KEGG T01001: 2064

nt06210  ERK signaling
nt06214  PI3K signaling
nt06216  NOTCH signaling
nt06219  JAK-STAT signaling
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06270  Breast cancer

Element

N00021

EGF-ERBB2-RAS-ERK signaling pathway

N00022

ERBB2-overexpression to RAS-ERK signaling pathway

N00034

ERBB2-overexpression to PI3K signaling pathway

N00087

NOTCH-overexpression to Notch signaling pathway

N00095

ERBB2-overexpression to EGF-Jak-STAT signaling pathway

N00252

Amplified ERBB2 to RAS-ERK signaling pathway

N00253

Amplified ERBB2 to PI3K signaling pathway

N10009

Tyrosine kinase inhibitor to HER2 overexpression/amplification

Disease

H00018

Gastric cancer

H00019

Pancreatic cancer

H00022

Bladder cancer

H00026

Endometrial cancer

H00027

Ovarian cancer

H00028

Choriocarcinoma

H00030

Cervical cancer

H00031

Breast cancer

H00046

Cholangiocarcinoma

H01508

Salivary gland cancer

H01554

Fallopian tube cancer

Drug target

Afatinib (DG00717):

D09724 D09733

Canertinib dihydrochloride:

D03350

Dacomitinib (DG01793):

Lapatinib (DG00715):

Lapuleucel-T:

Margetuximab:

Mubritinib:

Nelipepimut-S:

Neratinib (DG02303):

Pertuzumab:

Trastuzumab:

Trastuzumab deruxtecan:

D11529

Trastuzumab duocarmazine:

D11375

Trastuzumab emtansine:

D09980

Tucatinib:

D11141

Varlitinib (DG01357):

D09689 D09690

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2064 (ERBB2)
   04012 ErbB signaling pathway
    2064 (ERBB2)
   04066 HIF-1 signaling pathway
    2064 (ERBB2)
   04020 Calcium signaling pathway
    2064 (ERBB2)
   04151 PI3K-Akt signaling pathway
    2064 (ERBB2)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    2064 (ERBB2)
   04520 Adherens junction
    2064 (ERBB2)
   04530 Tight junction
    2064 (ERBB2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2064 (ERBB2)
   05206 MicroRNAs in cancer
    2064 (ERBB2)
   05205 Proteoglycans in cancer
    2064 (ERBB2)
   05230 Central carbon metabolism in cancer
    2064 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    2064 (ERBB2)
   05226 Gastric cancer
    2064 (ERBB2)
   05219 Bladder cancer
    2064 (ERBB2)
   05215 Prostate cancer
    2064 (ERBB2)
   05213 Endometrial cancer
    2064 (ERBB2)
   05224 Breast cancer
    2064 (ERBB2)
   05223 Non-small cell lung cancer
    2064 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    2064 (ERBB2)
   01524 Platinum drug resistance
    2064 (ERBB2)
   01522 Endocrine resistance
    2064 (ERBB2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2064 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2064 (ERBB2)
   04090 CD molecules [BR:hsa04090]
    2064 (ERBB2)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2064 (ERBB2)
Protein kinases [BR:hsa01001]
Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   2064 (ERBB2)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of breast cancer cells
   2064 (ERBB2)
CD molecules [BR:hsa04090]
Proteins
  2064 (ERBB2)

SSDB

Motif

Pfam:

Pkinase_Tyr Recep_L_domain GF_recep_IV Pkinase Furin-like Haspin_kinase APH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P04626(Tclin)

UniProt:

P04626 X5DNK3

LinkDB

Structure

PDB:

5MY6 3PP0 3H3B 2A91 1N8Z 4HRL 4HRN 6BGT 3MZW 3BE1 6J71 5O4G 3WLW 4HRM 3N85 3RCD 1S78 5K33 3WSQ 6ATT 5KWG 6OGE 5OB4 2N2A 2KS1 2JWA

Position

17q12

AA seq 1255 aa
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV
NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

NT seq 3768 nt +upstreamnt +downstreamnt
atggagctggcggccttgtgccgctgggggctcctcctcgccctcttgccccccggagcc
gcgagcacccaagtgtgcaccggcacagacatgaagctgcggctccctgccagtcccgag
acccacctggacatgctccgccacctctaccagggctgccaggtggtgcagggaaacctg
gaactcacctacctgcccaccaatgccagcctgtccttcctgcaggatatccaggaggtg
cagggctacgtgctcatcgctcacaaccaagtgaggcaggtcccactgcagaggctgcgg
attgtgcgaggcacccagctctttgaggacaactatgccctggccgtgctagacaatgga
gacccgctgaacaataccacccctgtcacaggggcctccccaggaggcctgcgggagctg
cagcttcgaagcctcacagagatcttgaaaggaggggtcttgatccagcggaacccccag
ctctgctaccaggacacgattttgtggaaggacatcttccacaagaacaaccagctggct
ctcacactgatagacaccaaccgctctcgggcctgccacccctgttctccgatgtgtaag
ggctcccgctgctggggagagagttctgaggattgtcagagcctgacgcgcactgtctgt
gccggtggctgtgcccgctgcaaggggccactgcccactgactgctgccatgagcagtgt
gctgccggctgcacgggccccaagcactctgactgcctggcctgcctccacttcaaccac
agtggcatctgtgagctgcactgcccagccctggtcacctacaacacagacacgtttgag
tccatgcccaatcccgagggccggtatacattcggcgccagctgtgtgactgcctgtccc
tacaactacctttctacggacgtgggatcctgcaccctcgtctgccccctgcacaaccaa
gaggtgacagcagaggatggaacacagcggtgtgagaagtgcagcaagccctgtgcccga
gtgtgctatggtctgggcatggagcacttgcgagaggtgagggcagttaccagtgccaat
atccaggagtttgctggctgcaagaagatctttgggagcctggcatttctgccggagagc
tttgatggggacccagcctccaacactgccccgctccagccagagcagctccaagtgttt
gagactctggaagagatcacaggttacctatacatctcagcatggccggacagcctgcct
gacctcagcgtcttccagaacctgcaagtaatccggggacgaattctgcacaatggcgcc
tactcgctgaccctgcaagggctgggcatcagctggctggggctgcgctcactgagggaa
ctgggcagtggactggccctcatccaccataacacccacctctgcttcgtgcacacggtg
ccctgggaccagctctttcggaacccgcaccaagctctgctccacactgccaaccggcca
gaggacgagtgtgtgggcgagggcctggcctgccaccagctgtgcgcccgagggcactgc
tggggtccagggcccacccagtgtgtcaactgcagccagttccttcggggccaggagtgc
gtggaggaatgccgagtactgcaggggctccccagggagtatgtgaatgccaggcactgt
ttgccgtgccaccctgagtgtcagccccagaatggctcagtgacctgttttggaccggag
gctgaccagtgtgtggcctgtgcccactataaggaccctcccttctgcgtggcccgctgc
cccagcggtgtgaaacctgacctctcctacatgcccatctggaagtttccagatgaggag
ggcgcatgccagccttgccccatcaactgcacccactcctgtgtggacctggatgacaag
ggctgccccgccgagcagagagccagccctctgacgtccatcatctctgcggtggttggc
attctgctggtcgtggtcttgggggtggtctttgggatcctcatcaagcgacggcagcag
aagatccggaagtacacgatgcggagactgctgcaggaaacggagctggtggagccgctg
acacctagcggagcgatgcccaaccaggcgcagatgcggatcctgaaagagacggagctg
aggaaggtgaaggtgcttggatctggcgcttttggcacagtctacaagggcatctggatc
cctgatggggagaatgtgaaaattccagtggccatcaaagtgttgagggaaaacacatcc
cccaaagccaacaaagaaatcttagacgaagcatacgtgatggctggtgtgggctcccca
tatgtctcccgccttctgggcatctgcctgacatccacggtgcagctggtgacacagctt
atgccctatggctgcctcttagaccatgtccgggaaaaccgcggacgcctgggctcccag
gacctgctgaactggtgtatgcagattgccaaggggatgagctacctggaggatgtgcgg
ctcgtacacagggacttggccgctcggaacgtgctggtcaagagtcccaaccatgtcaaa
attacagacttcgggctggctcggctgctggacattgacgagacagagtaccatgcagat
gggggcaaggtgcccatcaagtggatggcgctggagtccattctccgccggcggttcacc
caccagagtgatgtgtggagttatggtgtgactgtgtgggagctgatgacttttggggcc
aaaccttacgatgggatcccagcccgggagatccctgacctgctggaaaagggggagcgg
ctgccccagccccccatctgcaccattgatgtctacatgatcatggtcaaatgttggatg
attgactctgaatgtcggccaagattccgggagttggtgtctgaattctcccgcatggcc
agggacccccagcgctttgtggtcatccagaatgaggacttgggcccagccagtcccttg
gacagcaccttctaccgctcactgctggaggacgatgacatgggggacctggtggatgct
gaggagtatctggtaccccagcagggcttcttctgtccagaccctgccccgggcgctggg
ggcatggtccaccacaggcaccgcagctcatctaccaggagtggcggtggggacctgaca
ctagggctggagccctctgaagaggaggcccccaggtctccactggcaccctccgaaggg
gctggctccgatgtatttgatggtgacctgggaatgggggcagccaaggggctgcaaagc
ctccccacacatgaccccagccctctacagcggtacagtgaggaccccacagtacccctg
ccctctgagactgatggctacgttgcccccctgacctgcagcccccagcctgaatatgtg
aaccagccagatgttcggccccagcccccttcgccccgagagggccctctgcctgctgcc
cgacctgctggtgccactctggaaaggcccaagactctctccccagggaagaatggggtc
gtcaaagacgtttttgcctttgggggtgccgtggagaaccccgagtacttgacaccccag
ggaggagctgcccctcagccccaccctcctcctgccttcagcccagccttcgacaacctc
tattactgggaccaggacccaccagagcggggggctccacccagcaccttcaaagggaca
cctacggcagagaacccagagtacctgggtctggacgtgccagtgtga

Homo sapiens (human): 3280

Entry

3280 CDS T01001

Gene name

HES1, HES-1, HHL, HRY, bHLHb39

Definition

(RefSeq) hes family bHLH transcription factor 1

K06054

hairy and enhancer of split 1

Organism

hsa Homo sapiens (human)

Pathway

hsa03460

Fanconi anemia pathway

hsa04330

Notch signaling pathway

hsa04950

Maturity onset diabetes of the young

hsa05165

Human papillomavirus infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05224

Breast cancer

Network

nt06116  NOTCH signaling (viruses)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06216  NOTCH signaling
nt06270  Breast cancer

Element

N00086

Notch signaling pathway

N00087

NOTCH-overexpression to Notch signaling pathway

N00225

EBV EBNA2 to RBP-Jk-mediated transcription

N00380

HPV E6 to Notch signaling pathway

N00381

HPV E6 to Notch signaling pathway

N00382

HPV E6 to Notch signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    3280 (HES1)
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    3280 (HES1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3280 (HES1)
  09162 Cancer: specific types
   05224 Breast cancer
    3280 (HES1)
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    3280 (HES1)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    3280 (HES1)
   05165 Human papillomavirus infection
    3280 (HES1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    3280 (HES1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    3280 (HES1)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    3280 (HES1)
DNA repair and recombination proteins [BR:hsa03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   FA (Fanconi anemia) pathway
    FA core complex binding factors
     3280 (HES1)

SSDB

Motif

Pfam:

Hairy_orange HLH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q14469(Tbio)

UniProt:

Q14469

LinkDB

Structure

PDB:

2MH3

Position

3q29

AA seq 280 aa
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAP
FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAH
SGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN

NT seq 843 nt +upstreamnt +downstreamnt
atgccagctgatataatggagaaaaattcctcgtccccggtggctgctaccccagccagt
gtcaacacgacaccggataaaccaaagacagcatctgagcacagaaagtcatcaaagcct
attatggagaaaagacgaagagcaagaataaatgaaagtctgagccagctgaaaacactg
attttggatgctctgaagaaagatagctcgcggcattccaagctggagaaggcggacatt
ctggaaatgacagtgaagcacctccggaacctgcagcgggcgcagatgacggctgcgctg
agcacagacccaagtgtgctggggaagtaccgagccggcttcagcgagtgcatgaacgag
gtgacccgcttcctgtccacgtgcgagggcgttaataccgaggtgcgcactcggctgctc
ggccacctggccaactgcatgacccagatcaatgccatgacctaccccgggcagccgcac
cccgccttgcaggcgccgccaccgcccccaccgggacccggcggcccccagcacgcgccg
ttcgcgccgccgccgccactcgtgcccatccccgggggcgcggcgccccctcccggcggc
gccccctgcaagctgggcagccaggctggagaggcggctaaggtgtttggaggcttccag
gtggtaccggctcccgatggccagtttgctttcctcattcccaacggggccttcgcgcac
agcggccctgtcatccccgtctacaccagcaacagcggcacctccgtgggccccaacgca
gtgtcaccttccagcggcccctcgcttacggcggactccatgtggaggccgtggcggaac
tga

Homo sapiens (human): 388585

Entry

388585 CDS T01001

Gene name

HES5, bHLHb38

Definition

(RefSeq) hes family bHLH transcription factor 5

K06055

hairy and enhancer of split 5

Organism

hsa Homo sapiens (human)

Pathway

hsa04330

Notch signaling pathway

hsa05165

Human papillomavirus infection

hsa05200

Pathways in cancer

hsa05224

Breast cancer

Network

nt06216 NOTCH signaling
nt06270 Breast cancer

Element

N00087

NOTCH-overexpression to Notch signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    388585 (HES5)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    388585 (HES5)
  09162 Cancer: specific types
   05224 Breast cancer
    388585 (HES5)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    388585 (HES5)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    388585 (HES5)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    388585 (HES5)

SSDB

Motif

Pfam:

HLH Hairy_orange FancD2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q5TA89(Tbio)

UniProt:

Q5TA89

LinkDB

Position

1p36.32

AA seq 166 aa
MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKAD
ILEMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYHFQ
RPPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAAHQPACGLWRPW

NT seq 501 nt +upstreamnt +downstreamnt
atggcccccagcactgtggccgtggagctgctcagccccaaagagaaaaaccgactgcgg
aagccggtggtggagaagatgcgccgcgaccgcatcaacagcagcatcgagcagctgaag
ctgctgctggagcaggagttcgcgcggcaccagcccaactccaagctggagaaggccgac
atcctggagatggctgtcagctacctgaagcacagcaaagccttcgtcgccgccgccggc
cccaagagcctgcaccaggactacagcgaaggctactcgtggtgcctgcaggaggccgtg
cagttcctgacgctccacgccgccagcgacacgcagatgaagctgctgtaccacttccag
cggcccccggccgcgcccgccgcgcccgccaaggagcccaaggcgccgggcgccgcgccc
ccgcccgcgctctccgccaaggccaccgccgccgccgccgccgcgcaccagcccgcctgc
ggcctctggcggccctggtga

Homo sapiens (human): 23462

Entry

23462 CDS T01001

Gene name

HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, NERP2, OAF1, hHRT1

Definition

(RefSeq) hes related family bHLH transcription factor with YRPW motif 1

K09091

hairy and enhancer of split related with YRPW motif

Organism

hsa Homo sapiens (human)

Pathway

hsa04330

Notch signaling pathway

hsa05165

Human papillomavirus infection

hsa05200

Pathways in cancer

hsa05224

Breast cancer

Network

nt06116  NOTCH signaling (viruses)
nt06166  Human papillomavirus (HPV)
nt06216  NOTCH signaling
nt06270  Breast cancer

Element

N00086

Notch signaling pathway

N00087

NOTCH-overexpression to Notch signaling pathway

N00380

HPV E6 to Notch signaling pathway

N00381

HPV E6 to Notch signaling pathway

N00382

HPV E6 to Notch signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    23462 (HEY1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    23462 (HEY1)
  09162 Cancer: specific types
   05224 Breast cancer
    23462 (HEY1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    23462 (HEY1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    23462 (HEY1)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    23462 (HEY1)

SSDB

Motif

Pfam:

HLH Hairy_orange HTH_Crp_2 dCache_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9Y5J3(Tbio)

UniProt:

Q9Y5J3

LinkDB

Structure

PDB:

2DB7

Position

8q21.13

AA seq 304 aa
MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR
RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM
DYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPW
GTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV
LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE
IGAF

NT seq 915 nt +upstreamnt +downstreamnt
atgaagcgagctcaccccgagtacagctcctcggacagcgagctggacgagaccatcgag
gtggagaaggagagtgcggacgagaatggaaacttgagttcggctctaggttccatgtcc
ccaactacatcttcccagattttggccagaaaaagacggagaggaataattgagaagcgc
cgacgagaccggatcaataacagtttgtctgagctgagaaggctggtacccagtgctttt
gagaagcagggatctgctaagctagaaaaagccgagatcctgcagatgaccgtggatcac
ctgaaaatgctgcatacggcaggagggaaaggttactttgacgcgcacgcccttgctatg
gactatcggagtttgggatttcgggaatgcctggcagaagttgcgcgttatctgagcatc
attgaaggactagatgcctctgacccgcttcgagttcgactggtttcgcatctcaacaac
tacgcttcccagcgggaagccgcgagcggcgcccacgcgggcctcggacacattccctgg
gggaccgtcttcggacatcacccgcacatcgcgcacccgctgttgctgccccagaacggc
cacgggaacgcgggcaccacggcctcacccacggaaccgcaccaccagggcaggctgggc
tcggcacatccggaggcgcctgctttgcgagcgccccctagcggcagcctcggaccggtg
ctccctgtggtcacctccgcctccaaactgtcgccgcctctgctctcctcagtggcctcc
ctgtcggccttccccttctctttcggctccttccacttactgtctcccaatgcactgagc
ccttcagcacccacgcaggctgcaaaccttggcaagccctatagaccttgggggacggag
atcggagctttttaa

Homo sapiens (human): 23493

Entry

23493 CDS T01001

Gene name

HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32

Definition

(RefSeq) hes related family bHLH transcription factor with YRPW motif 2

K09091

hairy and enhancer of split related with YRPW motif

Organism

hsa Homo sapiens (human)

Pathway

hsa04330

Notch signaling pathway

hsa05165

Human papillomavirus infection

hsa05200

Pathways in cancer

hsa05224

Breast cancer

Network

nt06216 NOTCH signaling
nt06270 Breast cancer

Element

N00087

NOTCH-overexpression to Notch signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    23493 (HEY2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    23493 (HEY2)
  09162 Cancer: specific types
   05224 Breast cancer
    23493 (HEY2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    23493 (HEY2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    23493 (HEY2)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    23493 (HEY2)

SSDB

Motif

Pfam:

HLH Hairy_orange dCache_2 HTH_Crp_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9UBP5(Tbio)

UniProt:

Q9UBP5

LinkDB

Position

6q22.31

AA seq 337 aa
MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRR
RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMD
FMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPL
HPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRM
PSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAA
TAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF

NT seq 1014 nt +upstreamnt +downstreamnt
atgaagcgcccctgcgaggagacgacctccgagagcgacatggacgagaccatcgacgtg
gggagcgagaacaattactcggggcaaagtactagctctgtgattagattgaattctcca
acaacaacatctcagattatggcaagaaagaaaaggagagggattatagagaaaaggcgt
cgggatcggataaataacagtttatctgagttgagaagacttgtgccaactgcttttgaa
aaacaaggatctgcaaagttagaaaaagctgaaatattgcaaatgacagtggatcatttg
aagatgcttcaggcaacagggggtaaaggctactttgacgcacacgctcttgccatggac
ttcatgagcataggattccgagagtgcctaacagaagttgcgcggtacctgagctccgtg
gaaggcctggactcctcggatccgctgcgggtgcggcttgtgtctcatctcagcacttgc
gccacccagcgggaggcggcggccatgacatcctccatggcccaccaccatcatccgctc
cacccgcatcactgggccgccgccttccaccacctgcccgcagccctgctccagcccaac
ggcctccatgcctcagagtcaaccccttgtcgcctctccacaacttcagaagtgcctcct
gcccacggctctgctctcctcacggccacgtttgcccatgcggattcagccctccgaatg
ccatccacgggcagcgtcgccccctgcgtgccacctctctccacctctctcttgtccctc
tctgccaccgtccacgccgcagccgcagcagccaccgcggctgcacacagcttccctctg
tccttcgcgggggcattccccatgcttcccccaaacgcagcagcagcagtggccgcggcc
acagccatcagcccgcccttgtcagtatcagccacgtccagtcctcagcagaccagcagt
ggaacaaacaataaaccttaccgaccctgggggacagaagttggagctttttaa

Homo sapiens (human): 26508

Entry

26508 CDS T01001

Gene name

HEYL, HESR3, HEY3, HRT3, bHLHb33

Definition

(RefSeq) hes related family bHLH transcription factor with YRPW motif like

K09091

hairy and enhancer of split related with YRPW motif

Organism

hsa Homo sapiens (human)

Pathway

hsa04330

Notch signaling pathway

hsa05165

Human papillomavirus infection

hsa05200

Pathways in cancer

hsa05224

Breast cancer

Network

nt06216 NOTCH signaling
nt06270 Breast cancer

Element

N00087

NOTCH-overexpression to Notch signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    26508 (HEYL)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    26508 (HEYL)
  09162 Cancer: specific types
   05224 Breast cancer
    26508 (HEYL)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    26508 (HEYL)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    26508 (HEYL)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    26508 (HEYL)

SSDB

Motif

Pfam:

HLH Hairy_orange

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9NQ87(Tbio)

UniProt:

Q9NQ87

LinkDB

Position

1p34.2

AA seq 328 aa
MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRIN
SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG
FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF
HSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSR
GASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNS
SSPGPAGRPAGAMLYHSWVSEITEIGAF

NT seq 987 nt +upstreamnt +downstreamnt
atgaagcgacccaaggagccgagcggctccgacggggagtccgacggacccatcgacgtg
ggccaagagggccagctgagccagatggccaggccgctgtccacccccagctcttcgcag
atgcaagccaggaagaaacacagagggatcatagagaaacggcgtcgagaccgcatcaac
agtagcctttctgaattgcgacgcttggtccccactgcctttgagaaacagggctcttcc
aagctggagaaagccgaggtcttgcagatgacggtggatcacttgaaaatgctccatgcc
actggtgggacaggattctttgatgcccgagccctggcagttgacttccggagcattggt
tttcgggagtgcctcactgaggtcatcaggtacctgggggtccttgaagggcccagcagc
cgtgcagaccccgtccggattcgccttctctcccacctcaacagctacgcagccgagatg
gagccttcgcccacgcccactggccctttggccttccctgcctggccctggtctttcttc
catagctgtccagggctgccagccctgagcaaccagctcgccatcctgggaagagtgccc
agccctgtcctccccggtgtctcctctcctgcttaccccatcccagccctccgaaccgct
ccccttcgcagagccacaggcatcatcctgccagcccggaggaatgtgctgcccagtcga
ggggcatcttccacccggagggcccgccccctagagaggccagcgacccctgtgcctgtc
gcccccagcagcagggctgccaggagcagccacatcgctcccctcctgcagtcttcctcc
ccaacaccccctggtcctacagggtcggctgcttacgtggctgttcccacccccaactca
tcctccccagggccagctgggaggccagcgggagccatgctctaccactcctgggtctct
gaaatcactgaaatcggggctttctga

Homo sapiens (human): 2324

Entry

2324 CDS T01001

Gene name

FLT4, FLT-4, FLT41, LMPH1A, LMPHM1, PCL, VEGFR-3, VEGFR3

Definition

(RefSeq) fms related tyrosine kinase 4

K05097

FMS-like tyrosine kinase 4 [EC:2.7.10.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa05200

Pathways in cancer

hsa05224

Breast cancer

Network

nt06216 NOTCH signaling
nt06270 Breast cancer

Element

N00087

NOTCH-overexpression to Notch signaling pathway

Disease

H00535

Hereditary lymphedema

H01471

Lymphangioma

Drug target

Axitinib:

D03218

Cabozantinib (DG01670):

D10062 D10095

Cediranib (DG01360):

D08881 D08883

Dovitinib lactate:

D08907

Lenvatinib (DG01362):

D09919 D09920

Linifanib:

D09635

Motesanib (DG01262):

D06678 D08947

Nintedanib (DG01374):

D10396 D10481

Pazopanib:

D05380

Regorafenib (DG00720):

D10137 D10138

Sitravatinib (DG03045):

Sorafenib (DG00713):

Sunitinib (DG00712):

Tivozanib (DG01375):

Vatalanib:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2324 (FLT4)
   04015 Rap1 signaling pathway
    2324 (FLT4)
   04010 MAPK signaling pathway
    2324 (FLT4)
   04151 PI3K-Akt signaling pathway
    2324 (FLT4)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    2324 (FLT4)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2324 (FLT4)
  09162 Cancer: specific types
   05224 Breast cancer
    2324 (FLT4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2324 (FLT4)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2324 (FLT4)
Protein kinases [BR:hsa01001]
Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   2324 (FLT4)

SSDB

Motif

Pfam:

Pkinase_Tyr Ig_3 I-set Ig_2 Pkinase ig VEGFR-2_TMD V-set C1-set Haspin_kinase

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P35916(Tclin)

UniProt:

P35916

LinkDB

Structure

PDB:

4BSJ 4BSK

Position

5q35.3

AA seq 1363 aa
MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA
WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI
EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG
QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL
ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV
SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA
YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV
PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ
DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV
GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD
AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS
HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE
KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV
GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF
PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL
IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF
RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ
VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW
MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA
TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS
QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM
TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRR
RPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY

NT seq 4092 nt +upstreamnt +downstreamnt
atgcagcggggcgccgcgctgtgcctgcgactgtggctctgcctgggactcctggacggc
ctggtgagtggctactccatgacccccccgaccttgaacatcacggaggagtcacacgtc
atcgacaccggtgacagcctgtccatctcctgcaggggacagcaccccctcgagtgggct
tggccaggagctcaggaggcgccagccaccggagacaaggacagcgaggacacgggggtg
gtgcgagactgcgagggcacagacgccaggccctactgcaaggtgttgctgctgcacgag
gtacatgccaacgacacaggcagctacgtctgctactacaagtacatcaaggcacgcatc
gagggcaccacggccgccagctcctacgtgttcgtgagagactttgagcagccattcatc
aacaagcctgacacgctcttggtcaacaggaaggacgccatgtgggtgccctgtctggtg
tccatccccggcctcaatgtcacgctgcgctcgcaaagctcggtgctgtggccagacggg
caggaggtggtgtgggatgaccggcggggcatgctcgtgtccacgccactgctgcacgat
gccctgtacctgcagtgcgagaccacctggggagaccaggacttcctttccaaccccttc
ctggtgcacatcacaggcaacgagctctatgacatccagctgttgcccaggaagtcgctg
gagctgctggtaggggagaagctggtcctgaactgcaccgtgtgggctgagtttaactca
ggtgtcacctttgactgggactacccagggaagcaggcagagcggggtaagtgggtgccc
gagcgacgctcccagcagacccacacagaactctccagcatcctgaccatccacaacgtc
agccagcacgacctgggctcgtatgtgtgcaaggccaacaacggcatccagcgatttcgg
gagagcaccgaggtcattgtgcatgaaaatcccttcatcagcgtcgagtggctcaaagga
cccatcctggaggccacggcaggagacgagctggtgaagctgcccgtgaagctggcagcg
taccccccgcccgagttccagtggtacaaggatggaaaggcactgtccgggcgccacagt
ccacatgccctggtgctcaaggaggtgacagaggccagcacaggcacctacaccctcgcc
ctgtggaactccgctgctggcctgaggcgcaacatcagcctggagctggtggtgaatgtg
cccccccagatacatgagaaggaggcctcctcccccagcatctactcgcgtcacagccgc
caggccctcacctgcacggcctacggggtgcccctgcctctcagcatccagtggcactgg
cggccctggacaccctgcaagatgtttgcccagcgtagtctccggcggcggcagcagcaa
gacctcatgccacagtgccgtgactggagggcggtgaccacgcaggatgccgtgaacccc
atcgagagcctggacacctggaccgagtttgtggagggaaagaataagactgtgagcaag
ctggtgatccagaatgccaacgtgtctgccatgtacaagtgtgtggtctccaacaaggtg
ggccaggatgagcggctcatctacttctatgtgaccaccatccccgacggcttcaccatc
gaatccaagccatccgaggagctactagagggccagccggtgctcctgagctgccaagcc
gacagctacaagtacgagcatctgcgctggtaccgcctcaacctgtccacgctgcacgat
gcgcacgggaacccgcttctgctcgactgcaagaacgtgcatctgttcgccacccctctg
gccgccagcctggaggaggtggcacctggggcgcgccacgccacgctcagcctgagtatc
ccccgcgtcgcgcccgagcacgagggccactatgtgtgcgaagtgcaagaccggcgcagc
catgacaagcactgccacaagaagtacctgtcggtgcaggccctggaagcccctcggctc
acgcagaacttgaccgacctcctggtgaacgtgagcgactcgctggagatgcagtgcttg
gtggccggagcgcacgcgcccagcatcgtgtggtacaaagacgagaggctgctggaggaa
aagtctggagtcgacttggcggactccaaccagaagctgagcatccagcgcgtgcgcgag
gaggatgcgggacgctatctgtgcagcgtgtgcaacgccaagggctgcgtcaactcctcc
gccagcgtggccgtggaaggctccgaggataagggcagcatggagatcgtgatccttgtc
ggtaccggcgtcatcgctgtcttcttctgggtcctcctcctcctcatcttctgtaacatg
aggaggccggcccacgcagacatcaagacgggctacctgtccatcatcatggaccccggg
gaggtgcctctggaggagcaatgcgaatacctgtcctacgatgccagccagtgggaattc
ccccgagagcggctgcacctggggagagtgctcggctacggcgccttcgggaaggtggtg
gaagcctccgctttcggcatccacaagggcagcagctgtgacaccgtggccgtgaaaatg
ctgaaagagggcgccacggccagcgagcaccgcgcgctgatgtcggagctcaagatcctc
attcacatcggcaaccacctcaacgtggtcaacctcctcggggcgtgcaccaagccgcag
ggccccctcatggtgatcgtggagttctgcaagtacggcaacctctccaacttcctgcgc
gccaagcgggacgccttcagcccctgcgcggagaagtctcccgagcagcgcggacgcttc
cgcgccatggtggagctcgccaggctggatcggaggcggccggggagcagcgacagggtc
ctcttcgcgcggttctcgaagaccgagggcggagcgaggcgggcttctccagaccaagaa
gctgaggacctgtggctgagcccgctgaccatggaagatcttgtctgctacagcttccag
gtggccagagggatggagttcctggcttcccgaaagtgcatccacagagacctggctgct
cggaacattctgctgtcggaaagcgacgtggtgaagatctgtgactttggccttgcccgg
gacatctacaaagaccccgactacgtccgcaagggcagtgcccggctgcccctgaagtgg
atggcccctgaaagcatcttcgacaaggtgtacaccacgcagagtgacgtgtggtccttt
ggggtgcttctctgggagatcttctctctgggggcctccccgtaccctggggtgcagatc
aatgaggagttctgccagcggctgagagacggcacaaggatgagggccccggagctggcc
actcccgccatacgccgcatcatgctgaactgctggtccggagaccccaaggcgagacct
gcattctcggagctggtggagatcctgggggacctgctccagggcaggggcctgcaagag
gaagaggaggtctgcatggccccgcgcagctctcagagctcagaagagggcagcttctcg
caggtgtccaccatggccctacacatcgcccaggctgacgctgaggacagcccgccaagc
ctgcagcgccacagcctggccgccaggtattacaactgggtgtcctttcccgggtgcctg
gccagaggggctgagacccgtggttcctccaggatgaagacatttgaggaattccccatg
accccaacgacctacaaaggctctgtggacaaccagacagacagtgggatggtgctggcc
tcggaggagtttgagcagatagagagcaggcatagacaagaaagcggcttcagctgtaaa
ggacctggccagaatgtggctgtgaccagggcacaccctgactcccaagggaggcggcgg
cggcctgagcggggggcccgaggaggccaggtgttttacaacagcgagtatggggagctg
tcggagccaagcgaggaggaccactgctccccgtctgcccgcgtgactttcttcacagac
aacagctactaa

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