KEGG   PATHWAY: ptao04621
Entry
ptao04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Phyllopteryx taeniolatus (common seadragon)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
ptao04621  NOD-like receptor signaling pathway
ptao04621

Organism
Phyllopteryx taeniolatus (common seadragon) [GN:ptao]
Gene
133464966  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
133465039  brcc3; lys-63-specific deubiquitinase [KO:K11864] [EC:3.4.19.-]
133465148  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
133465533  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
133466092  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133466243  txn2; thioredoxin, mitochondrial [KO:K03671]
133466246  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
133466487  ifnphi1; interferon phi 1 [KO:K05414]
133466492  [KO:K06071] [EC:2.7.11.13]
133467112  casr; extracellular calcium-sensing receptor [KO:K04612]
133467360  dhx33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
133467404  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
133467682  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
133467710  [KO:K06630]
133467963  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
133467992  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
133468019  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
133468030  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
133468076  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
133468256  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
133468257  [KO:K05858] [EC:3.1.4.11]
133468453  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
133469052  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133469133  [KO:K04467] [EC:2.7.11.10]
133469153  fadd; protein FADD [KO:K02373]
133469376  antxr1c; anthrax toxin receptor 1 [KO:K20909]
133469710  ifnphi4; interferon phi 4 [KO:K05414]
133469749  [KO:K15040]
133469821  irf3; interferon regulatory factor 3 [KO:K05411]
133470109  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
133470416  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
133470551  [KO:K11974] [EC:2.3.2.31]
133470890  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
133471024  txnipa; thioredoxin interacting protein a [KO:K20910]
133471405  [KO:K05405]
133471697  [KO:K17065] [EC:3.6.5.5]
133471939  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
133472032  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
133472175  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
133472326  rela; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
133472394  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
133472512  txn; thioredoxin [KO:K03671]
133472776  trip6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
133472875  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
133473358  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
133474157  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
133474232  [KO:K04982] [EC:2.7.11.1]
133474258  [KO:K12804]
133474315  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
133474405  [KO:K08009]
133474485  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
133474596  [KO:K03173] [EC:2.3.2.27]
133474829  antxr2a; ANTXR cell adhesion molecule 2a isoform X1 [KO:K20909]
133474857  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133474919  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
133474935  il1b; interleukin-1 beta [KO:K04519]
133475038  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
133475135  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
133475138  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
133475520  antxr1a; anthrax toxin receptor 1 isoform X1 [KO:K20909]
133475750  [KO:K05220]
133476390  [KO:K03443]
133476575  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
133476686  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
133477042  [KO:K10030]
133477043  [KO:K10030]
133477199  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
133477578  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
133477684  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
133477708  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
133477782  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
133478102  [KO:K04513]
133478109  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
133478133  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
133478357  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a isoform X1 [KO:K12804]
133478909  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
133479006  gprc6a; G-protein coupled receptor family C group 6 member A [KO:K04622]
133479235  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
133479255  atg5; autophagy protein 5 [KO:K08339]
133479793  [KO:K12799]
133479860  atg12; ubiquitin-like protein ATG12 [KO:K08336]
133480559  jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
133480595  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
133480641  nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
133480845  [KO:K21421] [EC:1.-.-.-]
133481114  jun; transcription factor AP-1 [KO:K04448]
133481178  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
133481396  mfn1b; mitofusin-1b isoform X1 [KO:K21356] [EC:3.6.5.-]
133481912  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
133481934  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
133482023  [KO:K03443]
133482321  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
133482418  [KO:K01370] [EC:3.4.22.36]
133482658  [KO:K17890]
133483029  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
133483033  [KO:K06068] [EC:2.7.11.13]
133483087  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
133483294  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
133483313  stat2; signal transducer and activator of transcription 2 [KO:K11221]
133483373  [KO:K04513]
133483847  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
133484161  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A isoform X1 [KO:K10435]
133484190  [KO:K04513]
133484192  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
133484206  [KO:K04958]
133484364  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
133484417  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
133484743  map1lc3cl; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
133484904  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
133485215  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
133485477  bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
133485515  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
133485597  antxr1d; anthrax toxin receptor 1 isoform X1 [KO:K20909]
133485601  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133485724  [KO:K15040]
133485836  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
133485849  [KO:K04467] [EC:2.7.11.10]
133485980  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
133486338  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
133486453  mfn2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
133486548  [KO:K05130]
133486549  crfb2; cytokine receptor family member b2 isoform X1 [KO:K05131]
133486638  trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
133486779  [KO:K04513]
133487075  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
133487166  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
133487630  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
133487636  [KO:K04622]
133487956  traf3; TNF receptor-associated factor 3 [KO:K03174]
133488098  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
133488201  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
133488455  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
133488470  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
133488484  pkn2a; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
133488498  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
133488575  rnf31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
133488582  [KO:K04448]
133488714  [KO:K20894]
133488897  sugt1; protein SGT1 homolog [KO:K12795]
133489522  ripk1l; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
133489540  [KO:K08846] [EC:2.7.11.1]
133489938  erbin; erbin isoform X1 [KO:K12796]
133490065  antxr1b; anthrax toxin receptor 1 [KO:K20909]
133490079  [KO:K20909]
133490230  [KO:K03173] [EC:2.3.2.27]
133490304  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
133490325  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
ptao04010  MAPK signaling pathway
ptao04140  Autophagy - animal
ptao04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

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