KEGG   PATHWAY: pvt04510
Entry
pvt04510                    Pathway                                
Name
Focal adhesion - Pogona vitticeps (central bearded dragon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pvt04510  Focal adhesion
pvt04510

Other DBs
GO: 0005925
Organism
Pogona vitticeps (central bearded dragon) [GN:pvt]
Gene
110079135  COL1A1; collagen alpha-1(I) chain [KO:K06236]
110074712  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110071756  COL2A1; collagen alpha-1(II) chain [KO:K19719]
110080661  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
110078449  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
110078450  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
110074283  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
110090761  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
110083710  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
110086129  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
110086130  collagen alpha-6(VI) chain-like [KO:K06238]
110091155  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110091157  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
110082517  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
110075009  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
110084906  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
110077555  LAMA2; laminin subunit alpha-2 [KO:K05637]
110078890  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
110086875  LAMA5; laminin subunit alpha-5 [KO:K06240]
110074919  LAMA3; laminin subunit alpha-3 [KO:K06240]
110085314  LAMA4; laminin subunit alpha-4 [KO:K06241]
110070347  LAMB1; laminin subunit beta-1 [KO:K05636]
110079924  laminin subunit beta-2-like isoform X1 [KO:K06243]
110079958  laminin subunit beta-2-like [KO:K06243]
110072367  LAMB3; laminin subunit beta-3 [KO:K06244]
110080786  LAMB4; laminin subunit beta-4 [KO:K06245]
110091308  LAMC1; laminin subunit gamma-1 [KO:K05635]
110091307  LAMC2; laminin subunit gamma-2 [KO:K06246]
110079604  LAMC3; laminin subunit gamma-3 [KO:K06247]
110091203  CHAD; chondroadherin [KO:K06248]
110077192  RELN; reelin [KO:K06249] [EC:3.4.21.-]
110080127  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
110072531  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
110083084  THBS2; thrombospondin-2 [KO:K04659]
110080993  THBS3; thrombospondin-3 [KO:K04659]
110073932  THBS4; thrombospondin-4 [KO:K04659]
110081893  FN1; fibronectin isoform X1 [KO:K05717]
110080523  SPP1; osteopontin [KO:K06250]
110084310  VTN; vitronectin isoform X1 [KO:K06251]
110090180  tenascin-X-like [KO:K06252]
110089883  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
110081656  TNN; tenascin-N [KO:K06252]
110081672  TNR; tenascin-R isoform X1 [KO:K06252]
110074979  VWF; von Willebrand factor [KO:K03900]
110085320  IBSP; bone sialoprotein 2 [KO:K06253]
110073900  ITGA1; integrin alpha-1 [KO:K06480]
110073896  ITGA2; integrin alpha-2 [KO:K06481]
110081352  ITGA2B; integrin alpha-IIb [KO:K06476]
110079172  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
110086963  ITGA4; integrin alpha-4 [KO:K06483]
110071758  ITGA5; integrin alpha-5 [KO:K06484]
110086019  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
110073732  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
110085993  ITGA8; integrin alpha-8 [KO:K06584]
110084229  ITGA9; integrin alpha-9 [KO:K06585]
110088133  ITGA10; integrin alpha-10 [KO:K06586]
110086892  ITGA11; integrin alpha-11 [KO:K06587]
110089997  ITGAV; integrin alpha-V [KO:K06487]
110082773  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
110081384  ITGB3; integrin beta-3 [KO:K06493]
110085179  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
110090759  ITGB5; integrin beta-5 [KO:K06588]
110081565  ITGB6; integrin beta-6 [KO:K06589]
110070338  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
110072726  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
110087048  EMP2; epithelial membrane protein 2 [KO:K26256]
110090337  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
110075932  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110091114  PDGFD; platelet-derived growth factor D [KO:K05450]
110072781  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
110087292  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
110084792  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110074690  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110083368  VEGFB; vascular endothelial growth factor B [KO:K16858]
110075606  snake venom vascular endothelial growth factor toxin HF-like isoform X1 [KO:K16859]
110079090  PGF; placenta growth factor [KO:K16859]
110084103  VEGFC; vascular endothelial growth factor C [KO:K05449]
110075463  VEGFD; vascular endothelial growth factor D [KO:K05449]
110077194  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110078407  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110086089  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110072986  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110081594  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110076449  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110074293  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
110073488  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110077032  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
110082059  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
110076083  EMP1; epithelial membrane protein 1 [KO:K26255]
110076767  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110075631  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
110076362  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
110076866  RHOA; transforming protein RhoA [KO:K04513]
110081153  transforming protein RhoA-like [KO:K04513]
110082021  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
110079445  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110083697  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
110083871  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110070312  MYL5; myosin light chain 5 [KO:K12753]
110084339  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
110083027  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
110085140  MYL10; myosin regulatory light chain 10 [KO:K12756]
110079422  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
110090087  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
110078692  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110085633  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110083839  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110084990  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
110073397  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
110078487  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
110086708  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110083010  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
110076324  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
110090626  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
110072667  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
110081456  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110085457  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
110084467  actin, cytoplasmic type 5-like [KO:K05692]
110084468  actin, cytoplasmic 3-like isoform X1 [KO:K05692]
110089941  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110083726  ACTB; actin, cytoplasmic 1 [KO:K05692]
110084444  actin, cytoplasmic 2-like [KO:K05692]
110091400  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
110075406  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
110075766  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
110076389  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
110082832  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
110074573  TLN2; talin-2 [KO:K06271]
110078614  FLNA; filamin-A [KO:K04437]
110082409  FLNB; filamin-B isoform X1 [KO:K27392]
110088950  PXN; paxillin [KO:K05760]
110078157  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
110091405  ZYX; zyxin isoform X1 [KO:K06273]
110075672  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
110077797  VCL; vinculin isoform X1 [KO:K05700]
110076624  PARVB; beta-parvin isoform X1 [KO:K06275]
110076628  PARVG; gamma-parvin [KO:K06275]
110080927  PARVA; alpha-parvin isoform X1 [KO:K06275]
110085010  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
110090951  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110075943  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110075706  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110076947  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110086621  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
110088714  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110085019  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110078510  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110084855  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110081909  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110078719  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110073252  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110082359  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
110073778  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110072561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110073951  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110083120  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110089294  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
110077999  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
110074475  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
110082204  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110075970  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110091292  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110088575  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
110075278  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110074346  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
110075619  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
110090819  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
110080124  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110086811  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110081315  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
110084280  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
110081775  crk-like protein [KO:K04438]
110081994  CRKL; crk-like protein [KO:K04438]
110077909  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
110079600  RAPGEF1; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1 [KO:K06277]
110072354  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
110075099  RAP1B; ras-related protein Rap-1b [KO:K07836]
110087777  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110073473  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110085327  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110077124  JUN; transcription factor AP-1 [KO:K04448]
110082693  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110077030  CAV1; caveolin-1 isoform X1 [KO:K06278]
110077035  CAV2; caveolin-2 [KO:K12958]
110078663  caveolin-2-like [KO:K12958]
110078681  caveolin-3-like [KO:K12959]
110085313  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
110081020  SHC1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
110079278  SHC2; SHC-transforming protein 2 [KO:K17447]
110080566  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
110077281  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
110085805  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110089155  SOS2; son of sevenless homolog 2 [KO:K03099]
110079544  SOS1; son of sevenless homolog 1 [KO:K03099]
110074175  HRAS; GTPase HRas [KO:K02833]
110083799  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110085468  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110081803  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110088651  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110081152  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
110073542  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110078878  G1/S-specific cyclin-D3-like isoform X1 [KO:K10152]
110080664  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
110080243  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
110088616  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
110083340  BAD; bcl2-associated agonist of cell death [KO:K02158]
110075422  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pvt04010  MAPK signaling pathway
pvt04060  Cytokine-cytokine receptor interaction
pvt04070  Phosphatidylinositol signaling system
pvt04110  Cell cycle
pvt04310  Wnt signaling pathway
pvt04512  ECM-receptor interaction
pvt04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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