KEGG   PATHWAY: pspa04540
Entry
pspa04540                   Pathway                                
Name
Gap junction - Polyodon spathula (Mississippi paddlefish)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pspa04540  Gap junction
pspa04540

Other DBs
GO: 0005921
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121316168  gap junction alpha-1 protein [KO:K07372]
121317299  gap junction alpha-1 protein-like [KO:K07372]
121294549  gap junction delta-2 protein-like [KO:K07373]
121303777  gap junction delta-2 protein-like [KO:K07373]
121330272  gap junction delta-2 protein-like [KO:K07373]
121304897  gap junction delta-2 protein [KO:K07373]
121324658  gap junction delta-2 protein [KO:K07373]
121298561  lysophosphatidic acid receptor 1-A-like [KO:K04289]
121308569  lysophosphatidic acid receptor 1-A-like [KO:K04289]
121319720  lysophosphatidic acid receptor 1-A [KO:K04289]
121297680  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
121299816  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121299890  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121329128  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
121318357  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
121319742  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121300937  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
121330521  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
121306164  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
121295227  platelet-derived growth factor C-like [KO:K05450]
121320343  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
121322941  platelet-derived growth factor C-like [KO:K05450]
121295627  pro-epidermal growth factor-like isoform X1 [KO:K04357]
121322456  pro-epidermal growth factor-like [KO:K04357]
121298148  platelet-derived growth factor receptor alpha-like isoform X1 [KO:K04363] [EC:2.7.10.1]
121320036  platelet-derived growth factor receptor alpha-like isoform X1 [KO:K04363] [EC:2.7.10.1]
121297330  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
121324756  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
121314598  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
121313118  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
121295867  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
121296442  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
121316389  son of sevenless homolog 1-like [KO:K03099]
121316886  son of sevenless homolog 1 isoform X1 [KO:K03099]
121323793  sos2; son of sevenless homolog 2 [KO:K03099]
121294911  GTPase HRas [KO:K02833]
121330312  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121318385  GTPase KRas isoform X1 [KO:K07827]
121319713  GTPase KRas isoform X1 [KO:K07827]
121300074  GTPase NRas [KO:K07828]
121300091  GTPase NRas [KO:K07828]
121297980  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121328554  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121294557  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121304127  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121300828  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121301294  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121297147  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121307738  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121305215  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121297902  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
121319190  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
121322029  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
121294693  dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
121299180  dual specificity mitogen-activated protein kinase kinase 5-like [KO:K04463] [EC:2.7.12.2]
121306863  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
121299609  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
121299642  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
121307119  tubulin alpha-1C chain-like [KO:K07374]
121307131  tubulin alpha chain-like [KO:K07374]
121307163  tubulin alpha chain [KO:K07374]
121322033  tubulin alpha chain-like [KO:K07374]
121309064  tubulin alpha-1C chain-like [KO:K07374]
121322960  tubulin alpha chain-like [KO:K07374]
121323046  tubulin alpha chain [KO:K07374]
121329237  tubulin alpha chain, testis-specific [KO:K07374]
121323274  tubulin alpha-1A chain-like [KO:K07374]
121323275  tubulin alpha-1A chain-like [KO:K07374]
121323276  tubulin alpha chain-like [KO:K07374]
121323277  tubulin alpha chain-like [KO:K07374]
121323410  tubulin alpha-1A chain-like [KO:K07374]
121318517  tubulin alpha-8 chain-like [KO:K07374]
121304966  tubulin alpha-8 chain-like [KO:K07374]
121304974  tubulin alpha-8 chain-like [KO:K07374]
121304982  tubulin alpha-8 chain-like [KO:K07374]
121296579  tubulin beta-3 chain [KO:K07375]
121297788  tubulin beta-6 chain [KO:K07375]
121309628  tubulin beta-4B chain [KO:K07375]
121309629  tubulin beta-4B chain-like [KO:K07375]
121304125  tubulin beta chain [KO:K07375]
121304312  tubulin beta chain [KO:K07375]
121304610  tubulin beta chain [KO:K07375]
121313045  tubulin beta-2B chain-like [KO:K07375]
121313153  tubulin beta-5 chain isoform X1 [KO:K07375]
121314503  tubb6; tubulin beta-5 chain [KO:K07375]
121314529  tubulin beta-2B chain [KO:K07375]
121325316  LOW QUALITY PROTEIN: uncharacterized protein LOC121325316 [KO:K07375]
121295288  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
121296281  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
121325792  cyclin-dependent kinase 1-B-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121321871  cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121294726  tight junction protein ZO-1-like isoform X1 [KO:K05701]
121299175  tight junction protein ZO-1-like isoform X1 [KO:K05701]
121326155  beta-1 adrenergic receptor-like [KO:K04141]
121321699  beta-1 adrenergic receptor-like [KO:K04141]
121297444  D(1) dopamine receptor-like [KO:K04144]
121324078  D(1) dopamine receptor-like [KO:K04144]
121298118  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
121307824  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
121307832  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
121298675  D(2) dopamine receptor A-like [KO:K04145]
121303940  drd2a; dopamine receptor D2a [KO:K04145]
121304119  D(2) dopamine receptor A-like [KO:K04145]
121319020  D(2) dopamine receptor-like [KO:K04145]
121313146  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
121314511  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
121314788  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
121309305  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
121316002  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121305249  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
121307360  adenylate cyclase type 2-like isoform X1 [KO:K08044] [EC:4.6.1.1]
121322506  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
121322974  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
121309011  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121296167  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
121325516  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
121309014  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121300452  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
121330489  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
121326749  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121310175  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
121331016  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
121295630  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
121320807  htr2ab; 5-hydroxytryptamine receptor 2A [KO:K04157]
121326708  5-hydroxytryptamine receptor 2B-like [KO:K04157]
121327706  5-hydroxytryptamine receptor 2A-like [KO:K04157]
121322629  5-hydroxytryptamine receptor 2B-like isoform X1 [KO:K04157]
121317851  5-hydroxytryptamine receptor 2C-like [KO:K04157]
121315834  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
121316952  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
121321206  metabotropic glutamate receptor 5-like [KO:K04604]
121302602  metabotropic glutamate receptor 5-like [KO:K04604]
121300566  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
121301525  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
121318840  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
121315927  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
121315930  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121317052  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121310099  plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121317660  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
121329668  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
121323975  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
121298161  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121328701  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121318388  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
121319707  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
121299669  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
121304724  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
121295549  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121296360  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
121300719  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121331034  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
121302494  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
121320459  gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
121326435  guanylate cyclase soluble subunit alpha-1-like [KO:K12318] [EC:4.6.1.2]
121322959  guanylate cyclase soluble subunit alpha-1-like isoform X1 [KO:K12318] [EC:4.6.1.2]
121295205  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
121326609  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
121321092  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
121323450  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
121321863  cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
121303213  cGMP-dependent protein kinase 1-like isoform X1 [KO:K07376] [EC:2.7.11.12]
121325521  cGMP-dependent protein kinase 1-like isoform X1 [KO:K07376] [EC:2.7.11.12]
121300010  prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
121317145  prkg3; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
121318794  cGMP-dependent protein kinase 2-like [KO:K19477] [EC:2.7.11.12]
121325426  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
pspa04010  MAPK signaling pathway
pspa04020  Calcium signaling pathway
pspa04060  Cytokine-cytokine receptor interaction
pspa04070  Phosphatidylinositol signaling system
pspa04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
LinkDB

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