KEGG ORTHOLOGY: K10165

ORTHOLOGY: K10165

Entry

K10165                      KO

Symbol

NOD2, CARD15

Name

nucleotide-binding oligomerization domain-containing protein 2

Pathway

map04621

NOD-like receptor signaling pathway

map04668

TNF signaling pathway

map05152

Tuberculosis

map05321

Inflammatory bowel disease

Disease

H00285

Blau syndrome

H00286

Crohn disease

H01227

Inflammatory bowel disease (IBD)

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
  09163 Immune disease
   05321 Inflammatory bowel disease
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
Pattern recognition receptors [BR:ko04054]
Cytoplasmic pattern recognition receptors
  NOD-like receptors
   K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2

Genes

HSA:	64127(NOD2)

PTR:	454083(NOD2)

PPS:	100986116(NOD2)

GGO:	101129872(NOD2)

PON:	100440517(NOD2)

PPYG:

129015915(NOD2)

NLE:	100590851(NOD2)

HMH:	116471250(NOD2)

SSYN:

129492547(NOD2)

MCC:	695542(NOD2)

MCF:	102129800(NOD2)

MTHB:

126944903

MNI:	105492256(NOD2)

CSAB:

103232735(NOD2)

CATY:

105588835(NOD2)

PANU:

101002463(NOD2)

TGE:	112614372(NOD2)

MLEU:

105545641(NOD2)

RRO:	104672572(NOD2)

RBB:	108536321(NOD2)

TFN:	117087773(NOD2)

PTEH:

111541244(NOD2)

CANG:

105514951(NOD2)

CJC:	100414962(NOD2)

SBQ:	101034571(NOD2)

CIMI:

108305468(NOD2)

ANAN:

135277237 135277238(NOD2)

CSYR:

103259334(NOD2)

MMUR:

105871197(NOD2)

LCAT:

123625037(NOD2)

PCOQ:

105808868(NOD2)

OGA:	100961327(NOD2)

MMU:	257632(Nod2)

MCAL:

110300637(Nod2)

MPAH:

110337641(Nod2)

RNO:	291912(Nod2)

MCOC:

116069823(Nod2)

ANU:	117723222(Nod2)

ASYL:

127671735(Nod2)

MUN:	110560783(Nod2)

CGE:	100759694(Nod2)

MAUA:

101838071(Nod2)

PROB:

127229985(Nod2)

PLEU:

114708503(Nod2)

MORG:

121447371(Nod2)

MFOT:

126487162

AAMP:

119802037(Nod2)

NGI:	103730124(Nod2)

HGL:	101709371(Nod2)

CPOC:

100727812(Nod2)

CCAN:

109701706(Nod2)

DORD:

105994470(Nod2)

DSP:	122119374(Nod2)

DMER:

138820269(Nod2) 138839250

PLOP:

125358471(Nod2)

NCAR:

124966855

MMMA:

107144876(Nod2)

ITI:	101966373(Nod2)

OCU:	100356594 127487649

OPI:	101519922(NOD2)

TUP:	102497846(NOD2) 102500527

GVR:

103608208

CFA:	487286(NOD2)

CLUD:

112660146(NOD2)

VVP:	112929606(NOD2)

VLG:	121498130(NOD2)

NPO:	129513782(NOD2)

AML:	100469482(NOD2)

UMR:	103673911(NOD2)

UAH:	113252225(NOD2)

UAR:	123798397(NOD2)

ELK:

111157341

LLV:

125089231

MPUF:

101687569(NOD2)

MNP:	132005391(NOD2)

MLK:	131818263(NOD2)

NVS:	122911461(NOD2)

ORO:	101374813(NOD2)

EJU:	114199811(NOD2)

ZCA:	113936364(NOD2)

MLX:	118023796(NOD2)

NSU:	110593479(NOD2)

LWW:	102747207(NOD2)

FCA:	101096863(NOD2)

PYU:	121045276(NOD2)

PCOO:

112857305(NOD2)

PBG:	122494191(NOD2)

PVIV:

125153196(NOD2)

LRUF:

124511311

LGF:	123579134(NOD2)

AJU:

106977676

PTG:	102972059(NOD2)

PPAD:

109270946(NOD2)

PUC:

125915409

PLEZ:

122208363(NOD2)

HHV:	120237980(NOD2)

BTA:	444867(NOD2)

BOM:	102265346(NOD2)

BIU:	109572753(NOD2)

BBUB:

102390227(NOD2)

BBIS:

104999593(NOD2)

CHX:	102186424(NOD2)

OAS:	780465(NOD2)

BTAX:

128063305(NOD2)

CSUM:

138096661(NOD2)

ODA:	120872807(NOD2)

CCAD:

122420892(NOD2)

MREE:

136160970(NOD2)

OVR:	110136083(NOD2)

MBEZ:

129547114(NOD2)

SSC:	100125838(NOD2)

CFR:	102504506(NOD2)

CBAI:

105074268(NOD2)

CDK:	105097522(NOD2)

VPC:	102528524(NOD2)

BACU:

103020823(NOD2)

BMUS:

118885953(NOD2)

LVE:	103077202(NOD2)

OOR:	101271819(NOD2)

LALB:

132509967(NOD2)

GMF:	115840299(NOD2)

DLE:	111164994(NOD2)

PCAD:

102992305(NOD2)

PSIU:

116743980(NOD2)

PPHC:

136141154(NOD2)

NASI:

112401250(NOD2)

ECB:	100059123(NOD2)

EPZ:	103556599(NOD2)

EAI:	106822712(NOD2)

MYB:	102252363(NOD2)

MYD:	102765180(NOD2)

MMYO:

118674383(NOD2)

MLF:	102438897(NOD2)

MDT:	132217594(NOD2)

MYUM:

138996704(NOD2)

PKL:	118720889(NOD2)

EFUS:

103295893(NOD2)

MNA:	107531027(NOD2)

DRO:	112296773(NOD2)

SHON:

119001134(NOD2)

AJM:	119046462(NOD2)

PDIC:

114488239(NOD2)

PHAS:

123805853(NOD2)

MMF:	118639113(NOD2)

PPAM:

129068128(NOD2)

HAI:	109383342(NOD2)

RFQ:	117035598(NOD2)

PALE:

102881890(NOD2)

PGIG:

120617260(NOD2)

PVP:	105292084(NOD2)

RAY:	107512244(NOD2)

MJV:	108408571(NOD2)

TOD:	119248887(NOD2)

SARA:

101550117(NOD2)

SFUM:

130043936(NOD2)

SETR:

126027085(NOD2)

LAV:	100677763(NOD2)

TMU:

101340794

ETF:	101661310(NOD2)

DNM:	101444788(NOD2)

MDO:	100018299(NOD2)

GAS:	123235301(NOD2)

SHR:	100931097(NOD2)

AFZ:

127550701

PCW:	110207478(NOD2)

TVP:	118843575(NOD2)

PBRV:

138157063(NOD2)

OAA:	100090933(NOD2)

TACU:

119934630(NOD2)

XLA:	108713994(nod2l.L)

NPR:	108792772(NOD2)

ACAT:

141112306(NOD2)

BBUF:

120980301(NOD2)

BGAR:

122920582(NOD2)

DTC:	141089700(NOD2)

PWL:	138267473(NOD2)

GSH:	117359673(NOD2)

DRE:	777696(nod2)

SRX:	107742770 107750230

SANH:

107657121 107696706

SGH:	107550289 107551491

CCAR:

109068656 109113603

CAUA:

113051415 113106057

CGIB:

127961585 128016848

PTET:

122348386(nod2)

LROH:

127168013(nod2)

GRF:	141331980(nod2)

OMC:	131544961(nod2)

PPRM:

120468656(nod2)

RKG:	130069756(nod2)

MAMB:

125265063(nod2)

CIDE:

127515225

CERY:

137031342(nod2)

MASI:

127444217 127450049

TROS:

130557137(nod2)

TDW:	130428518(nod2)

MANU:

129444835(nod2)

PDAB:

135778893(nod2)

IPU:	100379166(nod2)

IFU:	128602783(nod2)

PHYP:

113541009(nod2)

SMEO:

124380155(nod2)

TFD:	113648465(nod2)

TVC:	132838879(nod2)

CGAR:

128519489(nod2)

NGRA:

132875267(nod2)

TRN:	134304020(nod2)

AMEX:

103045336(nod2)

CMAO:

118817664(nod2)

EEE:	113585364(nod2)

CHAR:

105899761(nod2) 105909368

SPIL:

134096078(nod2)

TRU:	724045(nod2)

TFS:	130513611(nod2)

LCO:	104940686(nod2)

NCC:	104958220(nod2)

TBEN:

117496709(nod2)

CGOB:

115028257(nod2)

PGEO:

117441096(nod2)

GACU:

117549154(nod2)

EMAC:

134863850(nod2)

ELY:	117251893(nod2)

EFO:	125879027(nod2)

PLEP:

121939067(nod2)

SLUC:

116037641(nod2)

ECRA:

117947517(nod2)

ESP:	116690303(nod2)

PFLV:

114561145(nod2)

GAT:	120812933(nod2)

PPUG:

119224275(nod2)

AFB:	129101580(nod2)

CLUM:

117728876(nod2)

PSWI:

130192558(nod2)

CANA:

137783315(nod2)

CVE:	137887867(nod2)

MSAM:

119890046(nod2)

SCHU:

122863685(nod2)

CUD:	121516240(nod2)

SPUL:

138585174(nod2)

LMIX:

132979672(nod2)

ALAT:

119017538(nod2)

ASTR:

137594212(nod2)

MZE:	101479180(nod2)

ONL:	100702947(nod2)

OAU:	116325623(nod2)

OLA:	101164467(nod2)

OML:	112161193(nod2)

CSAI:

133421499(nod2)

XMA:	102229465(nod2)

XCO:	114143165(nod2)

XHE:	116718573(nod2)

PRET:

103462648(nod2)

PFOR:

103138073(nod2)

PLAI:

106944704(nod2)

PMEI:

106914040(nod2)

GAF:	122820834(nod2)

PPRL:

129364170(nod2)

CVG:	107088493(nod2)

CTUL:

119797944(nod2)

GMU:	124867630(nod2)

NFU:

107379163

KMR:	108243321(nod2)

ALIM:

106517234(nod2)

NWH:	119430139(nod2)

AOCE:

111572260(nod2)

EJA:	138212996(nod2)

BFRE:

138616229(nod2)

MCEP:

125004979(nod2)

CSEM:

103398555(nod2)

POV:	109624923(nod2)

SSEN:

122772213(nod2)

SSOE:

131459128(nod2)

HHIP:

117759286(nod2)

HSP:	118097970(nod2)

PPLT:

128442193(nod2)

SMAU:

118301940(nod2)

LCF:

108876863

SDU:	111219530(nod2)

SLAL:

111651623 111672267(nod2)

XGL:	120795761(nod2)

HCQ:	109513982(nod2)

SSCV:

125967610(nod2)

SBIA:

133498328(nod2)

PEE:	133397722(nod2)

PTAO:

133474157(nod2)

BPEC:

110175243(nod2)

ENY:	140381350(nod2)

MALB:

109955896(nod2)

BSPL:

114852704(nod2)

SJO:	128356730(nod2)

SSCO:

134002386(nod2)

SASA:

106562391 106587579(nod2)

STRU:

115167029

OTW:	112239235(nod2)

OMY:	100529152(nod2)

OGO:	124033088(nod2)

ONE:	115116194 115116231

OKI:	109881664(nod2)

OKE:	118381069(nod2)

OMM:	135551009(nod2)

OCLA:

139412234

SALP:

111965017(nod2)

SNH:	120047979(nod2)

CCLU:

121535793(nod2)

ELS:	105025697(nod2)

OEP:	134028316(nod2)

SFM:	108932944(nod2)

PKI:	111832753(nod2)

AANG:

118227442(nod2)

AROT:

135255068(nod2)

CCOG:

133131680(nod2)

PSPA:

121296414(nod2)

ARUT:

117424718(nod2)

PSEX:

120535208(nod2)

LCM:	102355950(NOD2)

RTP:	109916031(nod2)

CPLA:

122558416(nod2)

LERI:

129705035(nod2)

HAKA:

140740657(nod2)

PMRN:

116952588 116956254

LRJ:	133353912 133353914 133357263

BBEL:

HAME:

MCAZ:

SPIS:

Reference

PMID:23806334

Authors

Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M

Title

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.

Journal

Mol Cell 50:818-30 (2013)
DOI:10.1016/j.molcel.2013.06.004

Reference

PMID:11087742

Authors

Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G

Title

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.

Journal

J Biol Chem 276:4812-8 (2001)
DOI:10.1074/jbc.M008072200

Sequence

[hsa:64127]

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