KEGG   PATHWAY: ssco03013
Entry
ssco03013                   Pathway                                
Name
Nucleocytoplasmic transport - Scomber scombrus (Atlantic mackerel)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ssco03013  Nucleocytoplasmic transport
ssco03013

Other DBs
GO: 0050658
Organism
Scomber scombrus (Atlantic mackerel) [GN:ssco]
Gene
133976320  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
133976422  kpnb3; importin-5 [KO:K20222]
133977089  cse1l; exportin-2 [KO:K18423]
133977408  sec13; protein SEC13 homolog [KO:K14004]
133977447  rae1; mRNA export factor isoform X1 [KO:K14298]
133977618  thoc7; THO complex subunit 7 homolog [KO:K13176]
133977940  ipo9; importin-9 [KO:K20224]
133978518  gle1; mRNA export factor GLE1 isoform X1 [KO:K18723]
133978914  thoc5; THO complex subunit 5 homolog [KO:K13174]
133979284  ipo11; importin-11 isoform X1 [KO:K25201]
133980310  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
133980621  nup88; nucleoporin 88 [KO:K14318]
133980834  kpna4; importin subunit alpha-3 [KO:K23583]
133981705  nup93; nuclear pore complex protein Nup93 [KO:K14309]
133982003  snupn; snurportin-1 [KO:K13151]
133982265  nup205; nuclear pore complex protein Nup205 [KO:K14310]
133982351  ahctf1; protein ELYS isoform X1 [KO:K25129]
133983226  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
133983234  kpna5; importin subunit alpha-6 [KO:K15042]
133983691  ipo7; importin-7 [KO:K20223]
133984066  seh1l; nucleoporin SEH1 [KO:K14299]
133984258  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
133984328  magoh; protein mago nashi homolog [KO:K12877]
133984713  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
133984935  [KO:K25202]
133985313  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
133985749  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
133985778  [KO:K12882]
133985847  tmem33; transmembrane protein 33 [KO:K20724]
133985854  nxf1a; nuclear RNA export factor 1 [KO:K14284]
133985892  nxt2; NTF2-related export protein 2 [KO:K14285]
133985979  thoc3; THO complex subunit 3 [KO:K12880]
133986260  ran; GTP-binding nuclear protein Ran [KO:K07936]
133987185  pym1; partner of Y14 and mago [KO:K14294]
133987482  ddx19a; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
133987875  [KO:K03231]
133987953  aaas; aladin [KO:K14320]
133988316  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
133989701  [KO:K15043]
133990264  xpo1a; exportin-1 [KO:K14290]
133990315  acin1a; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
133990445  [KO:K09291]
133990466  thoc1; THO complex subunit 1 [KO:K12878]
133990587  ndc1; nucleoporin NDC1 [KO:K14315]
133990666  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
133991003  [KO:K25202]
133991462  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
133991614  [KO:K14289]
133991646  nup133; nuclear pore complex protein Nup133 [KO:K14300]
133991856  tnpo2b; transportin-2 [KO:K18727]
133992352  xpo1b; exportin-1 isoform X1 [KO:K14290]
133992574  xpo4; exportin-4 [KO:K25203]
133992897  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
133993054  nup35; nucleoporin NUP35 [KO:K14313]
133993058  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
133993179  nup62l; nucleoporin 62 like [KO:K14306]
133993278  kpna3; importin subunit alpha-4 [KO:K23583]
133993363  ranbp2; RANBP2-like and GRIP domain-containing protein 8 isoform X1 [KO:K12172] [EC:2.3.2.-]
133993565  [KO:K12881]
133994084  nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
133994468  thoc2; THO complex subunit 2 [KO:K12879]
133994508  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
133994888  tnpo1; transportin-1 isoform X1 [KO:K18752]
133995037  xpo7; exportin-7 isoform X1 [KO:K18460]
133995097  nup155; nuclear pore complex protein Nup155 [KO:K14312]
133995388  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
133995791  nup54; nucleoporin p54 [KO:K14308]
133995808  nup188; nucleoporin NUP188 [KO:K14311]
133995835  [KO:K03231]
133995836  [KO:K03231]
133996031  kpna6; importin subunit alpha-7 [KO:K15042]
133996074  ddx39b; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:5.6.2.7]
133996560  nup42; nucleoporin NUP42 [KO:K14321]
133997008  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
133997547  sumo2a; small ubiquitin like modifier 2a [KO:K12160]
133997578  nup43; nucleoporin Nup43 [KO:K14305]
133998921  kpnb1; importin subunit beta-1 isoform X1 [KO:K14293]
133998928  thoc6; THO complex subunit 6 homolog [KO:K13175]
133999023  casc3; LOW QUALITY PROTEIN: protein CASC3 [KO:K14323]
133999106  [KO:K18727]
133999114  rangap1a; ran GTPase-activating protein 1a isoform X1 [KO:K14319]
133999483  xpo6; exportin-6 [KO:K25204]
133999580  [KO:K14325]
133999620  nup85; nuclear pore complex protein Nup85 [KO:K14304]
133999693  kpna2; importin subunit alpha-1 [KO:K15043]
133999763  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
133999810  [KO:K10577]
133999822  [KO:K12160]
134000581  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
134000750  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
134000904  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
134000967  pnn; pinin [KO:K13114]
134001956  eef1a1l3; elongation factor 1-alpha-like [KO:K03231]
134001967  kpna7; importin subunit alpha-8 [KO:K15043]
134002294  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
134002373  ipo4; importin-4 [KO:K20221]
134002574  kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
134003282  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
134003480  rangap1b; ran GTPase-activating protein 1b [KO:K14319]
134003782  [KO:K14325]
134004245  tnpo3; transportin-3 isoform X1 [KO:K15436]
134004255  nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
134004308  ipo8; importin-8 isoform X1 [KO:K18755]
134004378  ddx19b; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
134004392  xpot; exportin-T [KO:K14288]
134004446  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
134004546  phax; phosphorylated adapter RNA export protein [KO:K14291]
134004573  nup37; nucleoporin Nup37 [KO:K14302]
134004740  nup107; nuclear pore complex protein Nup107 [KO:K14301]
134006048  acin1b; apoptotic chromatin condensation inducer 1b [KO:K12875]
134006613  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ssco03015  mRNA surveillance pathway
KO pathway
ko03013   

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