
111834010  hus1; checkpoint protein HUS1 [KO:K10903]
111850499  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
111837953  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
111859867  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
111841248  gata4; transcription factor GATA-4 [KO:K09183]
111855361  transcription factor GATA-4-like [KO:K09183]
111838187  adapter protein CIKS-like isoform X1 [KO:K21124]
111857867  adapter protein CIKS-like isoform X1 [KO:K21124]
111833172  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111853948  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111851986  putative transcription factor p65 homolog [KO:K04735]
111855422  putative transcription factor p65 homolog [KO:K04735]
111846921  il6; interleukin-6 [KO:K05405]
111850975  alveolar macrophage chemotactic factor-like [KO:K10030]
111836793  permeability factor 2-like [KO:K10030]
111836794  permeability factor 2-like isoform X1 [KO:K10030]
111850332  interleukin-8-like [KO:K10030]
111855477  interleukin-8-like [KO:K10030]
111845974  igfbp3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
111850180  insulin-like growth factor-binding protein 3 [KO:K10138]
111852922  plasminogen activator inhibitor 1-like [KO:K03982]
111854452  plasminogen activator inhibitor 1-like [KO:K03982]
111860034  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
111834362  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
111854424  mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
111844037  mRNA decay activator protein ZFP36L1-like [KO:K18753]
111848344  mRNA decay activator protein ZFP36L2-like [KO:K18753]
111840007  zfp36l2; mRNA decay activator protein ZFP36L2 [KO:K18753]
111852004  mRNA decay activator protein ZFP36L1-like isoform X1 [KO:K18753]
111858986  mRNA decay activator protein ZFP36L1-like [KO:K18753]
111852542  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
111833375  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111854916  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
111845024  trpm7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
111846675  transient receptor potential cation channel subfamily M member 7-like [KO:K04982] [EC:2.7.11.1]
111857887  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111851624  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111852380  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111852307  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111860100  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111852308  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111835677  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111852340  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111852381  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111852382  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111841738  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
111836038  calml4; calmodulin-like protein 4 [KO:K02183]
111839522  calmodulin [KO:K02183]
111852631  calm1; calmodulin-1 [KO:K02183]
111844882  calm3; calmodulin-3 [KO:K02183]
111839995  calmodulin [KO:K02183]
111848450  calmodulin-A isoform X1 [KO:K02183]
111841764  calmodulin [KO:K02183]
111858903  calml6; calmodulin-like protein 6 [KO:K02183]
111848699  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111849849  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111853026  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111836737  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111857559  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
111850760  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111859769  calcineurin subunit B type 1 isoform X1 [KO:K06268]
111852343  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111845775  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
111835865  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
111855820  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111832689  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111843522  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111854528  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111839848  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111840603  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111845672  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111844730  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111837930  ADP/ATP translocase 1 [KO:K05863]
111838180  ADP/ATP translocase 3-like isoform X1 [KO:K05863]
111853629  slc25a4; ADP/ATP translocase 1 [KO:K05863]
111835009  ADP/ATP translocase 3 [KO:K05863]
111837310  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
111847941  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
111839550  voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
111839289  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
111837041  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111842143  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111854366  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111849606  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
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Related
pathway
pki04020  Calcium signaling pathway
pki04068  FoxO signaling pathway
pki04110  Cell cycle
pki04115  p53 signaling pathway
pki04150  mTOR signaling pathway
KO pathway
ko04218   
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