Entry
Name
Autophagy - animal - Sylvia atricapilla (blackcap)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Sylvia atricapilla (blackcap) [GN:
sati ]
Gene
136357637 ATG9B; LOW QUALITY PROTEIN: autophagy-related protein 9B [KO:K17907 ]
136357689 SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245 ]
136358004 LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528 ]
136358452 MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
136359639 RAB1A; LOW QUALITY PROTEIN: ras-related protein Rab-1A [KO:K07874 ]
136359718 RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977 ]
136360344 VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
136360639 WDFY3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262 ]
136360773 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382 ] [EC:3.1.3.16 ]
136361595 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
136362529 AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985 ]
136362549 VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181 ]
136362612 ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603 ]
136362655 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
136362760 ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889 ]
136362902 ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906 ]
136363400 CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724 ]
136363558 TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650 ]
136363618 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
136363933 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
136364853 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
136365371 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
136365461 RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330 ]
136365496 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
136366086 ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337 ]
136366227 ITPR1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958 ]
136366353 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
136366446 MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
136367430 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
136367925 WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908 ]
136368030 ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
136368331 MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
136368348 TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247 ]
136368639 RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589 ]
136369046 VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182 ]
136369326 WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991 ]
136369438 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
136369498 WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908 ]
136369505 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
136370598 ATG4A; cysteine protease ATG4A isoform X1 [KO:K08342 ] [EC:3.4.22.-]
136370868 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
136371057 VPS11; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
136371313 DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402 ]
136371898 UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927 ]
136371928 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
136372191 PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
136372245 NBR1; LOW QUALITY PROTEIN: next to BRCA1 gene 1 protein [KO:K17987 ]
136372470 VAMP8; vesicle-associated membrane protein 8 isoform X1 [KO:K08512 ]
136373532 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
136373946 PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198 ] [EC:2.7.11.31 ]
136374216 C9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609 ]
136374658 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
136375256 UVRAG; UV radiation resistance-associated gene protein isoform X1 [KO:K21249 ]
Compound
C00350 Phosphatidylethanolamine
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Meijer AJ, Codogno P.
Title
Regulation and role of autophagy in mammalian cells.
Journal
Reference
Authors
Deretic V.
Title
Autophagy in innate and adaptive immunity.
Journal
Reference
Authors
Levine B, Yuan J.
Title
Autophagy in cell death: an innocent convict?
Journal
Reference
Authors
Tanida I, Ueno T, Kominami E.
Title
LC3 conjugation system in mammalian autophagy.
Journal
Reference
Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
Title
Autophagy in metazoans: cell survival in the land of plenty.
Journal
Reference
Authors
Reggiori F, Klionsky DJ.
Title
Autophagosomes: biogenesis from scratch?
Journal
Reference
Authors
Klionsky DJ, Emr SD.
Title
Autophagy as a regulated pathway of cellular degradation.
Journal
Reference
Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
Title
Lysosomal proteolysis in skeletal muscle.
Journal
Reference
Authors
He C, Klionsky DJ
Title
Regulation mechanisms and signaling pathways of autophagy.
Journal
Reference
Authors
Yang Z, Klionsky DJ
Title
An overview of the molecular mechanism of autophagy.
Journal
Reference
Authors
Yang Z, Klionsky DJ
Title
Mammalian autophagy: core molecular machinery and signaling regulation.
Journal
Reference
Authors
Chen Y, Klionsky DJ
Title
The regulation of autophagy - unanswered questions.
Journal
Reference
Authors
Mizushima N, Yoshimori T, Ohsumi Y
Title
The role of Atg proteins in autophagosome formation.
Journal
Reference
Authors
Russell RC, Yuan HX, Guan KL
Title
Autophagy regulation by nutrient signaling.
Journal
Reference
Authors
Noda NN, Fujioka Y
Title
Atg1 family kinases in autophagy initiation.
Journal
Related pathway
sati04141 Protein processing in endoplasmic reticulum
KO pathway