KEGG    Network variation - Huntington disease
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ENTRYnt06461
NameHuntington disease
CategoryDisease view; Neurodegenerative disease
Pathwayhsa05016 Huntington disease
DiseaseH00059 Huntington disease
Display drug-target relation   disease type
Calcium signaling
N00984    GlutamateGRM5GNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N00985    GlutamateGRM5GNAQPLCBIP3(ITPR+HTT*)Ca2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N00967            Ca2+(extracellular..VGCCCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N00986          HTT*STX1AVGCC(N-type)Ca2+
N00970            GlutamateNMDARCa2+
N00987          HTT*DLG4NMDARCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9CASP3
 
Ubiquitin-proteasome system
N01029    (Protein+UB)26SPeptide
N01061    HTT*26S
 
Autophagy
N00155    mTORC1ULK1_complexPI3KC3-C1
N00993      HTT*(BECN1+PIK3C3+ATG1..
 
Apoptosis
N00145    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..FADDCASP8(CASP3,CASP7)
N00983        HTT*(HIP1+IFT57)CASP8CASP3
 
TNF signaling
N00446    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAK1+TAB1/2)MKK4/7JNKAP1
N00992        HTT*MLK2MKK7JNK
 
Oxidative phosphorylation
N00988    SuccinateCxIIQH2
N00989    HTT*CxIIQH2
N00990    QH2CxIIICytC
N00991    HTT*CxIIICytC
 
Microtubule-based transport
N00976        (DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
N00977      (HTT*+HAP1)(DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
N00978        (KIF5+KLC)=(TUBA+TUBB)
N00979    HTT*JNK3(KIF5+KLC)=(TUBA+TUBB)
 
Transcription
N00980    HTT*REST=(SIN3A+RCOR1+(HDAC..BDNF
N00981    HTT*(CREB+TAF4)PPARGC1A
N00982    HTT*TP53(BAX,BBC3)