KEGG   PATHWAY: ptr00230
Entry
ptr00230                    Pathway                                
Name
Purine metabolism - Pan troglodytes (chimpanzee)
Class
Metabolism; Nucleotide metabolism
Pathway map
ptr00230  Purine metabolism
ptr00230

Module
ptr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ptr00230]
ptr_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ptr00230]
ptr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ptr00230]
ptr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ptr00230]
ptr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ptr00230]
ptr_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ptr00230]
ptr_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ptr00230]
Other DBs
GO: 0006163 0042278
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
100533953  NME1; nucleoside diphosphate kinase A isoform X1 [KO:K00940] [EC:2.7.4.6]
100608010  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100608083  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
100608597  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X2 [KO:K12318] [EC:4.6.1.2]
100610494  URAD; LOW QUALITY PROTEIN: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
100611890  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
100614135  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X4 [KO:K01510] [EC:3.6.1.5]
104008182  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
107966544  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
107969275  [KO:K00940] [EC:2.7.4.6]
107970128  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X2 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
129135331  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X8 [KO:K13756] [EC:3.1.4.35]
450169  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
450306  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
450706  NT5C2; cytosolic purine 5'-nucleotidase isoform X8 [KO:K01081] [EC:3.1.3.5]
450902  ADK; adenosine kinase isoform X5 [KO:K00856] [EC:2.7.1.20]
450974  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
451041  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X3 [KO:K13296] [EC:3.1.4.17]
451405  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
451685  AMPD3; AMP deaminase 3 isoform X3 [KO:K01490] [EC:3.5.4.6]
451866  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
451962  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X3 [KO:K13755] [EC:3.1.4.17]
452569  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
452727  [KO:K12319] [EC:4.6.1.2]
452819  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
453027  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform X2 [KO:K01511] [EC:3.6.1.6]
453145  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
453612  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
453869  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
454474  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X5 [KO:K01081] [EC:3.1.3.5]
455093  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
456723  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
456908  PGM1; phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
456921  PDE4B; 3',5'-cyclic-AMP phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
456963  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
457144  AMPD1; AMP deaminase 1 isoform X2 [KO:K01490] [EC:3.5.4.6]
457329  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
457498  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
457865  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X2 [KO:K01939] [EC:6.3.4.4]
458146  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X2 [KO:K01511] [EC:3.6.1.6]
458631  ADA2; adenosine deaminase 2 isoform X2 [KO:K19572] [EC:3.5.4.4]
459024  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X3 [KO:K10808] [EC:1.17.4.1]
459070  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
459328  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
459797  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
459925  ATIC; bifunctional purine biosynthesis protein ATIC isoform X2 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
460286  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
460343  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
460362  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X4 [KO:K00088] [EC:1.1.1.205]
460797  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
461041  [KO:K13756] [EC:3.1.4.35]
461162  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
461273  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
461309  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
461422  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
461461  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X2 [KO:K13762] [EC:3.1.4.35]
461565  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
461796  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
461833  AK6; adenylate kinase isoenzyme 6 isoform X3 [KO:K18532] [EC:2.7.4.3]
461860  PDE4D; 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
462184  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
462453  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
462679  [KO:K11265] [EC:4.6.1.1]
462740  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X4 [KO:K18424] [EC:3.6.1.29]
462864  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
463000  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
463002  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
463123  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
463334  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
463392  ADCY1; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
463864  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X7 [KO:K00088] [EC:1.1.1.205]
464056  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
464213  PDE7A; high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3 [KO:K18436] [EC:3.1.4.53]
464400  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
464756  AK1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
464817  AK8; adenylate kinase 8 isoform X2 [KO:K00939] [EC:2.7.4.3]
464883  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
464977  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
465053  [KO:K00088] [EC:1.1.1.205]
465056  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
465084  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
465329  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
465800  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
465806  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
466140  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
466203  [KO:K22600] [EC:4.6.1.2]
466769  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
467568  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X4 [KO:K01939] [EC:6.3.4.4]
467867  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
468345  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
469289  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
469403  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
469570  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
470294  ALLC; probable inactive allantoicase isoform X2 [KO:K01477] [EC:3.5.3.4]
470316  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X4 [KO:K01081] [EC:3.1.3.5]
470347  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
470484  NT5DC4; 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
470905  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
471236  PAICS; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
471246  NUDT9; ADP-ribose pyrophosphatase, mitochondrial precursor [KO:K13988] [EC:3.6.1.13]
472640  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
472832  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
472950  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
473278  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
473375  GUCY2C; guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
473569  [KO:K00088] [EC:1.1.1.205]
474020  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2 [KO:K13761] [EC:3.1.4.35]
735422  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
735894  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
736305  APRT; adenine phosphoribosyltransferase isoform X2 [KO:K00759] [EC:2.4.2.7]
736760  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
736974  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
737850  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
738319  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
740432  GUK1; guanylate kinase isoform X3 [KO:K00942] [EC:2.7.4.8]
740456  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
740616  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
741760  ADA; adenosine deaminase isoform X6 [KO:K01488] [EC:3.5.4.4]
742049  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X5 [KO:K13760]
744714  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
745051  GMPR2; GMP reductase 2 isoform X5 [KO:K00364] [EC:1.7.1.7]
745642  PDE4A; 3',5'-cyclic-AMP phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
745728  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X2 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
746011  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X2 [KO:K21138] [EC:3.1.7.2]
746086  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X5 [KO:K07023] [EC:3.1.3.89]
746726  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13759]
746982  ITPA; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
747260  FHIT; bis(5'-adenosyl)-triphosphatase isoform X7 [KO:K01522] [EC:3.6.1.29]
747541  PDE7B; 3',5'-cyclic-AMP phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
748497  AK9; adenylate kinase 9 isoform X3 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
748644  PDE4C; 3',5'-cyclic-AMP phosphodiesterase 4C isoform X3 [KO:K13293] [EC:3.1.4.53]
749165  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
750641  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ptr00030  Pentose phosphate pathway
ptr00220  Arginine biosynthesis
ptr00250  Alanine, aspartate and glutamate metabolism
ptr00260  Glycine, serine and threonine metabolism
ptr00340  Histidine metabolism
ptr00630  Glyoxylate and dicarboxylate metabolism
ptr00730  Thiamine metabolism
ptr00740  Riboflavin metabolism
ptr00790  Folate biosynthesis
KO pathway
ko00230   

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