KEGG   PATHWAY: sati04140
Entry
sati04140                   Pathway                                
Name
Autophagy - animal - Sylvia atricapilla (blackcap)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
sati04140  Autophagy - animal
sati04140

Other DBs
GO: 0006914
Organism
Sylvia atricapilla (blackcap) [GN:sati]
Gene
136357637  ATG9B; LOW QUALITY PROTEIN: autophagy-related protein 9B [KO:K17907]
136357667  HMGB1; high mobility group protein B1 [KO:K10802]
136357689  SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245]
136358004  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
136358030  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
136358168  GORASP1; Golgi reassembly-stacking protein 1 [KO:K26797]
136358259  RHEB; GTP-binding protein Rheb [KO:K07208]
136358452  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
136358686  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
136358945  RRAGD; ras-related GTP-binding protein D [KO:K16186]
136358952  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
136358978  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
136359094  STX7; syntaxin-7 [KO:K08488]
136359341  [KO:K10586] [EC:2.3.2.23]
136359382  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
136359639  RAB1A; LOW QUALITY PROTEIN: ras-related protein Rab-1A [KO:K07874]
136359718  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
136360223  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
136360344  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
136360601  RAB33B; ras-related protein Rab-33B [KO:K07920]
136360639  WDFY3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
136360685  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
136360773  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
136361110  OPTN; optineurin isoform X1 [KO:K19946]
136361136  PRKCQ; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
136361298  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
136361407  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
136361595  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
136361624  KRAS; GTPase KRas isoform X1 [KO:K07827]
136362108  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
136362335  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
136362360  RRAS2; ras-related protein R-Ras2 [KO:K07830]
136362427  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
136362475  HRAS; GTPase HRas [KO:K02833]
136362483  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
136362526  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
136362529  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
136362549  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
136362580  VPS39; vam6/Vps39-like protein [KO:K20183]
136362612  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
136362655  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
136362672  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
136362760  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
136362789  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
136362823  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
136362902  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
136363178  INS; insulin [KO:K04526]
136363400  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
136363517  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
136363558  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
136363581  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
136363618  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
136363636  MRAS; ras-related protein M-Ras [KO:K07831]
136363933  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
136364206  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
136364355  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
136364366  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
136364387  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
136364401  PRAP1; proline-rich acidic protein 1 [KO:K21250]
136364853  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
136364928  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
136364950  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
136365083  ATG4C; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
136365107  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
136365371  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
136365461  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
136365496  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
136365497  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
136365555  ATG4B; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
136365614  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
136365646  IRS1; insulin receptor substrate 1 [KO:K16172]
136365903  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
136365952  RAB7A; ras-related protein Rab-7a [KO:K07897]
136366040  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
136366086  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
136366092  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
136366227  ITPR1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
136366353  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
136366446  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
136366623  STX17; syntaxin-17 [KO:K08491]
136366905  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
136366952  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
136367252  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
136367430  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
136367465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
136367483  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
136367925  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
136367970  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
136368004  TSC2; tuberin isoform X1 [KO:K07207]
136368010  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
136368030  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
136368230  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
136368331  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
136368348  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
136368497  BCL2L1; bcl-2-like protein 1 [KO:K04570]
136368555  [KO:K20402]
136368639  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
136368765  MTMR3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
136368906  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
136368917  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
136368958  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
136369046  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
136369064  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
136369326  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
136369438  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
136369498  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
136369505  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
136369759  TSC1; hamartin isoform X1 [KO:K07206]
136369968  MTMR4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
136370159  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
136370174  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
136370198  VMP1; vacuole membrane protein 1 [KO:K21248]
136370200  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
136370464  [KO:K16185]
136370597  IRS4; insulin receptor substrate 4 [KO:K07187]
136370598  ATG4A; cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
136370604  RAB39B; ras-related protein Rab-39B [KO:K07925]
136370769  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
136370868  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
136371057  VPS11; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
136371178  [KO:K07925]
136371313  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
136371340  RRAGC; ras-related GTP-binding protein C [KO:K16186]
136371498  NRAS; GTPase NRas [KO:K07828]
136371728  RAB7B; ras-related protein Rab-7b [KO:K07898]
136371752  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
136371801  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
136371898  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
136371914  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
136371928  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
136372035  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
136372191  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
136372245  NBR1; LOW QUALITY PROTEIN: next to BRCA1 gene 1 protein [KO:K17987]
136372250  BECN1; beclin-1 [KO:K08334]
136372470  VAMP8; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
136372564  YKT6; synaptobrevin homolog YKT6 [KO:K08516]
136372745  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
136372953  [KO:K08803] [EC:2.7.11.1]
136373235  [KO:K17606]
136373314  [KO:K06528]
136373501  ATG10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
136373532  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
136373766  IGBP1; immunoglobulin-binding protein 1 isoform X1 [KO:K17606]
136373946  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
136374028  EPG5; ectopic P granules protein 5 homolog [KO:K23883]
136374080  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
136374129  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
136374155  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
136374203  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
136374216  C9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
136374604  WDR41; WD repeat-containing protein 41 [KO:K23610]
136374658  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
136374919  [KO:K04456] [EC:2.7.11.1]
136375063  ATG4D; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
136375256  UVRAG; UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
136375417  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
sati04010  MAPK signaling pathway
sati04141  Protein processing in endoplasmic reticulum
sati04142  Lysosome
sati04150  mTOR signaling pathway
sati04910  Insulin signaling pathway
KO pathway
ko04140   

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