KEGG   PATHWAY: cpoo04820
Entry
cpoo04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Crocodylus porosus (Australian saltwater crocodile)
Class
Cellular Processes; Cell motility
Pathway map
cpoo04820  Cytoskeleton in muscle cells
cpoo04820

Organism
Crocodylus porosus (Australian saltwater crocodile) [GN:cpoo]
Gene
109305483  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109305615  MYH15; myosin-15 isoform X1 [KO:K24220]
109305855  ITGB1; integrin beta-1 [KO:K05719]
109305941  DMD; dystrophin isoform X1 [KO:K10366]
109306258  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
109306319  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109306343  MYL3; myosin light chain 3 [KO:K12749]
109306465  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
109306617  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
109306661  SGCG; gamma-sarcoglycan [KO:K12564]
109306692  VIM; vimentin [KO:K07606]
109307229  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
109307329  COL24A1; collagen alpha-1(XXIV) chain isoform X1 [KO:K19721]
109307896  ITGA1; integrin alpha-1 [KO:K06480]
109307900  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
109307935  ACTBL2; beta-actin-like protein 2 [KO:K05692]
109307991  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
109308039  NEBL; nebulette isoform X1 [KO:K25865]
109308080  VCAN; versican core protein isoform X1 [KO:K06793]
109308352  ITGA8; integrin alpha-8 [KO:K06584]
109308595  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
109308617  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109308618  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109308768  [KO:K07611]
109308866  [KO:K05692]
109308897  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
109308931  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
109308932  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
109308934  TLN2; talin-2 isoform X1 [KO:K06271]
109309017  TMOD3; tropomodulin-3 isoform X1 [KO:K10370]
109309018  [KO:K10370]
109309040  FBN1; fibrillin-1 isoform X1 [KO:K06825]
109309184  [KO:K05692]
109309210  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
109309352  MYOZ2; myozenin-2 [KO:K26050]
109309353  SYNPO2; synaptopodin-2 [KO:K24066]
109309369  ANK2; ankyrin-2 isoform X1 [KO:K09255]
109309616  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109309838  ITGA9; integrin alpha-9 [KO:K06585]
109309884  [KO:K19867]
109310076  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
109310120  MYOT; myotilin isoform X1 [KO:K19875]
109310171  MYOZ3; myozenin-3 [KO:K26050]
109310201  SGCD; delta-sarcoglycan [KO:K12563]
109310381  SNTB2; beta-2-syntrophin [KO:K24064]
109311005  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
109311034  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
109311090  [KO:K24220]
109311091  [KO:K24220]
109311182  LMOD3; leiomodin-3 [KO:K22030]
109311199  [KO:K06238]
109311253  TMEM43; transmembrane protein 43 [KO:K27488]
109311346  FBLN2; fibulin-2 isoform X1 [KO:K17307]
109311572  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
109311710  MYOM2; myomesin-2 [KO:K24495]
109312080  SDC1; syndecan-1 [KO:K06257]
109312111  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
109312162  LAMA2; laminin subunit alpha-2 [KO:K05637]
109312347  COMP; cartilage oligomeric matrix protein [KO:K04659]
109312383  TPM4; tropomyosin alpha-4 chain [KO:K10375]
109312452  MYPN; myopalladin isoform X1 [KO:K22028]
109312539  ANK3; ankyrin-3 isoform X1 [KO:K09259]
109312653  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109313119  TNNC2; troponin C, skeletal muscle [KO:K12042]
109313179  SDC4; syndecan-4 [KO:K16338]
109313214  MYH7B; myosin-7B [KO:K24220]
109313257  [KO:K12755]
109313262  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
109313312  SNTA1; alpha-1-syntrophin [KO:K24063]
109313577  ATP1B4; protein ATP1B4 [KO:K01540]
109313718  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109313720  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
109313841  [KO:K19721]
109313864  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
109313880  LAMA1; laminin subunit alpha-1 [KO:K05637]
109313894  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
109314132  [KO:K19721]
109314359  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
109314435  AGRN; agrin isoform X1 [KO:K06254]
109314446  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
109314483  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
109314507  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
109314576  MYH11; myosin-11 isoform X1 [KO:K10352]
109314696  ACTB; actin, cytoplasmic 1 [KO:K05692]
109314752  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
109314911  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109315079  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109315233  MYH10; myosin-10 [KO:K10352]
109315366  DSP; desmoplakin isoform X1 [KO:K10381]
109315471  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
109315538  OBSCN; obscurin [KO:K17531] [EC:2.7.11.1]
109315621  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
109315649  LMOD2; leiomodin-2 [KO:K22030]
109316328  FBLN1; fibulin-1 isoform X1 [KO:K17307]
109316377  SSPN; sarcospan [KO:K22194]
109316416  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
109316505  PKP2; plakophilin-2 isoform X1 [KO:K12642]
109316547  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
109316616  MYH9; myosin-9 [KO:K10352]
109316683  SUN2; SUN domain-containing protein 2 [KO:K19347]
109316870  DCN; decorin [KO:K04660]
109317543  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
109317579  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
109317581  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
109317582  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
109317590  MYBPH; myosin-binding protein H isoform X1 [KO:K24494]
109317615  LMOD1; leiomodin-1 [KO:K22030]
109317687  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
109317747  MYOM1; myomesin-1 isoform X1 [KO:K24495]
109317874  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
109318225  DSC1; desmocollin-1 isoform X1 [KO:K07601]
109318247  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
109318257  [KO:K07597]
109318269  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
109318324  DAG1; dystroglycan [KO:K06265]
109318387  MYOM3; myomesin-3 [KO:K24495]
109318422  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
109318481  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
109318587  FHL3; four and a half LIM domains protein 3 [KO:K24414]
109318647  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
109318649  SDC3; syndecan-3 [KO:K16337]
109318829  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
109318862  [KO:K10654]
109318944  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
109318952  MYL4; myosin light chain 4 [KO:K12750]
109318975  ITGB3; integrin beta-3 [KO:K06493]
109318983  ZYX; zyxin isoform X1 [KO:K06273]
109319000  ITGA3; integrin alpha-3 [KO:K06482]
109319209  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
109319226  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
109319346  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
109319385  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
109319601  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
109319772  LBR; lamin-B receptor isoform X1 [KO:K19532] [EC:1.3.1.70]
109319824  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
109319950  FMN2; LOW QUALITY PROTEIN: formin-2 [KO:K02184]
109319957  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
109319965  NID1; nidogen-1 [KO:K06826]
109319995  ACTA1; actin, alpha skeletal muscle [KO:K10354]
109320024  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
109320106  SYNE1; nesprin-1 [KO:K19326]
109320282  [KO:K19879]
109320283  TCAP; telethonin [KO:K19879]
109320343  JUP; junction plakoglobin [KO:K10056]
109320520  LMNB2; lamin-B2 [KO:K07611]
109320529  FBN3; fibrillin-3 [KO:K23342]
109320623  [KO:K23958]
109320650  SYNE2; nesprin-2 [KO:K19346]
109320654  SDC2; syndecan-2 [KO:K16336]
109320682  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
109320787  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
109320792  THBS1; thrombospondin-1 [KO:K16857]
109321048  [KO:K12314]
109321181  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
109321286  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
109321300  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
109321511  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
109321517  MYBPC3; myosin-binding protein C, cardiac-type isoform X1 [KO:K12568]
109321560  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
109321572  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
109321649  SNTB1; beta-1-syntrophin [KO:K24064]
109321726  SYNE3; nesprin-3 isoform X1 [KO:K21761]
109321961  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
109322036  SGCB; beta-sarcoglycan [KO:K12566]
109322127  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
109322340  SGCZ; zeta-sarcoglycan [KO:K27062]
109322476  TTN; titin [KO:K12567] [EC:2.7.11.1]
109322492  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
109322550  NEB; nebulin [KO:K18267]
109322551  FMNL2; formin-like protein 2 [KO:K23957]
109322648  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
109322680  FN1; fibronectin isoform X1 [KO:K05717]
109322701  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
109322710  COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720]
109322723  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
109322751  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109322812  ITGAV; integrin alpha-V [KO:K06487]
109322850  ITGA4; integrin alpha-4 [KO:K06483]
109322870  ITGB5; integrin beta-5 [KO:K06588]
109322928  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109323033  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109323128  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
109323135  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
109323217  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
109323322  MYL5; myosin light chain 5 [KO:K12753]
109323411  FBN2; fibrillin-2 isoform X1 [KO:K23342]
109323441  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
109323590  LMNB1; lamin-B1 [KO:K07611]
109323700  LMNA; lamin [KO:K12641]
109323907  VCL; vinculin isoform X1 [KO:K05700]
109323961  CUNH10orf71; uncharacterized protein C10orf71 homolog [KO:K28413]
109324054  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
109324196  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
109324200  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
109324253  NRAP; nebulin-related-anchoring protein [KO:K24421]
109324328  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
109324333  MYOZ1; myozenin-1 [KO:K26050]
109324573  NID2; nidogen-2 [KO:K06826]
109324656  COL5A3; collagen alpha-3(V) chain [KO:K19721]
109324699  THBS3; thrombospondin-3 [KO:K04659]
109324775  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
109324832  TMOD4; tropomodulin-4 [KO:K10370]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
cpoo04512  ECM-receptor interaction
cpoo04814  Motor proteins
KO pathway
ko04820   

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