KEGG   PATHWAY: sind03015
Entry
sind03015                   Pathway                                
Name
mRNA surveillance pathway - Sesamum indicum (sesame)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
sind03015  mRNA surveillance pathway
sind03015

Other DBs
GO: 0071028
Organism
Sesamum indicum (sesame) [GN:sind]
Gene
105175094  nuclear cap-binding protein subunit 1 [KO:K12882]
105175364  nuclear cap-binding protein subunit 2 [KO:K12883]
105172520  regulator of nonsense transcripts UPF3-like [KO:K14328]
105169421  regulator of nonsense transcripts UPF3-like [KO:K14328]
105163640  RNA-binding protein 8A [KO:K12876]
105170907  RNA-binding protein 8A [KO:K12876]
105160662  protein mago nashi homolog [KO:K12877]
105179194  protein mago nashi homolog [KO:K12877]
105159075  eukaryotic initiation factor 4A-3 isoform X1 [KO:K13025] [EC:5.6.2.7]
105164974  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
105166109  histone deacetylase complex subunit SAP18 [KO:K14324]
105169168  pinin [KO:K13114]
105176487  histone acetyltransferase KAT6A [KO:K12875]
105176526  serine/arginine-rich splicing factor SR45 [KO:K14325]
105175064  serine/arginine-rich splicing factor SR45 isoform X2 [KO:K14325]
105170644  THO complex subunit 4A [KO:K12881]
105174434  THO complex subunit 4A [KO:K12881]
105176361  THO complex subunit 4D isoform X2 [KO:K12881]
105174226  DEAD-box ATP-dependent RNA helicase 38 isoform X1 [KO:K18655] [EC:5.6.2.7]
105168333  protein GLE1 [KO:K18723]
105156085  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:5.6.2.7]
105164585  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
105169162  partner of Y14 and mago [KO:K14294]
105172572  partner of Y14 and mago [KO:K14294]
105163886  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
105161563  mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
105161296  mRNA cap guanine-N7 methyltransferase 2 [KO:K00565] [EC:2.1.1.56]
105174798  mRNA cap guanine-N7 methyltransferase 1 isoform X1 [KO:K00565] [EC:2.1.1.56]
105176745  mRNA cap guanine-N7 methyltransferase 1 [KO:K00565] [EC:2.1.1.56]
105163938  transcription initiation factor TFIID subunit 15b [KO:K13098]
105160673  polyadenylate-binding protein 1 [KO:K14396]
105169244  polyadenylate-binding protein 2-like isoform X1 [KO:K14396]
105166947  polyadenylate-binding protein 1 [KO:K14396]
105176444  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
105172613  polyadenylate-binding protein 2-like [KO:K14396]
105160489  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
105161889  pre-mRNA cleavage factor Im 25 kDa subunit 1 [KO:K14397]
105166668  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
105156664  cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
105176598  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit CG7185-like [KO:K14398]
105175160  uncharacterized protein LOC105175160 [KO:K14398]
105156340  nuclear poly(A) polymerase 1 [KO:K14376] [EC:2.7.7.19]
105160462  nuclear poly(A) polymerase 1-like [KO:K14376] [EC:2.7.7.19]
105157694  nuclear poly(A) polymerase 4-like isoform X1 [KO:K14376] [EC:2.7.7.19]
105163656  nuclear poly(A) polymerase 4-like isoform X1 [KO:K14376] [EC:2.7.7.19]
105178237  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
105159100  polyadenylation and cleavage factor homolog 4 isoform X1 [KO:K14400]
105179553  LOW QUALITY PROTEIN: polyadenylation and cleavage factor homolog 4-like [KO:K14400]
105174118  polyadenylation and cleavage factor homolog 4 isoform X1 [KO:K14400]
105179235  cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
105166679  cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
105169117  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
105167270  30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404]
105175783  30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404]
105172298  uncharacterized protein LOC105172298 [KO:K14404]
105169750  flowering time control protein FY isoform X1 [KO:K15542]
105178149  protein ANTHESIS POMOTING FACTOR 1 isoform X2 [KO:K14962]
105176343  protein ANTHESIS POMOTING FACTOR 1 [KO:K14962]
105158455  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
105167119  serine/threonine-protein phosphatase PP1 isozyme 3 isoform X1 [KO:K06269] [EC:3.1.3.16]
105168929  serine/threonine-protein phosphatase PP1-like isoform X1 [KO:K06269] [EC:3.1.3.16]
105170449  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
105170456  serine/threonine-protein phosphatase PP1 isozyme 2-like [KO:K06269] [EC:3.1.3.16]
105171711  serine/threonine-protein phosphatase PP1 isozyme 3 isoform X2 [KO:K06269] [EC:3.1.3.16]
105171876  serine/threonine-protein phosphatase PP1 isoform X1 [KO:K06269] [EC:3.1.3.16]
105172393  serine/threonine-protein phosphatase PP1 isozyme 9 [KO:K06269] [EC:3.1.3.16]
105165811  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
105176886  cleavage stimulating factor 64 [KO:K14407]
105172853  cleavage stimulation factor subunit 77 [KO:K14408]
105159059  symplekin isoform X1 [KO:K06100]
105174569  symplekin [KO:K06100]
105165669  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
105177086  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
105177616  heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K14411]
105171748  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
105171750  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
105176615  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
105174937  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
105175256  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
110012746  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
105168752  30S ribosomal protein 2, chloroplastic [KO:K13126]
105157835  polyadenylate-binding protein 6 isoform X1 [KO:K13126]
105159137  polyadenylate-binding protein 8-like [KO:K13126]
105159138  polyadenylate-binding protein 8-like [KO:K13126]
105178857  polyadenylate-binding protein 3 [KO:K13126]
105174151  polyadenylate-binding protein 7 [KO:K13126]
105172706  polyadenylate-binding protein 2-like [KO:K13126]
105172707  polyadenylate-binding protein 2-like [KO:K13126]
105179514  polyadenylate-binding protein 7 [KO:K13126]
105161003  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
105159510  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
105176371  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
105177498  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
105178853  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
105155974  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105165822  regulator of nonsense transcripts UPF2 isoform X1 [KO:K14327]
105169593  LOW QUALITY PROTEIN: uncharacterized protein LOC105169593 [KO:K08873] [EC:2.7.11.1]
105159901  protein SMG7-like [KO:K14409]
105180149  protein SMG7 [KO:K14409]
105156575  serine/threonine-protein phosphatase PP2A catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
105168180  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
105168462  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
105170175  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like isoform X1 [KO:K04382] [EC:3.1.3.16]
105169250  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
105173386  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
105156399  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
105161209  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105157240  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
105163538  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105157725  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105161279  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
105171898  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
105172221  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
105156674  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
105161351  LOW QUALITY PROTEIN: serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
105164806  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform-like [KO:K11584]
105166573  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
105169812  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
105168665  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
105168362  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
105176280  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
105177382  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
105177383  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
105174181  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
105168522  HBS1-like protein isoform X1 [KO:K14416]
105166558  protein PELOTA 1 [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
sind03013  Nucleocytoplasmic transport
sind03018  RNA degradation
sind03040  Spliceosome
KO pathway
ko03015   
LinkDB

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