KEGG    Network variation - Non-small cell lung cancer
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ENTRYnt06266
NameNon-small cell lung cancer
CategoryDisease view; Cancer
Pathwayhsa05223 Non-small cell lung cancer
DiseaseH00014 Non-small cell lung cancer
Display drug-target relation   disease type
ERK signaling
   D1,D2
 |		         D25
 |		    
N00001    EGF→EGFR→GRB2→SOS→RAS→RAF→MEK→ERK→CCND1
   D3,D4,D5,D6,D7,D1,D8,D9,D10
 |		         D25
 |		    
N00014      EGFR*→GRB2→SOS→RAS→RAF→MEK→ERK→CCND1
             D25
 |		  
N00041      EGFR*→GRB2→SOS→RAS→RAF→MEK→ERK
   D13,D2,D1
 |		         D25
 |		  
N00022    EGF→(ERBB2*+EGFR)→GRB2→SOS→RAS→RAF→MEK→ERK
       D26,D27
 |		     D25
 |		  
N00008          RET*→RAS→RAF→MEK→ERK
       D16,D17,D18,D15,D19
 |		     D25
 |		    
N00007          EML4-ALK→RAS→RAF→MEK→ERK→CCND1
         D20,D21
 |		   D25
 |		    
N00012            (KRAS*,NRAS*)→RAF→MEK→ERK→CCND1
   D1
 |		         D25
 |		  
N00216    HGF→MET→GRB2→SOS→RAS→RAF→MEK→ERK
   D22,D23,D24
 |		         D25
 |		  
N01062      MET*→GRB2→SOS→RAS→RAF→MEK→ERK
 
Calcium signaling
   D1,D2
 |		           D25
 |		    
N00023    EGF→EGFR→PLCG→IP3→(Ca2+,DAG)→PKC→RAF→MEK→ERK→CCND1
   D3,D4,D5,D6,D7,D1,D8,D9,D10
 |		           D25
 |		    
N00024      EGFR*→PLCG→IP3→(Ca2+,DAG)→PKC→RAF→MEK→ERK→CCND1
   D16,D17,D18,D15,D19
 |		           D25
 |		    
N00025      EML4-ALK→PLCG→IP3→(Ca2+,DAG)→PKC→RAF→MEK→ERK→CCND1
 
PI3K signaling
   D1,D2
 |		        
N00033    EGF→EGFR→PI3K→PIP3→AKT⊣BAD
   D3,D4,D5,D6,D7,D1,D8,D9,D10
 |		        
N00036      EGFR*→PI3K→PIP3→AKT⊣BAD
   D16,D17,D18,D15,D19
 |		        
N00047      EML4-ALK→PI3K→PIP3→AKT⊣BAD
   D20,D21
 |		        
N00032      (KRAS*,NRAS*)→PI3K→PIP3→AKT⊣BAD
   D1
 |		          
N00043    HGF→MET→GAB1→PI3K→PIP3→AKT⊣BAD
   D22,D23,D24
 |		          
N01063      MET*→GAB1→PI3K→PIP3→AKT→MTOR
 
Other RAS signaling
   D1,D2
 |		          
N00096    EGF→EGFR→GRB2→SOS→RAS→(RASSF1+RASSF5)→STK4
N00097            RAS⌿(RASSF1*+RASSF5)⌿STK4
 
JAK-STAT signaling
N00053    Cytokine→Receptor→JAK→STAT⇒PIM1
   D16,D17,D18,D15,D19
 |		    
N00105      EML4-ALK→JAK3→STAT3,STAT5
 
Cell cycle
N00066    CDKN2A⊣MDM2⊣TP53⇒CDKN1A⊣(CCND+CDK4/6)→RB1⌿E2F
N00070          CDKN2A*⌿(CCND+CDK4/6)→RB1⌿E2F
 
Transcription
N00115    TP53*⌿(CDKN1A,GADD45,BAX..


Drug name
D1D11894Amivantamab (USAN/INN)
D2D13116Sevabertinib hydrate (JAN)
D3D01977Gefitinib (JP18/USAN/INN)
D4D04023Erlotinib hydrochloride (JAN/USAN)
D5D09733Afatinib dimaleate (USAN)
D6D10514Dacomitinib (USAN)
D7D10766Osimertinib mesylate (USAN)
D8D11969Mobocertinib succinate (JAN)
D9D12245Lazertinib mesylate (USAN)
D10D12506Sunvozertinib (USAN/INN)
D11D11991Zenocutuzumab (USAN/INN)
D12D12879Zongertinib (JAN/USAN/INN)
D13D11529Trastuzumab deruxtecan (USAN/INN)
D14D10926Entrectinib (JAN/USAN/INN)
D15D11012Lorlatinib (JAN/USAN/INN)
D16D09731Crizotinib (JAN/USAN/INN)
D17D10450Alectinib hydrochloride (JAN)
D18D10551Ceritinib (JAN/USAN/INN)
D19D11356Ensartinib hydrochloride (USAN)
D20D12055Sotorasib (JAN/USAN)
D21D12301Adagrasib (USAN/INN)
D22D10891Capmatinib hydrochloride (USAN)
D23D11073Tepotinib hydrochloride (USAN)
D24D12705Gumarontinib hydrate (JAN)
D25D10176Trametinib dimethyl sulfoxide (JAN/USAN)
D26D11712Pralsetinib (USAN/INN)
D27D11713Selpercatinib (JAN/USAN/INN)