KEGG   PATHWAY: sluc04144
Entry
sluc04144                   Pathway                                
Name
Endocytosis - Sander lucioperca (pikeperch)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sluc04144  Endocytosis
sluc04144

Other DBs
GO: 0006897
Organism
Sander lucioperca (pikeperch) [GN:sluc]
Gene
116057942  arf6a; ADP-ribosylation factor 6a [KO:K07941]
116035601  arf6b; ADP-ribosylation factor 6b [KO:K07941]
116049525  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X2 [KO:K00889] [EC:2.7.1.68]
116047502  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116037298  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116063377  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X4 [KO:K00889] [EC:2.7.1.68]
116056706  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
116034728  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
116041450  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
116039990  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
116064856  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
116057457  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
116045653  dnm3b; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
116056974  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
116034945  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
116042795  dnm2b; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
116059432  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
116042908  clta; clathrin light chain A isoform X1 [KO:K04644]
116064405  cltb; clathrin light chain B isoform X1 [KO:K04645]
116058157  cltca; clathrin, heavy chain a (Hc) isoform X3 [KO:K04646]
116043862  clathrin heavy chain 1 isoform X1 [KO:K04646]
116054244  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
116043766  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
116045034  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
116055933  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
116037238  AP-2 complex subunit mu-A isoform X2 [KO:K11826]
116057056  AP-2 complex subunit mu-B-like [KO:K11826]
116047745  ap2s1; AP-2 complex subunit sigma [KO:K11827]
116045532  EH domain-containing protein 2-like [KO:K12469]
116041142  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
116065006  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
116066638  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
116046615  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
116047287  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116051004  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
116045823  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
116063227  zfyve9b; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
116050506  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116043529  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
116038466  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
116045518  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
116048550  tfr1b; transferrin receptor 1b isoform X1 [KO:K06503]
116046206  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116056499  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
116058814  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116039340  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116040274  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
116036735  fgfr3; fibroblast growth factor receptor 3 isoform X3 [KO:K05094] [EC:2.7.10.1]
116055969  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
116045678  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116057296  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116056043  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
116047981  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
116058320  cblb; E3 ubiquitin-protein ligase CBL-B-B isoform X1 [KO:K22517] [EC:2.3.2.27]
116042576  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
116048548  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
116036432  endophilin-A1-like [KO:K11247]
116037374  endophilin-A2-like isoform X2 [KO:K11247]
116045210  sh3gl3a; endophilin-A3a isoform X1 [KO:K11247]
116065654  sh3gl3b; endophilin-A3b isoform X1 [KO:K11247]
116063501  sh3gl1b; endophilin-A2 [KO:K11247]
116034273  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
116046319  sh3glb1a; endophilin-B1a [KO:K11248]
116057471  endophilin-B1-like [KO:K11248]
116041401  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
116050452  endophilin-B2-like isoform X1 [KO:K21269]
116044833  bin1b; myc box-dependent-interacting protein 1b isoform X2 [KO:K12562]
116049936  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
116064101  amph; amphiphysin isoform X1 [KO:K12562]
116059359  epn3a; epsin-3 isoform X1 [KO:K12471]
116043013  epn3b; epsin-3 isoform X2 [KO:K12471]
116049683  epn1; epsin-1 isoform X1 [KO:K12471]
116046364  epsin-1-like isoform X1 [KO:K12471]
116065228  epn2; epsin-2 isoform X1 [KO:K12471]
116043935  dentin sialophosphoprotein-like isoform X1 [KO:K12472]
116058754  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
116055260  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
116037093  sparta; spartin a isoform X1 [KO:K19366]
116048356  spartb; spartin b isoform X1 [KO:K19366]
116060531  nedd4a; E3 ubiquitin-protein ligase NEDD4a isoform X1 [KO:K10591] [EC:2.3.2.26]
116062788  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
116047922  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
116043440  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116043555  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
116051414  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
116040739  itchb; itchy E3 ubiquitin protein ligase b isoform X1 [KO:K05632] [EC:2.3.2.26]
116043036  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
116065242  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
116065443  E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
116055719  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
116040497  ldlrb; low-density lipoprotein receptor isoform X1 [KO:K12473]
116065316  ldlra; low density lipoprotein receptor a [KO:K12473]
116042482  ldlrap1b; low density lipoprotein receptor adapter protein 1b [KO:K12474]
116043258  si:dkey-19b23.8; low density lipoprotein receptor adapter protein 1 isoform X2 [KO:K12474]
116066309  si:dkey-71h2.2; LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1 [KO:K12474]
116041327  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
116062930  dab2; disabled homolog 2 isoform X1 [KO:K12475]
116035340  C-C chemokine receptor type 1-like isoform X1 [KO:K04180]
118496129  C-C chemokine receptor type 2-like [KO:K04180]
116035267  C-C chemokine receptor type 5-like [KO:K04180]
116044187  C-X-C chemokine receptor type 2-like isoform X1 [KO:K05050]
116044311  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
116037714  cxcr4b; C-X-C chemokine receptor type 4 [KO:K04189]
116055083  C-X-C chemokine receptor type 4-like [KO:K04189]
116045586  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
116046308  rhodopsin kinase GRK1-like [KO:K00909] [EC:2.7.11.14]
116064963  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
116048811  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
116034025  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
116041782  grk3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
116041785  grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
116055945  grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
116039552  grk4; G protein-coupled receptor kinase 4 isoform X2 [KO:K08291] [EC:2.7.11.16]
116057255  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
116057889  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
116044004  arrestin red cell-like [KO:K04439]
116065626  arrestin red cell isoform X3 [KO:K04439]
116041680  si:dkey-197j19.6; neural Wiskott-Aldrich syndrome protein [KO:K23612]
116060063  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
116036271  wasla; WASP like actin nucleation promoting factor a isoform X2 [KO:K23612]
116059209  actin-related protein 2-B [KO:K17260]
116053379  zgc:101810; actin-related protein 2 [KO:K17260]
116061799  actin-related protein 2-A [KO:K17260]
116057840  actin-related protein 3B-like isoform X1 [KO:K18584]
116035670  actin-related protein 3-like [KO:K18584]
116044500  actin-related protein 3 [KO:K18584]
116042845  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
116042922  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
116045089  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
116044451  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116035011  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116041524  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
116035524  actin-related protein 2/3 complex subunit 4 [KO:K05755]
116060354  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
116043988  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
116066956  wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
116062302  WAS/WASL-interacting protein family member 2-like isoform X1 [KO:K19475]
116049848  wipf2a; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
116061620  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
116049337  hsc70; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
116058073  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
116060866  heat shock 70 kDa protein 1 [KO:K03283]
116047557  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
116040740  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
116039120  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
116038329  washc4; WASH complex subunit 4 isoform X2 [KO:K18465]
116035290  washc5; WASH complex subunit 5 [KO:K18464]
116054075  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
116045630  wash1; WASH complex subunit 1 isoform X1 [KO:K18461]
116060115  washc3; WASH complex subunit 3 [KO:K18463]
116051556  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
116036291  F-actin-capping protein subunit alpha-2 [KO:K10364]
116061971  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
116041608  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
116036800  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
116058239  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
116060705  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
116047549  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
116041243  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
116066237  snx3; sorting nexin-3 [KO:K17918]
116037027  snx12; sorting nexin-12 isoform X2 [KO:K17918]
116054634  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
116054043  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
116041682  ras-related protein rab7-like [KO:K07897]
116035362  rab7a; ras-related protein Rab-7a [KO:K07897]
116035995  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
116059498  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
116066873  stam2; signal transducing adapter molecule 2 [KO:K04705]
116045943  stam; signal transducing adapter molecule 1 [KO:K04705]
116038739  tsg101a; tumor susceptibility 101a [KO:K12183]
116042820  mvb12a; multivesicular body subunit 12A [KO:K12186]
116050546  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
116038264  mvb12ba; multivesicular body subunit 12Ba [KO:K12186]
116047469  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
116042895  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
116045735  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
116047655  vps37ba; VPS37B subunit of ESCRT-I a isoform X1 [KO:K12185]
116056099  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
116061301  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
116064764  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
116060967  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
116059494  charged multivesicular body protein 6-like isoform X1 [KO:K12195]
116061017  chmp6b; charged multivesicular body protein 6 [KO:K12195]
116051122  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
116040162  charged multivesicular body protein 4b-like isoform X1 [KO:K12194]
116040688  charged multivesicular body protein 4b [KO:K12194]
116045356  chmp4c; charged multivesicular body protein 4c [KO:K24782]
116035642  chmp3; charged multivesicular body protein 3 [KO:K12193]
116061303  chmp2a; charged multivesicular body protein 2a [KO:K12191]
116037741  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
116050566  chmp7; charged multivesicular body protein 7 [KO:K15053]
116058924  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
116046057  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
116040159  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
116045371  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
116036606  charged multivesicular body protein 1b-like [KO:K12197]
116040161  chmp1a; charged multivesicular body protein 1a [KO:K12197]
116064888  charged multivesicular body protein 1b [KO:K12197]
116045323  chmp5b; charged multivesicular body protein 5 [KO:K12198]
116045954  chmp5a; charged multivesicular body protein 5 [KO:K12198]
116067746  ist1; IST1 homolog isoform X1 [KO:K19476]
116066920  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
116041252  spg21; maspardin [KO:K19367]
116060332  igf2r; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
116043409  sorting nexin-1 [KO:K17917]
116054071  snx2; sorting nexin-2 isoform X2 [KO:K17917]
116062045  snx1a; sorting nexin-1a [KO:K17917]
116051500  snx5; sorting nexin-5 [KO:K17920]
118494559  sorting nexin-6-like [KO:K17920]
116039070  snx6; sorting nexin-6 [KO:K17920]
116065849  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
116043666  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116051428  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
116038742  GTPase HRas [KO:K02833]
116042721  uncharacterized protein LOC116042721 isoform X2 [KO:K05069]
116065251  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
116037024  cytokine receptor common subunit gamma-like [KO:K05070]
116058705  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
116051439  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
116041618  rho-related GTP-binding protein RhoA-B [KO:K04513]
116038421  rho-related GTP-binding protein RhoA-D [KO:K04513]
116040854  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
116047044  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116039732  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116046375  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
116051694  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
116037655  major histocompatibility complex class I-related gene protein-like [KO:K06751]
118493475  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116039733  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116047040  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116046343  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116046344  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
116046371  major histocompatibility complex class I-related gene protein-like isoform X2 [KO:K06751]
116046376  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116062343  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116046442  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116047035  major histocompatibility complex class I-related gene protein-like isoform X2 [KO:K06751]
116047037  major histocompatibility complex class I-related gene protein-like isoform X2 [KO:K06751]
116047038  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116045603  folr; folate receptor [KO:K13649]
116065299  rtbdn; retbindin [KO:K13649]
116036240  cav1; caveolin-1 [KO:K06278]
116041703  caveolin-2-like [KO:K12958]
116051572  zgc:172270; caveolin-2 [KO:K12958]
116036393  cav2; caveolin-2 [KO:K12958]
116040623  zgc:158296; caveolin-2 [KO:K12958]
116041723  cav3; caveolin-3 [KO:K12959]
116066130  ehd3; EH domain-containing protein 3 [KO:K12476]
116058060  ehd4; EH domain-containing protein 4 [KO:K12477]
116062346  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
116066840  rab5aa; ras-related protein Rab-5A [KO:K07887]
116036000  rab5ab; ras-related protein Rab-5A [KO:K07887]
116047637  rab5b; ras-related protein Rab-5B [KO:K07888]
116059728  rab5c; ras-related protein Rab-5C [KO:K07889]
116061315  ras-related protein Rab-5C-like [KO:K07889]
116056115  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
116062016  rabenosyn-5 [KO:K12481]
116060530  rab4a; ras-related protein Rab-4A [KO:K07879]
116060665  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
116064246  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
116052547  ehd1a; EH domain-containing protein 1a [KO:K12483]
116050032  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
116042066  sorting nexin-4-like [KO:K17919]
116049910  sorting nexin-4-like isoform X1 [KO:K17919]
116051426  rab22a; ras-related protein Rab-22A [KO:K07891]
116045848  rab31; ras-related protein Rab-31 [KO:K07891]
116066366  rab10; ras-related protein Rab-10 [KO:K07903]
116045892  ras-related protein Rab-8A-like [KO:K07901]
116055234  ras-related protein Rab-8A [KO:K07901]
116051667  rab35b; ras-related protein Rab-35b isoform X1 [KO:K07876]
116063785  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
116067298  ras-related protein Rab-11A [KO:K07904]
116035957  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
116037391  ras-related protein Rab-11B [KO:K07905]
116063391  ras-related protein Rab-11B-like [KO:K07905]
116063392  ras-related protein Rab-11B-like [KO:K07905]
116052584  rab11 family-interacting protein 1 isoform X1 [KO:K12484]
116053868  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
116039396  rab11 family-interacting protein 2 isoform X2 [KO:K12484]
116057616  rab11fip5a; uncharacterized protein rab11fip5a [KO:K12484]
116035043  rab11fip1b; trichohyalin isoform X1 [KO:K12484]
116043089  zfyve27; protrudin isoform X1 [KO:K19368]
116051364  kif5ab; kinesin heavy chain isoform X1 [KO:K10396]
116044913  kinesin-1 heavy chain [KO:K10396]
116064169  kinesin heavy chain-like [KO:K10396]
116048619  kinesin heavy chain isoform X1 [KO:K10396]
116041080  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396]
116048939  kinesin-1 heavy chain isoform X1 [KO:K10396]
116044249  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
116063166  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
116040448  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
116044926  pard3ab; par-3 family cell polarity regulator alpha, b isoform X2 [KO:K04237]
116064851  partitioning defective 3 homolog isoform X1 [KO:K04237]
116047424  pard6gb; par-6 family cell polarity regulator gamma b isoform X1 [KO:K06093]
116040212  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
116041083  pard6b; partitioning defective 6 homolog beta [KO:K06093]
116058169  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116045919  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
116049717  cdc42l; cell division cycle 42, like [KO:K04393]
116043633  cell division control protein 42 homolog isoform X1 [KO:K04393]
116046410  cell division control protein 42 homolog [KO:K04393]
116055515  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116042860  stromal membrane-associated protein 1-like [KO:K12486]
116067057  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
116044110  smap1; stromal membrane-associated protein 1 [KO:K12486]
116046559  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
116056875  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
116034939  ARF GTPase-activating protein GIT2-like isoform X2 [KO:K12487]
116035532  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X2 [KO:K12488]
116045268  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
116061337  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b isoform X1 [KO:K12488]
116037593  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
116047819  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
116067382  acap3b; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b isoform X1 [KO:K12489]
116043750  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
116055374  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
116057152  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein isoform X1 [KO:K12489]
116048987  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
116045550  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
116043305  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
116062362  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18440]
116051159  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12490]
116044455  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
116045988  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
116066200  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
116059409  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
116066757  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
116067170  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
116060097  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
116052813  uncharacterized protein LOC116052813 [KO:K12494]
116060938  uncharacterized protein LOC116060938 isoform X1 [KO:K12494]
116036500  psd2; PH and SEC7 domain-containing protein 2 [KO:K12494]
116034991  PH and SEC7 domain-containing protein 4 [KO:K12494]
116059987  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
116043575  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
116036507  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
116045652  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
116062059  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
116059899  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
116049608  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
116042632  cyth4b; cytohesin 4b isoform X1 [KO:K18441]
116059313  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
116059537  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
116044233  cytohesin-3 [KO:K18441]
116061279  cytohesin-1-like isoform X1 [KO:K18441]
116063940  cytohesin-4-like isoform X1 [KO:K18441]
116037864  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X4 [KO:K18442]
116041082  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
116050378  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4 [KO:K18443]
116059491  arf2a; ADP-ribosylation factor 2a [KO:K07937]
116061143  arf2b; ADP-ribosylation factor 2b [KO:K07937]
116045979  arf1; ADP-ribosylation factor 1 [KO:K07937]
116041711  arf3b; ADP-ribosylation factor 3b [KO:K07938]
116038822  arf3a; ADP-ribosylation factor 3a [KO:K07938]
116045648  ADP-ribosylation factor 5-like [KO:K07939]
116065890  ADP-ribosylation factor 4 [KO:K07939]
116037526  ADP-ribosylation factor 2-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sluc04060  Cytokine-cytokine receptor interaction
sluc04070  Phosphatidylinositol signaling system
sluc04130  SNARE interactions in vesicular transport
sluc04142  Lysosome
sluc04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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