KEGG   PATHWAY: schu04270
Entry
schu04270                   Pathway                                
Name
Vascular smooth muscle contraction - Siniperca chuatsi (mandarin fish)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
schu04270  Vascular smooth muscle contraction
schu04270

Other DBs
GO: 0014829
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122876648  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
122865928  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
122888718  alpha-1A adrenergic receptor-like isoform X1 [KO:K04136]
122880175  alpha-1A adrenergic receptor-like [KO:K04136]
122873738  adra1d; alpha-1D adrenergic receptor [KO:K04137]
122884230  agt; angiotensinogen [KO:K09821]
122866663  agtr1b; type-1 angiotensin II receptor isoform X1 [KO:K04166]
122865017  edn1; endothelin-1 [KO:K16366]
122881532  endothelin-2 [KO:K16367]
122862626  si:ch211-202p1.5; endothelin-1 isoform X1 [KO:K16367]
122864029  edn2; endothelin-2 [KO:K16367]
122883436  edn3b; endothelin-3b [KO:K05227]
122866015  endothelin-3 [KO:K05227]
122870157  endothelin-1 receptor-like isoform X1 [KO:K04197]
122873671  ednraa; endothelin receptor type Aa [KO:K04197]
122876901  vasopressin-neurophysin 2-copeptin [KO:K05242]
122871233  arg8-vasotocin receptor-like [KO:K04226]
122874999  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
122875665  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122862096  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04634]
122877558  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
122866022  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
122876036  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122869469  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122876655  group 3 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
122878434  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
122872315  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
122884949  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
122865926  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122865927  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122873226  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122866099  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122869250  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122877624  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122884098  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122871804  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
122884388  kcnma1a; calcium-activated potassium channel subunit alpha-1a isoform X1 [KO:K04936]
122867222  calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
122877567  si:ch211-247n2.1; calcium-activated potassium channel subunit beta-2 isoform X1 [KO:K04938]
122886594  kcnmb2; calcium-activated potassium channel subunit beta-2 isoform X1 [KO:K04938]
122886595  kcnmb3; calcium-activated potassium channel subunit beta-3 isoform X1 [KO:K04939]
122870944  calcium-activated potassium channel subunit beta-4-like [KO:K04941]
122871614  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122863128  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122882704  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122883241  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
122883424  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
122882919  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
122861584  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
122863352  calm1b; calmodulin-1b [KO:K02183]
122884956  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
122885282  calglandulin-like [KO:K02183]
122879636  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122873955  calml4a; calmodulin-like protein 4a [KO:K02183]
122874568  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
122861589  calm1a; calmodulin-1a [KO:K02183]
122868166  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
122868334  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122877993  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122885290  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122887400  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122882928  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
122867202  myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
122868634  myl9b; myosin regulatory light polypeptide 9b isoform X1 [KO:K12755]
122869075  myosin-11-like isoform X1 [KO:K10352]
122869405  myosin-10-like isoform X1 [KO:K10352]
122869441  myosin-9-like isoform X1 [KO:K10352]
122870658  myosin-9-like isoform X1 [KO:K10352]
122872346  myh11a; myosin-11a isoform X1 [KO:K10352]
122873803  myosin-10 isoform X1 [KO:K10352]
122869921  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122863603  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122863604  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
122884740  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
122861332  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
122869241  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
122861809  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122875567  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122868700  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122873474  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
122874066  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122882022  prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122865392  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
122866851  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
122884321  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
122867302  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
122861504  prkcha; protein kinase C eta type [KO:K18051] [EC:2.7.11.13]
122871297  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
122876305  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122871272  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122871051  cald1a; caldesmon 1a isoform X1 [KO:K12327]
122884798  lymphocyte-specific protein 1-like isoform X1 [KO:K12327]
122874977  lsp1a; non-muscle caldesmon isoform X1 [KO:K12327]
122874777  caldesmon-like isoform X1 [KO:K12327]
122868196  acta2; actin, aortic smooth muscle [KO:K12313]
122888101  ppp1r14aa; protein phosphatase 1, regulatory (inhibitor) subunit 14Aa [KO:K12328]
122879239  ppp1r14ab; protein phosphatase 1, regulatory (inhibitor) subunit 14Ab [KO:K12328]
122862044  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
122868775  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
122877056  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
122863717  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
122870617  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
122867951  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
122871502  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
122883108  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K12329]
122875420  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
122872832  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
122874052  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
122869561  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
122867246  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
122887838  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
122879347  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
122881966  arhgef1b; rho guanine nucleotide exchange factor 1b isoform X1 [KO:K12330]
122869883  arhgef11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
122882438  rho-related GTP-binding protein RhoA-D [KO:K04513]
122882439  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
122883454  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
122883743  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
122884474  transforming protein RhoA [KO:K04513]
122884762  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
122886396  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
122863432  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
122861382  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
122877052  adora2aa; adenosine A2a receptor a [KO:K04266]
122865761  adora2ab; adenosine A2a receptor b isoform X1 [KO:K04266]
122888111  adora2b; adenosine receptor A2b [KO:K04267]
122879635  ptgir; prostacyclin receptor [KO:K04263]
122873266  calca; calcitonin/calcitonin-related polypeptide, alpha isoform X1 [KO:K12332]
122874582  calcitonin-1-like isoform X1 [KO:K12332]
122879342  adma; adrenomedullin a [KO:K12333]
122874488  admb; uncharacterized protein admb isoform X1 [KO:K12333]
122875505  adm2b; protein ADM2 [KO:K25343]
122871652  adm2a; protein ADM2a [KO:K25343]
122883768  calcrl2; calcitonin gene-related peptide type 1 receptor isoform X1 [KO:K04577]
122872328  calcitonin gene-related peptide type 1 receptor-like isoform X1 [KO:K04577]
122885817  calcitonin gene-related peptide type 1 receptor [KO:K04577]
122872381  receptor activity-modifying protein 1-like [KO:K08447]
122885256  ramp1; receptor activity-modifying protein 1 [KO:K08447]
122868034  receptor activity-modifying protein 1-like [KO:K08447]
122868346  ramp2; receptor activity-modifying protein 2 isoform X1 [KO:K08448]
122866949  receptor activity-modifying protein 3-like [KO:K08449]
122862652  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
122882719  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
122877981  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
122887421  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
122881549  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122864522  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
122863563  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
122880946  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122885099  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122882904  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
122883618  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
122863875  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122862945  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122887074  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122868809  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
122873932  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122868669  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122877466  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122873333  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122887397  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122883720  nppa; natriuretic peptides A isoform X1 [KO:K12334]
122881162  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
122864525  npr1a; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
122882101  wu:fj39g12; C-type natriuretic peptide-like [KO:K12336]
122870317  si:ch73-265d7.2; C-type natriuretic peptide 2 [KO:K12336]
122883723  nppal; natriuretic peptide A-like [KO:K12336]
122878076  nppc; C-type natriuretic peptide [KO:K12336]
122870325  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
122877875  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
122866004  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
122884081  cGMP-dependent protein kinase 1-like isoform X1 [KO:K07376] [EC:2.7.11.12]
122878879  mrvi1; ciliary rootlet coiled-coil protein 2 [KO:K12337]
122872979  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
122879456  gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
122872199  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
122872980  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
122879686  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
Reference
PMID:18703404
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
Reference
PMID:15725705
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
DOI:10.1152/ajpcell.1998.274.1.C282
Reference
PMID:12060106
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
schu00590  Arachidonic acid metabolism
schu04020  Calcium signaling pathway
KO pathway
ko04270   
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