Entry Name FoxO signaling pathway - Sinocyclocheilus rhinocerous
Description The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Sinocyclocheilus rhinocerous [GN:
srx ]
Gene 107738715 mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605 ]
107748643 5'-AMP-activated protein kinase subunit beta-2-like isoform X1 [KO:K07199 ]
107711714 5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200 ]
107750059 5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200 ]
107757712 5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200 ]
107729655 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
107757841 slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191 ]
107718208 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107718809 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
107719529 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
107708832 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107747314 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107717145 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
107730332 phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649 ]
107722495 phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
107731623 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
107709897 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
107727530 pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
107738919 phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649 ]
107711700 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
107714923 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848 ]
107731003 signal transducer and activator of transcription 3-like [KO:K04692 ]
107754129 signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
107727064 sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099 ]
107744263 cyclin-dependent kinase 4 inhibitor D-like isoform X1 [KO:K06623 ]
107711842 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107716939 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107733895 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107724875 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107706329 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107747145 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107743369 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107738256 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107705317 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107706448 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107757925 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107708506 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107708507 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107712839 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
107739860 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
107741286 tumor necrosis factor ligand superfamily member 6-like [KO:K04721 ]
107725847 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
107721849 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
107717070 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
107706607 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
107725129 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
107750884 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
107753263 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
107740242 gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
107726389 gamma-aminobutyric acid receptor-associated protein-like [KO:K08341 ]
107724707 gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341 ]
107744286 gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
107728423 gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
107744462 gamma-aminobutyric acid receptor-associated protein-like [KO:K08341 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Glauser DA, Schlegel W
Title The emerging role of FOXO transcription factors in pancreatic beta cells.
Journal Reference Authors van der Horst A, Burgering BM
Title Stressing the role of FoxO proteins in lifespan and disease.
Journal Reference Authors Zhang X, Tang N, Hadden TJ, Rishi AK
Title Akt, FoxO and regulation of apoptosis.
Journal Reference Authors Eijkelenboom A, Burgering BM
Title FOXOs: signalling integrators for homeostasis maintenance.
Journal Reference Authors Daitoku H, Fukamizu A
Title FOXO transcription factors in the regulatory networks of longevity.
Journal Reference Authors Hedrick SM
Title The cunning little vixen: Foxo and the cycle of life and death.
Journal Reference Authors Coffer PJ, Burgering BM
Title Forkhead-box transcription factors and their role in the immune system.
Journal Reference Authors Ro SH, Liu D, Yeo H, Paik JH
Title FoxOs in neural stem cell fate decision.
Journal Reference Authors Maiese K, Chong ZZ, Shang YC
Title OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
Journal Reference Authors Hagenbuchner J, Ausserlechner MJ
Title Mitochondria and FOXO3: breath or die.
Journal Reference Authors Maiese K, Chong ZZ, Shang YC
Title "Sly as a FOXO": new paths with Forkhead signaling in the brain.
Journal Reference Authors Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
Title STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
Journal Reference Authors Huang H, Tindall DJ
Title Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
Journal Reference Authors Greer EL, Brunet A
Title FOXO transcription factors at the interface between longevity and tumor suppression.
Journal Reference Authors Seoane J, Le HV, Shen L, Anderson SA, Massague J
Title Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Journal Reference Authors Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
Title Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
Journal Reference Authors van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
Title FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
Journal Reference Authors Zhang Y, Gan B, Liu D, Paik JH
Title FoxO family members in cancer.
Journal Reference Authors Van Der Heide LP, Hoekman MF, Smidt MP
Title The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
Journal Related KO pathway LinkDB All DBs
