KEGG   PATHWAY: schu04020
Entry
schu04020                   Pathway                                
Name
Calcium signaling pathway - Siniperca chuatsi (mandarin fish)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
schu04020  Calcium signaling pathway
schu04020

Other DBs
GO: 0019722
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861332  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
122861412  [KO:K04963]
122861477  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
122861524  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
122861558  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122861584  [KO:K04857]
122861589  calm1a; calmodulin-1a [KO:K02183]
122861621  bdkrb1; B1 bradykinin receptor [KO:K03916]
122861689  oxtrb; LOW QUALITY PROTEIN: oxytocin receptor b [KO:K04229]
122861809  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122861919  [KO:K05214]
122861958  [KO:K03916]
122861969  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
122861987  ptafr; platelet-activating factor receptor [KO:K04279]
122861998  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
122862010  [KO:K03916]
122862011  [KO:K03916]
122862096  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04634]
122862147  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
122862207  drd5a; D(1B) dopamine receptor [KO:K05840]
122862652  [KO:K04632]
122862871  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
122862945  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122863018  [KO:K23449]
122863126  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
122863128  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122863129  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
122863172  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122863255  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
122863352  calm1b; calmodulin-1b [KO:K02183]
122863379  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
122863516  [KO:K03916]
122863522  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
122863563  [KO:K08043] [EC:4.6.1.1]
122863603  [KO:K05858] [EC:3.1.4.11]
122863604  [KO:K05858] [EC:3.1.4.11]
122863875  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122863921  [KO:K13755] [EC:3.1.4.17]
122864285  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122864347  chrna11; cholinergic receptor, nicotinic, alpha 11 isoform X1 [KO:K04809]
122864390  grin2da; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
122864429  [KO:K05850] [EC:7.2.2.10]
122864522  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
122864778  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
122865119  oxtra; oxytocin receptor [KO:K04229]
122865171  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122865182  cacna1bb; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
122865318  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
122865403  [KO:K03914]
122865420  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1 [KO:K05853] [EC:7.2.2.10]
122865556  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
122865659  [KO:K04515] [EC:2.7.11.17]
122865665  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
122865672  [KO:K04222]
122865688  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
122865728  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
122865735  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
122865761  adora2ab; adenosine A2a receptor b isoform X1 [KO:K04266]
122865880  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
122865899  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
122865928  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
122866022  [KO:K04634]
122866108  zgc:56235; voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
122866137  hrh1; histamine H1 receptor [KO:K04149]
122866261  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122866446  unm_hu7910; calponin homology domain-containing protein DDB_G0272472 isoform X1 [KO:K00476] [EC:1.14.11.16]
122866464  [KO:K04361] [EC:2.7.10.1]
122866627  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122866628  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122866631  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122866663  agtr1b; type-1 angiotensin II receptor isoform X1 [KO:K04166]
122866689  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
122866706  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
122866718  [KO:K13755] [EC:3.1.4.17]
122866762  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
122866933  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
122867169  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
122867210  adrb1; beta-1 adrenergic receptor [KO:K04141]
122867228  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
122867243  [KO:K05211]
122867283  [KO:K04515] [EC:2.7.11.17]
122867306  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
122867379  [KO:K09565] [EC:5.2.1.8]
122867463  [KO:K15040]
122867590  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
122867631  chrm3b; muscarinic acetylcholine receptor M1 [KO:K04131]
122867845  tfeb; transcription factor EB isoform X1 [KO:K15590]
122867896  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122867949  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
122868011  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
122868050  [KO:K05840]
122868074  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
122868085  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
122868166  [KO:K00907] [EC:2.7.11.18]
122868334  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122868463  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122868473  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
122868508  [KO:K06856]
122868594  [KO:K05210]
122868649  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
122868669  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122868700  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122868809  [KO:K08049] [EC:4.6.1.1]
122868816  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
122869085  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca isoform X1 [KO:K05211]
122869241  [KO:K04958]
122869457  mcoln1b; mucolipin-1b isoform X1 [KO:K04992]
122869465  [KO:K04258]
122869502  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
122869742  casq1b; calsequestrin-1b isoform X1 [KO:K23468]
122869868  [KO:K04348] [EC:3.1.3.16]
122869878  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122869921  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122869960  cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
122870056  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
122870157  [KO:K04197]
122870203  [KO:K04322]
122870383  slc8a4b; solute carrier family 8 member 4b isoform X1 [KO:K05849]
122870447  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
122870496  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 isoform X1 [KO:K04157]
122871016  fgf23; fibroblast growth factor 23 [KO:K22428]
122871018  [KO:K04358]
122871127  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
122871233  [KO:K04226]
122871280  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
122871376  camk1da; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
122871483  [KO:K05460]
122871614  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122871754  si:ch211-79m20.1; serine/threonine-protein kinase Doa [KO:K17386]
122871787  [KO:K05085] [EC:2.7.10.1]
122871805  [KO:K05871] [EC:2.7.10.2]
122871829  [KO:K04359]
122872068  pln; cardiac phospholamban [KO:K05852]
122872123  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
122872241  cckbra; cholecystokinin receptor-like [KO:K04194]
122872261  [KO:K23445]
122872426  [KO:K05449]
122872873  [KO:K04856]
122872877  fgf7; fibroblast growth factor 7 [KO:K04358]
122872973  tacr3l; tachykinin receptor 3-like [KO:K04224]
122872977  slc25a4; ADP/ATP translocase 1 [KO:K05863]
122872997  tacr3a; tachykinin receptor 3a [KO:K04224]
122873039  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
122873103  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
122873219  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
122873322  vegfc; vascular endothelial growth factor C [KO:K05449]
122873333  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122873436  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
122873474  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
122873491  tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
122873499  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122873582  [KO:K04718] [EC:2.7.1.91]
122873596  mcoln1a; mucolipin-1a [KO:K04992]
122873610  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1 [KO:K05210]
122873658  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
122873660  fgf8b; fibroblast growth factor 8b [KO:K04358]
122873671  ednraa; endothelin receptor type Aa [KO:K04197]
122873692  [KO:K04809]
122873738  adra1d; alpha-1D adrenergic receptor [KO:K04137]
122873739  [KO:K04160]
122873756  stim2a; stromal interaction molecule 2 isoform X1 [KO:K18196]
122873795  [KO:K04358]
122873800  ptger1a; prostaglandin E receptor 1a (subtype EP1) isoform X1 [KO:K04258]
122873808  p2rx3b; P2X purinoceptor 3b isoform X1 [KO:K05217]
122873854  [KO:K04144]
122873932  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122873955  calml4a; calmodulin-like protein 4a [KO:K02183]
122874066  [KO:K19662] [EC:2.7.11.13]
122874443  nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
122874454  [KO:K05859] [EC:3.1.4.11]
122874514  vegfd; vascular endothelial growth factor D [KO:K05449]
122874539  grpr; gastrin-releasing peptide receptor [KO:K04169]
122874568  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
122874636  [KO:K05861] [EC:3.1.4.11]
122874651  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122874663  [KO:K05850] [EC:7.2.2.10]
122874706  [KO:K04130]
122874761  [KO:K22428]
122874762  [KO:K04358]
122874846  [KO:K04809]
122874999  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
122875050  camk1db; calcium/calmodulin-dependent protein kinase 1Db [KO:K08794] [EC:2.7.11.17]
122875077  ntrk3a; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
122875371  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
122875530  [KO:K05460]
122875567  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122875665  [KO:K04634]
122875695  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122875708  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
122875719  [KO:K04849]
122875735  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
122876041  gna14a; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
122876058  tacr2; substance-K receptor isoform X1 [KO:K04223]
122876076  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122876179  adrb3a; adrenoceptor beta 3a [KO:K04143]
122876204  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
122876283  fgf10b; fibroblast growth factor 10b [KO:K04358]
122876285  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
122876330  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
122876438  fgf19; fibroblast growth factor 19 [KO:K22603]
122876446  fgf3; fibroblast growth factor 3 [KO:K04358]
122876450  fgf4; fibroblast growth factor 4 [KO:K04358]
122876456  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
122876474  p2rx2; P2X purinoceptor 2 [KO:K05216]
122876536  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
122876609  [KO:K16056]
122876648  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
122876709  fgf5; fibroblast growth factor 5 [KO:K04358]
122876743  gdnfb; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122876746  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
122876853  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
122876871  f2r; proteinase-activated receptor 1 [KO:K03914]
122877020  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
122877029  tacr1a; tachykinin receptor 1a isoform X1 [KO:K04222]
122877047  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122877052  adora2aa; adenosine A2a receptor a [KO:K04266]
122877054  p2rx4b; P2X purinoceptor 4b [KO:K05218]
122877219  [KO:K04852]
122877458  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122877466  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122877481  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
122877558  [KO:K04634]
122877754  [KO:K04637]
122877851  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
122877877  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
122877921  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122877969  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
122877981  [KO:K08041] [EC:4.6.1.1]
122877993  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122878002  fgf22; fibroblast growth factor 22 [KO:K04358]
122878068  [KO:K01116] [EC:3.1.4.11]
122878183  ntrk3b; LOW QUALITY PROTEIN: NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
122878298  grin3bb; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
122878323  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
122878365  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
122878382  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
122878457  [KO:K05219]
122878663  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
122878820  [KO:K00871] [EC:2.7.11.19]
122878951  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
122879024  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
122879072  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
122879440  grm5b; metabotropic glutamate receptor 5b isoform X1 [KO:K04604]
122879451  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122879462  [KO:K22642]
122879636  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122879663  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
122879801  fgf20b; fibroblast growth factor 20b [KO:K04358]
122879818  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122879862  [KO:K04198]
122879865  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
122879881  chrna7a; neuronal acetylcholine receptor subunit alpha-7a isoform X1 [KO:K04809]
122879892  fgf2; fibroblast growth factor 2 [KO:K18497]
122879918  fgf16; fibroblast growth factor 16 [KO:K04358]
122879980  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
122880049  [KO:K04358]
122880065  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
122880119  [KO:K04358]
122880167  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
122880175  [KO:K04136]
122880236  si:ch73-22a13.3; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
122880286  [KO:K04809]
122880301  p2rx3a; P2X purinoceptor 3a [KO:K05217]
122880357  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122880497  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
122880534  vegfba; vascular endothelial growth factor A [KO:K05448]
122880564  hrh2a; histamine receptor H2a isoform X1 [KO:K04150]
122880573  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
122880594  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122880599  slc25a5; ADP/ATP translocase 2 [KO:K05863]
122880618  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
122880838  drd1a; D(1) dopamine receptor [KO:K04144]
122880858  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
122880946  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122881515  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122881549  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122881622  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
122881863  [KO:K04446]
122881924  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
122881933  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
122881997  [KO:K05212]
122882022  prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122882169  [KO:K04809]
122882429  ngfa; neurotrophin-7 [KO:K02582]
122882525  camk1gb; calcium/calmodulin-dependent protein kinase IGb isoform X1 [KO:K08794] [EC:2.7.11.17]
122882704  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122882719  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
122882809  [KO:K12042]
122882810  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
122882919  [KO:K04857]
122882987  tnnc1b; troponin C type 1b (slow) [KO:K05865]
122883015  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
122883072  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
122883099  atp2b3b; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
122883134  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122883241  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
122883424  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
122883495  ntsr1; neurotensin receptor type 1 [KO:K04211]
122883581  tnnc1a; troponin C type 1a (slow) [KO:K05865]
122883643  [KO:K04282]
122883686  [KO:K08794] [EC:2.7.11.17]
122883778  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
122883895  lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
122884075  camk2g2; calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122884142  [KO:K06268]
122884289  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122884314  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122884336  [KO:K04163]
122884386  ppifa; peptidylprolyl isomerase Fa [KO:K09565] [EC:5.2.1.8]
122884485  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
122884627  ngfb; nerve growth factor [KO:K02582]
122884629  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
122884740  [KO:K05858] [EC:3.1.4.11]
122884743  chrm3a; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
122884744  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
122884802  [KO:K04248]
122884853  [KO:K17332]
122884854  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
122884887  [KO:K05840]
122884948  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
122884956  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
122885075  fgf9; fibroblast growth factor 4A [KO:K04358]
122885236  mst1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
122885282  [KO:K02183]
122885290  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122885341  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
122885383  [KO:K04194]
122885438  casq2; calsequestrin-2 [KO:K23445]
122885453  [KO:K05100] [EC:2.7.10.1]
122885592  [KO:K05085] [EC:2.7.10.1]
122885785  [KO:K04198]
122885842  htr2aa; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
122886069  [KO:K04169]
122886089  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
122886155  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
122886268  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122886551  mcoln3a; mucolipin-3 [KO:K04994]
122886560  [KO:K04633]
122886615  [KO:K04189]
122886763  pde1cb; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
122887074  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122887167  ednrba; endothelin receptor Ba [KO:K04198]
122887219  casq1a; calsequestrin-1a [KO:K23468]
122887381  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122887397  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122887400  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122887421  [KO:K08041] [EC:4.6.1.1]
122887472  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
122887493  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
122887507  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1 [KO:K05857] [EC:3.1.4.11]
122887798  [KO:K16059]
122887900  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
122887934  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
122887983  orai2; protein orai-2 [KO:K16057]
122888025  camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
122888104  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
122888111  adora2b; adenosine receptor A2b [KO:K04267]
122888154  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
122888176  grm5a; glutamate receptor, metabotropic 5a isoform X1 [KO:K04604]
122888178  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122888272  [KO:K05089] [EC:2.7.10.1]
122888332  [KO:K04142]
122888350  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
122888510  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122888570  hrh2b; histamine receptor H2b [KO:K04150]
122888670  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
122888696  drd1b; dopamine receptor D1b [KO:K04144]
122888718  [KO:K04136]
122888733  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
122888753  [KO:K18496]
122888781  [KO:K04961]
122888786  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
schu04010  MAPK signaling pathway
schu04070  Phosphatidylinositol signaling system
schu04210  Apoptosis
KO pathway
ko04020   

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